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map04064
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NF-kappa B signaling pathway |
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that fu... |
...(BCL2) K16060 (BIRC2_3) K04734 (NFKBIA) K04730 (IRAK1), K04733 (IRAK4) K04729 (MYD88) K03173 (TRAF2)... |
...receptor interaction Bcl-XL Bcl-2 c-IAP1/2 IκBα IRAK1/4 MyD88 TRAF2/5 RIP1 TRADD IL-1R TNF-R1 IL-1β ... |
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map04620
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Toll-like receptor signaling pathway |
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens... |
...15 (IFNB) K04467 (IKBKA) K03175 (TRAF6) K04730 (IRAK1) K04733 (IRAK4) K04729 (MYD88) K04729 (MYD88) ... |
IFN-β IKKα TRAF6 IRAK1 IRAK4 MyD88 MyD88 MyD88 TRAF6 ERK Tpl2 p105 OPN TRAF3 RIP1 IRF7 IRF5 I-TAC I... |
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map05417
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Lipid and atherosclerosis |
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-r... |
...10 (IKBKG) K04427 (MAP3K7) K04441 (P38) K04730 (IRAK1) K05403 (TIRAP) K04440 (JNK) K03175 (TRAF6) K0... |
... VCAM-1 ICAM-1 MCP-1 DNA DNA MyD88 IKK TAK1 p38 IRAK1 TIRAP JNK TRAF6 TAB1 TAB2 IκBα MD-2 LBP TLR4 C... |
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map05162
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Measles |
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the uniq... |
...04 (TLR7), K10161 (TLR9) K04729 (MYD88) K04730 (IRAK1), K04733 (IRAK4) K09447 (IRF7) K05414 (IFNA) K... |
MEASLES MV proteins TLR7/9 MyD88 IRAK IRF7 IFNα DNA TLR2/4 RIG-I MyD88 IRAK IκB NFκB LPS MDA5 IPS1 I... |
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map04010
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MAPK signaling pathway |
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... |
...16 (PSPN) K03171 (TRADD) K04729 (MYD88) K04730 (IRAK1), K04733 (IRAK4) K08845 (ARAF) K04453 (MAX) |
...k tyrosinkinase downstream TRADD MYD88 IRAK1/4 TNF signaling pathway RafA MAX |
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map04936
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Alcoholic liver disease |
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol ov... |
...15 (IFNB) K05414 (IFNA) K04427 (MAP3K7) K04730 (IRAK1) K10030 (IL8) K05403 (TIRAP) K04519 (IL1B) K05... |
MyD88 TRAF3 IFN-β IFN-α TAK1 IRAK1 IL-8 TIRAP IL-1β TBK1 TRAF6 IKKε IL-6 TAB1 TAB2 IκBα TNFα IRF3 MD... |
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map05130
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Pathogenic Escherichia coli infection |
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic ... |
...3 (TRAF2) K02861 (RIPK1) K03171 (TRADD) K04730 (IRAK1), K04733 (IRAK4) K04729 (MYD88) K04386 (IL1R1)... |
... IKKβ TRAF2 RIP1 TRADD NF-κ B signaling pathway IRAK1/4 MyD88 IL-1R IL-1β TRAF6 TLR4 GAPDH NleE DNA ... |
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map05132
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Salmonella infection |
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid ... |
...09 (IKBKB) K04427 (MAP3K7) K04441 (P38) K04730 (IRAK1), K04733 (IRAK4) K04467 (IKBKA) K10030 (IL8) K... |
SopB AvrA MyD88 MyD88 MyD88 ERK IKKβ TAK1 p38 IRAK1/4 IKKα IL-8 TIRAP MyD88 JNK IL-1β TRAF6 IL-6 TAB... |
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map05133
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Pertussis |
Pertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bact... |
... K04448 (JUN) K04440 (JNK) K03156 (TNF) K04730 (IRAK1) K03175 (TRAF6) K05409 (TIRP) K05842 (TRIF) K1... |
...ion /ATP depletion p38 ERK1/2 AP-1 JNK DNA TNFα IRAK1 TRAF6 TRAM TRIF PtxB PtxC PtxD PtxE ER, Golgi ... |
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map05135
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Yersinia infection |
Pathogenic Yersinia injects virulent Yersinia outer proteins (Yops) into the host cell through a typ... |
...4379 (FOS), K04448 (JUN) K04729 (MYD88) K04730 (IRAK1) K10160 (TLR4) K04733 (IRAK4) K04371 (ERK) K04... |
... +p +p +p +p MKK4/7 NF-κB MKK3/6 AP-1 MyD88 IRAK1 TLR4 IRAK4 ERK +p MEK1/2 +p YopP/J IL-8 TNFα... |
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map05152
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Tuberculosis |
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the... |
...(TGFB1), K13376 (TGFB2), K13377 (TGFB3) K04730 (IRAK1), K04731 (IRAK2) K05135 (IL10RB) K03990 (C3) K... |
...ManLAM) CAMKII TGFβ Anti-inflammatory cytokines IRAK1/2 IL-10RB C3b C3bi DNA ESAT-6 iNOS CD14 Myd88 ... |
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map05161
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Hepatitis B |
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circu... |
...(IKBKB), K07210 (IKBKG) K04427 (MAP3K7) K04730 (IRAK1) K05403 (TIRAP) K04729 (MYD88) K03175 (TRAF6) ... |
...e receptor signaling pathway MyD88 ERK IKK TAK1 IRAK1 TIRAP MyD88 TRAF6 TAB1 TAB2 IκB TLR2 TLR4 TIRA... |
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map05168
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Herpes simplex virus 1 infection |
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal ... |
... (IKBKB), K07210 (IKBKG) K04733 (IRAK4) K04730 (IRAK1) K09447 (IRF7) K03174 (TRAF3) K17834 (CGAS) K1... |
...A BIRC2 BIRC3 NFKB1 REL CCL2 NFκB IκB IKK IRAK4 IRAK1 IRF7 TRAF3 cGAS STING TBK1 cGAMP ICP0 US3 ICP0... |
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map05170
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Human immunodeficiency virus 1 infection |
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency... |
...4371 (ERK) K04427 (MAP3K7) K04441 (P38) K04730 (IRAK1) K04440 (JNK) K03175 (TRAF6) K04403 (MAP3K7IP1... |
...poptosis Tat Nef Vpr Nef Tat MyD88 ERK TAK1 p38 IRAK1 JNK TRAF6 TAB1 TAB2 IκBα TNFα TLR2 TLR4 IRAK4 ... |
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map04624
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Toll and Imd signaling pathway |
Insects, such as Drosophila, have evolved complex mechanisms to combat microbial infection. TOLL and... |
...en peroxide) K18809 (TL) K04729 (MYD88) K04730 (IRAK1) K04733 (IRAK4) K09254 (REL) K20701 (PIRK) K24... |
TOLL AND IMD SIGNALING PATHWAY Toll MyD88 Pelle Tube Dl/Dif Pirk PGRP-LC Spz PGRP-SA Fungi PGR... |
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map04722
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Neurotrophin signaling pathway |
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cel... |
...(PRDM4) K12465 (NGFRAP1) K08846 (RIPK2) K04730 (IRAK1), K04731 (IRAK2), K04732 (IRAK3), K04733 (IRAK... |
Plasticity Cell survival TrkA TrkB TrkC Apoptosis BDNF NT4 NT3 Cellular differentiation PI3K PLCγ D... |
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map05140
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Leishmaniasis |
Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and ... |
...1 (NOX2) K13536 (MARCKSL1) K04441 (P38) K04730 (IRAK1), K04733 (IRAK4) K03175 (TRAF6) K04403 (MAP3K7... |
Macrophage FNR FcγR C3b PKC p47phox Complement cascade Leishmania promastigote LPG Calcium signa... |
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map05142
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Chagas disease |
Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease, also called Ame... |
...988 (C1QG) K10161 (TLR9) K04729 (MYD88) K04730 (IRAK1), K04733 (IRAK4) K03175 (TRAF6) K04430 (MAP2K4... |
TLR2 TLR4 IFNγ gp160 TcCRT C3b C1q Complement pathway Toll-like receptor signaling pathway TLR9 ... |
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map05145
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Toxoplasmosis |
Toxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite ... |
... C00076 (Calcium cation) K04729 (MYD88) K04730 (IRAK1), K04733 (IRAK4) K03175 (TRAF6) K04427 (MAP3K7... |
MyD88 IRAK TRAF6 TAK TAB1/2 IKK IκB NFκB ERK JNK p38 MKK3/6 GRA3/5 Toxoplasma gondii tachyzoite Para... |
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map05169
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Epstein-Barr virus infection |
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly... |
... (ISG15) K04729 (MYD88) K04733 (IRAK4), K04730 (IRAK1) K04467 (IKBKA), K07209 (IKBKB), K07210 (IKBKG... |
gp350 gH/gL gp42 CD21 MHC-II EBNA2 EPSTEIN-BARR VIRUS INFECTION B cell RBP-Jκ SKIP SMRT EBNA3C Vir... |