KEGG   PATHWAY: sme00630
Entry
sme00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Sinorhizobium meliloti 1021
Class
Metabolism; Carbohydrate metabolism
Pathway map
sme00630  Glyoxylate and dicarboxylate metabolism
sme00630

Module
sme_M00012  Glyoxylate cycle [PATH:sme00630]
sme_M00621  Glycine cleavage system [PATH:sme00630]
sme_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:sme00630]
Other DBs
GO: 0046487 0043648
Organism
Sinorhizobium meliloti 1021 [GN:sme]
Gene
SM_b20007  katC; KatC [KO:K03781] [EC:1.11.1.6]
SM_b20197  cbbS; putative ribulose-1,5-bisphosphate carboxylase small subunit protein [KO:K01602] [EC:4.1.1.39]
SM_b20198  cbbL; putative ribulose-1,5-bisphosphate carboxylase large subunit protein [KO:K01601] [EC:4.1.1.39]
SM_b20678  ttuD2; putative hydroxypyruvate reductase protein [KO:K11529] [EC:2.7.1.165]
SM_b20679  QglxR; probable tartronic semialdehyde reductase [KO:K00042] [EC:1.1.1.60]
SM_b20680  hyi; putative hydroxypyruvate isomerase protein [KO:K01816] [EC:5.3.1.22]
SM_b20681  gcl; putative glyoxylate carboligase protein [KO:K01608] [EC:4.1.1.47]
SM_b20745  glnII; glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
SM_b20755  pccB; putative propionyl-CoA carboxylase beta chain protein [KO:K01966] [EC:6.4.1.3 2.1.3.15]
SM_b20756  pccA; putative propionyl-CoA carboxylase alpha chain protein [KO:K01965] [EC:6.4.1.3]
SM_b20757  bhbA; methylmalonyl-CoA mutase protein [KO:K01847] [EC:5.4.99.2]
SM_b21164  hutG; putative formiminoglutamase protein [KO:K01458] [EC:3.5.1.68]
SMa0002  fdoG; formate dehydrogenase, major subunit (formate dehydrogenase alpha subunit) [KO:K00123] [EC:1.17.1.9]
SMa0005  fdoH; formate dehydrogenase-O, iron-sulfur subunit [KO:K00124]
SMa0007  fdoI; formate dehydrogenase, cytochrome B556 (FDO) subunit [KO:K00127]
SMa0237  [KO:K00042] [EC:1.1.1.60]
SMa0478  [KO:K00122] [EC:1.17.1.9]
SMa0516  [KO:K00042] [EC:1.1.1.60]
SMa1406  ttuD3; TtuD3 hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
SMa1450  [KO:K00626] [EC:2.3.1.9]
SMa1495  [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SMa1838  [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SMa1846  [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
SMa2135  glyA2; GlyA2 serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SMa2139  sgaA; SgaA serine-glyoxylate aminotransferase (SGAT) [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SMa2141  purU3; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
SMa2145  [KO:K00605] [EC:2.1.2.10]
SMc00151  gph1; Probable phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
SMc00262  [KO:K00626] [EC:2.3.1.9]
SMc00741  acsA3; Probable acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
SMc00762  [KO:K01915] [EC:6.3.1.2]
SMc00768  aceA; Probable isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
SMc00819  katA; Catalase [KO:K03781] [EC:1.11.1.6]
SMc00832  glcD; Probable glycolate oxidase subunit [KO:K00104] [EC:1.1.99.14]
SMc00833  glcE; Probable glycolate oxidase subunit [KO:K11472] [EC:1.1.99.14]
SMc00893  [KO:K01091] [EC:3.1.3.18]
SMc00926  glcF; Probable glycolate oxidase iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
SMc00948  glnA; Glutamine synthetase I [KO:K01915] [EC:6.3.1.2]
SMc00966  [KO:K00626] [EC:2.3.1.9]
SMc01035  lpdA1; Probable dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex) protein [KO:K00382] [EC:1.8.1.4]
SMc01276  gph2; Putative phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
SMc01594  [KO:K01915] [EC:6.3.1.2]
SMc01770  glyA1; Probable serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SMc01930  [KO:K05606] [EC:5.1.99.1]
SMc01973  puuA; Putative gamma-glutamylputrescine synthetase [KO:K01915] [EC:6.3.1.2]
SMc02043  eda1; Probable KHG/KDPG aldolase (includes: 4-hydroxy-2-oxoglutarate aldolase, 2-dehydro-3-deoxyphosphogluconate aldolase) [KO:K01625] [EC:4.1.2.14 4.1.3.42]
SMc02047  gcvT; Probable aminomethyltransferase (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
SMc02048  gcvH; Probable glycine cleavage system H [KO:K02437]
SMc02049  gcvP; Probable glycine dehydrogenase decarboxylating protein [KO:K00281] [EC:1.4.4.2]
SMc02087  gltA; Citrate synthase [KO:K01647] [EC:2.3.3.1]
SMc02228  fadA; Putative acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
SMc02352  [KO:K01915] [EC:6.3.1.2]
SMc02479  mdh; Probable malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
SMc02487  lpdA2; Probable dihydrolipoamide dehydrogenase (E3 component of 2-oxoglutarate dehydrogenase complex) transmembrane protein [KO:K00382] [EC:1.8.1.4]
SMc02524  fdsG; Putative NAD-dependent formate dehydrogenase gamma subunit [KO:K00127]
SMc02525  fdsB; Putative NAD-dependent formate dehydrogenase beta subunit [KO:K00124]
SMc02581  glcB; Probable malate synthase G [KO:K01638] [EC:2.3.3.9]
SMc02613  glnT; Glutamine synthetase III [KO:K01915] [EC:6.3.1.2]
SMc02828  [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SMc02849  gyaR; Probable glyoxylate reductase [KO:K00015] [EC:1.1.1.26]
SMc03086  fdsD; Putative NAD-dependent formate dehydrogenase delta subunit [KO:K00126] [EC:1.17.1.9]
SMc03153  eda2; Probable KHG/KDPG aldolase (includes: 4-hydroxy-2-oxoglutarate aldolase, 2-dehydro-3-deoxyphosphogluconate aldolase) [KO:K01625] [EC:4.1.2.14 4.1.3.42]
SMc03204  lpdA3; Probable dihydrolipoamide dehydrogenase (E3 component of branched-chain alpha-keto acid dehydrogenase complex) protein [KO:K00382] [EC:1.8.1.4]
SMc03205  purU1; Putative formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
SMc03846  acnA; Probable aconitate hydratase [KO:K27802]
SMc03878  phbB; Acetoacetyl-CoA reductase [KO:K00023] [EC:1.1.1.36]
SMc03879  phbA; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SMc04093  acsA1; Probable acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
SMc04148  [KO:K00605] [EC:2.1.2.10]
SMc04153  [KO:K00605] [EC:2.1.2.10]
SMc04154  purU2; Probable formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
SMc04389  ttuD1; Putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
SMc04444  fdsA; Probable NAD-dependent formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
sme00010  Glycolysis / Gluconeogenesis
sme00020  Citrate cycle (TCA cycle)
sme00030  Pentose phosphate pathway
sme00053  Ascorbate and aldarate metabolism
sme00071  Fatty acid degradation
sme00230  Purine metabolism
sme00250  Alanine, aspartate and glutamate metabolism
sme00260  Glycine, serine and threonine metabolism
sme00270  Cysteine and methionine metabolism
sme00620  Pyruvate metabolism
sme00710  Carbon fixation by Calvin cycle
sme00750  Vitamin B6 metabolism
sme00910  Nitrogen metabolism
KO pathway
ko00630   

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