KEGG   PATHWAY: ppyr00982
Entry
ppyr00982                   Pathway                                
Name
Drug metabolism - cytochrome P450 - Photinus pyralis (common eastern firefly)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ppyr00982  Drug metabolism - cytochrome P450
ppyr00982

Organism
Photinus pyralis (common eastern firefly) [GN:ppyr]
Gene
116167738  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116177271  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
116168599  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116158692  pyrimidodiazepine synthase-like [KO:K00799] [EC:2.5.1.18]
116158715  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116158987  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116178787  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116179223  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
116159428  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116159657  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
116161781  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116181425  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
116181532  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
116163152  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116172953  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116172954  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116173220  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116173484  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
116173907  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116173965  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
116173999  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
116174000  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116174001  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
116174039  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116174040  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
116174466  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116174517  uncharacterized protein LOC116174517 [KO:K00799] [EC:2.5.1.18]
116174643  pyrimidodiazepine synthase-like [KO:K00799] [EC:2.5.1.18]
116174966  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
116175139  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
116166776  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
116177328  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
116180617  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
116180621  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
116180795  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
116180827  LOW QUALITY PROTEIN: glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
116181370  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
116181371  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
116181373  glutathione S-transferase-like isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
116173916  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
116174942  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
116165342  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
116163525  aldehyde dehydrogenase family 3 member B1-like isoform X1 [KO:K00129] [EC:1.2.1.5]
116168251  UDP-glucuronosyltransferase 1-5-like [KO:K00699] [EC:2.4.1.17]
116168252  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
116169126  UDP-glucuronosyltransferase 2B19-like [KO:K00699] [EC:2.4.1.17]
116169468  UDP-glucuronosyltransferase 1-9-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116169469  UDP-glucuronosyltransferase 1-7C-like [KO:K00699] [EC:2.4.1.17]
116159877  UDP-glucuronosyltransferase 2B19-like [KO:K00699] [EC:2.4.1.17]
116169888  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116179952  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
116180065  UDP-glucuronosyltransferase 2B16-like [KO:K00699] [EC:2.4.1.17]
116160027  UDP-glucuronosyltransferase 2B19-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116160091  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
116160151  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116160160  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
116160546  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116160558  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
116170684  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116180302  UDP-glucuronosyltransferase 2B1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116180609  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116161274  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
116180810  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116180931  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
116180962  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116181004  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116181045  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
116181047  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
116181111  UDP-glucuronosyltransferase 3A2-like [KO:K00699] [EC:2.4.1.17]
116181155  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116181211  UDP-glucuronosyltransferase 1-3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116181215  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116181246  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
116181248  UDP-glucuronosyltransferase 2B2-like [KO:K00699] [EC:2.4.1.17]
116181270  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116161729  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
116161730  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116161818  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
116161886  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116161950  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
116161952  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116161953  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
116161954  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
116181343  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116181350  UDP-glucuronosyltransferase 2B1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116181443  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116181489  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
116181742  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116162392  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116182652  UDP-glucuronosyltransferase 2B19-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116173883  UDP-glucuronosyltransferase 2B10-like [KO:K00699] [EC:2.4.1.17]
116174532  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116174692  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
116174748  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
116175826  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116176217  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
LinkDB

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