KEGG   PATHWAY: smp04141
Entry
smp04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Sordaria macrospora
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
smp04141  Protein processing in endoplasmic reticulum
smp04141

Other DBs
GO: 0030433 0034976
Organism
Sordaria macrospora [GN:smp]
Gene
10804312  SMAC4_05120; uncharacterized protein [KO:K10956]
10802744  SMAC4_04645; uncharacterized protein [KO:K09481]
36391702  SMAC4_12704; uncharacterized protein [KO:K07342]
10807631  SMAC4_01015; uncharacterized protein [KO:K12275]
10808090  SMAC4_02255; uncharacterized protein [KO:K09540]
10803660  SMAC4_05819; uncharacterized protein [KO:K12666]
10805902  SMAC4_02943; uncharacterized protein [KO:K12667]
10809431  SMAC4_00392; uncharacterized protein [KO:K12668]
10802204  SMAC4_06173; uncharacterized protein [KO:K12669]
10810469  SMAC4_01348; uncharacterized protein [KO:K12670]
10808629  SMAC4_04366; uncharacterized protein [KO:K07151] [EC:2.4.99.18]
10809779  SMAC4_02532; uncharacterized protein [KO:K01228] [EC:3.2.1.106]
10809291  SMAC4_00245; uncharacterized protein [KO:K14001]
10808749  SMAC4_08187; uncharacterized protein [KO:K09486]
10802188  SMAC4_06157; uncharacterized protein [KO:K09490] [EC:3.6.4.10]
10803583  SMAC4_05738; uncharacterized protein [KO:K09490] [EC:3.6.4.10]
10801657  SMAC4_08314; uncharacterized protein [KO:K09523]
10806750  SMAC4_05549; uncharacterized protein [KO:K14002]
10800990  SMAC4_04391; uncharacterized protein [KO:K05546] [EC:3.2.1.207]
10810657  SMAC4_03320; uncharacterized protein [KO:K08288]
10804977  SMAC4_04852; uncharacterized protein [KO:K08054]
10803233  SMAC4_09232; uncharacterized protein [KO:K01230] [EC:3.2.1.113]
10809007  SMAC4_03674; uncharacterized protein [KO:K01230] [EC:3.2.1.113]
10809029  SMAC4_07614; uncharacterized protein [KO:K01230] [EC:3.2.1.113]
10805220  SMAC4_03884; uncharacterized protein [KO:K01230] [EC:3.2.1.113]
10805826  SMAC4_02865; uncharacterized protein [KO:K01230] [EC:3.2.1.113]
10809927  SMAC4_02735; uncharacterized protein [KO:K01230] [EC:3.2.1.113]
10804969  SMAC4_04842; uncharacterized protein [KO:K23741] [EC:3.2.1.209]
10803164  SMAC4_07079; uncharacterized protein [KO:K10082]
10808096  SMAC4_02261; uncharacterized protein [KO:K10080]
10801525  SMAC4_06445; uncharacterized protein [KO:K07953] [EC:3.6.5.-]
10807276  SMAC4_00646; uncharacterized protein [KO:K14004]
10802275  SMAC4_06728; uncharacterized protein [KO:K14005]
10805613  SMAC4_04008; uncharacterized protein [KO:K14006]
10803122  SMAC4_05922; uncharacterized protein [KO:K14007]
10808992  SMAC4_03493; uncharacterized protein [KO:K14007]
10808815  SMAC4_03536; uncharacterized protein [KO:K11718] [EC:2.4.1.-]
10809423  SMAC4_00384; uncharacterized protein [KO:K09580] [EC:5.3.4.1]
10810285  SMAC4_01494; uncharacterized protein [KO:K09584] [EC:5.3.4.1]
10809771  SMAC4_02589; uncharacterized protein [KO:K09584] [EC:5.3.4.1]
10807620  SMAC4_01003; uncharacterized protein [KO:K13996] [EC:5.3.4.1]
10810480  SMAC4_04971; uncharacterized protein [KO:K10976] [EC:1.8.4.-]
10802006  SMAC4_09409; uncharacterized protein [KO:K10088]
10803607  SMAC4_05764; uncharacterized protein [KO:K14009]
10805597  SMAC4_03991; uncharacterized protein [KO:K13989]
10808113  SMAC4_02278; uncharacterized protein [KO:K13989]
10806726  SMAC4_05524; uncharacterized protein [KO:K24348]
10807083  SMAC4_03176; uncharacterized protein [KO:K14012]
10809161  SMAC4_00109; uncharacterized protein [KO:K13525]
10808632  SMAC4_04337; uncharacterized protein [KO:K14015]
10804174  SMAC4_04187; uncharacterized protein [KO:K14016]
10801348  SMAC4_08900; uncharacterized protein [KO:K03283]
10810481  SMAC4_04972; uncharacterized protein [KO:K03283]
10809404  SMAC4_00364; uncharacterized protein [KO:K09503]
10806336  SMAC4_01899; uncharacterized protein [KO:K09503]
10804057  SMAC4_04098; uncharacterized protein [KO:K09518]
10801112  SMAC4_04445; uncharacterized protein [KO:K04079]
10801014  SMAC4_04417; uncharacterized protein [KO:K09562]
10808810  SMAC4_03531; uncharacterized protein [KO:K13719] [EC:3.1.2.-]
10810356  SMAC4_01567; uncharacterized protein [KO:K14018]
10806475  SMAC4_02013; uncharacterized protein [KO:K10839]
10809449  SMAC4_00410; uncharacterized protein [KO:K04523]
10810128  SMAC4_01332; uncharacterized protein [KO:K01456] [EC:3.5.1.52]
10804034  SMAC4_04077; uncharacterized protein [KO:K10597] [EC:2.3.2.27]
10807558  SMAC4_00938; uncharacterized protein [KO:K03237]
10808918  SMAC4_03644; uncharacterized protein [KO:K08852] [EC:2.7.11.1 3.1.26.-]
10805715  SMAC4_08017; uncharacterized protein [KO:K10661] [EC:2.3.2.27]
10805570  SMAC4_03964; uncharacterized protein [KO:K10578] [EC:2.3.2.23]
10810640  SMAC4_03303; uncharacterized protein [KO:K04554] [EC:2.3.2.23]
10807423  SMAC4_00799; uncharacterized protein [KO:K10575] [EC:2.3.2.23]
10807008  SMAC4_03099; uncharacterized protein [KO:K04555] [EC:2.3.2.23]
10807854  SMAC4_00879; uncharacterized protein [KO:K14022]
10801849  SMAC4_07521; uncharacterized protein [KO:K10601] [EC:2.3.2.27]
10803633  SMAC4_05791; uncharacterized protein [KO:K14026]
10807764  SMAC4_01151; uncharacterized protein [KO:K09561] [EC:2.3.2.27]
10801783  SMAC4_08740; uncharacterized protein [KO:K06689] [EC:2.3.2.23]
10803180  SMAC4_07095; uncharacterized protein [KO:K03868] [EC:2.3.2.32]
10804780  SMAC4_07196; uncharacterized protein [KO:K03347]
10806381  SMAC4_01944; uncharacterized protein [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
smp00510  N-Glycan biosynthesis
smp03050  Proteasome
smp03060  Protein export
KO pathway
ko04141   
LinkDB

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