KEGG   PATHWAY: tua00999
Entry
tua00999                    Pathway                                
Name
Biosynthesis of various plant secondary metabolites - Triticum urartu (red wild einkorn wheat)
  Including
Crocin biosynthesis, Ginsenoside biosynthesis, Saponin adjuvant biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
tua00999  Biosynthesis of various plant secondary metabolites
tua00999

Module
tua_M00953  Mugineic acid biosynthesis, methionine => 3-epihydroxymugineic acid [PATH:tua00999]
Organism
Triticum urartu (red wild einkorn wheat) [GN:tua]
Gene
125514020  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
125514022  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
125517549  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
125554651  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
125543937  S-adenosylmethionine synthase 1 isoform X1 [KO:K00789] [EC:2.5.1.6]
125527469  probable nicotianamine synthase 4 [KO:K05953] [EC:2.5.1.43]
125511657  probable nicotianamine synthase 2 [KO:K05953] [EC:2.5.1.43]
125512992  probable nicotianamine synthase 4 [KO:K05953] [EC:2.5.1.43]
125513000  probable nicotianamine synthase 4 [KO:K05953] [EC:2.5.1.43]
125513062  nicotianamine synthase-like 5 protein [KO:K05953] [EC:2.5.1.43]
125549185  nicotianamine synthase-like 5 protein [KO:K05953] [EC:2.5.1.43]
125514551  nicotianamine synthase 1 [KO:K05953] [EC:2.5.1.43]
125514663  nicotianamine synthase 1-like [KO:K05953] [EC:2.5.1.43]
125535178  nicotianamine synthase-like 5 protein [KO:K05953] [EC:2.5.1.43]
125535247  probable nicotianamine synthase 2 [KO:K05953] [EC:2.5.1.43]
125535551  nicotianamine synthase 9 [KO:K05953] [EC:2.5.1.43]
125553908  probable nicotianamine synthase 6 [KO:K05953] [EC:2.5.1.43]
125553909  probable nicotianamine synthase 6 [KO:K05953] [EC:2.5.1.43]
125540768  probable nicotianamine synthase 2 [KO:K05953] [EC:2.5.1.43]
125536048  nicotianamine aminotransferase A isoform X1 [KO:K14271] [EC:2.6.1.80]
125521156  nicotianamine aminotransferase A-like [KO:K14271] [EC:2.6.1.80]
125534930  probable NAD(P)H-dependent oxidoreductase 1 [KO:K22374] [EC:1.1.1.285]
125552360  deoxymugineic acid synthase 1-A [KO:K22374] [EC:1.1.1.285]
125538422  D-galacturonate reductase-like [KO:K22374] [EC:1.1.1.285]
125538423  deoxymugineic acid synthase 1-D-like [KO:K22374] [EC:1.1.1.285]
125523862  deoxymugineic acid synthase 1-D-like [KO:K22374] [EC:1.1.1.285]
125528513  2'-deoxymugineic-acid 2'-dioxygenase-like [KO:K18054] [EC:1.14.11.24 1.14.11.25]
125528766  2'-deoxymugineic-acid 2'-dioxygenase-like [KO:K18054] [EC:1.14.11.24 1.14.11.25]
125529970  2'-deoxymugineic-acid 2'-dioxygenase-like [KO:K18054] [EC:1.14.11.24 1.14.11.25]
125548929  gibberellin 20 oxidase 3-like [KO:K18054] [EC:1.14.11.24 1.14.11.25]
125514132  2'-deoxymugineic-acid 2'-dioxygenase-like [KO:K18054] [EC:1.14.11.24 1.14.11.25]
125514172  2'-deoxymugineic-acid 2'-dioxygenase-like [KO:K18054] [EC:1.14.11.24 1.14.11.25]
125515769  2'-deoxymugineic-acid 2'-dioxygenase-like [KO:K18054] [EC:1.14.11.24 1.14.11.25]
125516388  2'-deoxymugineic-acid 2'-dioxygenase-like [KO:K18054] [EC:1.14.11.24 1.14.11.25]
125520118  2'-deoxymugineic-acid 2'-dioxygenase-like [KO:K18054] [EC:1.14.11.24 1.14.11.25]
125521867  2'-deoxymugineic-acid 2'-dioxygenase-like [KO:K18054] [EC:1.14.11.24 1.14.11.25]
125508456  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic isoform X1 [KO:K13832] [EC:4.2.1.10 1.1.1.25]
125543787  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like isoform X1 [KO:K13832] [EC:4.2.1.10 1.1.1.25]
125506147  tryptophan synthase alpha chain-like [KO:K13222] [EC:4.1.2.8]
125506148  tryptophan synthase alpha chain-like [KO:K13222] [EC:4.1.2.8]
125506150  tryptophan synthase alpha chain-like [KO:K13222] [EC:4.1.2.8]
125506153  tryptophan synthase alpha chain-like [KO:K13222] [EC:4.1.2.8]
125506154  tryptophan synthase alpha chain-like [KO:K13222] [EC:4.1.2.8]
125506155  tryptophan synthase alpha chain-like [KO:K13222] [EC:4.1.2.8]
125553965  indole-3-glycerol phosphate lyase, chloroplastic-like [KO:K13222] [EC:4.1.2.8]
125542439  indole-3-glycerol phosphate lyase, chloroplastic-like [KO:K13222] [EC:4.1.2.8]
125553966  indole-2-monooxygenase-like [KO:K13223] [EC:1.14.14.153]
125506870  indolin-2-one monooxygenase-like [KO:K13224] [EC:1.14.14.157]
125539751  indolin-2-one monooxygenase-like [KO:K13224] [EC:1.14.14.157]
125555414  3-hydroxyindolin-2-one monooxygenase-like [KO:K13225] [EC:1.14.14.109]
125506869  cytochrome P450 71C3-like [KO:K13226] [EC:1.14.14.110]
125523142  DIMBOA UDP-glucosyltransferase BX8-like [KO:K13227] [EC:2.4.1.202]
125523860  DIMBOA UDP-glucosyltransferase BX8-like [KO:K13227] [EC:2.4.1.202]
125511240  DIMBOA UDP-glucosyltransferase BX8-like [KO:K13227] [EC:2.4.1.202]
125509768  beta-glucosidase 30-like [KO:K01188] [EC:3.2.1.21]
125509774  beta-glucosidase 30-like [KO:K01188] [EC:3.2.1.21]
125509999  beta-glucosidase 31-like isoform X1 [KO:K01188] [EC:3.2.1.21]
125510002  beta-glucosidase 31-like [KO:K01188] [EC:3.2.1.21]
125528364  beta-glucosidase 5-like isoform X1 [KO:K01188] [EC:3.2.1.21]
125545133  beta-glucosidase 2-like isoform X1 [KO:K01188] [EC:3.2.1.21]
125545521  beta-glucosidase 4 [KO:K01188] [EC:3.2.1.21]
125510619  beta-glucosidase BoGH3B-like [KO:K01188] [EC:3.2.1.21]
125545854  beta-glucosidase 5-like isoform X1 [KO:K01188] [EC:3.2.1.21]
125545855  beta-glucosidase 5-like isoform X1 [KO:K01188] [EC:3.2.1.21]
125545857  beta-glucosidase 3-like [KO:K01188] [EC:3.2.1.21]
125545858  beta-glucosidase 5-like [KO:K01188] [EC:3.2.1.21]
125530822  beta-glucosidase 31-like [KO:K01188] [EC:3.2.1.21]
125530823  beta-glucosidase 31-like isoform X1 [KO:K01188] [EC:3.2.1.21]
125534587  beta-glucosidase 22-like [KO:K01188] [EC:3.2.1.21]
125535564  beta-glucosidase 5-like [KO:K01188] [EC:3.2.1.21]
125552499  beta-glucosidase 6 [KO:K01188] [EC:3.2.1.21]
125552510  beta-glucosidase 6-like [KO:K01188] [EC:3.2.1.21]
125519523  beta-glucosidase 25 isoform X1 [KO:K01188] [EC:3.2.1.21]
125519601  beta-glucosidase 25 isoform X1 [KO:K01188] [EC:3.2.1.21]
125519850  beta-glucosidase 24-like [KO:K01188] [EC:3.2.1.21]
125538702  beta-glucosidase 12-like isoform X1 [KO:K01188] [EC:3.2.1.21]
125538703  beta-glucosidase 12-like [KO:K01188] [EC:3.2.1.21]
125521421  beta-glucosidase 28-like [KO:K01188] [EC:3.2.1.21]
125540120  beta-glucosidase 12-like [KO:K01188] [EC:3.2.1.21]
125540121  beta-glucosidase 12-like [KO:K01188] [EC:3.2.1.21]
125522028  uncharacterized protein LOC125522028 [KO:K01188] [EC:3.2.1.21]
125522552  beta-glucosidase 34-like [KO:K01188] [EC:3.2.1.21]
125522648  beta-glucosidase 28-like [KO:K01188] [EC:3.2.1.21]
125543536  beta-glucosidase 10-like isoform X1 [KO:K01188] [EC:3.2.1.21]
125510618  beta-glucosidase BoGH3B-like isoform X1 [KO:K05349] [EC:3.2.1.21]
125544924  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
125544938  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
125510617  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
125548271  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
125531234  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
125541460  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
125544391  beta-glucosidase 7-like [KO:K05350] [EC:3.2.1.21]
125547483  beta-glucosidase 26-like [KO:K05350] [EC:3.2.1.21]
125531158  beta-glucosidase 16-like [KO:K05350] [EC:3.2.1.21]
125550356  beta-glucosidase 8-like [KO:K05350] [EC:3.2.1.21]
125550357  beta-glucosidase 7-like [KO:K05350] [EC:3.2.1.21]
125535217  beta-glucosidase 16-like isoform X1 [KO:K05350] [EC:3.2.1.21]
125535900  beta-glucosidase 26-like [KO:K05350] [EC:3.2.1.21]
125539180  probable inactive beta-glucosidase 14 isoform X1 [KO:K05350] [EC:3.2.1.21]
125524825  beta-glucosidase 38-like [KO:K05350] [EC:3.2.1.21]
125535496  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
125535498  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
125523955  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
Compound
C00019  S-Adenosyl-L-methionine
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00049  L-Aspartate
C00073  L-Methionine
C00074  Phosphoenolpyruvate
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00108  Anthranilate
C00179  Agmatine
C00223  p-Coumaroyl-CoA
C00251  Chorismate
C00254  Prephenate
C00323  Caffeoyl-CoA
C00353  Geranylgeranyl diphosphate
C00406  Feruloyl-CoA
C00423  trans-Cinnamate
C00448  trans,trans-Farnesyl diphosphate
C00463  Indole
C00493  Shikimate
C00590  Coniferyl alcohol
C00751  Squalene
C00758  Bergaptol
C00841  Xanthotoxol
C01054  (S)-2,3-Epoxysqualene
C01158  1-O-Galloyl-beta-D-glucose
C01198  3-(2-Hydroxyphenyl)propanoate
C01424  Gallate
C01527  Scopolin
C01557  Bergapten
C01752  Scopoletin
C01772  trans-2-Hydroxycinnamate
C01864  Xanthotoxin
C02162  Isopimpinellin
C02274  Dihydrocoumarin
C02637  3-Dehydroshikimate
C02951  5-Hydroxyxanthotoxin
C03506  Indoleglycerol phosphate
C04498  p-Coumaroylagmatine
C04576  Pentagalloylglucose
C04831  DIMBOA-glucoside
C05158  trans-beta-D-Glucosyl-2-hydroxycinnamate
C05324  Nicotianamine
C05366  (+)-Pinoresinol
C05838  cis-2-Hydroxycinnamate
C05839  cis-beta-D-Glucosyl-2-hydroxycinnamate
C05851  Coumarin
C06098  Zeaxanthin
C06972  Dronabinol
C07578  Cannabidiol
C08304  Gramine
C08307  Hordatine A
C08308  Hordatine B
C08588  Crocetin
C08589  Crocin
C08616  beta-Amyrin
C08942  Echinocystic acid
C08946  Ginsenoside Rg1
C08972  Quillaic acid
C09060  Angelicin
C09263  Esculetin
C09265  Fraxetin
C09276  Marmesin
C09305  Psoralen
C09311  Scoparone
C09315  Umbelliferone
C10556  Deoxypodophyllotoxin
C10557  Dihydroanhydropodorhizol
C10646  Lariciresinol
C10682  Matairesinol
C10784  Cannabidiolic acid
C10874  Podophyllotoxin
C11130  3-Hydroxyindolin-2-one
C12312  Indolin-2-one
C15485  2'-Deoxymugineic acid
C15486  3''-Deamino-3''-oxonicotianamine
C15500  Mugineic acid
C15501  3-Epihydroxymugineic acid
C15502  3-Epihydroxy-2'-deoxymugineic acid
C15769  HBOA
C15770  DIBOA
C15772  DIBOA-glucoside
C17055  Picrocrocin
C17062  Safranal
C17148  Oleanolic acid
C17513  trans-Crocetin (beta-D-glucosyl) (beta-D-gentibiosyl) ester
C18062  TRIBOA-glucoside
C18079  Isoscopoletin
C18080  Osthenol
C18083  Demethylsuberosin
C18167  Secoisolariciresinol
C18325  Feruloylagmatine
C19707  (+)-Columbianetin
C19730  Crocetin dialdehyde
C19731  (3S)-3-Hydroxycyclocitral
C19829  Dammarenediol-II
C19867  beta-D-Glucosyl crocetin
C19868  Bis(beta-D-glucosyl) crocetin
C19869  beta-D-Gentiobiosyl crocetin
C20406  Cannabigerolate
C20413  3,5,7-Trioxododecanoyl-CoA
C20417  2,4-Dihydroxy-6-pentylbenzoate
C20454  (-)-Lariciresinol
C20455  (-)-Pinoresinol
C20456  (+)-Secoisolariciresinol
C20713  Ginsenoside Rb1
C20715  Protopanaxadiol
C20716  Protopanaxatriol
C20725  Ginsenoside Rd
C20778  Ginsenoside Rg3
C20779  Ginsenoside F2
C20780  Ginsenoside F1
C20894  beta-Citraurin
C21183  Bursehernin
C21184  (-)-5'-Demethylyatein
C21191  Pluviatolide
C21459  6-Hydroxyferuloyl-CoA
C21601  3-(Aminomethyl)indole
C21602  (1H-Indol-3-yl)-N-methylmethanamine
C21903  Delta9-Tetrahydrocannabinolate
C22007  Sideretin
C22070  2,4-Dihydroxycinnamoyl-CoA
C22127  Ginsenoside C-K
C22128  (20S)-Ginsenoside Rh2
C22129  Ginsenoside Rh1
C22152  Bergamottin
C22153  Epoxybergamottin
C22156  6',7'-Dihydroxybergamottin
C22438  3,5-Dehydroshikimate
C22444  5,8-Dihydroxypsoralen
C22445  8-Hydroxybergapten
C22452  6,7,8-Trihydroxycoumarin
C22652  Quillaic acid 3-O-beta-D-glucuronide
C22653  Quillaic acid 3-O-beta-D-galactosyl-1,2-beta-D-glucuronide
C22654  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22655  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22656  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22657  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22658  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22659  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22660  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22661  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22662  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22663  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22664  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22665  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22666  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide 28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-(beta-D-glucosyl-1,3)-alpha-L-rhamnosyl-1,2-(alpha-L-rhamnosyl-1,3)-4-O-acetyl-beta-D-fucoside
Reference
PMID:22569263
  Authors
Nagatoshi M, Terasaka K, Owaki M, Sota M, Inukai T, Nagatsu A, Mizukami H
  Title
UGT75L6 and UGT94E5 mediate sequential glucosylation of crocetin to crocin in Gardenia jasminoides.
  Journal
FEBS Lett 586:1055-61 (2012)
DOI:10.1016/j.febslet.2012.03.003
Reference
PMID:17544411
  Authors
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
  Title
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
  Journal
FEBS Lett 581:2929-34 (2007)
DOI:10.1016/j.febslet.2007.05.043
Reference
PMID:9952442
  Authors
Higuchi K, Suzuki K, Nakanishi H, Yamaguchi H, Nishizawa NK, Mori S
  Title
Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores.
  Journal
Plant Physiol 119:471-80 (1999)
DOI:10.1104/pp.119.2.471
Reference
PMID:7622460
  Authors
Ma JF, Shinada T, Matsuda C, Nomoto K
  Title
Biosynthesis of phytosiderophores, mugineic acids, associated with methionine cycling.
  Journal
J Biol Chem 270:16549-54 (1995)
DOI:10.1074/jbc.270.28.16549
Reference
PMID:33346890
  Authors
Tahara K, Nishiguchi M, Funke E, Miyazawa SI, Miyama T, Milkowski C
  Title
Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis.
  Journal
Planta 253:3 (2020)
DOI:10.1007/s00425-020-03516-w
Reference
PMID:26558757
  Authors
Dugrand-Judek A, Olry A, Hehn A, Costantino G, Ollitrault P, Froelicher Y, Bourgaud F.
  Title
The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the Organization of Biosynthetic Pathways.
  Journal
PLoS One 10:e0142757 (2015)
DOI:10.1371/journal.pone.0142757
Reference
PMID:15009205
  Authors
Hehmann M, Lukacin R, Ekiert H, Matern U
  Title
Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.
  Journal
Eur J Biochem 271:932-40 (2004)
DOI:10.1111/j.1432-1033.2004.03995.x
Reference
PMID:26359402
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
Reference
PMID:36952412
  Authors
Reed J, Orme A, El-Demerdash A, Owen C, Martin LBB, Misra RC, Kikuchi S, Rejzek M, Martin AC, Harkess A, Leebens-Mack J, Louveau T, Stephenson MJ, Osbourn A.
  Title
Elucidation of the pathway for biosynthesis of saponin adjuvants from the soapbark tree.
  Journal
Science 379:1252-1264 (2023)
DOI:10.1126/science.adf3727
Related
pathway
tua00010  Glycolysis / Gluconeogenesis
tua00020  Citrate cycle (TCA cycle)
tua00270  Cysteine and methionine metabolism
tua00400  Phenylalanine, tyrosine and tryptophan biosynthesis
tua00900  Terpenoid backbone biosynthesis
tua00940  Phenylpropanoid biosynthesis
KO pathway
ko00999   
LinkDB

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