KEGG   PATHWAY: roa00290
Entry
roa00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Rhodococcus opacus PD630
Class
Metabolism; Amino acid metabolism
Pathway map
roa00290  Valine, leucine and isoleucine biosynthesis
roa00290

Module
roa_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:roa00290]
roa_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:roa00290]
roa_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:roa00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Rhodococcus opacus PD630 [GN:roa]
Gene
Pd630_LPD05159  putative threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
Pd630_LPD02473  Threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
Pd630_LPD06115  putative serine racemase [KO:K01754] [EC:4.3.1.19]
Pd630_LPD03167  3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
Pd630_LPD07315  3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
Pd630_LPD00126  3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
Pd630_LPD03168  3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
Pd630_LPD07316  3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
Pd630_LPD12059  3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
Pd630_LPD00127  3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
Pd630_LPD00315  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
Pd630_LPD03158  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
Pd630_LPD05072  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
Pd630_LPD04403  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
Pd630_LPD02328  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
Pd630_LPD03152  Acetolactate synthase [KO:K01652] [EC:2.2.1.6]
Pd630_LPD12030  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
Pd630_LPD00370  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
Pd630_LPD01005  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
Pd630_LPD01014  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
Pd630_LPD05360  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
Pd630_LPD00207  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
Pd630_LPD03153  Acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
Pd630_LPD03156  Ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
Pd630_LPD04342  Ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
Pd630_LPD03149  Dihydroxy-acid dehydratase 3 [KO:K01687] [EC:4.2.1.9]
Pd630_LPD01604  Dihydroxy-acid dehydratase 1 [KO:K01687] [EC:4.2.1.9]
Pd630_LPD05244  Branched-chain-amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
Pd630_LPD07207  Putative branched-chain-amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
Pd630_LPD02037  putative aspartate aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
Pd630_LPD00626  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Pd630_LPD01686  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
roa00260  Glycine, serine and threonine metabolism
roa00280  Valine, leucine and isoleucine degradation
roa00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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