Entry
Name
Peptidoglycan biosynthesis - Staphylococcus aureus subsp. aureus MW2 (CA-MRSA)
Description
Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lipid I and II). Polymerization of disaccharide subunits by transglycosylases and cross-linking of glycan strands by transpeptidases occur on the other side of the membrane. Bacterial cell wall biosynthesis inhibitors form a major class of antibiotics.
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
Ortholog table
Organism
Staphylococcus aureus subsp. aureus MW2 (CA-MRSA) [GN:
sam ]
Gene
MW0700 ORFID:MW0700; hypothetical protein, similar to UDP-N-acetylenolpyruvoylglucosamine reductase [KO:K00075 ] [EC:1.3.1.98 ]
MW2005 murF; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase [KO:K01929 ] [EC:6.3.2.10 ]
MW1521 ORFID:MW1521; hypothetical protein, similar to diacylglycerol kinase [KO:K00887 ] [EC:2.7.1.66 ]
MW0645 bacA; ORFID:MW0645; bacitracin resistance protein (putative undecaprenol kinase) homologue [KO:K06153 ] [EC:3.6.1.27 ]
MW0899 murE; UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase [KO:K05362 ] [EC:6.3.2.7 ]
MW1833 ORFID:MW1833; hypothetical protein, similar to UDP-N-acetylmuramyl tripeptide synthetase homolo [KO:K23393 ] [EC:6.3.5.13 ]
MW1832 ORFID:MW1832; hypothetical protein, similar to cobyric acid synthase CobQ [KO:K07009 ] [EC:6.3.5.13 ]
MW1814 sgtB; ORFID:MW1814; hypothetical protein, similar to penicillin-binding protein 1A/1B [KO:K04478 ] [EC:2.4.99.28 ]
MW1064 pbpA; penicillin-binding protein 1 [KO:K12552 ] [EC:3.4.-.-]
MW1504 pbp3; penicillin-binding protein 3 [KO:K12553 ] [EC:3.4.-.-]
Compound
C00043 UDP-N-acetyl-alpha-D-glucosamine
C00448 trans,trans-Farnesyl diphosphate
C00692 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
C01212 UDP-N-acetylmuramoyl-L-alanine
C04574 di-trans,poly-cis-Undecaprenyl diphosphate
C04631 UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C04702 UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)
C04851 MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol
C04877 UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05892 UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
C05893 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
C05894 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine
C05895 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine
C05896 Crosslinked peptidoglycan
C05897 Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C05898 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C17541 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine
C17542 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)3-D-alanyl-D-alanine
C17549 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl-L-alanyl)-D-alanyl-D-alanine
C17550 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
C17556 di-trans,poly-cis-Undecaprenyl phosphate
C17558 di-trans,poly-cis-Undecaprenol
C22053 UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
Reference
Authors
Bouhss A, Trunkfield AE, Bugg TD, Mengin-Lecreulx D
Title
The biosynthesis of peptidoglycan lipid-linked intermediates.
Journal
Reference
Authors
Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG
Title
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
Journal
Reference
Authors
Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D
Title
Cytoplasmic steps of peptidoglycan biosynthesis.
Journal
Reference
Authors
van Heijenoort J
Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
Journal
Reference
Authors
van Heijenoort J
Title
Formation of the glycan chains in the synthesis of bacterial peptidoglycan.
Journal
Related pathway
sam00520 Amino sugar and nucleotide sugar metabolism
sam00900 Terpenoid backbone biosynthesis
KO pathway
LinkDB
All DBs