KEGG   PATHWAY: roa00260
Entry
roa00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhodococcus opacus PD630
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
roa00260  Glycine, serine and threonine metabolism
roa00260

Module
roa_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:roa00260]
roa_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:roa00260]
roa_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:roa00260]
roa_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:roa00260]
roa_M00555  Betaine biosynthesis, choline => betaine [PATH:roa00260]
roa_M00621  Glycine cleavage system [PATH:roa00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhodococcus opacus PD630 [GN:roa]
Gene
Pd630_LPD00737  Aspartokinase [KO:K00928] [EC:2.7.2.4]
Pd630_LPD00738  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Pd630_LPD05618  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Pd630_LPD05616  Homoserine kinase [KO:K00872] [EC:2.7.1.39]
Pd630_LPD05617  Threonine synthase [KO:K01733] [EC:4.2.3.1]
Pd630_LPD05981  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Pd630_LPD02486  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Pd630_LPD07166  Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
Pd630_LPD06800  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Pd630_LPD05238  Uncharacterized protein [KO:K00865] [EC:2.7.1.165]
Pd630_LPD01313  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Pd630_LPD01434  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Pd630_LPD06613  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Pd630_LPD07678  Glycerate kinase 2 [KO:K00865] [EC:2.7.1.165]
Pd630_LPD01919  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Pd630_LPD03633  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Pd630_LPD07833  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Pd630_LPD07389  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Pd630_LPD06247  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Pd630_LPD03157  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Pd630_LPD01848  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Pd630_LPD01859  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Pd630_LPD13120  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Pd630_LPD01509  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Pd630_LPD03113  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Pd630_LPD02323  putative flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
Pd630_LPD05929  Amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
Pd630_LPD06190  L-amino acid oxidase [KO:K00274] [EC:1.4.3.4]
Pd630_LPD02195  Copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
Pd630_LPD06835  Histamine oxidase [KO:K00276] [EC:1.4.3.21]
Pd630_LPD06996  Histamine oxidase [KO:K00276] [EC:1.4.3.21]
Pd630_LPD04987  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Pd630_LPD07163  Glycine dehydrogenase [decarboxylating] [KO:K00281] [EC:1.4.4.2]
Pd630_LPD05245  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
Pd630_LPD07164  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
Pd630_LPD01804  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Pd630_LPD07578  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Pd630_LPD16176  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Pd630_LPD07696  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Pd630_LPD06320  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Pd630_LPD07161  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Pd630_LPD04992  Glycine cleavage system H protein [KO:K02437]
Pd630_LPD07165  Glycine cleavage system H protein [KO:K02437]
Pd630_LPD05988  putative glycine cleavage system H protein [KO:K02437]
Pd630_LPD05992  Creatinase [KO:K08688] [EC:3.5.3.3]
Pd630_LPD06342  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Pd630_LPD05964  Choline dehydrogenase [KO:K17755] [EC:1.1.3.17]
Pd630_LPD06042  Choline dehydrogenase [KO:K17755] [EC:1.1.3.17]
Pd630_LPD02197  Gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Pd630_LPD05966  Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Pd630_LPD06044  Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Pd630_LPD01026  Gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Pd630_LPD01818  Gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Pd630_LPD01819  Gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Pd630_LPD06607  Aldehyde dehydrogenase family 2 member C4 [KO:K00130] [EC:1.2.1.8]
Pd630_LPD04268  Aldehyde dehydrogenase, thermostable [KO:K00130] [EC:1.2.1.8]
Pd630_LPD03646  Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Pd630_LPD05975  sarcosine dehydrogenase [KO:K00309] [EC:1.5.3.10]
Pd630_LPD07560  Monomeric sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
Pd630_LPD05984  Sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Pd630_LPD05982  Sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Pd630_LPD05985  Sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Pd630_LPD05983  Sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Pd630_LPD02470  Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
Pd630_LPD04811  Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
Pd630_LPD16016  Putative cysteine synthase [KO:K01697] [EC:4.2.1.22]
Pd630_LPD03174  Putative cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
Pd630_LPD05989  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
Pd630_LPD07167  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
Pd630_LPD00230  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
Pd630_LPD05159  putative threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
Pd630_LPD02473  Threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
Pd630_LPD06115  putative serine racemase [KO:K01754] [EC:4.3.1.19]
Pd630_LPD05105  Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
Pd630_LPD05106  Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Pd630_LPD00975  Tryptophan synthase beta chain 2 [KO:K06001] [EC:4.2.1.20]
Pd630_LPD05410  Diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
Pd630_LPD05409  L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
Pd630_LPD05411  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
Pd630_LPD01448  Ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Pd630_LPD01050  Ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
roa00010  Glycolysis / Gluconeogenesis
roa00020  Citrate cycle (TCA cycle)
roa00230  Purine metabolism
roa00250  Alanine, aspartate and glutamate metabolism
roa00270  Cysteine and methionine metabolism
roa00290  Valine, leucine and isoleucine biosynthesis
roa00300  Lysine biosynthesis
roa00330  Arginine and proline metabolism
roa00460  Cyanoamino acid metabolism
roa00470  D-Amino acid metabolism
roa00564  Glycerophospholipid metabolism
roa00600  Sphingolipid metabolism
roa00620  Pyruvate metabolism
roa00630  Glyoxylate and dicarboxylate metabolism
roa00640  Propanoate metabolism
roa00680  Methane metabolism
roa00860  Porphyrin metabolism
roa00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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