KEGG   PATHWAY: rhi03070
Entry
rhi03070                    Pathway                                
Name
Bacterial secretion system - Sinorhizobium fredii NGR234
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
rhi03070  Bacterial secretion system
rhi03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Sinorhizobium fredii NGR234 [GN:rhi]
Gene
NGR_a00530  rhcV; innermembrane protein RhcV; component of type III secretion apparatus [KO:K03230]
NGR_a00580  rhcU; innermembrane protein RhcU; component of type III secretion apparatus [KO:K03229]
NGR_a00590  rhcT; innermembrane protein RhcT; component of type III secretion apparatus [KO:K03228]
NGR_a00600  rhcS; innermembrane protein RhcS; component of type III secretion apparatus [KO:K03227]
NGR_a00610  rhcR; innermembrane protein RhcR; component of type III secretion apparatus [KO:K03226]
NGR_a00620  rhcQ; component RhcQ of type III secretion apparatus [KO:K03225]
NGR_a00640  rhcN; ATPase RhcN for type III secretion [KO:K03224] [EC:7.4.2.8]
NGR_a00650  rhcL; nodulation protein RhcL; putative regulator of RhcN activity in type III secretion [KO:K03223]
NGR_a00670  rhcJ; outermembrane protein RhcJ; component of type III secretion apparatus [KO:K03222]
NGR_a03950  traG; conjugal transfer protein TraG [KO:K03205] [EC:7.4.2.8]
NGR_b10250  virB1; VirB1 type IV secretion protein [KO:K03194]
NGR_b10260  virB2; VirB2 type IV secretion protein [KO:K03197]
NGR_b10270  virB3; VirB3 type IV secretion protein [KO:K03198]
NGR_b10280  virB4; VirB4 type IV secretion protein [KO:K03199] [EC:7.4.2.8]
NGR_b10290  virB5; VirB5 type IV secretion protein [KO:K03200]
NGR_b10310  virB6; VirB6 type IV secretion protein [KO:K03201]
NGR_b10320  virB7; VirB7 type IV secretion related protein [KO:K03202]
NGR_b10330  virB8; VirB8 type IV secretion protein [KO:K03203]
NGR_b10340  virB9; VirB9 type IV secretion protein [KO:K03204]
NGR_b10350  virB10; VirB10 transmembrane type IV secretion protein [KO:K03195]
NGR_b10360  virB11; VirB11 type IV secretion protein [KO:K03196] [EC:7.4.2.8]
NGR_b10520  traG; TraG conjugal transfer protein [KO:K03205] [EC:7.4.2.8]
NGR_b22800  rhcU; translocation protein in type III secretion system, RhcU [KO:K03229]
NGR_b22840  rhcV; type III secretion protein, RhcV family [KO:K03230]
NGR_b22920  rhcJ; type III secretion component, RhcJ protein [KO:K03222]
NGR_b22940  [KO:K03223]
NGR_b22950  rhcN; type III secretion component, RhcN, ATP synthase [KO:K03224] [EC:7.4.2.8]
NGR_b22960  rhcZ; type III secretion component, RhcZ [KO:K04056]
NGR_b22970  rhcQ; type III secretion system translocation protein, RhcQ [KO:K03225]
NGR_b22980  rhcR; translocation protein in type III secretion RhcR [KO:K03226]
NGR_b22990  rhcS; type III secretion component, RhcS [KO:K03227]
NGR_b23000  rhcT; type III secretion component, RhcT [KO:K03228]
NGR_c00820  [KO:K03217]
NGR_c02010  secD1; protein-export membrane protein SecD/SecF [KO:K12257]
NGR_c11760  secE; putative preprotein translocase, SecE subunit [KO:K03073]
NGR_c12100  secY; secretion protein SecY [KO:K03076]
NGR_c13520  tolC; putative TolC outer membrane protein [KO:K12340]
NGR_c13710  tatA_E; putative sec-independent protein translocase protein TatA/E [KO:K03116]
NGR_c13720  tatB; putative sec-independent protein secretion pathway component TatB [KO:K03117]
NGR_c13730  tatC; predicted sec-independent protein translocase component TatC [KO:K03118]
NGR_c13800  yajC; preprotein translocase [KO:K03210]
NGR_c13810  secD2; protein-export membrane protein SecD [KO:K12257]
NGR_c22990  gspJ; general secretion protein GspJ [KO:K02459]
NGR_c23000  gspI; putative general secretion pathway protein I, GspI [KO:K02458]
NGR_c23010  gspH; general secretion pathway protein GspH [KO:K02457]
NGR_c23020  gspF; general secretion pathway protein F, GspF [KO:K02455]
NGR_c23030  gspE; general secretion pathway protein E, GspE [KO:K02454] [EC:7.4.2.8]
NGR_c23040  gspK; general secretory pathway protein K, GspK [KO:K02460]
NGR_c23060  [KO:K02462]
NGR_c23070  gspL; putative general secretion pathway protein L, GspL [KO:K02461]
NGR_c23080  gspG; general secretion pathway protein G, GspG [KO:K02456]
NGR_c23100  gspD; general secretion pathway protein D, GspD [KO:K02453]
NGR_c26720  secA; protein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
NGR_c32250  [KO:K03106] [EC:3.6.5.4]
NGR_c32300  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
NGR_c33550  secB; protein-export chaperone SecB [KO:K03071]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   

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