Entry
Name
Drug metabolism - cytochrome P450 - Thamnophis sirtalis (common garter snake)
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
tsr00982 Drug metabolism - cytochrome P450
Ortholog table
Organism
Thamnophis sirtalis (common garter snake) [GN:
tsr ]
Gene
Compound
C07496 Carbamazepine-10,11-epoxide
C07643 4-Hydroxycyclophosphamide
C11583 4-Glutathionyl cyclophosphamide
C16548 N,N-Didesmethyltamoxifen
C16549 alpha-Hydroxy-N-desmethyltamoxifen
C16550 Dechloroethylcyclophosphamide
C16555 2-Dechloroethylifosfamide
C16559 Isophosphoramide mustard
C16561 Monoethylglycinexylidide
C16570 4-Hydroxy-2,6-dimethylaniline
C16571 2-Amino-3-methylbenzoate
C16572 3-Hydroxymonoethylglycinexylidide
C16586 2-Phenyl-1,3-propanediol monocarbamate
C16587 3-Carbamoyl-2-phenylpropionaldehyde
C16591 3-Carbamoyl-2-phenylpropionic acid
C16595 4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596 5-Phenyl-1,3-oxazinane-2,4-dione
C16603 2,3-Dihydroxycarbamazepine
C16605 2H-Dibenz[b,f]azepin-2-one
C16606 Carbamazepine-o-quinone
C16610 Citalopram propionic acid
C16648 2-n-Propyl-4-pentenoic acid
C16653 2-n-Propyl-2-pentenoic acid
C16654 2-n-Propyl-3-pentenoic acid
C16655 2-n-Propyl-4-oxopentanoic acid
C16656 2-Propyl-2,4-pentadienoic acid
C16659 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660 2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661 L-alpha-Acetyl-N-normethadol
C16662 L-alpha-Acetyl-N,N-dinormethadol
D00252 Carbamazepine (JP18/USP/INN)
D00343 Ifosfamide (JAN/USP/INN)
D00358 Lidocaine (JP18/USP/INN)
D00533 Oxcarbazepine (JAN/USP/INN)
D04716 Levomethadyl acetate (USAN)
Reference
Authors
Kato R, Kamatari T (eds).
Title
[Drug Metabolism] (In Japanese)
Journal
Tokyo Kagaku Dojin (2000)
Reference
Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
Journal
Reference
Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
Journal
Reference
Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
Title
Cytochrome P450 pharmacogenetics and cancer.
Journal
Reference
Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
Journal
Reference
Authors
Kosel M, Amey M, Aubert AC, Baumann P.
Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
Journal
Reference
Authors
Olesen OV, Linnet K.
Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
Journal
Reference
Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
Journal
Reference
Authors
David AW, Thomas LL, William OF.
Title
Foye's Principles of Medicinal Chemistry (5th ed)
Journal
Lippincott Williams & Wilkins (2002)
Reference
Authors
Oda Y, Kharasch ED.
Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
Journal
Reference
Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Journal
Reference
Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Journal
Reference
Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
Authors
Bernad T, Joachim M.
Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
Journal
Wiley-VCH (2003)
KO pathway
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