KEGG   PATHWAY: smi00061
Entry
smi00061                    Pathway                                
Name
Fatty acid biosynthesis - Sinorhizobium meliloti Rm41
Class
Metabolism; Lipid metabolism
Pathway map
smi00061  Fatty acid biosynthesis
smi00061

Module
smi_M00082  Fatty acid biosynthesis, initiation [PATH:smi00061]
smi_M00083  Fatty acid biosynthesis, elongation [PATH:smi00061]
smi_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:smi00061]
Other DBs
GO: 0006633
Organism
Sinorhizobium meliloti Rm41 [GN:smi]
Gene
BN406_02540  accA; Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha [KO:K01962] [EC:6.4.1.2 2.1.3.15]
BN406_01053  accB; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit [KO:K02160]
BN406_01052  accC; Biotin carboxylase [KO:K01961] [EC:6.4.1.2 6.3.4.14]
BN406_03165  accD; Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta [KO:K01963] [EC:6.4.1.2 2.1.3.15]
BN406_06793  bccA; Acetyl-/propionyl-coenzyme A carboxylase alpha chain [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
BN406_00877  fabD; Malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
BN406_00958  fabH; 3-oxoacyl-ACP synthase [KO:K00648] [EC:2.3.1.180]
BN406_03378  fabB; 3-oxoacyl-[acyl-carrier-protein] synthase 1 [KO:K00647] [EC:2.3.1.41]
BN406_00880  fabF; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
BN406_01668  3-oxoacyl-ACP synthase [KO:K09458] [EC:2.3.1.179]
BN406_01669  3-oxoacyl-ACP synthase [KO:K09458] [EC:2.3.1.179]
BN406_03879  3-ketoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
BN406_00878  nodG; Nodulation protein G [KO:K00059] [EC:1.1.1.100]
BN406_02869  oxidoreductase [KO:K00059] [EC:1.1.1.100]
BN406_03494  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
BN406_03670  Short-chain type dehydrogenase/reductase [KO:K00059] [EC:1.1.1.100]
BN406_03760  short-chain dehydrogenase/reductase SDR [KO:K00059] [EC:1.1.1.100]
BN406_01391  putative short-chain dehydrogenase/reductase [KO:K00059] [EC:1.1.1.100]
BN406_04264  nodG; Nodulation protein G [KO:K00059] [EC:1.1.1.100]
BN406_04355  Short-chain type dehydrogenase/reductase [KO:K00059] [EC:1.1.1.100]
BN406_06191  Short-chain type dehydrogenase/reductase [KO:K00059] [EC:1.1.1.100]
BN406_06222  3-oxoacyl-(acyl-carrier-protein) reductase [KO:K00059] [EC:1.1.1.100]
BN406_06762  hypothetical protein [KO:K00059] [EC:1.1.1.100]
BN406_03731  short chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
BN406_03856  short-chain dehydrogenase/reductase SDR [KO:K00059] [EC:1.1.1.100]
BN406_03092  fabG; 3-ketoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
BN406_03379  fabA; 3-hydroxydecanoyl-ACP dehydratase [KO:K01716] [EC:4.2.1.59 5.3.3.14]
BN406_01236  fabZ; (3R)-hydroxymyristoyl-[acyl-carrier-protein]dehydratase [KO:K02372] [EC:4.2.1.59]
BN406_01670  beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ [KO:K02372] [EC:4.2.1.59]
BN406_03377  fabI2; Enoyl-[acyl-carrier-protein] reductase [NADH] 2 [KO:K00208] [EC:1.3.1.9 1.3.1.10]
BN406_04095  fabI1; Enoyl-[acyl-carrier-protein] reductase [NADH] 1 [KO:K00208] [EC:1.3.1.9 1.3.1.10]
BN406_00553  fabI1; Enoyl-[acyl-carrier-protein] reductase [NADH] 1 [KO:K00208] [EC:1.3.1.9 1.3.1.10]
BN406_00132  fadD; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
BN406_05342  long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
PMID:12061798
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
PMID:12518017
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
PMID:11337402
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
PMID:17573542
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
PMID:30201289
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
PMID:25203508
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
PMID:19686777
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
PMID:27553474
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
smi00020  Citrate cycle (TCA cycle)
smi00071  Fatty acid degradation
smi00410  beta-Alanine metabolism
smi00561  Glycerolipid metabolism
smi00564  Glycerophospholipid metabolism
smi00620  Pyruvate metabolism
smi00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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