KEGG PATHWAY: rn00623

PATHWAY: rn00623

Entry

rn00623                     Pathway

Name

Toluene degradation

Class

Metabolism; Xenobiotics biodegradation and metabolism

Pathway map

rn00623

Toluene degradation

Module

M00418

Toluene degradation, anaerobic, toluene => benzoyl-CoA [PATH:rn00623]

M00538

Toluene degradation, toluene => benzoate [PATH:rn00623]

M00547

Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol [PATH:rn00623]

Other DBs

GO:

0042203

UMBBD:

tol tol2 tsa dct

Reaction

R01293

4-hydroxybenzaldehyde:NAD+ oxidoreductase

R01294

4-hydroxybenzaldehyde:NADP+ oxidoreductase

R01419

benzaldehyde:NAD+ oxidoreductase

R01420

benzaldehyde:NADP+ oxidoreductase

R01636

4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)

R01763

benzyl alcohol:NAD+ oxidoreductase

R02550

toluene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating); toluene/o-xylene monooxygenase

R02675

4-methylphenol:oxidized azurin oxidoreductase (methyl-hydroxylating)

R03559

toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)

R03560

toluene,NADH:oxygen oxidoreductase (2,3-dihydroxylating)

R03562

toluene,NADPH:oxogen oxidoreductase (3-hydroxylating)

R03566

3-cresol,NADPH:oxogen oxidoreductase (2-hydroxylating)

R03608

o-cresol,NADH:oxygen oxidoreductase (2,3-dihydroxylating)

R04088

toluene-cis-1,2-dihydrodiol:NAD+ oxidoreductase

R04136

3-hydroxybenzyl-alcohol:NADP+ oxidoreductase

R04510

4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase

R05271

4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase

R05272

4-formylbenzenesulfonate:NAD+ oxidoreductase

R05281

R05294

toluene-4-sulfonate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)

R05299

4-methylcatechol:oxygen 1,2-oxidoreductase(decyclizing)

R05300

4-methylmuconolactone lyase (decyclizing)

R05575

(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA:NAD+ oxidoreductase

R05584

(R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase

R05587

R05588

R05598

benzylsuccinate fumarate-lyase

R05599

(R,S)-2-(alpha-hydroxybenzyl)succinyl-CoA hydro-lyase

R05666

toluene,NADH:oxygen oxidoreductase (4-hydroxylating)

R07663

R07665

R07666

3-hydroxybenzaldehyde:NADP+ oxidoreductase

R07667

3-hydroxybenzaldehyde:NAD+ oxidoreductase

R09201

R09213

R09214

R09215

chloromuconate chloromuconate

R09217

chloromuconate cycloisomerase

R09220

dienelactone hydrolase

R09221

chloromuconate cycloisomerase

R09222

dienelactone hydrolase

R09223

maleylacetate reductase

R09224

maleylacetate reductase

R09225

3-methyl-5-oxo-2,5-dihydrofuran-2-acetate delta3-delat2-isomerase

R09226

R09229

muconate cycloisomerase

R11194

2,4-dimethylphenol:oxidized azurin oxidoreductase (methyl-hydroxylating)

R11195

4-hydroxy-3-methylbenzaldehyde:NADP+ oxidoreductase

R11196

R11197

R11198

Compound

C00091

Succinyl-CoA

C00156

4-Hydroxybenzoate

C00180

Benzoate

C00230

3,4-Dihydroxybenzoate

C00261

Benzaldehyde

C00512

Benzoyl-CoA

C00556

Benzyl alcohol

C00587

3-Hydroxybenzoate

C00633

4-Hydroxybenzaldehyde

C01455

Toluene

C01467

3-Cresol

C01468

4-Cresol

C01542

o-Cresol

C02236

4-Sulfobenzoate

C02923

2,3-Dihydroxytoluene

C03067

3-Hydroxybenzaldehyde

C03351

3-Hydroxybenzyl alcohol

C04112

3-Methyl-cis,cis-hexadienedioate

C04558

3-Methylmuconolactone

C04559

4-Methylmuconolactone

C04592

Toluene-cis-dihydrodiol

C06677

Toluene-4-sulfonate

C06678

4-Sulfobenzyl alcohol

C06679

4-Sulfobenzaldehyde

C06730

4-Methylcatechol

C09816

Benzylsuccinate

C09817

Benzylsuccinyl-CoA

C09818

E-Phenylitaconyl-CoA

C09819

(2S)-[(R)-Hydroxy(phenyl)methyl]succinyl-CoA

C09820

(S)-2-Benzoylsuccinyl-CoA

C14582

2,4-Dimethylphenol

C18300

2,4-Dichlorotoluene

C18301

4,6-Dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene

C18302

4,6-Dichloro-3-methylcatechol

C18303

3,5-Dichloro-2-methylmuconate

C18304

2-Chloro-5-methyl-cis-dienelactone

C18305

2-Chloro-5-methylmaleylacetate

C18306

5-Methylmaleylacetate

C18307

2-Methyl-3-oxoadipate

C18308

3,5-Dichloro-2-methylmuconolactone

C18309

3-Chloro-2-methyldienelactone

C18310

3-Chloro-2-methylmaleylacetate

C18311

4-Methyl-3-oxoadipate-enol-lactone

C18312

4-Methyl-3-oxoadipate

C21166

4-Hydroxy-3-methylbenzaldehyde

C21167

4-Hydroxy-3-methylbenzoate

C21168

4-Hydroxyisophthalate

Reference

PMID:15184119

Authors

Vardar G, Wood TK

Title

Protein engineering of toluene-o-xylene monooxygenase from Pseudomonas stutzeri OX1 for synthesizing 4-methylresorcinol, methylhydroquinone, and pyrogallol.

Journal

Appl Environ Microbiol 70:3253-62 (2004)
DOI:10.1128/AEM.70.6.3253-3262.2004

Reference

PMID:10629170

Authors

Leuthner B, Heider J

Title

Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.

Journal

J Bacteriol 182:272-7 (2000)
DOI:10.1128/JB.182.2.272-277.2000

Reference

PMID:11418570

Authors

Leutwein C, Heider J

Title

Succinyl-CoA:(R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria.

Journal

J Bacteriol 183:4288-95 (2001)
DOI:10.1128/JB.183.14.4288-4295.2001

Reference

PMID:15687214

Authors

Kuhner S, Wohlbrand L, Fritz I, Wruck W, Hultschig C, Hufnagel P, Kube M, Reinhardt R, Rabus R

Title

Substrate-dependent regulation of anaerobic degradation pathways for toluene and ethylbenzene in a denitrifying bacterium, strain EbN1.

Journal

J Bacteriol 187:1493-503 (2005)
DOI:10.1128/JB.187.4.1493-1503.2005

Reference

PMID:2050632

Authors

Locher HH, Leisinger T, Cook AM

Title

4-Toluene sulfonate methyl-monooxygenase from Comamonas testosteroni T-2: purification and some properties of the oxygenase component.

Journal

J Bacteriol 173:3741-8 (1991)
DOI:10.1128/JB.173.12.3741-3748.1991

Reference

PMID:8828208

Authors

Junker F, Saller E, Schlafli Oppenberg HR, Kroneck PM, Leisinger T, Cook AM

Title

Degradative pathways for p-toluenecarboxylate and p-toluenesulfonate and their multicomponent oxygenases in Comamonas testosteroni strains PSB-4 and T-2.

Journal

Microbiology 142 ( Pt 9):2419-27 (1996)
DOI:10.1099/00221287-142-9-2419

Reference

PMID:10589735

Authors

Mampel J, Ruff J, Junker F, Cook AM.

Title

The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.

Journal

Microbiology 145 ( Pt 11):3255-64 (1999)
DOI:10.1099/00221287-145-11-3255

Reference

PMID:9006050