KEGG   PATHWAY: ko00404
Entry
ko00404                     Pathway                                
Name
Staurosporine biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
ko00404  Staurosporine biosynthesis
ko00404

Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A [PATH:ko00404]
M00789  Rebeccamycin biosynthesis, tryptophan => rebeccamycin [PATH:ko00404]
M00790  Pyrrolnitrin biosynthesis, tryptophan => pyrrolnitrin [PATH:ko00404]
M00805  Staurosporine biosynthesis, tryptophan => staurosporine [PATH:ko00404]
M00808  Violacein biosynthesis, tryptophan => violacein [PATH:ko00404]
Orthology
K14132  FTMPT1; tryprostatin B synthase [EC:2.5.1.106]
K14134  FTMPT2; 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase [EC:2.5.1.110]
K14257  ctcP, cts4, prnC; tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-]
K14266  prnA, rebH, ktzQ; tryptophan 7-halogenase [EC:1.14.19.9]
K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase [EC:5.1.3.-]
K17475  FTMC, CYP5076C; tryprostatin B 6-hydroxylase [EC:1.14.14.118]
K17825  FTMF; verruculogen synthase [EC:1.14.11.38]
K17826  FTMG, CYP5067A; fumitremorgin C monooxygenase [EC:1.14.14.119]
K17827  FTME, CYP5066A; fumitremorgin C synthase [EC:1.14.19.71]
K18279  FTMPT3; verruculogen prenyltransferase [EC:2.5.1.107]
K18280  FTMD; 6-hydroxytryprostatin B O-methyltransferase [EC:2.1.1.293]
K18281  FTMA; brevianamide F synthase [EC:6.3.2.-]
K19884  rebO; 7-chloro-L-tryptophan oxidase [EC:1.4.3.23]
K19885  rebD; dichlorochromopyrrolate synthase / catalase [EC:1.21.98.2 1.11.1.6]
K19886  rebC; flavin-dependent monooxygenase RebC [EC:1.13.12.17]
K19887  rebP; cytochrome P450 RebP [EC:1.13.12.17]
K19888  rebG; 4'-demethylrebeccamycin synthase [EC:4.3.3.5]
K19889  rebM; demethylrebeccamycin-D-glucose O-methyltransferase [EC:2.1.1.164]
K19981  prnB; monodechloroaminopyrrolnitrin synthase
K19982  prnD; aminopyrrolnitrin oxygenase [EC:1.14.13.-]
K20075  staO; tryptophan oxidase StaO [EC:1.4.3.-]
K20076  staD; chromopyrrolic acid synthase
K20077  staC; flavin-dependent monooxygenase StaC [EC:1.13.12.-]
K20078  staP; cytochrome P450 StaP [EC:1.13.12.-]
K20079  staG; N-glycosyltransferase StaG [EC:2.4.-.-]
K20080  staN; cytochrome P450 StaN [EC:1.14.-.-]
K20081  staMA; N-methyltransferase StaMA [EC:2.1.1.-]
K20082  staMB; O-methyltransferase StaMB [EC:2.1.1.139]
K20085  staK; dTDP-3-amino-4-oxo-2,3,6-trideoxy-L-allose reductase [EC:1.1.1.-]
K20086  vioA; tryptophan oxidase VioA [EC:1.4.3.-]
K20087  vioB; violacein biosynthesis protein VioB
K20088  vioE; violacein biosynthesis protein VioE
K20089  vioD; protodeoxyviolaceinate monooxygenase [EC:1.14.13.217]
K20090  vioC; violacein synthase [EC:1.14.13.224]
K21294  GLIC, ACLC, ROQR; gliotoxin/aspirochlorine/mycotoxins biosynthesis cytochrome P450 monooxygenase [EC:1.-.-.-]
K23888  ROQA; histidyltryptophyldiketopiperazine synthetase
K23889  ROQD; roquefortine prenyltransferase
K23890  ROQM; mycotoxins biosynthesis FAD-dependent monooxygenase
K23891  ROQN; glandicoline B O-methyltransferase
K23892  ROQO; mycotoxins biosynthesis cytochrome P450 monooxygenase RoqO
Compound
C00078  L-Tryptophan
C00135  L-Histidine
C00148  L-Proline
C02079  Staurosporine
C07349  3'-Demethylstaurosporine
C12318  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose
C12491  Pyrrolnitrin
C18092  dTDP-L-ristosamine
C19687  7-Chloro-L-tryptophan
C19688  2-Imino-3-(7-chloroindol-3-yl)propanoate
C19698  3,4-Bis(7-chloroindol-3-yl)pyrrole-2,5-dicarboxylate
C19699  Dichloroarcyriaflavin A
C19700  4'-O-Demethylrebeccamycin
C19701  Rebeccamycin
C20045  Verruculogen
C20512  Tryprostatin B
C20513  6-Hydroxytryprostatin B
C20563  Brevianamide F
C20564  Fumitremorgin A
C20604  Fumitremorgin C
C20605  12alpha,13alpha-Dihydroxyfumitremorgin C
C20607  Tryprostatin A
C20630  Fumitremorgin B
C21109  Aminopyrrolnitrin
C21110  Monodechloroaminopyrrolnitrin
C21124  IPA imine
C21125  Chromopyrrolate
C21126  K-252c
C21127  Holyrine A
C21128  O-Demethyl-N-demethyl-staurosporine
C21131  Protodeoxyviolaceinic acid
C21132  Deoxyviolaceinic acid
C21133  Deoxyviolacein
C21134  Protoviolaceinic acid
C21135  Violaceinic acid
C21136  Violacein
C21137  dTDP-3-amino-4-oxo-2,3,6-trideoxy-L-allose
C22162  Histidyltryptophyldiketopiperazine
C22163  Roquefortine D
C22164  Dehydrohistidyltryptophyldiketopiperazine
C22165  Roquefortine C
C22166  Glandicoline A
C22167  Glandicoline B
C22168  Meleagrin
C22169  N1-Hydroxy-roquefortine C
C22170  Roquefortine L
C22171  Roquefortine F
C22172  Neoxaline
Reference
PMID:17119643
  Authors
Sanchez C, Mendez C, Salas JA
  Title
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity.
  Journal
Nat Prod Rep 23:1007-45 (2006)
DOI:10.1039/b601930g
Reference
PMID:12617516
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.
  Journal
J Antibiot (Tokyo) 55:1063-71 (2002)
DOI:10.7164/antibiotics.55.1063
Reference
PMID:24038353
  Authors
Lee ME, Aswani A, Han AS, Tomlin CJ, Dueber JE
  Title
Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay.
  Journal
Nucleic Acids Res 41:10668-78 (2013)
DOI:10.1093/nar/gkt809
Reference
PMID:12619684
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.
  Journal
Biosci Biotechnol Biochem 67:127-38 (2003)
DOI:10.1271/bbb.67.127
Reference
PMID:9172332
  Authors
Hammer PE, Hill DS, Lam ST, Van Pee KH, Ligon JM
  Title
Four genes from Pseudomonas fluorescens that encode the biosynthesis of pyrrolnitrin.
  Journal
Appl Environ Microbiol 63:2147-54 (1997)
DOI:10.1128/AEM.63.6.2147-2154.1997
Reference
PMID:23109474
  Authors
Mundt K, Wollinsky B, Ruan HL, Zhu T, Li SM
  Title
Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.
  Journal
Chembiochem 13:2583-92 (2012)
DOI:10.1002/cbic.201200523
Related
pathway
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00523  Polyketide sugar unit biosynthesis

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