Entry |
|
Name |
Thiamine metabolism |
Class |
Metabolism; Metabolism of cofactors and vitamins
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Pathway map |

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Module |
M00127 | Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:rn00730] |
M00895 | Thiamine biosynthesis, prokaryotes, AIR (+ DXP/glycine) => TMP/TPP [PATH:rn00730] |
M00896 | Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:rn00730] |
M00897 | Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP [PATH:rn00730] |
M00898 | Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP [PATH:rn00730] |
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Other DBs |
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Reaction |
R00033 | thiamine:oxygen 5-oxidoreductase |
R00072 | thiamine-aldehyde:oxygen 5-oxidoreductase |
R00615 | thiamin diphosphate phosphohydrolase |
R00616 | ATP:thiamine-diphosphate phosphotransferase |
R00617 | ATP:thiamin-phosphate phosphotransferase |
R00618 | thiamin-triphosphate phosphohydrolase |
R00619 | ATP:thiamine diphosphotransferase |
R02134 | ATP:thiamine phosphotransferase |
R02135 | thiamin monophosphate phosphohydrolase |
R02863 | thiamin:beta 2-methyl-4-aminopyrimidine-5-methenyltransferase |
R03223 | 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase |
R03471 | ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase |
R03472 | 5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-phosphomethylpyrimidine-forming) |
R04448 | ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase |
R04509 | ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase |
R05636 | 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) |
R07459 | ATP:[sulfur-carrier protein] adenylyltransferase |
R07460 | L-cysteine:[enzyme]-cysteine sulfurtransferase |
R07461 | [enzyme]-S-sulfanyl-L-cysteine:adenylyl-[sulfur-carrier protein] sulfurtransferase |
R07463 | glycine:oxygen oxidoreductase |
R09977 | 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase |
R09993 | 4-amino-5-aminomethyl-2-methylpyrimidine aminohydrolase |
R10246 | L-tyrosine 4-methylphenol-lyase (2-iminoacetate-forming) |
R10247 | 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase |
R10685 | NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing) |
R10712 | 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase |
R11313 | N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine amidohydrolase |
R11319 | ADP:thiamin-diphosphate phosphotransferase |
R12026 | NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding) |
|
Compound |
C00118 | D-Glyceraldehyde 3-phosphate |
C01279 | 4-Amino-5-hydroxymethyl-2-methylpyrimidine |
C03373 | Aminoimidazole ribotide |
C04294 | 5-(2-Hydroxyethyl)-4-methylthiazole |
C04327 | 4-Methyl-5-(2-phosphooxyethyl)thiazole |
C04556 | 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine |
C04752 | 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate |
C11437 | 1-Deoxy-D-xylulose 5-phosphate |
C15812 | [Enzyme]-S-sulfanylcysteine |
C15813 | Adenylyl-[sulfur-carrier protein] |
C15814 | Thiocarboxy-[sulfur-carrier protein] |
C19872 | N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine |
C20246 | 2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate |
C20247 | 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate |
C20267 | 4-Amino-5-aminomethyl-2-methylpyrimidine |
C20784 | ADP-5-ethyl-4-methylthiazole-2-carboxylate |
|
Reference |
|
Authors |
Kawasaki Y, Onozuka M, Mizote T, Nosaka K. |
Title |
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae. |
Journal |
|
Reference |
|
Authors |
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP. |
Title |
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). |
Journal |
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Reference |
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Authors |
Begley TP, Ealick SE, McLafferty FW |
Title |
Thiamin biosynthesis: still yielding fascinating biological chemistry. |
Journal |
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Reference |
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Authors |
Wightman R, Meacock PA |
Title |
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine. |
Journal |
|
Reference |
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Authors |
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP |
Title |
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. |
Journal |
|
Reference |
|
Authors |
Jurgenson CT, Begley TP, Ealick SE |
Title |
The structural and biochemical foundations of thiamin biosynthesis. |
Journal |
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Related pathway |
rn00010 | Glycolysis / Gluconeogenesis |
rn00260 | Glycine, serine and threonine metabolism |
rn00270 | Cysteine and methionine metabolism |
rn00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
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KO pathway |
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