KEGG PATHWAY: ko00623

PATHWAY: ko00623

Entry

ko00623                     Pathway

Name

Toluene degradation

Class

Metabolism; Xenobiotics biodegradation and metabolism

Pathway map

ko00623

Toluene degradation

Module

M00418

Toluene degradation, anaerobic, toluene => benzoyl-CoA [PATH:ko00623]

M00538

Toluene degradation, toluene => benzoate [PATH:ko00623]

M00547

Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol [PATH:ko00623]

Other DBs

GO:

0042203

UMBBD:

tol tol2 tsa dct

Orthology

K00055

E1.1.1.90; aryl-alcohol dehydrogenase [EC:1.1.1.90]

K00141

xylC; benzaldehyde dehydrogenase (NAD) [EC:1.2.1.28]

K00217

E1.3.1.32; maleylacetate reductase [EC:1.3.1.32]

K01061

E3.1.1.45; carboxymethylenebutenolidase [EC:3.1.1.45]

K01856

catB; muconate cycloisomerase [EC:5.5.1.1]

K01860

E5.5.1.7; chloromuconate cycloisomerase [EC:5.5.1.7]

K03268

todC1, bedC1, tcbAa; benzene/toluene/chlorobenzene dioxygenase subunit alpha [EC:1.14.12.3 1.14.12.11 1.14.12.26]

K03380

E1.14.13.7; phenol 2-monooxygenase (NADPH) [EC:1.14.13.7]

K03381

catA; catechol 1,2-dioxygenase [EC:1.13.11.1]

K05797

pchF; 4-cresol dehydrogenase (hydroxylating) flavoprotein subunit [EC:1.17.9.1]

K07540

E4.1.99.11; benzylsuccinate synthase [EC:4.1.99.11]

K07543

bbsE; benzylsuccinate CoA-transferase BbsE subunit [EC:2.8.3.15]

K07544

bbsF; benzylsuccinate CoA-transferase BbsF subunit [EC:2.8.3.15]

K07545

bbsG; (R)-benzylsuccinyl-CoA dehydrogenase [EC:1.3.8.3]

K07546

bbsH; (E)-benzylidenesuccinyl-CoA hydratase [EC:4.2.1.180]

K07547

bbsC; (2S)-[(R)-hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase BbsC subunit [EC:1.1.1.429]

K07548

bbsD; (2S)-[(R)-hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase BbsD subunit [EC:1.1.1.429]

K07549

bbsA; benzoylsuccinyl-CoA thiolase BbsA subunit [EC:2.3.1.310]

K07550

bbsB; benzoylsuccinyl-CoA thiolase BbsB subunit [EC:2.3.1.310]

K15757

xylM; toluene methyl-monooxygenase [EC:1.14.15.26]

K15758

xylA; toluene methyl-monooxygenase electron transfer component [EC:1.18.1.3]

K15760

tmoA, tbuA1, touA; toluene monooxygenase system protein A [EC:1.14.13.236 1.14.13.-]

K15761

tmoB, tbuU, touB; toluene monooxygenase system protein B [EC:1.14.13.236 1.14.13.-]

K15762

tmoC, tbuB, touC; toluene monooxygenase system ferredoxin subunit

K15763

tmoD, tbuV, touD; toluene monooxygenase system protein D [EC:1.14.13.236 1.14.13.-]

K15764

tmoE, tbuA2, touE; toluene monooxygenase system protein E [EC:1.14.13.236 1.14.13.-]

K15765

tmoF, tbuC, touF; toluene monooxygenase electron transfer component [EC:1.18.1.3]

K15766

absAa; 2-aminobenzenesulfonate 2,3-dioxygenase subunit alpha [EC:1.14.12.14]

K15767

absAb; 2-aminobenzenesulfonate 2,3-dioxygenase subunit beta [EC:1.14.12.14]

K15768

tsaM; p-toluenesulfonate methyl-monooxygenase oxygenase component TsaM [EC:1.14.13.-]

K15769

tsaB; p-toluenesulfonate methyl-monooxygenase reductase component TsaB [EC:1.5.1.-]

K16242

dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:1.14.13.244 1.14.13.243]

K16243

dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:1.14.13.244 1.14.13.243]

K16244

dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:1.14.13.244 1.14.13.243]

K16245

dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:1.14.13.244 1.14.13.243]

K16246

dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:1.14.13.244 1.14.13.243]

K16249

dmpK, poxA, tomA0; phenol/toluene 2-monooxygenase (NADH) P0/A0

K16268

todC2, bedC2, tcbAb; benzene/toluene/chlorobenzene dioxygenase subunit beta [EC:1.14.12.3 1.14.12.11 1.14.12.26]

K16269

todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase [EC:1.3.1.19 1.3.1.119]

K18089

todB, tcbAc; benzene/toluene/chlorobenzene dioxygenase ferredoxin component

K18090

todA, tcbAd; benzene/toluene/chlorobenzene dioxygenase ferredoxin reductase component [EC:1.18.1.3 1.18.1.-]

K19629

tsaD1; 4-(hydroxymethyl)benzenesulfonate dehydrogenase [EC:1.1.1.257]

K19630

tsaC1; 4-formylbenzenesulfonate dehydrogenase [EC:1.2.1.62]

K20199

pchA; 4-hydroxybenzaldehyde dehydrogenase (NADP+) [EC:1.2.1.96]

K20200

pchC; 4-cresol dehydrogenase (hydroxylating) cytochrome subunit

K20218

hipH; 4-hydroxyisophthalate hydroxylase

Compound

C00091

Succinyl-CoA

C00156

4-Hydroxybenzoate

C00180

Benzoate

C00230

3,4-Dihydroxybenzoate

C00261

Benzaldehyde

C00512

Benzoyl-CoA

C00556

Benzyl alcohol

C00587

3-Hydroxybenzoate

C00633

4-Hydroxybenzaldehyde

C01455

Toluene

C01467

3-Cresol

C01468

4-Cresol

C01542

o-Cresol

C02236

4-Sulfobenzoate

C02923

2,3-Dihydroxytoluene

C03067

3-Hydroxybenzaldehyde

C03351

3-Hydroxybenzyl alcohol

C04112

3-Methyl-cis,cis-hexadienedioate

C04558

3-Methylmuconolactone

C04559

4-Methylmuconolactone

C04592

Toluene-cis-dihydrodiol

C06677

Toluene-4-sulfonate

C06678

4-Sulfobenzyl alcohol

C06679

4-Sulfobenzaldehyde

C06730

4-Methylcatechol

C09816

Benzylsuccinate

C09817

Benzylsuccinyl-CoA

C09818

E-Phenylitaconyl-CoA

C09819

(2S)-[(R)-Hydroxy(phenyl)methyl]succinyl-CoA

C09820

(S)-2-Benzoylsuccinyl-CoA

C14582

2,4-Dimethylphenol

C18300

2,4-Dichlorotoluene

C18301

4,6-Dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene

C18302

4,6-Dichloro-3-methylcatechol

C18303

3,5-Dichloro-2-methylmuconate

C18304

2-Chloro-5-methyl-cis-dienelactone

C18305

2-Chloro-5-methylmaleylacetate

C18306

5-Methylmaleylacetate

C18307

2-Methyl-3-oxoadipate

C18308

3,5-Dichloro-2-methylmuconolactone

C18309

3-Chloro-2-methyldienelactone

C18310

3-Chloro-2-methylmaleylacetate

C18311

4-Methyl-3-oxoadipate-enol-lactone

C18312

4-Methyl-3-oxoadipate

C21166

4-Hydroxy-3-methylbenzaldehyde

C21167

4-Hydroxy-3-methylbenzoate

C21168

4-Hydroxyisophthalate

Reference

PMID:15184119

Authors

Vardar G, Wood TK

Title

Protein engineering of toluene-o-xylene monooxygenase from Pseudomonas stutzeri OX1 for synthesizing 4-methylresorcinol, methylhydroquinone, and pyrogallol.

Journal

Appl Environ Microbiol 70:3253-62 (2004)
DOI:10.1128/AEM.70.6.3253-3262.2004

Reference

PMID:10629170

Authors

Leuthner B, Heider J

Title

Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.

Journal

J Bacteriol 182:272-7 (2000)
DOI:10.1128/JB.182.2.272-277.2000

Reference

PMID:11418570

Authors

Leutwein C, Heider J

Title

Succinyl-CoA:(R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria.

Journal

J Bacteriol 183:4288-95 (2001)
DOI:10.1128/JB.183.14.4288-4295.2001

Reference

PMID:15687214

Authors

Kuhner S, Wohlbrand L, Fritz I, Wruck W, Hultschig C, Hufnagel P, Kube M, Reinhardt R, Rabus R

Title

Substrate-dependent regulation of anaerobic degradation pathways for toluene and ethylbenzene in a denitrifying bacterium, strain EbN1.

Journal

J Bacteriol 187:1493-503 (2005)
DOI:10.1128/JB.187.4.1493-1503.2005

Reference

PMID:2050632

Authors

Locher HH, Leisinger T, Cook AM

Title

4-Toluene sulfonate methyl-monooxygenase from Comamonas testosteroni T-2: purification and some properties of the oxygenase component.

Journal

J Bacteriol 173:3741-8 (1991)
DOI:10.1128/JB.173.12.3741-3748.1991

Reference

PMID:8828208

Authors

Junker F, Saller E, Schlafli Oppenberg HR, Kroneck PM, Leisinger T, Cook AM

Title

Degradative pathways for p-toluenecarboxylate and p-toluenesulfonate and their multicomponent oxygenases in Comamonas testosteroni strains PSB-4 and T-2.

Journal

Microbiology 142 ( Pt 9):2419-27 (1996)
DOI:10.1099/00221287-142-9-2419

Reference

PMID:10589735

Authors

Mampel J, Ruff J, Junker F, Cook AM.

Title

The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.

Journal

Microbiology 145 ( Pt 11):3255-64 (1999)
DOI:10.1099/00221287-145-11-3255

Reference

PMID:9006050