PATHWAY: rn00362 Help
Entry Name Benzoate degradation
Class Metabolism; Xenobiotics biodegradation and metabolism
Pathway map Module M00540 Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA [PATH:rn00362 ]
M00541 Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA [PATH:rn00362 ]
M00547 Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol [PATH:rn00362 ]
M00551 Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:rn00362 ]
M00568 Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:rn00362 ]
M00569 Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA [PATH:rn00362 ]
Other DBs Reaction R00008 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)
R00228 acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)
R00238 acetyl-CoA:acetyl-CoA C-acetyltransferase
R00350 4-carboxy-4-hydroxy-2-oxoadipate oxaloacetate-lyase (pyruvate-forming)
R00750 4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
R00812 cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase
R00813 (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)
R00816 catechol:oxygen 2,3-oxidoreductase (decyclizing)
R00817 catechol:oxygen 1,2-oxidoreductase(decyclizing)
R00821 2,3-dihydroxybenzoate carboxy-lyase
R00822 3,4-dihydroxybenzoate carboxy-lyase (catechol-forming); protocatechuate carboxy-lyase
R00829 succinyl-CoA:acetyl-CoA C-acyltransferase; beta-ketoadipyl-CoA thiolase
R01295 benzoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
R01296 4-hydroxybenzoate,NADH:oxygen oxidoreductase (3-hydroxylating)
R01297 4-hydroxybenzoate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
R01298 4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)
R01299 4-hydroxybenzoate,NADPH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
R01300 4-hydroxybenzoate:CoA ligase (AMP-forming)
R01301 4-hydroxybenzoyl-CoA hydrolase
R01306 4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)
R01422 benzoate:CoA ligase (AMP-forming)
R01507 2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)
R01508 3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreduxtase (2-hydroxylating)
R01628 3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)
R01629 protocatechuate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
R01630 protocatechuate,NADPH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
R01631 protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)
R01632 protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)
R01976 (S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase
R02451 cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming)
R02488 glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)
R02589 3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)
R02601 4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)
R02602 4-oxalocrotonate carboxy-lyase
R02604 2-hydroxymuconate-semialdehyde formylhydrolase
R02762 2-hydroxymuconate semialdehyde:NAD+ 6-oxidoreductase
R02988 3-oxoadipate:NAD+ oxidoreductase
R02989 3-oxoadipate:NADP+ oxidoreductase
R02990 succinyl-CoA:3-oxoadipate CoA-transferase
R02991 4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase
R03026 (S)-3-hydroxybutanoyl-CoA hydro-lyase
R03028 glutaconyl-1-CoA carboxy-lyase; 4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)
R03307 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
R03308 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
R03470 4-carboxymuconolactone carboxy-lyase
R03543 benzene,NADH:oxygene 1,2-oxidoreductase
R04061 benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)
R04277 2-pyrone-4,6-dicarboxylate lactonohydrolase
R04278 2-hydroxy-2-hydropyrone-4,6-dicarboxylate:NAD+ 6-oxidoreductase
R04279 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase
R04307 trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase
R04478 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase
R05156 2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)
R05249 resorcinol,NADPH:oxogen oxidoreductase (2-hydroxylating)
R05305 3-hydroxypimeloyl-CoA:NAD+ oxidoreductase
R05311 pimeloyl-CoA:NAD+ oxidoreductase
R05316 benzoyl-CoA:acceptor oxidoreductase
R05579 glutaryl-CoA:(acceptor) 2,3-oxidoreductase (non-decarboxylating)
R05581 6-hydroxycyclohex-1-ene-1-carbonyl-CoA:NAD+ 6-oxidoreductase
R05594 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase (decyclizing)
R05597 6-hydroxycyclohex-1-ene-1-carbonyl-CoA hydro-lyase (cyclohexa-1,5-diene-1-carbonyl-CoA-forming)
R06989 2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
R06990 (S)-5-oxo-2,5-dihydrofuran-2-acetate delta3-delat2-isomerase
R07795 2,3-dihydroxybenzenesulfonate 2,3-dioxygenase
R07839 4-oxalomesaconate keto---enol-isomerase
R09252 cyclohex-1-ene-1-carbonyl-CoA:electron transfer flavoprotein oxidoreductase
R09554 3,4-didehydroadipyl-CoA semialdehyde:NADP+ oxidoreductase
R09555 benzoyl-CoA,NADPH:oxygen oxidoreductase (2,3-epoxydizing)
R09556 2,3-epoxy-2,3-dihydrobenzoyl-CoA (3Z)-6-oxohex-3-enoyl-CoA-lyase (formate-forming)
R10042 benzene,NADH:oxygen oxidoreductase
R10043 phenol,NADH:oxygen oxidoreductase (2-hydroxylating)
R10601 cyclohexane-1-carbonyl-CoA:electron transfer flavoprotein oxidoreductase
R11347 resorcinol,NADH:oxygen oxidoreductase (4-hydroxylating)
R11348 resorcinol,FADH2:oxygen oxidoreductase (4-hydroxylating)
R11353 2,6-dihydroxybenzoate carboxy-lyase
R13283 cis-4-hydroxycyclohexane-1-carboxylate:NAD+ 4-oxidoreductase
R13285 4-oxocyclohexane-1-carboxylate:oxygen oxidoreductase (4-oxocyclohex-2-ene-1-carboxylate-forming)
R13299 succinyl-CoA---cyclohexane-1-carboxylate CoA-transferase
R13327 cyclohexane-1-carboxylate,ferredoxin:oxygen oxidoreductase (4-trans-hydroxylating)
R13360 3-oxoadipate:acetyl-CoA acetyltransferase
Compound C00596 2-Hydroxy-2,4-pentadienoate
C00682 2-Hydroxymuconate semialdehyde
C01144 (S)-3-Hydroxybutanoyl-CoA
C01163 3-Carboxy-cis,cis-muconate
C01278 2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C03586 2-Oxo-2,3-dihydrofuran-5-acetate
C03589 4-Hydroxy-2-oxopentanoate
C03671 2-Pyrone-4,6-dicarboxylate
C03676 3-Hydroxy-cis,cis-muconate
C03767 4-Oxocyclohexanecarboxylate
C04091 cis-1,2-Dihydrobenzene-1,2-diol
C04115 4-Carboxy-4-hydroxy-2-oxoadipate
C04324 (1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04404 trans-4-Hydroxycyclohexanecarboxylate
C04434 (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480 3-Carboxy-2-hydroxymuconate semialdehyde
C04484 4-Carboxy-2-hydroxymuconate semialdehyde
C04553 3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375 2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06035 4-Methylene-2-oxoglutarate
C06321 (1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322 Cyclohexa-1,5-diene-1-carbonyl-CoA
C06333 2-Aminobenzenesulfonate
C06723 6-Carboxyhex-2-enoyl-CoA
C06749 6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
C09809 Cyclohexa-2,5-diene-1-carbonyl-CoA
C09810 Cyclohexa-1,4-diene-1-carbonyl-CoA
C09811 Cyclohex-1-ene-1-carbonyl-CoA
C09812 2-Hydroxycyclohexane-1-carbonyl-CoA
C09813 2-Oxocyclohexane-1-carbonyl-CoA
C09821 6-Oxocyclohex-1-ene-1-carbonyl-CoA
C09822 Cyclohexane-1-carboxylate
C09823 Cyclohexane-1-carbonyl-CoA
C14144 5-Carboxy-2-pentenoyl-CoA
C14610 (S)-5-Oxo-2,5-dihydrofuran-2-acetate
C19682 3,4-Didehydroadipyl-CoA
C19683 3,4-Didehydroadipyl-CoA semialdehyde
C19684 2,3-Epoxy-2,3-dihydrobenzoyl-CoA
C22885 cis-4-Hydroxycyclohexane-1-carboxylate
C22887 4-Oxocyclohex-2-ene-1-carboxylate
C22920 4-Oxocyclohex-2,5-dienecarboxylate
Reference Authors Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
Title Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
Journal Reference Authors Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
Title Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
Journal Reference Authors Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
Title Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
Journal Reference Authors Mampel J, Ruff J, Junker F, Cook AM.
Title The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
Journal Reference Authors Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
Title Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
Journal Reference Authors Harwood CS, Gibson J.
Title Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
Journal Reference Authors Peters F, Shinoda Y, McInerney MJ, Boll M.
Title Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
Journal Reference Authors Cowles CE, Nichols NN, Harwood CS.
Title BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
Journal Reference Authors Smith MA, Weaver VB, Young DM, Ornston LN.
Title Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
Journal Reference Authors Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
Title 6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.
Journal Reference Authors Pelletier DA, Harwood CS
Title 2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
Journal Reference Authors Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
Title Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
Journal Reference Authors Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
Title Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
Journal Related rn00010 Glycolysis / Gluconeogenesis
rn00361 Chlorocyclohexane and chlorobenzene degradation
KO pathway
