KEGG   PATHWAY: rei02020
Entry
rei02020                    Pathway                                
Name
Two-component system - Rhizobium etli bv. mimosae IE4771
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
rei02020  Two-component system
rei02020

Other DBs
GO: 0000160
Organism
Rhizobium etli bv. mimosae IE4771 [GN:rei]
Gene
IE4771_CH00574  sensor histidine kinase protein [KO:K07636] [EC:2.7.13.3]
IE4771_PE00279  response regulator protein [KO:K07657]
IE4771_PE00290  response regulator CheY-like domain-containing protein [KO:K07657]
IE4771_CH00580  phoB; phosphate regulon transcriptional regulatory protein PhoB [KO:K07657]
IE4771_CH01631  pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
IE4771_CH00575  ABC transporter substrate-binding protein [KO:K02040]
IE4771_CH03265  sensor histidine kinase protein [KO:K07638] [EC:2.7.13.3]
IE4771_CH03266  transcriptional regulatory OmpR protein [KO:K07659]
IE4771_CH01380  degP-3; serine protease Do 3 [KO:K04771] [EC:3.4.21.107]
IE4771_CH01180  degP-1; serine protease Do 1 [KO:K04771] [EC:3.4.21.107]
IE4771_CH02963  degP-5; serine protease Do 5 [KO:K04771] [EC:3.4.21.107]
IE4771_CH01393  RND family efflux transporter protein [KO:K07799]
IE4771_CH03068  flagellin domain-containing protein [KO:K02406]
IE4771_CH04449  flaC-6; flagellin C 6 [KO:K02406]
IE4771_CH02995  flaC-5; flagellin C 5 [KO:K02406]
IE4771_PC00369  flaC-7; flagellin C 7 [KO:K02406]
IE4771_CH00723  flaC-1; flagellin C 1 [KO:K02406]
IE4771_CH00724  flaC-2; flagellin C 2 [KO:K02406]
IE4771_CH00725  flaC-3; flagellin C 3 [KO:K02406]
IE4771_CH00726  flaC-4; flagellin C 4 [KO:K02406]
IE4771_CH00708  motA; motility protein MotA [KO:K02556]
IE4771_PC00208  kdpD; sensor histidine kinase KdpD [KO:K07646] [EC:2.7.13.3]
IE4771_PC00207  kdpE; response regulator protein KdpE [KO:K07667]
IE4771_PC00211  kdpA; potassium-transporting ATPase A subunit [KO:K01546]
IE4771_PC00210  kdpB; potassium-transporting ATPase B subunit [KO:K01547] [EC:7.2.2.6]
IE4771_PC00209  kdpC; potassium-transporting ATPase C subunit [KO:K01548]
IE4771_CH03905  sensor histidine kinase protein [KO:K07649] [EC:2.7.13.3]
IE4771_PD00317  sensor histidine kinase protein [KO:K07649] [EC:2.7.13.3]
IE4771_PD00318  tctD; transcriptional regulatory protein TctD [KO:K07774]
IE4771_CH03904  response regulator protein [KO:K07774]
IE4771_CH03899  TctA family tripartite tricarboxylate transporter protein [KO:K07793]
IE4771_CH03696  TctA family tripartite tricarboxylate transporter protein [KO:K07793]
IE4771_CH03900  TctB family tripartite tricarboxylate transporter protein [KO:K07794]
IE4771_CH03697  TctB family tripartite tricarboxylate transporter protein [KO:K07794]
IE4771_PD00156  TctB family tripartite tricarboxylate transporter protein [KO:K07794]
IE4771_CH03901  bordetella uptake domain-containing protein [KO:K07795]
IE4771_CH03698  bordetella uptake domain-containing protein [KO:K07795]
IE4771_CH01613  ctaA; heme A synthase [KO:K02259] [EC:1.17.99.9]
IE4771_CH00395  dnaA; chromosomal replication initiation protein DnaA [KO:K02313]
IE4771_CH03779  lysylphosphatidylglycerol synthetase domain-containing protein [KO:K14205] [EC:2.3.2.3]
IE4771_CH00035  chvG; sensor histidine kinase ChvG [KO:K14980] [EC:2.7.13.3]
IE4771_CH00036  chvI; response regulator ChvI [KO:K14981]
IE4771_CH04425  citrate lyase beta subunit protein [KO:K01644] [EC:4.1.3.34]
IE4771_PE00058  citrate lyase subunit beta-like protein [KO:K01644] [EC:4.1.3.34]
IE4771_CH01803  response regulator CheY-like domain-containing protein [KO:K07684]
IE4771_PE00607  response regulator CheY-like domain-containing protein [KO:K07684]
IE4771_CH04337  LuxR family transcriptional regulator protein [KO:K07782]
IE4771_PE00450  LuxR family transcriptional regulator protein [KO:K07782]
IE4771_CH00681  LuxR family transcriptional regulator protein [KO:K07782]
IE4771_CH03461  ampC; beta-lactamase [KO:K01467] [EC:3.5.2.6]
IE4771_CH01353  fatty acid desaturase protein [KO:K10255] [EC:1.14.19.23 1.14.19.45]
IE4771_PE00308  hypothetical protein [KO:K02651]
IE4771_CH04078  Flp/Fap pilin component protein [KO:K02651]
IE4771_CH00226  Flp/Fap pilin component protein [KO:K02651]
IE4771_PE00307  cpaB-2; Flp pilus assembly protein CpaB 2 [KO:K02279]
IE4771_CH00228  cpaB-1; Flp pilus assembly protein CpaB 1 [KO:K02279]
IE4771_PE00306  cpaC-2; Flp pilus assembly secretion protein CpaC 2 [KO:K02280]
IE4771_CH00229  cpaC-1; Flp pilus assembly secretion protein CpaC 1 [KO:K02280]
IE4771_PE00301  response regulator/pilus assembly domain-containing protein [KO:K02282]
IE4771_CH00231  cpaE; Flp pilus assembly ATP-binding protein CpaE [KO:K02282]
IE4771_PE00299  cpaF-2; Flp pilus assembly ATP-binding protein CpaF 2 [KO:K02283] [EC:7.4.2.8]
IE4771_CH00232  cpaF-1; Flp pilus assembly ATP-binding protein CpaF 1 [KO:K02283] [EC:7.4.2.8]
IE4771_PE00298  type II secretion system F domain-containing protein [KO:K12510]
IE4771_CH00233  type II secretion system F domain-containing protein [KO:K12510]
IE4771_PE00297  type II secretion system F domain-containing protein [KO:K12511]
IE4771_CH00234  type II secretion system F domain-containing protein [KO:K12511]
IE4771_CH00424  glnD; PII uridylyl-transferase [KO:K00990] [EC:2.7.7.59]
IE4771_CH02202  glnB-1; nitrogen regulatory protein P-II GlnB 1 [KO:K04751]
IE4771_CH02082  ntrB; nitrogen regulation protein NtrB [KO:K07708] [EC:2.7.13.3]
IE4771_CH02083  ntrC; nitrogen assimilation regulatory protein NtrC [KO:K07712]
IE4771_CH00760  glutamine synthetase GlnA-like protein [KO:K01915] [EC:6.3.1.2]
IE4771_CH03365  glnII; glutamine synthetase 2 [KO:K01915] [EC:6.3.1.2]
IE4771_CH01404  glutamine synthetase GlnA-like protein [KO:K01915] [EC:6.3.1.2]
IE4771_CH02201  glnA; glutamine synthetase 1 [KO:K01915] [EC:6.3.1.2]
IE4771_CH03152  glutamine synthetase protein [KO:K01915] [EC:6.3.1.2]
IE4771_PC00383  glnT; glutamine synthetase 3 [KO:K01915] [EC:6.3.1.2]
IE4771_CH02107  ntrY; sensor histidine kinase nitrogen regulation protein NtrY [KO:K13598] [EC:2.7.13.3]
IE4771_CH02108  ntrX; response regulator nitrogen regulation protein NtrX [KO:K13599]
IE4771_PB00109  nifA-1; Nif-specific regulatory protein NifA 1 [KO:K02584]
IE4771_PB00180  nifA-2; Nif-specific regulatory protein NifA 2 [KO:K02584]
IE4771_CH04354  phbA-1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
IE4771_PB00267  phbA-2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
IE4771_PC00307  acetyl-CoA acetyltransferase protein [KO:K00626] [EC:2.3.1.9]
IE4771_PD00023  vraB; acetyl-CoA C-acetyltransferase VraB [KO:K00626] [EC:2.3.1.9]
IE4771_PE00068  acetyl-CoA acetyltransferase protein [KO:K00626] [EC:2.3.1.9]
IE4771_CH00625  fadA; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
IE4771_CH03700  sensor histidine kinase protein [KO:K10125] [EC:2.7.13.3]
IE4771_CH03237  dctB; C4-dicarboxylate transport sensor histidine kinase DctB [KO:K10125] [EC:2.7.13.3]
IE4771_CH03238  dctD; C4-dicarboxylate transport response regulator DctD [KO:K10126]
IE4771_CH03699  response regulator protein [KO:K10126]
IE4771_CH03236  dctA; C4-dicarboxylate transport protein DctA [KO:K11103]
IE4771_PB00190  rpoN-2; RNA polymerase sigma-54 factor RpoN 2 [KO:K03092]
IE4771_CH00442  rpoN-1; RNA polymerase sigma-54 factor RpoN 1 [KO:K03092]
IE4771_PB00311  hupK; hydrogenase expression/formation protein HupK [KO:K23549] [EC:1.12.99.6]
IE4771_PB00320  hupA; uptake hydrogenase small subunit [KO:K06282] [EC:1.12.99.6]
IE4771_PB00319  hupB; uptake hydrogenase large subunit [KO:K06281] [EC:1.12.99.6]
IE4771_PB00318  hupC; Ni/Fe hydrogenase B-type cytochrome subunit HupC [KO:K03620]
IE4771_CH03814  cheR-2; methyl-accepting chemotaxis protein O-methyltransferase 2 [KO:K00575] [EC:2.1.1.80]
IE4771_CH00695  cheR-1; methyl-accepting schemotaxis protein O-methyltransferase 1 [KO:K00575] [EC:2.1.1.80]
IE4771_PD00069  chemotaxis protein-glutamate methyltransferase CheR-type protein [KO:K13924] [EC:2.1.1.80 3.1.1.61]
IE4771_CH00929  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH00954  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH01031  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH00476  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH00598  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH00690  mcpE; methyl-accepting chemotaxis protein McpE [KO:K03406]
IE4771_CH00763  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH00764  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH04177  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH02679  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_PD00198  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_PD00289  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_PD00299  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH01229  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH01340  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH03767  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH03816  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH03817  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_PE00604  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_PA00146  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_PA00166  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_CH03091  methyl-accepting chemotaxis protein [KO:K03406]
IE4771_PD00512  methyl-accepting chemotaxis protein [KO:K05874]
IE4771_CH04176  cheW-3; chemotaxis signal transduction protein CheW 3 [KO:K03408]
IE4771_CH03092  cheW-2; chemotaxis signal transduction protein CheW 2 [KO:K03408]
IE4771_CH03815  chemotaxis signal transduction CheW-like protein [KO:K03408]
IE4771_CH03818  chemotaxis signal transduction CheW-like protein [KO:K03408]
IE4771_CH00694  cheW-1; chemotaxis signal transduction protein CheW 1 [KO:K03408]
IE4771_CH03819  cheA-2; histidine kinase chemotaxis protein CheA 2 [KO:K03407] [EC:2.7.13.3]
IE4771_CH00693  cheA-1; histidine kinase chemotaxis protein CheA 1 [KO:K03407] [EC:2.7.13.3]
IE4771_CH03606  response regulator CheY-like domain-containing protein [KO:K03413]
IE4771_CH03820  response regulator CheY-like domain-containing protein [KO:K03413]
IE4771_CH00692  response regulator CheY-like domain-containing protein [KO:K03413]
IE4771_CH00697  cheY; chemotaxis protein CheY [KO:K03413]
IE4771_CH03813  cheB-2; methyl-accepting chemotaxis protein methylesterase 2 [KO:K03412] [EC:3.1.1.61 3.5.1.44]
IE4771_PD00068  chemotaxis protein-glutamate methylesterase CheB-type protein [KO:K03412] [EC:3.1.1.61 3.5.1.44]
IE4771_CH00696  cheB-1; methyl-accepting chemotaxis protein methylesterase 1 [KO:K03412] [EC:3.1.1.61 3.5.1.44]
IE4771_CH02576  sensor histidine kinase protein [KO:K07716] [EC:2.7.13.3]
IE4771_CH01384  sensor histidine kinase protein [KO:K07716] [EC:2.7.13.3]
IE4771_CH01688  pleD; response regulator PleD [KO:K02488] [EC:2.7.7.65]
IE4771_CH01338  sensor histidine kinase protein [KO:K11357] [EC:2.7.13.3]
IE4771_CH01687  divK; polar-differentiation response regulator DivK [KO:K11443]
IE4771_CH02455  sensor histidine kinase/response regulator hybrid protein [KO:K13587] [EC:2.7.13.3]
IE4771_CH03607  hypothetical protein [KO:K13588]
IE4771_CH03605  ctrA; cell cycle response regulator CtrA [KO:K13584]
IE4771_CH03887  response regulator CheY-like domain-containing protein [KO:K13589]
IE4771_CH04115  response regulator CheY-like domain-containing protein [KO:K13589]
IE4771_CH02438  glsA; glutaminase [KO:K01425] [EC:3.5.1.2]
IE4771_CH00060  regB; sensor histidine kinase RegB [KO:K15011] [EC:2.7.13.3]
IE4771_CH00059  actR; acid tolerance response regulator ActR [KO:K15012]
IE4771_CH03295  petA; ubiquinol--cytochrome-c reductase iron-sulfur subunit [KO:K00411] [EC:7.1.1.8]
IE4771_CH03294  petB; cytochrome b [KO:K00412]
IE4771_CH03293  petC; cytochrome c1 [KO:K00413]
IE4771_CH02762  cytochrome-c class 1 protein [KO:K08738]
IE4771_PB00062  cytochrome-c protein [KO:K08738]
IE4771_CH00151  cycM; cytochrome-c CycM [KO:K08738]
IE4771_PB00141  fixN; cbb3-type cytochrome-c oxidase subunit FixN [KO:K00404] [EC:7.1.1.9]
IE4771_PB00142  fixO; cbb3-type cytochrome-c oxidase subunit FixO [KO:K00405]
IE4771_PB00143  fixQ; cbb3-type cytochrome-c oxidase subunit FixQ [KO:K00407]
IE4771_PB00144  fixP; cbb3-type cytochrome-c oxidase subunit FixP [KO:K00406]
IE4771_PE00511  cydA; cytochrome d terminal oxidase subunit 1 [KO:K00425] [EC:7.1.1.7]
IE4771_PE00512  cydB; cytochrome d terminal oxidase subunit 2 [KO:K00426] [EC:7.1.1.7]
IE4771_PE00513  Cyd operon protein YbgT-like protein [KO:K00424] [EC:7.1.1.7]
IE4771_PE00409  polysaccharide biosynthesis/export protein [KO:K01991]
IE4771_PD00458  polysaccharide export protein [KO:K01991]
IE4771_CH03503  polysaccharide export protein [KO:K01991]
IE4771_CH01609  polysaccharide biosynthesis/export protein [KO:K01991]
IE4771_CH04269  low molecular weight protein-tyrosine-phosphatase domain-containing protein [KO:K25307] [EC:3.1.3.48]
IE4771_CH01610  lipopolysaccharide biosynthesis protein [KO:K16692] [EC:2.7.10.3]
IE4771_CH00250  glycoside hydrolase family 5 protein [KO:K01179] [EC:3.2.1.4]
IE4771_CH00078  endoglucanase protein [KO:K01179] [EC:3.2.1.4]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
DOI:10.1128/JB.187.12.4064-4076.2005
Reference
  Authors
He H, Zahrt TC.
  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
DOI:10.1128/JB.187.1.202-212.2005
Reference
  Authors
Hutchings MI
  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
DOI:10.1016/S0065-2164(06)61001-0
Reference
  Authors
Kramer R
  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
DOI:10.1007/s00726-009-0271-6
Reference
PMID:7751278
  Authors
Eraso JM, Kaplan S.
  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
  Journal
J Bacteriol 177:2695-706 (1995)
DOI:10.1128/JB.177.10.2695-2706.1995
Reference
  Authors
Haydel SE, Dunlap NE, Benjamin WH Jr.
  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
  Journal
Microb Pathog 26:195-206 (1999)
DOI:10.1006/mpat.1998.0265
Reference
  Authors
Quisel JD, Burkholder WF, Grossman AD.
  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
DOI:10.1128/JB.183.22.6573-6578.2001
Reference
  Authors
Kaspar S, Bott M.
  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
Arch Microbiol 177:313-21 (2002)
DOI:10.1007/s00203-001-0393-z
Reference
  Authors
Janausch IG, Garcia-Moreno I, Unden G.
  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
DOI:10.1074/jbc.M204482200
Reference
PMID:8550490
  Authors
Brunskill EW, Bayles KW.
  Title
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
  Journal
J Bacteriol 178:611-8 (1996)
DOI:10.1128/JB.178.3.611-618.1996
Reference
  Authors
Fujimoto DF, Brunskill EW, Bayles KW.
  Title
Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
  Journal
J Bacteriol 182:4822-8 (2000)
DOI:10.1128/JB.182.17.4822-4828.2000
Reference
  Authors
Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G.
  Title
High genetic variability of the agr locus in Staphylococcus species.
  Journal
J Bacteriol 184:1180-6 (2002)
DOI:10.1128/JB.184.4.1180-1186.2002
Reference
PMID:8501030
  Authors
Rabin RS, Stewart V.
  Title
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
  Journal
J Bacteriol 175:3259-68 (1993)
DOI:10.1128/JB.175.11.3259-3268.1993
Reference
PMID:9220011
  Authors
Chiang RC, Cavicchioli R, Gunsalus RP.
  Title
'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
  Journal
Mol Microbiol 24:1049-60 (1997)
DOI:10.1046/j.1365-2958.1997.4131779.x
Reference
  Authors
Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
  Title
Cooperativity in signal transfer through the Uhp system of Escherichia coli.
  Journal
J Bacteriol 184:4205-10 (2002)
DOI:10.1128/JB.184.15.4205-4210.2002
Reference
  Authors
Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
  Title
Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
  Journal
J Bacteriol 185:5735-46 (2003)
DOI:10.1128/JB.185.19.5735-5746.2003
Reference
  Authors
Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.
  Title
Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
  Journal
J Antimicrob Chemother 52:576-82 (2003)
DOI:10.1093/jac/dkg406
Reference
  Authors
Suzuki K, Wang X, Weilbacher T, Pernestig AK, Melefors O, Georgellis D, Babitzke P, Romeo T.
  Title
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.
  Journal
J Bacteriol 184:5130-40 (2002)
DOI:10.1128/JB.184.18.5130-5140.2002
Reference
  Authors
Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R.
  Title
Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.
  Journal
Biosci Biotechnol Biochem 64:1203-9 (2000)
DOI:10.1271/bbb.64.1203
Reference
  Authors
Ansaldi M, Dubnau D.
  Title
Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.
  Journal
J Bacteriol 186:15-21 (2004)
DOI:10.1128/JB.186.1.15-21.2004
Reference
  Authors
Gabdrakhmanova L, Vishniakov I, Sharipova M, Balaban N, Kostrov S, Leshchinskaya I.
  Title
Salt stress induction of glutamyl endopeptidase biosynthesis in Bacillus intermedius.
  Journal
Microbiol Res 160:233-42 (2005)
DOI:10.1016/j.micres.2004.05.005
Reference
  Authors
Aguilar PS, Hernandez-Arriaga AM, Cybulski LE, Erazo AC, de Mendoza D.
  Title
Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis.
  Journal
EMBO J 20:1681-91 (2001)
DOI:10.1093/emboj/20.7.1681
Reference
  Authors
Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.
  Title
Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.
  Journal
Mol Microbiol 49:807-21 (2003)
DOI:10.1046/j.1365-2958.2003.03599.x
Reference
  Authors
Saini DK, Malhotra V, Dey D, Pant N, Das TK, Tyagi JS.
  Title
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
  Journal
Microbiology 150:865-75 (2004)
DOI:10.1099/mic.0.26218-0
Reference
  Authors
Fedtke I, Kamps A, Krismer B, Gotz F.
  Title
The nitrate reductase and nitrite reductase operons and the narT gene of Staphylococcus carnosus are positively controlled by the novel two-component system NreBC.
  Journal
J Bacteriol 184:6624-34 (2002)
DOI:10.1128/JB.184.23.6624-6634.2002
Reference
PMID:8416895
  Authors
Shiau SP, Chen P, Reitzer LJ.
  Title
Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation.
  Journal
J Bacteriol 175:190-9 (1993)
DOI:10.1128/JB.175.1.190-199.1993
Reference
  Authors
Leonhartsberger S, Huber A, Lottspeich F, Bock A.
  Title
The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
  Journal
J Mol Biol 307:93-105 (2001)
DOI:10.1006/jmbi.2000.4451
Reference
  Authors
Lioliou EE, Kyriakidis DA.
  Title
The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator.
  Journal
Microb Cell Fact 3:8 (2004)
DOI:10.1186/1475-2859-3-8
Reference
  Authors
Yamamoto K, Ishihama A
  Title
Transcriptional response of Escherichia coli to external copper.
  Journal
Mol Microbiol 56:215-27 (2005)
DOI:10.1111/j.1365-2958.2005.04532.x
Reference
  Authors
Ashby MK, Mullineaux CW
  Title
Cyanobacterial ycf27 gene products regulate energy transfer from phycobilisomes to photosystems I and II.
  Journal
FEMS Microbiol Lett 181:253-60 (1999)
DOI:10.1111/j.1574-6968.1999.tb08852.x
Reference
  Authors
Lopez-Maury L, Garcia-Dominguez M, Florencio FJ, Reyes JC
  Title
A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Mol Microbiol 43:247-56 (2002)
DOI:10.1046/j.1365-2958.2002.02741.x
Reference
  Authors
Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr
  Title
The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
  Journal
J Bacteriol 189:5495-503 (2007)
DOI:10.1128/JB.00190-07
Reference
  Authors
Hsiao HY, He Q, Van Waasbergen LG, Grossman AR
  Title
Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways.
  Journal
J Bacteriol 186:3882-8 (2004)
DOI:10.1128/JB.186.12.3882-3888.2004
Reference
  Authors
Mutsuda M, Michel KP, Zhang X, Montgomery BL, Golden SS
  Title
Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942.
  Journal
J Biol Chem 278:19102-10 (2003)
DOI:10.1074/jbc.M213255200
Reference
PMID:9278513
  Authors
Yeh KC, Wu SH, Murphy JT, Lagarias JC
  Title
A cyanobacterial phytochrome two-component light sensory system.
  Journal
Science 277:1505-8 (1997)
DOI:10.1126/science.277.5331.1505
Reference
PMID:7635815
  Authors
Niu S, Jiang SQ, Hong J
  Title
Salmonella typhimurium pgtB mutants conferring constitutive expression of phosphoglycerate transporter pgtP independent of pgtC.
  Journal
J Bacteriol 177:4297-302 (1995)
DOI:10.1128/JB.177.15.4297-4302.1995
Reference
  Authors
Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
  Title
A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
  Journal
Proc Natl Acad Sci U S A 103:12109-14 (2006)
DOI:10.1073/pnas.0602955103
Reference
  Authors
Janausch IG, Zientz E, Tran QH, Kroger A, Unden G
  Title
C4-dicarboxylate carriers and sensors in bacteria.
  Journal
Biochim Biophys Acta 1553:39-56 (2002)
DOI:10.1016/S0005-2728(01)00233-X
Reference
  Authors
Zhou YF, Nan B, Nan J, Ma Q, Panjikar S, Liang YH, Wang Y, Su XD
  Title
C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
  Journal
J Mol Biol 383:49-61 (2008)
DOI:10.1016/j.jmb.2008.08.010
Reference
  Authors
Novick RP, Jiang D
  Title
The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing.
  Journal
Microbiology 149:2709-17 (2003)
DOI:10.1099/mic.0.26575-0
Reference
  Authors
Leech AJ, Sprinkle A, Wood L, Wozniak DJ, Ohman DE
  Title
The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
  Journal
J Bacteriol 190:581-9 (2008)
DOI:10.1128/JB.01307-07
Reference
  Authors
Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U
  Title
Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
  Journal
Cell 133:452-61 (2008)
DOI:10.1016/j.cell.2008.02.045
Reference
  Authors
Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.
  Title
Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.
  Journal
Mol Microbiol 52:873-93 (2004)
DOI:10.1111/j.1365-2958.2004.04026.x
Reference
  Authors
Yoshihara S, Ikeuchi M.
  Title
Phototactic motility in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Photochem Photobiol Sci 3:512-8 (2004)
DOI:10.1039/b402320j
Reference
  Authors
Ogawa T, Bao DH, Katoh H, Shibata M, Pakrasi HB, Bhattacharyya-Pakrasi M
  Title
A two-component signal transduction pathway regulates manganese homeostasis in Synechocystis 6803, a photosynthetic organism.
  Journal
J Biol Chem 277:28981-6 (2002)
DOI:10.1074/jbc.M204175200
Reference
  Authors
Yamaguchi K, Suzuki I, Yamamoto H, Lyukevich A, Bodrova I, Los DA, Piven I, Zinchenko V, Kanehisa M, Murata N
  Title
A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis.
  Journal
Plant Cell 14:2901-13 (2002)
DOI:10.1105/tpc.006262
Reference
  Authors
Mascher T, Zimmer SL, Smith TA, Helmann JD
  Title
Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.
  Journal
Antimicrob Agents Chemother 48:2888-96 (2004)
DOI:10.1128/AAC.48.8.2888-2896.2004
Reference
  Authors
Hyyrylainen HL, Sarvas M, Kontinen VP
  Title
Transcriptome analysis of the secretion stress response of Bacillus subtilis.
  Journal
Appl Microbiol Biotechnol 67:389-96 (2005)
DOI:10.1007/s00253-005-1898-1
Reference
  Authors
Serizawa M, Sekiguchi J
  Title
The Bacillus subtilis YdfHI two-component system regulates the transcription of ydfJ, a member of the RND superfamily.
  Journal
Microbiology 151:1769-78 (2005)
DOI:10.1099/mic.0.27619-0
Reference
  Authors
Ohki R, Giyanto, Tateno K, Masuyama W, Moriya S, Kobayashi K, Ogasawara N
  Title
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
  Journal
Mol Microbiol 49:1135-44 (2003)
DOI:10.1046/j.1365-2958.2003.03653.x
Reference
  Authors
Ogura M, Tsukahara K, Hayashi K, Tanaka T
  Title
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
  Journal
Microbiology 153:667-75 (2007)
DOI:10.1099/mic.0.2006/003673-0
Reference
  Authors
Yamamoto H, Murata M, Sekiguchi J
  Title
The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis.
  Journal
Mol Microbiol 37:898-912 (2000)
DOI:10.1046/j.1365-2958.2000.02055.x
Reference
  Authors
Satomura T, Shimura D, Asai K, Sadaie Y, Hirooka K, Fujita Y
  Title
Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
  Journal
J Bacteriol 187:4813-21 (2005)
DOI:10.1128/JB.187.14.4813-4821.2005
Reference
  Authors
Doan T, Servant P, Tojo S, Yamaguchi H, Lerondel G, Yoshida K, Fujita Y, Aymerich S
  Title
The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate.
  Journal
Microbiology 149:2331-43 (2003)
DOI:10.1099/mic.0.26256-0
Reference
  Authors
Tanaka K, Kobayashi K, Ogasawara N
  Title
The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium.
  Journal
Microbiology 149:2317-29 (2003)
DOI:10.1099/mic.0.26257-0
Reference
  Authors
Asai K, Baik SH, Kasahara Y, Moriya S, Ogasawara N
  Title
Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
  Journal
Microbiology 146 ( Pt 2):263-71 (2000)
DOI:10.1099/00221287-146-2-263
Reference
PMID:8455557
  Authors
Hamblin MJ, Shaw JG, Kelly DJ
  Title
Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus.
  Journal
Mol Gen Genet 237:215-24 (1993)
DOI:10.1007/BF00282803
Reference
PMID:9287004
  Authors
Forward JA, Behrendt MC, Wyborn NR, Cross R, Kelly DJ
  Title
TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.
  Journal
J Bacteriol 179:5482-93 (1997)
DOI:10.1128/JB.179.17.5482-5493.1997
Reference
  Authors
Martin B, Quentin Y, Fichant G, Claverys JP
  Title
Independent evolution of competence regulatory cascades in streptococci?
  Journal
Trends Microbiol 14:339-45 (2006)
DOI:10.1016/j.tim.2006.06.007
Reference
  Authors
Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC
  Title
The genetic basis of tetrathionate respiration in Salmonella typhimurium.
  Journal
Mol Microbiol 32:275-87 (1999)
DOI:10.1046/j.1365-2958.1999.01345.x
Reference
  Authors
Guvener ZT, Harwood CS
  Title
Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
  Journal
Mol Microbiol 66:1459-73 (2007)
DOI:10.1111/j.1365-2958.2007.06008.x
Reference
  Authors
Bantinaki E, Kassen R, Knight CG, Robinson Z, Spiers AJ, Rainey PB
  Title
Adaptive divergence in experimental populations of Pseudomonas fluorescens. III. Mutational origins of wrinkly spreader diversity.
  Journal
Genetics 176:441-53 (2007)
DOI:10.1534/genetics.106.069906
Reference
  Authors
Jiang M, Shao W, Perego M, Hoch JA
  Title
Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
  Journal
Mol Microbiol 38:535-42 (2000)
DOI:10.1046/j.1365-2958.2000.02148.x
Reference
  Authors
Jenal U
  Title
The role of proteolysis in the Caulobacter crescentus cell cycle and development.
  Journal
Res Microbiol 160:687-95 (2009)
DOI:10.1016/j.resmic.2009.09.006
Reference
  Authors
Jenal U, Galperin MY
  Title
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
  Journal
Curr Opin Microbiol 12:152-60 (2009)
DOI:10.1016/j.mib.2009.01.010
Reference
  Authors
Drepper T, Wiethaus J, Giaourakis D, Gross S, Schubert B, Vogt M, Wiencek Y, McEwan AG, Masepohl B
  Title
Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus.
  Journal
FEMS Microbiol Lett 258:250-6 (2006)
DOI:10.1111/j.1574-6968.2006.00228.x
Reference
PMID:1661370
  Authors
Pawlowski K, Klosse U, de Bruijn FJ
  Title
Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism.
  Journal
Mol Gen Genet 231:124-38 (1991)
DOI:10.1007/BF00293830
Reference
  Authors
Chatterjee S, Almeida RP, Lindow S
  Title
Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
  Journal
Annu Rev Phytopathol 46:243-71 (2008)
DOI:10.1146/annurev.phyto.45.062806.094342
Reference
  Authors
Dow M
  Title
Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
  Journal
Sci Signal 1:pe23 (2008)
DOI:10.1126/stke.121pe23
Reference
  Authors
Colnaghi Simionato AV, da Silva DS, Lambais MR, Carrilho E
  Title
Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS.
  Journal
J Mass Spectrom 42:1375-81 (2007)
DOI:10.1002/jms.1325
Reference
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Reference
PMID:8760916
  Authors
Eder S, Shi L, Jensen K, Yamane K, Hulett FM
  Title
A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.
  Journal
Microbiology 142 ( Pt 8):2041-7 (1996)
DOI:10.1099/13500872-142-8-2041
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pathway
rei00190  Oxidative phosphorylation
rei00550  Peptidoglycan biosynthesis
rei00910  Nitrogen metabolism
rei02030  Bacterial chemotaxis
rei02040  Flagellar assembly
rei03070  Bacterial secretion system
KO pathway
ko02020   
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