KEGG   PATHWAY: tsa00260
Entry
tsa00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Terriglobus saanensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
tsa00260  Glycine, serine and threonine metabolism
tsa00260

Module
tsa_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:tsa00260]
tsa_M00621  Glycine cleavage system [PATH:tsa00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Terriglobus saanensis [GN:tsa]
Gene
AciPR4_0859  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AciPR4_0946  Semialdehyde dehydrogenase NAD - binding protein [KO:K00133] [EC:1.2.1.11]
AciPR4_0860  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AciPR4_3474  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AciPR4_1189  homoserine kinase [KO:K00872] [EC:2.7.1.39]
AciPR4_1188  threonine synthase [KO:K01733] [EC:4.2.3.1]
AciPR4_0850  threonine synthase [KO:K01733] [EC:4.2.3.1]
AciPR4_0976  threonine synthase [KO:K01733] [EC:4.2.3.1]
AciPR4_1646  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
AciPR4_2203  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
AciPR4_4070  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AciPR4_1527  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
AciPR4_1500  phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [KO:K15633] [EC:5.4.2.12]
AciPR4_0546  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AciPR4_0053  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
AciPR4_0838  short-chain dehydrogenase/reductase SDR [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AciPR4_0726  Glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
AciPR4_0725  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AciPR4_0468  L-amino-acid oxidase [KO:K00274] [EC:1.4.3.4]
AciPR4_3406  amine oxidase [KO:K00274] [EC:1.4.3.4]
AciPR4_3616  amine oxidase [KO:K00274] [EC:1.4.3.4]
AciPR4_4021  amine oxidase [KO:K00274] [EC:1.4.3.4]
AciPR4_0473  Copper amine oxidase domain-containing protein [KO:K00276] [EC:1.4.3.21]
AciPR4_3083  Glycine cleavage system P-protein-like protein [KO:K00282] [EC:1.4.4.2]
AciPR4_3085  aminotransferase class V [KO:K00283] [EC:1.4.4.2]
AciPR4_3080  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
AciPR4_0011  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AciPR4_3081  glycine cleavage system H protein [KO:K02437]
AciPR4_0945  CDP-diacylglycerol/serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AciPR4_2446  Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
AciPR4_0798  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
AciPR4_3858  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AciPR4_2794  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K01754] [EC:4.3.1.19]
AciPR4_3865  tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
AciPR4_3866  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
tsa00010  Glycolysis / Gluconeogenesis
tsa00020  Citrate cycle (TCA cycle)
tsa00230  Purine metabolism
tsa00250  Alanine, aspartate and glutamate metabolism
tsa00270  Cysteine and methionine metabolism
tsa00290  Valine, leucine and isoleucine biosynthesis
tsa00300  Lysine biosynthesis
tsa00330  Arginine and proline metabolism
tsa00460  Cyanoamino acid metabolism
tsa00470  D-Amino acid metabolism
tsa00564  Glycerophospholipid metabolism
tsa00600  Sphingolipid metabolism
tsa00620  Pyruvate metabolism
tsa00630  Glyoxylate and dicarboxylate metabolism
tsa00640  Propanoate metabolism
tsa00680  Methane metabolism
tsa00860  Porphyrin metabolism
tsa00920  Sulfur metabolism
KO pathway
ko00260   
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