KEGG PATHWAY: rn00730

PATHWAY: rn00730

Entry

rn00730                     Pathway

Name

Thiamine metabolism

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

rn00730

Thiamine metabolism

Module

M00127

Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:rn00730]

M00895

Thiamine biosynthesis, prokaryotes, AIR (+ DXP/glycine) => TMP/TPP [PATH:rn00730]

M00896

Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:rn00730]

M00897

Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP [PATH:rn00730]

M00898

Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP [PATH:rn00730]

M00899

Thiamine salvage pathway, HMP/HET => TMP [PATH:rn00730]

Other DBs

GO:

0006772

Reaction

R00033

thiamine:oxygen 5-oxidoreductase

R00072

thiamine-aldehyde:oxygen 5-oxidoreductase

R00615

thiamin diphosphate phosphohydrolase

R00616

ATP:thiamine-diphosphate phosphotransferase

R00617

ATP:thiamin-phosphate phosphotransferase

R00618

thiamin-triphosphate phosphohydrolase

R00619

ATP:thiamine diphosphotransferase

R02133

thiamin hydrolase

R02134

ATP:thiamine phosphotransferase

R02135

thiamin monophosphate phosphohydrolase

R02863

thiamin:beta 2-methyl-4-aminopyrimidine-5-methenyltransferase

R03223

2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase

R03471

ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase

R03472

5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-phosphomethylpyrimidine-forming)

R04448

ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase

R04509

ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase

R05636

1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating)

R07459

ATP:[sulfur-carrier protein] adenylyltransferase

R07460

L-cysteine:[enzyme]-cysteine sulfurtransferase

R07461

[enzyme]-S-sulfanyl-L-cysteine:adenylyl-[sulfur-carrier protein] sulfurtransferase

R07463

glycine:oxygen oxidoreductase

R09977

2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase

R09993

4-amino-5-aminomethyl-2-methylpyrimidine aminohydrolase

R10246

L-tyrosine 4-methylphenol-lyase (2-iminoacetate-forming)

R10247

1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase

R10685

NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing)

R10686

R10711

R10712

2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase

R11313

N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine amidohydrolase

R11314

R11319

ADP:thiamin-diphosphate phosphotransferase

R12026

NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)

Compound

C00003

NAD+

C00018

Pyridoxal phosphate

C00022

Pyruvate

C00037

Glycine

C00068

Thiamin diphosphate

C00082

L-Tyrosine

C00097

L-Cysteine

C00118

D-Glyceraldehyde 3-phosphate

C00378

Thiamine

C01081

Thiamin monophosphate

C01279

4-Amino-5-hydroxymethyl-2-methylpyrimidine

C02892

Thiamine acetic acid

C03028

Thiamin triphosphate

C03373

Aminoimidazole ribotide

C04294

5-(2-Hydroxyethyl)-4-methylthiazole

C04327

4-Methyl-5-(2-phosphooxyethyl)thiazole

C04556

4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine

C04752

4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate

C05856

Thiamine aldehyde

C11437

1-Deoxy-D-xylulose 5-phosphate

C15809

Iminoglycine

C15810

Sulfur-carrier protein

C15811

[Enzyme]-cysteine

C15812

[Enzyme]-S-sulfanylcysteine

C15813

Adenylyl-[sulfur-carrier protein]

C15814

Thiocarboxy-[sulfur-carrier protein]

C19872

N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine

C20246

2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate

C20247

2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate

C20267

4-Amino-5-aminomethyl-2-methylpyrimidine

C20784

ADP-5-ethyl-4-methylthiazole-2-carboxylate

Reference

PMID:15614489

Authors

Kawasaki Y, Onozuka M, Mizote T, Nosaka K.

Title

Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.

Journal

Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x

Reference

PMID:14567704

Authors

Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.

Title

Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).

Journal

Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z

Reference

PMID:22616866

Authors

Begley TP, Ealick SE, McLafferty FW

Title

Thiamin biosynthesis: still yielding fascinating biological chemistry.

Journal

Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084

Reference

PMID:12777485

Authors

Wightman R, Meacock PA

Title

The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.

Journal

Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0

Reference

PMID:22031445

Authors

Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP

Title

Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.

Journal

Nature 478:542-6 (2011)
DOI:10.1038/nature10503

Reference

PMID:19348578