KEGG PATHWAY: ppoi04145

KEGG

PATHWAY: ppoi04145

Entry

ppoi04145                   Pathway

Name

Phagosome - Pollicipes pollicipes (gooseneck barnacle)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

Phagosome

Other DBs

GO:

Organism

Pollicipes pollicipes (gooseneck barnacle) [GN:ppoi]

Gene

LOW QUALITY PROTEIN: syntaxin-7-like [KO:K13813]

actin, clone 403 [KO:K05692]

actin, clone 403 [KO:K05692]

actin-85C-like [KO:K05692]

actin, clone 403 [KO:K05692]

syntaxin-18-like isoform X1 [KO:K08492]

syntaxin-18-like [KO:K08492]

vesicle-trafficking protein SEC22b-B-like [KO:K08517]

vesicle-trafficking protein SEC22b-B-like [KO:K08517]

ras-related protein Rab-5B-like [KO:K07888]

ras-related protein Rab5A-like [KO:K07889]

phosphatidylinositol 3-kinase catalytic subunit type 3-like [KO:K00914] [EC:2.7.1.137]

phosphatidylinositol 3-kinase catalytic subunit type 3-like [KO:K00914] [EC:2.7.1.137]

hepatocyte growth factor-regulated tyrosine kinase substrate-like [KO:K12182]

hepatocyte growth factor-regulated tyrosine kinase substrate-like [KO:K12182]

LOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase subunit B-like [KO:K02147]

V-type proton ATPase subunit B isoform X1 [KO:K02147]

V-type proton ATPase subunit C 1-A-like [KO:K02148]

V-type proton ATPase subunit C 1-A-like [KO:K02148]

V-type proton ATPase subunit D-like [KO:K02149]

V-type proton ATPase subunit E-like [KO:K02150]

V-type proton ATPase subunit E-like [KO:K02150]

V-type proton ATPase subunit F-like [KO:K02151]

V-type proton ATPase subunit G-like [KO:K02152]

V-type proton ATPase subunit G-like [KO:K02152]

V-type proton ATPase subunit e-like [KO:K02153]

V-type proton ATPase 116 kDa subunit a1-like [KO:K02154]

V-type proton ATPase 116 kDa subunit a1-like isoform X1 [KO:K02154]

V-type proton ATPase 116 kDa subunit a1-like [KO:K02154]

V-type proton ATPase subunit d [KO:K02146]

V-type proton ATPase subunit H-like isoform X1 [KO:K02144]

V-type proton ATPase subunit H-like [KO:K02144]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 21 kDa proteolipid subunit-like [KO:K03661]

V-type proton ATPase subunit S1-like [KO:K03662]

V-type proton ATPase subunit S1-like [KO:K03662]

ras-related protein Rab-7a-like [KO:K07897]

LOW QUALITY PROTEIN: dynein heavy chain, cytoplasmic-like [KO:K10413]

LOW QUALITY PROTEIN: dynein heavy chain, cytoplasmic-like [KO:K10413]

cytoplasmic dynein 2 heavy chain 1-like [KO:K10414]

cytoplasmic dynein 1 intermediate chain-like [KO:K10415]

LOW QUALITY PROTEIN: cytoplasmic dynein 1 intermediate chain-like [KO:K10415]

cytoplasmic dynein 1 intermediate chain-like [KO:K10415]

cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]

tubulin alpha-2/alpha-4 chain-like [KO:K07374]

tubulin alpha-2/alpha-4 chain-like [KO:K07374]

tubulin alpha-3 chain-like [KO:K07374]

tubulin alpha-1D chain-like [KO:K07374]

tubulin alpha-1 chain-like [KO:K07374]

tubulin alpha-1 chain-like [KO:K07374]

tubulin alpha-1 chain-like [KO:K07374]

tubulin alpha-3 chain-like isoform X1 [KO:K07374]

tubulin alpha-1 chain-like [KO:K07374]

tubulin alpha-1C chain-like [KO:K07374]

tubulin alpha-1C chain-like [KO:K07374]

tubulin alpha chain-like [KO:K07374]

tubulin alpha-1C chain-like [KO:K07374]

tubulin alpha-1D chain-like [KO:K07374]

tubulin alpha-1 chain-like [KO:K07374]

tubulin alpha-3 chain [KO:K07374]

tubulin alpha chain-like [KO:K07374]

tubulin beta-4B chain-like [KO:K07375]

tubulin beta-4B chain-like [KO:K07375]

tubulin beta chain-like [KO:K07375]

tubulin beta-4B chain-like [KO:K07375]

tubulin beta-4B chain-like [KO:K07375]

tubulin beta chain-like [KO:K07375]

tubulin beta-4B chain [KO:K07375]

tubulin beta-4B chain-like [KO:K07375]

tubulin beta-4B chain [KO:K07375]

tubulin beta chain-like [KO:K07375]

tubulin beta chain-like [KO:K07375]

tubulin beta-1 chain [KO:K07375]

tubulin beta chain-like [KO:K07375]

lysosome-associated membrane glycoprotein 1-like [KO:K06528]

1-phosphatidylinositol 3-phosphate 5-kinase-like [KO:K00921] [EC:2.7.1.150]

uncharacterized protein LOC119097788 [KO:K10089]

cation-dependent mannose-6-phosphate receptor-like [KO:K10089]

cation-dependent mannose-6-phosphate receptor-like [KO:K10089]

nitric oxide synthase-like protein [KO:K13240] [EC:1.14.13.39]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

LOW QUALITY PROTEIN: digestive cysteine proteinase 2-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

LOW QUALITY PROTEIN: digestive cysteine proteinase 2-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

digestive cysteine proteinase 2-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

procathepsin L-like [KO:K01365] [EC:3.4.22.15]

protein transport protein Sec61 subunit alpha [KO:K10956]

protein transport protein Sec61 subunit alpha-like [KO:K10956]

protein transport protein Sec61 subunit beta-like [KO:K09481]

protein transport protein Sec61 subunit beta-like [KO:K09481]

protein transport protein Sec61 subunit beta-like [KO:K09481]

LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]

calreticulin-like [KO:K08057]

calnexin-like [KO:K08054]

uncharacterized protein LOC119099730 [KO:K10067]

uncharacterized protein LOC119093348 [KO:K10067]

integrin alpha pat-2-like [KO:K06487]

integrin beta-PS-like isoform X1 [KO:K05719]

integrin beta-PS-like isoform X1 [KO:K05719]

integrin beta pat-3-like [KO:K05719]

uncharacterized protein LOC119106191 [KO:K05719]

integrin beta-PS-like [KO:K05719]

integrin beta-PS-like [KO:K05719]

integrin beta-PS-like [KO:K05719]

cartilage oligomeric matrix protein-like [KO:K04659]

cartilage oligomeric matrix protein-like isoform X1 [KO:K04659]

LOW QUALITY PROTEIN: cartilage oligomeric matrix protein-like [KO:K04659]

toll-like receptor 2 type-2 [KO:K10159]

macrophage mannose receptor 1-like [KO:K06560]

C-type mannose receptor 2-like [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1-like isoform X1 [KO:K06560]

protein croquemort-like [KO:K13885]

ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]

ras-related C3 botulinum toxin substrate 1-like [KO:K04392]

ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K04392]

ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]

Compound

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002

Reference

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R

Reference

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036

Reference

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005

Reference

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511

Reference

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217

Reference

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x

Related
pathway

Lysosome

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system