KEGG   PATHWAY: zce03013
Entry
zce03013                    Pathway                                
Name
Nucleocytoplasmic transport - Zerene cesonia (dogface butterfly)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
zce03013  Nucleocytoplasmic transport
zce03013

Other DBs
GO: 0050658
Organism
Zerene cesonia (dogface butterfly) [GN:zce]
Gene
119840241  LOW QUALITY PROTEIN: aladin-like [KO:K14320]
119840081  nucleoporin-like protein amo1 [KO:K14321]
119828848  nucleoporin Gle1 [KO:K18723]
119833210  DEAD-box helicase Dbp80 isoform X1 [KO:K18655] [EC:5.6.2.7]
119836884  mRNA export factor [KO:K14298]
119838444  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
119838446  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
119832248  nuclear pore complex protein Nup214-like isoform X1 [KO:K14317]
119836168  nucleoporin 88 [KO:K14318]
119830187  E3 SUMO-protein ligase RanBP2-like [KO:K12172] [EC:2.3.2.-]
119839262  ran GTPase-activating protein 1 [KO:K14319]
119830752  SUMO-conjugating enzyme UBC9-A [KO:K10577]
119834028  small ubiquitin-related modifier 3 [KO:K12160]
119832660  nuclear pore complex protein Nup85 [KO:K14304]
119828853  protein SEC13 homolog [KO:K14004]
119833747  nuclear pore complex protein Nup107 [KO:K14301]
119828686  nuclear pore complex protein Nup133 [KO:K14300]
119832025  nucleoporin SEH1 [KO:K14299]
119829707  nucleoporin Nup43 [KO:K14305]
119840708  protein ELYS [KO:K25129]
119836738  nuclear pore glycoprotein p62-like isoform X1 [KO:K14306]
119837415  nuclear pore complex protein Nup58-like [KO:K14307]
119830286  probable nucleoporin Nup54 isoform X1 [KO:K14308]
119830490  nuclear pore complex protein Nup205 [KO:K14310]
119829563  nucleoporin Nup188 [KO:K14311]
119835246  nuclear pore complex protein Nup154 [KO:K14312]
119831329  nuclear pore complex protein Nup93-like [KO:K14309]
119831506  nucleoporin Nup35-like [KO:K14313]
119831517  nucleoporin Nup35-like [KO:K14313]
119838251  nucleoporin NDC1 [KO:K14315]
119840088  nuclear pore membrane glycoprotein 210 [KO:K14314]
119840650  nucleoprotein TPR-like [KO:K09291]
119833287  nuclear pore complex protein Nup50 [KO:K14295]
119835389  nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
119838143  importin subunit alpha-5-like [KO:K15043]
119828153  importin subunit alpha-3 [KO:K23583]
119840413  importin subunit alpha-7 [KO:K15042]
119837653  importin subunit beta-1 isoform X1 [KO:K14293]
119829324  transportin-1 [KO:K18752]
119834572  LOW QUALITY PROTEIN: transportin-3 [KO:K15436]
119830452  importin-5 [KO:K20222]
119835824  importin-7 isoform X1 [KO:K20223]
119839668  importin-11 [KO:K25201]
119831489  importin-13 [KO:K25202]
119829625  snurportin-1 isoform X1 [KO:K13151]
119834735  exportin-1 [KO:K14290]
119837175  exportin-2 [KO:K18423]
119833961  exportin-4-like [KO:K25203]
119833672  exportin-5 [KO:K14289]
119830963  exportin-6 [KO:K25204]
119838892  exportin-7 [KO:K18460]
119834946  GTP-binding nuclear protein Ran [KO:K07936]
119829450  elongation factor 1-alpha [KO:K03231]
119830043  elongation factor 1-alpha 2-like [KO:K03231]
119830537  elongation factor 1-alpha 2-like [KO:K03231]
119831859  phosphorylated adapter RNA export protein [KO:K14291]
119839801  nuclear cap-binding protein subunit 1 [KO:K12882]
119830037  nuclear cap-binding protein subunit 2 [KO:K12883]
119838366  60S ribosomal export protein NMD3 [KO:K07562]
119836517  RNA-binding protein 8A [KO:K12876]
119830355  protein mago nashi [KO:K12877]
119830384  protein mago nashi [KO:K12877]
119836910  protein CASC3-like isoform X1 [KO:K14323]
119828851  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
119833743  histone deacetylase complex subunit SAP18 [KO:K14324]
119830761  RNA-binding protein with serine-rich domain 1-A-like [KO:K14325]
119828465  pinin [KO:K13114]
119830729  THO complex subunit 4 [KO:K12881]
119829113  regulator of nonsense transcripts 2 [KO:K14327]
119829648  regulator of nonsense transcripts 3B [KO:K14328]
119828944  nuclear RNA export factor 1-like [KO:K14284]
119832765  uncharacterized protein LOC119832765 isoform X1 [KO:K14284]
119832783  nuclear RNA export factor 1 [KO:K14284]
119828650  NTF2-related export protein-like [KO:K14285]
119828651  NTF2-related export protein-like [KO:K14285]
119833546  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
119831148  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
119838616  partner of Y14 and mago [KO:K14294]
119828286  THO complex subunit 1 [KO:K12878]
119833185  THO complex subunit 2 [KO:K12879]
119830750  THO complex subunit 5 homolog [KO:K13174]
119835292  THO complex subunit 6 [KO:K13175]
119837771  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
zce03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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