KEGG   PATHWAY: ypr00061
Entry
ypr00061                    Pathway                                
Name
Fatty acid biosynthesis - Yersinia pseudotuberculosis EP2/+
Class
Metabolism; Lipid metabolism
Pathway map
ypr00061  Fatty acid biosynthesis
ypr00061

Module
ypr_M00082  Fatty acid biosynthesis, initiation [PATH:ypr00061]
ypr_M00083  Fatty acid biosynthesis, elongation [PATH:ypr00061]
ypr_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:ypr00061]
Other DBs
GO: 0006633
Organism
Yersinia pseudotuberculosis EP2/+ [GN:ypr]
Gene
BZ20_3178  accA; acetyl-CoA carboxylase, carboxyl transferase, alpha subunit [KO:K01962] [EC:6.4.1.2 2.1.3.15]
BZ20_2544  accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein [KO:K02160]
BZ20_2543  accC; acetyl-CoA carboxylase, biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
BZ20_3594  accD; acetyl-CoA carboxylase, carboxyl transferase, beta subunit [KO:K01963] [EC:6.4.1.2 2.1.3.15]
BZ20_488  pksC; polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase pksC [KO:K00645] [EC:2.3.1.39]
BZ20_3736  fabD; malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
BZ20_144  FAE1/Type III polyketide synthase-like family protein [KO:K00648] [EC:2.3.1.180]
BZ20_3735  fabH; 3-oxoacyl-[acyl-carrier-] synthase III family protein [KO:K00648] [EC:2.3.1.180]
BZ20_496  hypothetical protein [KO:K00647] [EC:2.3.1.41]
BZ20_3584  fabB; 3-oxoacyl-[acyl-carrier-protein] synthase 1 [KO:K00647] [EC:2.3.1.41]
BZ20_524  fabF; beta-ketoacyl-acyl-carrier-protein synthase II [KO:K09458] [EC:2.3.1.179]
BZ20_3739  fabF; beta-ketoacyl-acyl-carrier-protein synthase II [KO:K09458] [EC:2.3.1.179]
BZ20_495  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
BZ20_3737  fabG; 3-oxoacyl-[acyl-carrier-protein] reductase [KO:K00059] [EC:1.1.1.100]
BZ20_522  fabA; beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA [KO:K01716] [EC:4.2.1.59 5.3.3.14]
BZ20_497  fabA-like domain protein [KO:K02372] [EC:4.2.1.59]
BZ20_3173  fabZ; beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
BZ20_2152  NAD(P)H binding domain of trans-2-enoyl-CoA reductase family protein [KO:K00209] [EC:1.3.1.9 1.3.1.44]
BZ20_54  AMP-binding enzyme family protein [KO:K01897] [EC:6.2.1.3]
BZ20_1422  AMP-binding enzyme family protein [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
ypr00020  Citrate cycle (TCA cycle)
ypr00071  Fatty acid degradation
ypr00074  Mycolic acid biosynthesis
ypr00410  beta-Alanine metabolism
ypr00561  Glycerolipid metabolism
ypr00564  Glycerophospholipid metabolism
ypr00620  Pyruvate metabolism
ypr00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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