Entry |
|
Name |
Staurosporine biosynthesis |
Class |
Metabolism; Biosynthesis of other secondary metabolites
|
Pathway map |
|
Module |
M00786 | Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A [PATH:rn00404] |
M00789 | Rebeccamycin biosynthesis, tryptophan => rebeccamycin [PATH:rn00404] |
M00790 | Pyrrolnitrin biosynthesis, tryptophan => pyrrolnitrin [PATH:rn00404] |
M00805 | Staurosporine biosynthesis, tryptophan => staurosporine [PATH:rn00404] |
M00808 | Violacein biosynthesis, tryptophan => violacein [PATH:rn00404] |
|
Reaction |
R05757 | S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase |
R09560 | 7-chloro-L-tryptophan:oxygen oxidoreductase |
R09566 | 2-imino-3-(7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming) |
R09567 | dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming) |
R09568 | 4'-demethylrebeccamycin D-glucose-lyase |
R09569 | S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase |
R09570 | L-tryptophan:FADH2 oxidoreductase (7-halogenating) |
R10321 | tryprostatin B,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxytryprostatin B-forming) |
R10340 | dimethylallyl-diphosphate:brevianamide-F dimethylallyl-C-2-transferase |
R10341 | dimethylallyl-diphosphate:verruculogen dimethylallyl-O-transferase |
R10414 | fumitremorgin C,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming) |
R10416 | tryprostatin A,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase |
R10445 | fumitremorgin B,2-oxoglutarate:oxygen oxidoreductase (verruculogen-forming) |
R10457 | dimethylallyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C dimethylallyl-N-1-transferase |
R10588 | S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase |
R11132 | protodeoxyviolaceinate,NADPH:O2 oxidoreductase |
R11134 | protodeoxyviolaceinate,NADPH:O2 oxidoreductase |
R11135 | protoviolaceinate,NADPH:O2 oxidoreductase |
R11158 | protodeoxyviolaceinate,NADH:O2 oxidoreductase |
R11373 | protoviolaceinate,NADH:O2 oxidoreductase |
R11374 | protodeoxyviolaceinate,NADH:O2 oxidoreductase |
|
Compound |
C07349 | 3'-Demethylstaurosporine |
C12318 | dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose |
C19688 | 2-Imino-3-(7-chloroindol-3-yl)propanoate |
C19698 | 3,4-Bis(7-chloroindol-3-yl)pyrrole-2,5-dicarboxylate |
C19699 | Dichloroarcyriaflavin A |
C19700 | 4'-O-Demethylrebeccamycin |
C20513 | 6-Hydroxytryprostatin B |
C20605 | 12alpha,13alpha-Dihydroxyfumitremorgin C |
C21110 | Monodechloroaminopyrrolnitrin |
C21128 | O-Demethyl-N-demethyl-staurosporine |
C21131 | Protodeoxyviolaceinic acid |
C21137 | dTDP-3-amino-4-oxo-2,3,6-trideoxy-L-allose |
C22162 | Histidyltryptophyldiketopiperazine |
C22164 | Dehydrohistidyltryptophyldiketopiperazine |
C22169 | N1-Hydroxy-roquefortine C |
|
Reference |
|
Authors |
Sanchez C, Mendez C, Salas JA |
Title |
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity. |
Journal |
|
Reference |
|
Authors |
Onaka H, Taniguchi S, Igarashi Y, Furumai T |
Title |
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans. |
Journal |
|
Reference |
|
Authors |
Lee ME, Aswani A, Han AS, Tomlin CJ, Dueber JE |
Title |
Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay. |
Journal |
|
Reference |
|
Authors |
Onaka H, Taniguchi S, Igarashi Y, Furumai T |
Title |
Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243. |
Journal |
|
Reference |
|
Authors |
Hammer PE, Hill DS, Lam ST, Van Pee KH, Ligon JM |
Title |
Four genes from Pseudomonas fluorescens that encode the biosynthesis of pyrrolnitrin. |
Journal |
|
Reference |
|
Authors |
Mundt K, Wollinsky B, Ruan HL, Zhu T, Li SM |
Title |
Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches. |
Journal |
|
Related pathway |
rn00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
rn00523 | Polyketide sugar unit biosynthesis |
|
KO pathway |
|
LinkDB |
|