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ENTRY	nt06510
Name	Telomere length regulation
Category	Pathway view; Replication, repair and transcription
Disease	H00507 Dyskeratosis congenita H02569 Pulmonary fibrosis and/or bone marrow failure, telomere-related H02251 Cerebroretinal microangiopathy with calcifications and cysts
Display	drug-target relation   disease type

N01475    TERC+TGS1 → TERC+PAPD5 → TERC+PARN+ZCCHC8     DKCA1/PFBMFT2/AA TERC*     DKCB6/PFBMFT4         PARN*     PFBMFT5         ZCCHC8*   N01476    TERC+TERT+Pontin+R.. = DKC1+NOP10+NHP2+GA.. → TERC+TERT+Pontin+R.. = WRAP53+TriC     DKCA2/PFBMFT1/AA/CMM9 TERT*     DKCX     DKC1*     DKCB1/PFBMFT9     NOP10*     DKCB2     NHP2*     PFBMFT7     NAF1*     DKCB3             WRAP53*     IDDPMGS             TCP1*     NEDSVH             CCT3*     HSNSP             CCT5*   N01477    RTEL1+RAP1+TRF2+TI.. = telomerase → Shelterin = CTC1+STN1+TEN1     DKCA4/PFBMFT3 RTEL1*     DKCA3_A5 TIN2*     DKCA6_B7 ACD*     TPDS3/PFBMFT8/CRMCC3 POT1*     CRMCC1             CTC1*     CRMCC2             STN1*

		Disease name	Disease category
DKCA1/PFBMFT2/AA	H00507	Dyskeratosis congenita	Ribosomopathy
	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
	H01132	Aplastic anemia	Hematologic disease
DKCB6/PFBMFT4	H00507	Dyskeratosis congenita	Ribosomopathy
	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
PFBMFT5	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
DKCA2/PFBMFT1/AA/CMM9	H00507	Dyskeratosis congenita	Ribosomopathy
	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
	H01132	Aplastic anemia	Hematologic disease
	H00038	Melanoma	Cancer
DKCX	H00507	Dyskeratosis congenita	Ribosomopathy
DKCB1/PFBMFT9	H00507	Dyskeratosis congenita	Ribosomopathy
	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
DKCB2	H00507	Dyskeratosis congenita	Ribosomopathy
PFBMFT7	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
DKCB3	H00507	Dyskeratosis congenita	Ribosomopathy
IDDPMGS	H02843	Brain malformations and seizures by impaired function of TRiC	Congenital malformation
NEDSVH	H02843	Brain malformations and seizures by impaired function of TRiC	Congenital malformation
HSNSP	H02580	Hereditary sensory neuropathy with spastic paraplegia	Nervous system disease
DKCA4/PFBMFT3	H00507	Dyskeratosis congenita	Ribosomopathy
	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
DKCA3_A5	H00507	Dyskeratosis congenita	Ribosomopathy
DKCA6_B7	H00507	Dyskeratosis congenita	Ribosomopathy
TPDS3/PFBMFT8/CRMCC3	H02624	Tumor predisposition syndrome	Cancer
	H02569	Pulmonary fibrosis and/or bone marrow failure, telomere-related	Hematologic disease
	H02251	Cerebroretinal microangiopathy with calcifications and cysts	Nervous system disease
CRMCC1	H02251	Cerebroretinal microangiopathy with calcifications and cysts	Nervous system disease
CRMCC2	H02251	Cerebroretinal microangiopathy with calcifications and cysts	Nervous system disease