Entry
Name
ABC transporters - Yersinia pestis KIM10+ (biovar Mediaevalis)
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Yersinia pestis KIM10+ (biovar Mediaevalis) [GN:
ypk ]
Gene
y1466 cysP; thiosulfate binding periplasmic protein of sulfate/thiosulfate ABC transporter [KO:K02048 ]
y0058 sbp; periplasmic sulfate-binding protein of sulfate/thiosulfate ABC transporter [KO:K23163 ]
y1467 cysU; inner membrane permease T of sulfate/thiosulfate ABC transporter [KO:K02046 ]
y3963 tauA; taurine-binding periplasmic protein of taurine ABC transport system [KO:K15551 ]
y3965 tauC; taurine ABC transport system inner membrane permease protein [KO:K15552 ]
y3964 tauB; taurine ATP-binding component of ABC transport system [KO:K10831 ] [EC:7.6.2.7 ]
y0245 ssuA; solute-binding periplasmic protein of aliphatic sulfonates, ABC transporter [KO:K15553 ]
y0243 ssuC; putative transport system permease protein of aliphatic sulfonates ABC transporter [KO:K15554 ]
y0242 ssuB; putative ATP-binding component of a transport system of aliphatic sulfonates ABC transporter [KO:K15555 ] [EC:7.6.2.14 ]
y3037 modA; molybdate-binding periplasmic protein of molybdate ABC transporter [KO:K02020 ]
y0057 modA; molybdate-binding periplasmic protein precursor [KO:K02020 ]
y3036 modB; inner membrane permease protein of molybdate ABC transport system [KO:K02018 ]
y3041 modF; ATP-binding component of molybdate transport system [KO:K05776 ]
y1526 yfuA; solute-binding periplasmic protein for iron ABC transporter [KO:K02012 ]
y1430 putative solute-binding periplasmic protein of ABC transporter [KO:K02012 ]
y1525 yfuB; inner membrane permease of iron ABC transporter [KO:K02011 ]
y1431 putative inner membrane permease of ABC transporter [KO:K02011 ]
y3651 tbpA; thiamin-binding periplasmic protein of ABC transporter [KO:K02064 ]
y3652 thiP; putative ABC transport system thiamine permease protein [KO:K02063 ]
y2851 potF; periplasmic putrescine-binding protein of putrescine ABC transporter [KO:K11073 ]
y2847 potI; putrescine ABC transport protein; permease [KO:K11074 ]
y2848 potH; putrescine permease of ABC transporter [KO:K11075 ]
y1219 proX; solute-binding periplasmic protein of high-affinity glycine betaine/proline ABC transporterhigh-affinity ABC transport system for glycine betaine and proline [KO:K02002 ]
y1220 proW; permease of high-affinity ABC transport system for glycine betaine and proline [KO:K02001 ]
y1221 proV; ATP-binding component of high affinity transport system for glycine, betaine and proline [KO:K02000 ] [EC:7.6.2.9 ]
y2992 putative ABC transport system inner membrane permease [KO:K05846 ]
y2990 putative inner membrane permease of ABC transport system [KO:K05846 ]
y0028 malE; periplasmic maltose-binding protein [KO:K10108 ]
y0027 malF; inner membrane permease of maltose ABC transporter [KO:K10109 ]
y0026 malG; inner membrane permease of maltose/maltodextran ABC transporter [KO:K10110 ]
y0031 malK; ATP-binding component of ABC transport system for maltose [KO:K10111 ] [EC:7.5.2.-]
y1709 malK; inner membrane ABC transporter [KO:K10111 ] [EC:7.5.2.-]
y3242 putative transport ATP-binding protein [KO:K10111 ] [EC:7.5.2.-]
y2414 malK; ATP-binding component of transport system for maltose [KO:K10111 ] [EC:7.5.2.-]
y3569 ATP-binding component of sn-glycerol 3-phosphate transport system [KO:K10112 ] [EC:7.5.2.-]
y0715 ugpC; ATP-binding component of sn-glycerol 3-phosphate transport system [KO:K10112 ] [EC:7.5.2.-]
y1881 togB; putative solute-binding periplasmic protein of oligogalacturonide ABC transporter [KO:K10192 ]
y1884 togM; putative inner membrane permease of oligogalacturonide ABC transporter [KO:K10193 ]
y1883 togN; putative inner membrane permease of oligogalacturonide ABC transporter [KO:K10194 ]
y1882 togA; ABC transporter, ATP-binding protein [KO:K10195 ]
y0146 putative ATP-binding component of ABC transport system [KO:K02065 ]
y1687 putative solute binding protein of ABC transporter [KO:K10439 ]
y3346 periplasmic binding protein for ABC transporter [KO:K10439 ]
y3867 D-ribose-binding periplasmic protein of ABC transporter [KO:K10439 ]
y1689 rbsC; D-ribose high-affinity transport system [KO:K10440 ]
y3866 rbsC; D-ribose high-affinity transport protein [KO:K10440 ]
y1688 rbsA; ATP-binding component of D-ribose high-affinity transport system [KO:K10441 ] [EC:7.5.2.7 ]
y3865 rbsA; ATP-binding component of D-ribose high-affinity transport system [KO:K10441 ] [EC:7.5.2.7 ]
y0007 rbsD; D-ribose high-affinity transport system; membrane-associated protein [KO:K06726 ] [EC:5.4.99.62 ]
y2096 araF; L-arabinose-binding periplasmic protein [KO:K10537 ]
y2098 araH; high-affinity L-arabinose transport system membrane protein [KO:K10538 ]
y2097 araG; ATP-binding component of high-affinity L-arabinose transport system [KO:K10539 ] [EC:7.5.2.12 ]
y0328 solute-binding periplasmic protein of ABC transporter [KO:K23508 ]
y0331 putative ABC transporter permease protein [KO:K23509 ]
y0330 putative ABC transport system inner membrane permease protein [KO:K23509 ]
y2662 mglB; periplasmic D-galactose-binding ABC transport protein [KO:K10540 ]
y2660 mglC; inner membrane permease of galactoside ABC transporter [KO:K10541 ]
y2661 mglA; ATP-binding component of methyl-galactoside ABC transporter and galactose taxis [KO:K10542 ] [EC:7.5.2.11 ]
y4056 xylF; xylose binding periplasmic protein of ABC transport system [KO:K10543 ]
y4054 xylH; inner membrane permease of D-xylose ABC transporter [KO:K10544 ]
y4055 xylG; putative ATP-binding protein of xylose ABC transport system [KO:K10545 ] [EC:7.5.2.10 ]
y0871 putative solute-binding periplasmic protein of ABC transporter [KO:K17202 ]
y0874 rbsC; sugar (D-ribose) transport system permease protein [KO:K17203 ]
y0873 putative ATP-binding protein of ABC transport system [KO:K17204 ]
y3245 putative periplasmic binding protein precursor [KO:K17205 ]
y3244 rbsC; D-ribose high-affinity transport system protein [KO:K17206 ]
y3243 rbsA; ATP-binding component of D-ribose high-affinity transport system [KO:K17207 ]
y1149 putative periplasmic solute-binding protein of ABC transporter [KO:K17208 ]
y1151 rbsC; D-ribose high-affinity transport system [KO:K17209 ]
y1150 rbsA; ATP-binding component of D-ribose high-affinity transport system [KO:K17210 ]
y0435 ugpA; integral membrane protein, permease [KO:K05814 ]
y4131 pstS; periplasmic phosphate-binding protein [KO:K02040 ]
y0980 putative solute-binding periplasmic protein for ABC transport system [KO:K02040 ]
y1399 putative inner membrane permease of high-affinity phosphate-specific transport system [KO:K02037 ]
y1400 putative inner membrane permease of high-affinity phosphate-specific ABC transporter [KO:K02038 ]
y4128 pstB; ATP-binding component of high-affinity phosphate-specific ABC transport system [KO:K02036 ] [EC:7.3.2.1 ]
y3006 putative solute-binding protein of ABC transporter [KO:K02044 ]
y3004 putative inner membrane permease of ABC transporter [KO:K02042 ]
y3005 putative inner membrane permease of ABC transporter [KO:K02042 ]
y1609 hisM; histidine ABC transporter, inner membrane permease [KO:K10015 ]
y1608 hisQ; histidine ABC transport system inner membrane permease [KO:K10016 ]
y1607 hisJ; histidine-binding periplasmic protein of high-affinity histidine transport system [KO:K10014 ]
y1675 glnH; glutamine-binding periplasmic protein for high-affinity glutamine ABC transporter [KO:K10036 ]
y1673 glnQ; ATP-binding component of glutamine high-affinity glutamine ABC transport system [KO:K10038 ] [EC:7.4.2.1 ]
y2844 artJ; arginine 3rd transport system periplasmic binding protein [KO:K09996 ]
y2830 artI; arginine 3rd transport system periplasmic binding protein [KO:K09997 ]
y2832 artM; arginine 3rd transport system permease protein [KO:K09998 ]
y2831 artQ; arginine 3rd transport system permease protein [KO:K09999 ]
y2829 artP; ATP-binding component of 3rd arginine transport system [KO:K10000 ] [EC:7.4.2.1 ]
y1189 gltI; solute-binding periplasmic protein of glutamate/aspartate ABC transporter [KO:K10001 ]
y1187 gltK; glutamate/aspartate inner membrane permease [KO:K10002 ]
y1188 gltJ; glutamate/aspartate ABC transport system inner membrane permease [KO:K10003 ]
y1186 gltL; ATP-binding protein of glutamate/aspartate transport system [KO:K10004 ] [EC:7.4.2.1 ]
y2460 fliY; putative periplasmic cysteine-binding ABC transport protein [KO:K02424 ]
y2459 putative ABC transporter permease for cystine [KO:K10009 ]
y0422 livK; high-affinity leucine-specificleucine-specific-binding periplasmic protein of high-affinity branched-chain amino acid ABC transporter transport system; periplasmic binding protein [KO:K01999 ]
y0423 livH; high-affinity branched-chain amino acid ABC transport system membrane permease [KO:K01997 ]
y0424 livM; inner membrane permease of high-affinity branched-chain amino acid ABC transport system [KO:K01998 ]
y0425 livG; ATP-binding component of high-affinity branched-chain amino acid ABC transport system [KO:K01995 ]
y0426 livF; ATP-binding component of leucine transport [KO:K01996 ]
y2865 putative transport system permease protein [KO:K02072 ]
y3105 putative transport system permease protein [KO:K02072 ]
y3104 abc; ATP-binding component of a transporter [KO:K02071 ]
y2866 abc; ATP-binding component of ATP transporter [KO:K02071 ]
y3002 putative Leu/Ile/Val/Thr binding protein of ABC transporter [KO:K11959 ]
y3001 putative branched chain inner membrane permease of ABC transporter [KO:K11960 ]
y3000 putative inner membrane permease of ABC transporter [KO:K11961 ]
y2999 hypothetical ABC transporter ATP-binding protein [KO:K11962 ]
y2998 livF; ATP-binding component of ABC transporter [KO:K11963 ]
y3027 putative ATP-binding protein of ABC transporter [KO:K11963 ]
y2026 oppA; oligopeptide ABC transporter; periplasmic binding protein [KO:K15580 ]
y1993 putative transport periplasmic protein [KO:K15580 ]
y2027 oppB; oligopeptide ABC transporter; permease protein [KO:K15581 ]
y2028 oppC; oligopeptide ABC transporter; permease protein [KO:K15582 ]
y2029 oppD; ATP-binding protein of oligopetide ABC transporter [KO:K15583 ]
y2030 oppF; ATP-binding protein of oligopetide ABC transporter [KO:K10823 ]
y3825 dppA; periplasmic dipeptide transport protein of ABC transporter [KO:K12368 ]
y3826 dppB; dipeptide transport system inner membrane permease [KO:K12369 ]
y3828 dppC; dipeptide transport system permease protein 2 [KO:K12370 ]
y3829 dppD; putative ATP-binding component of dipeptide ABC transport system [KO:K12371 ]
y3830 dppF; putative ATP-binding component of dipeptide ABC transport system [KO:K12372 ]
y1977 sapA; peptide-binding periplasmic protein of peptide ABC transport system [KO:K19226 ]
y1976 sapB; peptide ABC transport inner membrane permease protein [KO:K19227 ]
y1975 sapC; homolog of Salmonella peptide transport permease protein [KO:K19228 ]
y1974 sapD; putative ATP-binding protein of peptide ABC transport system [KO:K19229 ]
y1973 sapF; putative ATP-binding protein of peptide ABC transport system [KO:K19230 ]
y2911 putative transport system permease protein [KO:K13894 ]
y2912 putative transport system permease protein [KO:K13895 ]
y2913 putative ATP-binding component of a transport system [KO:K13896 ]
y3477 fepB; ferric enterobactin (enterochelin) binding protein [KO:K23185 ]
y2634 ysuA; putative solute-binding periplasmic protein of ABC transporter [KO:K25286 ]
y2635 ysuB; putative permease for iron transport system [KO:K23186 ]
y2636 ysuC; putative inner membrane permease of ABC transporter [KO:K23187 ]
y2637 ysuD; putative ATP-binding component for iron transport system [KO:K23188 ] [EC:7.2.2.17 7.2.2.-]
y0797 fhuD; solute-binding periplasmic protein of hydroxamate-dependent iron ABC transporter [KO:K23227 ]
y0798 fhuB; inner membrane permease of ABC transporter [KO:K23228 ]
y0796 fhuC; ATP-binding component of hydroxymate-dependent iron ABC transporter [KO:K10829 ] [EC:7.2.2.16 ]
y1914 btuC; vitamin B12 transport permease protein [KO:K06073 ]
y1916 btuD; ATP-binding component of vitamin B12 transport system [KO:K06074 ] [EC:7.6.2.8 ]
y2249 znuA; solute-binding periplasmic protein for zinc ABC transporter [KO:K09815 ]
y2251 znuB; inner membrane permease of zinc ABC transporter [KO:K09816 ]
y1897 yfeA; periplasmic-binding protein for iron and manganese ABC transporter [KO:K11604 ]
y1895 yfeC; permease for iron and manganese ABC transporter [KO:K11605 ]
y1894 yfeD; permease for iron and manganese ABC transporter [KO:K11606 ]
y1896 yfeB; ATP-binding protein for iron and manganese ABC transporter [KO:K11607 ]
y3772 putative LACI-type transcriptional regulator [KO:K10555 ]
y3770 putative ABC transport system permease protein [KO:K10556 ]
y3771 putative ABC transport system permease protein [KO:K10557 ]
y3769 putative ATP-binding component of a transport system [KO:K10558 ]
y1786 putative ATP-binding component of a transport system [KO:K09810 ] [EC:7.6.2.-]
y0417 ftsE; ATP-binding component of a membrane-associated complex involved in cell division [KO:K09812 ]
y2397 ybtP; permease and ATP-binding protein of yersiniabactin-iron ABC transporter [KO:K14698 ] [EC:7.-.-.-]
y3422 ATP-binding cassette transporter A [KO:K14698 ] [EC:7.-.-.-]
y2396 ybtQ; permease and ATP-binding protein of yersiniabactin-iron ABC transporter [KO:K14699 ] [EC:7.-.-.-]
y2777 msbA; ATP-binding transport protein; multicopy suppressor of htrB [KO:K11085 ] [EC:7.5.2.6 ]
y1039 mdlA; ATP-binding component of a transport system [KO:K18889 ]
y1040 mdlB; putative ATP-binding component of a transport system [KO:K18890 ]
y1158 putative ABC transporter, ATP-binding protein [KO:K24821 ]
y0315 hasD; secretion ATPase, Type I secretion system [KO:K12536 ]
y2805 cydC; ATP-binding component of cytochrome-related transport [KO:K16012 ]
y2803 cydD; ATP-binding component of cytochrome-related transport [KO:K16013 ]
y2813 putative ATP-binding component of ABC transport system [KO:K05685 ] [EC:7.6.2.-]
y1480 putative ATP-binding component of a transport system [KO:K05685 ] [EC:7.6.2.-]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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