KEGG   PATHWAY: rn00730
Entry
rn00730                     Pathway                                

Name
Thiamine metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
rn00730  Thiamine metabolism
rn00730

Module
M00127  Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:rn00730]
M00895  Thiamine biosynthesis, prokaryotes, AIR (+ DXP/glycine) => TMP/TPP [PATH:rn00730]
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:rn00730]
M00897  Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP [PATH:rn00730]
M00898  Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP [PATH:rn00730]
M00899  Thiamine salvage pathway, HMP/HET => TMP [PATH:rn00730]
Other DBs
GO: 0006772
Reaction
R00033  thiamine:oxygen 5-oxidoreductase
R00072  thiamine-aldehyde:oxygen 5-oxidoreductase
R00615  Thiamin diphosphate phosphohydrolase
R00616  ATP:thiamine-diphosphate phosphotransferase
R00617  ATP:thiamin-phosphate phosphotransferase
R00618  Thiamin-triphosphate phosphohydrolase
R00619  ATP:thiamine diphosphotransferase
R02133  Thiamin hydrolase
R02134  ATP:thiamine phosphotransferase
R02135  thiamin monophosphate phosphohydrolase
R02863  Thiamin:beta 2-methyl-4-aminopyrimidine-5-methenyltransferase
R03223  2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase
R03471  ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase
R03472  5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-phosphomethylpyrimidine-forming)
R04448  ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase
R04509  ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase
R05636  1-Deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating)
R07459  ATP:[sulfur-carrier protein] adenylyltransferase
R07460  L-cysteine:[enzyme]-cysteine sulfurtransferase
R07461  [enzyme]-S-sulfanyl-L-cysteine:adenylyl-[sulfur-carrier protein] sulfurtransferase
R07463  glycine:oxygen oxidoreductase
R09977  2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase
R09993  4-amino-5-aminomethyl-2-methylpyrimidine aminohydrolase
R10246  L-tyrosine 4-methylphenol-lyase (2-iminoacetate-forming)
R10247  1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase
R10685  NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing)
R10686   
R10711   
R10712  2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase
R11313  N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine amidohydrolase
R11314   
R11319  ADP:thiamin-diphosphate phosphotransferase
R12026  NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Compound
C00003  NAD+
C00018  Pyridoxal phosphate
C00022  Pyruvate
C00037  Glycine
C00068  Thiamin diphosphate
C00082  L-Tyrosine
C00097  L-Cysteine
C00118  D-Glyceraldehyde 3-phosphate
C00378  Thiamine
C01081  Thiamin monophosphate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02892  Thiamine acetic acid
C03028  Thiamin triphosphate
C03373  Aminoimidazole ribotide
C04294  5-(2-Hydroxyethyl)-4-methylthiazole
C04327  4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C05856  Thiamine aldehyde
C11437  1-Deoxy-D-xylulose 5-phosphate
C15809  Iminoglycine
C15810  Sulfur-carrier protein
C15811  [Enzyme]-cysteine
C15812  [Enzyme]-S-sulfanylcysteine
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267  4-Amino-5-aminomethyl-2-methylpyrimidine
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00230  Purine metabolism
rn00260  Glycine, serine and threonine metabolism
rn00270  Cysteine and methionine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00750  Vitamin B6 metabolism
KO pathway
ko00730   
LinkDB

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