KEGG   PATHWAY: rn00404
Entry
rn00404                     Pathway                                
Name
Staurosporine biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
rn00404  Staurosporine biosynthesis
rn00404

Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A [PATH:rn00404]
M00789  Rebeccamycin biosynthesis, tryptophan => rebeccamycin [PATH:rn00404]
M00790  Pyrrolnitrin biosynthesis, tryptophan => pyrrolnitrin [PATH:rn00404]
M00805  Staurosporine biosynthesis, tryptophan => staurosporine [PATH:rn00404]
M00808  Violacein biosynthesis, tryptophan => violacein [PATH:rn00404]
Reaction
R05757  S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase
R09560  7-chloro-L-tryptophan:oxygen oxidoreductase
R09566  2-imino-3-(7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming); 2-imino-3-(7-chloroindol-3-yl)propanoate:oxygen oxidoreductase (dichlorochromopyrrolate-forming)
R09567  dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming)
R09568  4'-demethylrebeccamycin D-glucose-lyase
R09569  S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase
R09570  L-tryptophan:FADH2 oxidoreductase (7-halogenating)
R10321  tryprostatin B,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxytryprostatin B-forming)
R10340  dimethylallyl-diphosphate:brevianamide-F dimethylallyl-C-2-transferase
R10341  dimethylallyl-diphosphate:verruculogen dimethylallyl-O-transferase
R10414  fumitremorgin C,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming)
R10416  tryprostatin A,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
R10445  fumitremorgin B,2-oxoglutarate:oxygen oxidoreductase (verruculogen-forming)
R10457  dimethylallyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C dimethylallyl-N-1-transferase
R10588  S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
R10661  
R11105  
R11106  
R11107  
R11119  
R11120  
R11121  
R11122  
R11123  
R11129  
R11131  
R11132  protodeoxyviolaceinate,NADPH:O2 oxidoreductase
R11133  
R11134  protodeoxyviolaceinate,NADPH:O2 oxidoreductase
R11135  protoviolaceinate,NADPH:O2 oxidoreductase
R11136  
R11138  
R11139  
R11158  protodeoxyviolaceinate,NADH:O2 oxidoreductase
R11373  protoviolaceinate,NADH:O2 oxidoreductase
R11374  protodeoxyviolaceinate,NADH:O2 oxidoreductase
R12436  
R12437  
R12438  
R12439  
R12440  
R12441  
R12442  
R12443  
R12444  
R12445  
R12446  
R12447  
R12448  
Compound
C00078  L-Tryptophan
C00135  L-Histidine
C00148  L-Proline
C02079  Staurosporine
C07349  3'-Demethylstaurosporine
C12318  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose
C12491  Pyrrolnitrin
C18092  dTDP-L-ristosamine
C19687  7-Chloro-L-tryptophan
C19688  2-Imino-3-(7-chloroindol-3-yl)propanoate
C19698  3,4-Bis(7-chloroindol-3-yl)pyrrole-2,5-dicarboxylate
C19699  Dichloroarcyriaflavin A
C19700  4'-O-Demethylrebeccamycin
C19701  Rebeccamycin
C20045  Verruculogen
C20512  Tryprostatin B
C20513  6-Hydroxytryprostatin B
C20563  Brevianamide F
C20564  Fumitremorgin A
C20604  Fumitremorgin C
C20605  12alpha,13alpha-Dihydroxyfumitremorgin C
C20607  Tryprostatin A
C20630  Fumitremorgin B
C21109  Aminopyrrolnitrin
C21110  Monodechloroaminopyrrolnitrin
C21124  IPA imine
C21125  Chromopyrrolate
C21126  K-252c
C21127  Holyrine A
C21128  O-Demethyl-N-demethyl-staurosporine
C21131  Protodeoxyviolaceinic acid
C21132  Deoxyviolaceinic acid
C21133  Deoxyviolacein
C21134  Protoviolaceinic acid
C21135  Violaceinic acid
C21136  Violacein
C21137  dTDP-3-amino-4-oxo-2,3,6-trideoxy-L-allose
C22162  Histidyltryptophyldiketopiperazine
C22163  Roquefortine D
C22164  Dehydrohistidyltryptophyldiketopiperazine
C22165  Roquefortine C
C22166  Glandicoline A
C22167  Glandicoline B
C22168  Meleagrin
C22169  N1-Hydroxy-roquefortine C
C22170  Roquefortine L
C22171  Roquefortine F
C22172  Neoxaline
Reference
PMID:17119643
  Authors
Sanchez C, Mendez C, Salas JA
  Title
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity.
  Journal
Nat Prod Rep 23:1007-45 (2006)
DOI:10.1039/b601930g
Reference
PMID:12617516
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.
  Journal
J Antibiot (Tokyo) 55:1063-71 (2002)
DOI:10.7164/antibiotics.55.1063
Reference
PMID:24038353
  Authors
Lee ME, Aswani A, Han AS, Tomlin CJ, Dueber JE
  Title
Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay.
  Journal
Nucleic Acids Res 41:10668-78 (2013)
DOI:10.1093/nar/gkt809
Reference
PMID:12619684
  Authors
Onaka H, Taniguchi S, Igarashi Y, Furumai T
  Title
Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.
  Journal
Biosci Biotechnol Biochem 67:127-38 (2003)
DOI:10.1271/bbb.67.127
Reference
PMID:9172332
  Authors
Hammer PE, Hill DS, Lam ST, Van Pee KH, Ligon JM
  Title
Four genes from Pseudomonas fluorescens that encode the biosynthesis of pyrrolnitrin.
  Journal
Appl Environ Microbiol 63:2147-54 (1997)
DOI:10.1128/AEM.63.6.2147-2154.1997
Reference
PMID:23109474
  Authors
Mundt K, Wollinsky B, Ruan HL, Zhu T, Li SM
  Title
Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.
  Journal
Chembiochem 13:2583-92 (2012)
DOI:10.1002/cbic.201200523
Related
pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00523  Polyketide sugar unit biosynthesis
KO pathway
ko00404   

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