KEGG PATHWAY: smil04145

KEGG

PATHWAY: smil04145

Entry

smil04145                   Pathway

Name

Phagosome - Salvia miltiorrhiza (redroot sage)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

Phagosome

Other DBs

GO:

Organism

Salvia miltiorrhiza (redroot sage) [GN:smil]

Gene

syntaxin-81-like [KO:K08492]

syntaxin-81-like [KO:K08492]

syntaxin-81-like [KO:K08492]

25.3 kDa vesicle transport protein SEC22-1-like [KO:K08517]

25.3 kDa vesicle transport protein SEC22-1 [KO:K08517]

LOW QUALITY PROTEIN: ras-related protein RHN1-like [KO:K07889]

ras-related protein RABF1 isoform X1 [KO:K07889]

phosphatidylinositol 3-kinase, root isoform [KO:K00914] [EC:2.7.1.137]

V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase subunit B 2 isoform X1 [KO:K02147]

V-type proton ATPase subunit B2-like isoform X1 [KO:K02147]

V-type proton ATPase subunit C-like [KO:K02148]

V-type proton ATPase subunit C-like [KO:K02148]

V-type proton ATPase subunit D-like [KO:K02149]

V-type proton ATPase subunit D-like [KO:K02149]

V-type proton ATPase subunit E-like isoform X1 [KO:K02150]

V-type proton ATPase subunit E-like [KO:K02150]

V-type proton ATPase subunit E2-like [KO:K02150]

V-type proton ATPase subunit E-like [KO:K02150]

V-type proton ATPase subunit F isoform X1 [KO:K02151]

V-type proton ATPase subunit G-like [KO:K02152]

V-type proton ATPase subunit G 1-like [KO:K02152]

V-type proton ATPase subunit G 1 [KO:K02152]

V-type proton ATPase subunit e1 [KO:K02153]

V-type proton ATPase subunit a1-like isoform X1 [KO:K02154]

V-type proton ATPase subunit a1-like [KO:K02154]

V-type proton ATPase subunit a3 [KO:K02154]

V-type proton ATPase subunit H-like [KO:K02144]

V-type proton ATPase subunit H-like [KO:K02144]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]

V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase subunit c''2-like [KO:K03661]

V-type proton ATPase subunit c''2 [KO:K03661]

ras-related protein Rab7 [KO:K07897]

ras-related protein Rab7 [KO:K07897]

ras-related protein Rab7 [KO:K07897]

ras-related protein Rab7-like [KO:K07897]

ras-related protein Rab7-like isoform X1 [KO:K07897]

tubulin alpha-5 chain [KO:K07374]

tubulin alpha-5 chain-like [KO:K07374]

tubulin alpha chain-like [KO:K07374]

tubulin alpha chain-like [KO:K07374]

tubulin alpha-5 chain-like [KO:K07374]

tubulin alpha chain [KO:K07374]

tubulin beta chain [KO:K07375]

tubulin beta-1 chain [KO:K07375]

tubulin beta-9 chain [KO:K07375]

tubulin beta-1 chain [KO:K07375]

tubulin beta-1 chain [KO:K07375]

tubulin beta-1 chain-like [KO:K07375]

tubulin beta chain-like [KO:K07375]

tubulin beta-1 chain [KO:K07375]

tubulin beta-5 chain-like [KO:K07375]

tubulin beta-2 chain [KO:K07375]

1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like [KO:K00921] [EC:2.7.1.150]

putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D isoform X1 [KO:K00921] [EC:2.7.1.150]

1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like isoform X1 [KO:K00921] [EC:2.7.1.150]

putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D [KO:K00921] [EC:2.7.1.150]

putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]

LOW QUALITY PROTEIN: 1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like [KO:K00921] [EC:2.7.1.150]

1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like isoform X1 [KO:K00921] [EC:2.7.1.150]

uncharacterized protein LOC131013000 [KO:K10956]

uncharacterized protein LOC130985262 [KO:K10956]

uncharacterized protein LOC130986888 [KO:K10956]

protein transport protein Sec61 subunit beta [KO:K09481]

protein transport protein Sec61 subunit beta-like [KO:K09481]

protein transport protein Sec61 subunit beta-like [KO:K09481]

protein transport protein Sec61 subunit gamma-1-like [KO:K07342]

protein transport protein Sec61 subunit gamma-1-like [KO:K07342]

protein transport protein Sec61 subunit gamma-1-like [KO:K07342]

protein transport protein Sec61 subunit gamma-1 [KO:K07342]

protein transport protein Sec61 subunit gamma-1-like [KO:K07342]

calreticulin-like [KO:K08057]

calreticulin-3 [KO:K08057]

calnexin homolog 1-like [KO:K08054]

rac-like GTP-binding protein RHO1 [KO:K04392]

rac-like GTP-binding protein 5 [KO:K04392]

rac-like GTP-binding protein RAC13 [KO:K04392]

rac-like GTP-binding protein RAC13 [KO:K04392]

rac-like GTP-binding protein ARAC7 [KO:K04392]

rac-like GTP-binding protein 5 [KO:K04392]

rac-like GTP-binding protein 5 [KO:K04392]

LOW QUALITY PROTEIN: rac-like GTP-binding protein ARAC7 [KO:K04392]

rac-like GTP-binding protein ARAC7 [KO:K04392]

rac-like GTP-binding protein RHO1 [KO:K04392]

rac-like GTP-binding protein ARAC7 isoform X1 [KO:K04392]

rac-like GTP-binding protein RHO1 [KO:K04392]

rac-like GTP-binding protein ARAC7 [KO:K04392]

rac-like GTP-binding protein ARAC3 [KO:K04392]

rac-like GTP-binding protein ARAC8 [KO:K04392]

Compound

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002

Reference

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R

Reference

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036

Reference

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005

Reference

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511

Reference

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217

Reference

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x

Related
pathway

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system