KEGG   PATHWAY: rn00750
Entry
rn00750                     Pathway                                
Name
Vitamin B6 metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
rn00750  Vitamin B6 metabolism
rn00750

Module
M00124  Pyridoxal-P biosynthesis, erythrose-4P => pyridoxal-P [PATH:rn00750]
M00916  Pyridoxal-P biosynthesis, R5P + glyceraldehyde-3P + glutamine => pyridoxal-P [PATH:rn00750]
Other DBs
GO: 0042816
Reaction
R00173  pyridoxal-5'-phosphate phosphohydrolase
R00174  ATP:pyridoxal 5'-phosphotransferase
R00277  pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)
R00278  pyridoxine 5'-phosphate:oxygen oxidoreductase
R01580  pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)
R01649  2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)
R01707  pyridoxal:NAD+ 4-oxidoreductase
R01708  pyridoxine:NADP+ 4-oxidoreductase
R01709  pyridoxal:oxygen 4-oxidoreductase
R01710  pyridoxamine:oxygen oxidoreductase (deaminating)
R01711  pyridoxine:oxygen oxidoreductase (deaminating)
R01712  pyridoxamine:pyruvate aminotransferase
R01713  pyridoxamine:oxaloacetate aminotransferase
R01825  D-erythrose 4-phosphate:NAD+ oxidoreductase
R01909  ATP:pyridoxine 5'-phosphotransferase
R01910  primary alcohol:(acceptor) oxidoreductase
R01911  pyridoxine-5'-phosphate phosphohydrolase
R01913  
R02493  ATP:pyridoxal 5'-phosphotransferase
R02494  pyridoxamine-5'-phosphate phosphohydrolase
R02992  4-pyridoxolactone lactonohydrolase
R02993  
R03385  3-hydroxy-2-methylpyridine-5-carboxylate,NADH:oxygen oxidoreductase (ring-opening)
R03386  3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (ring-opening)
R03461  3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase
R04210  4-phospho-D-erythronate:NAD+ 2-oxidoreductase
R04397  2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase
R04524  5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate:NAD+ 5-oxidoreductase
R04570  5-pyridoxate,NADPH:oxygen oxidoreductase (ring-opening)
R04593  
R05084  isopyridoxal:NAD+ oxidoreductase (5-pyridoxolactone-forming)
R05085  O-phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase
R05086  O-phospho-4-hydroxy-L-threonine phospho-lyase (adding water)
R05681  NAD-dependent threonine 4-phosphate dehydrogenase
R05838  pyridoxine 5'-phosphate synthase
R05839  pyridoxamine:2-oxoglutarate aminotransferase
R05840  
R07406  
R10089  D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5'-phosphate-lyase (glutamine-hydrolyzing)
R12265  isopyridoxal:NAD+ oxidoreductase (5-pyridoxate-forming)
Compound
C00018  Pyridoxal phosphate
C00064  L-Glutamine
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00232  Succinate semialdehyde
C00250  Pyridoxal
C00266  Glycolaldehyde
C00279  D-Erythrose 4-phosphate
C00314  Pyridoxine
C00534  Pyridoxamine
C00627  Pyridoxine phosphate
C00647  Pyridoxamine phosphate
C00847  4-Pyridoxate
C00971  4-Pyridoxolactone
C01215  2-(Acetamidomethylene)succinate
C01270  3-Hydroxy-2-methylpyridine-5-carboxylate
C03393  4-Phospho-D-erythronate
C04106  2-(Hydroxymethyl)-4-oxobutanoate
C04604  3-Hydroxy-2-methylpyridine-4,5-dicarboxylate
C04690  2-(Hydroxymethyl)-3-(acetamidomethylene)succinate
C04773  3-Hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate
C06050  2-Methyl-3-hydroxy-5-formylpyridine-4-carboxylate
C06051  Isopyridoxal
C06052  5-Pyridoxolactone
C06054  2-Oxo-3-hydroxy-4-phosphobutanoate
C06055  O-Phospho-4-hydroxy-L-threonine
C06056  4-Hydroxy-L-threonine
C07335  2-Amino-3-oxo-4-phosphonooxybutyrate
C11638  3-Amino-2-oxopropyl phosphate
Reference
PMID:10753941
  Authors
Tazoe M, Ichikawa K, Hoshino T.
  Title
Biosynthesis of vitamin B(6) in rhizobium.
  Journal
J Biol Chem 275:11300-5 (2000)
DOI:10.1074/jbc.275.15.11300
Reference
PMID:9696782
  Authors
Yang Y, Zhao G, Man TK, Winkler ME.
  Title
Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12.
  Journal
J Bacteriol 180:4294-9 (1998)
DOI:10.1128/JB.180.16.4294-4299.1998
Reference
PMID:12269807
  Authors
Yeh JI, Du S, Pohl E, Cane DE.
  Title
Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate.
  Journal
Biochemistry 41:11649-57 (2002)
DOI:10.1021/bi026292t
Reference
PMID:10225425
  Authors
Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS.
  Title
Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.
  Journal
FEBS Lett 449:45-8 (1999)
DOI:10.1016/S0014-5793(99)00393-2
Reference
PMID:16157873
  Authors
Tambasco-Studart M, Titiz O, Raschle T, Forster G, Amrhein N, Fitzpatrick TB.
  Title
Vitamin B6 biosynthesis in higher plants.
  Journal
Proc Natl Acad Sci U S A 102:13687-92 (2005)
DOI:10.1073/pnas.0506228102
Reference
PMID:22276911
  Authors
Nagase T, Mugo AN, Chu HN, Yoshikane Y, Ohnishi K, Yagi T
  Title
The mll6786 gene encodes a repressor protein controlling the degradation pathway for vitamin B6 in Mesorhizobium loti.
  Journal
FEMS Microbiol Lett 329:116-22 (2012)
DOI:10.1111/j.1574-6968.2012.02510.x
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00030  Pentose phosphate pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn00650  Butanoate metabolism
rn00730  Thiamine metabolism
KO pathway
ko00750   

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