KEGG ORTHOLOGY: K10630

ORTHOLOGY: K10630

Entry

K10630                      KO

Symbol

RBCK1, HOIL1

Name

RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]

Pathway

map04217

Necroptosis

map04621

NOD-like receptor signaling pathway

map05131

Shigellosis

Disease

H01744

Polyglucosan body myopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
  Multi subunit Ring-finger type E3
   LUBAC complex
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1

Genes

HSA:	10616(RBCK1)

PTR:	458025(RBCK1)

PPS:	100981890(RBCK1)

GGO:	101147960(RBCK1)

PON:	100438712(RBCK1)

NLE:	100603577(RBCK1)

HMH:	116461172(RBCK1)

MCC:	714692(RBCK1)

MCF:	102126740(RBCK1)

MTHB:

126964219

MNI:	105496133(RBCK1)

CSAB:

103247827(RBCK1)

CATY:

105582208(RBCK1)

PANU:

101001673(RBCK1)

TGE:	112632766(RBCK1)

MLEU:

105539526(RBCK1)

RRO:	104660808(RBCK1)

RBB:	108544535(RBCK1)

TFN:	117068595(RBCK1)

PTEH:

111548114(RBCK1)

CANG:

105524951(RBCK1)

CJC:	100411512(RBCK1)

SBQ:	101038299(RBCK1)

CIMI:

108293676(RBCK1)

CSYR:

103263739(RBCK1)

MMUR:

105866006(RBCK1)

LCAT:

123622872(RBCK1)

PCOQ:

105804939(RBCK1)

OGA:	100948586(RBCK1)

MMU:	24105(Rbck1)

MCAL:

110284393(Rbck1)

MPAH:

110317671(Rbck1)

RNO:	60383(Rbck1)

MCOC:

116091162(Rbck1)

ANU:	117703104(Rbck1)

MUN:	110555817(Rbck1)

CGE:	100761016(Rbck1)

MAUA:

101826261(Rbck1)

PROB:

127228458(Rbck1)

PLEU:

114705539(Rbck1)

MORG:

121460448(Rbck1)

MFOT:

126506904

AAMP:

119815042(Rbck1)

NGI:	103751631(Rbck1)

HGL:	101721667(Rbck1)

CPOC:

100734748(Rbck1)

CCAN:

109687017(Rbck1)

DORD:

105981716(Rbck1)

DSP:	122120321(Rbck1)

PLOP:

125353345(Rbck1)

NCAR:

124975316

MMMA:

107142337

OCU:

100347560

OPI:	101516505(RBCK1)

TUP:	102473168(RBCK1)

GVR:	103593134(RBCK1)

CFA:	485818(RBCK1)

CLUD:

112673740(RBCK1)

VVP:	112909903(RBCK1)

VLG:	121478243(RBCK1)

NPO:	129497072(RBCK1)

AML:	100471387(RBCK1)

UMR:	103674489(RBCK1)

UAH:	113258444(RBCK1)

UAR:	123798793(RBCK1)

ELK:

111141517

LLV:

125108516

MPUF:

101684000(RBCK1)

MNP:	132021811(RBCK1)

MLK:	131807909(RBCK1)

NVS:	122916183(RBCK1)

ORO:	101374350(RBCK1)

EJU:	114220650(RBCK1)

ZCA:	113937832(RBCK1)

MLX:	118011363(RBCK1)

NSU:	110579506(RBCK1)

LWW:	102734423(RBCK1)

FCA:	101083505(RBCK1)

PYU:	121012362(RBCK1)

PCOO:

112869555(RBCK1)

PBG:	122496433(RBCK1)

PVIV:

125161950(RBCK1)

LRUF:

124503413

PTG:	102970756(RBCK1)

PPAD:

109272618(RBCK1)

PUC:

125936723

AJU:

106985976

HHV:	120235414(RBCK1)

BTA:	504400(RBCK1)

BOM:	102280624(RBCK1)

BIU:	109567335(RBCK1)

BBUB:

102406758(RBCK1)

BBIS:

104990011(RBCK1)

CHX:	102181220(RBCK1)

OAS:	101122207(RBCK1)

BTAX:

128058275(RBCK1)

ODA:	120868779(RBCK1)

CCAD:

122448024(RBCK1)

MBEZ:

129561959(RBCK1)

SSC:	100519985(RBCK1)

CFR:	102513471(RBCK1)

CBAI:

105073600(RBCK1)

CDK:	105100807(RBCK1)

VPC:	102534329(RBCK1)

BACU:

103000245(RBCK1)

BMUS:

118881708(RBCK1)

LVE:	103084814(RBCK1)

OOR:	101285270(RBCK1)

DLE:	111184340(RBCK1)

PCAD:

102977045(RBCK1)

PSIU:

116739761(RBCK1)

NASI:

112398450(RBCK1)

ECB:	100067987(RBCK1)

EPZ:	103556916(RBCK1)

EAI:	106833755(RBCK1)

MYB:	102252422(RBCK1)

MYD:	102759068(RBCK1)

MMYO:

118663047(RBCK1)

MLF:	102438617(RBCK1)

PKL:	118708002(RBCK1)

EFUS:

103285594(RBCK1)

MNA:	107527772(RBCK1)

DRO:	112304086(RBCK1)

SHON:

118985581(RBCK1)

AJM:	119047780(RBCK1) 119047782

PDIC:

114506892(RBCK1)

PHAS:

123814743(RBCK1)

MMF:	118618822(RBCK1)

PPAM:

129070792(RBCK1)

HAI:	109384455(RBCK1)

RFQ:	117015714(RBCK1)

PALE:

102884021(RBCK1)

PGIG:

120603499(RBCK1)

PVP:	105305490(RBCK1)

RAY:	107512902(RBCK1)

MJV:	108400431(RBCK1)

TOD:	119234512(RBCK1)

SARA:

101537477(RBCK1)

SETR:

126017340(RBCK1)

LAV:	100654220(RBCK1)

TMU:

101349597

ETF:	101649553(RBCK1)

DNM:	101414533(RBCK1)

MDO:	100011102(RBCK1)

GAS:	123237392(RBCK1)

SHR:	100919033(RBCK1)

AFZ:

127550477

PCW:	110211403(RBCK1)

OAA:	114806007(RBCK1)

PCOC:

116239376(SHARPIN)

MGP:	104915434(RBCK1)

CJO:

NMEL:

APLA:

ACYG:

AFUL:

TGU:

LSR:

PMOA:

OMA:	130250284(SHARPIN)

PHI:

102106906

FPG:	101917453(SHARPIN)

FCH:

CLV:

NNI:

ACUN:

ACHC:

115340166(SHARPIN)

HLE:

104831307

AGEN:

126047029

SHAB:

115608344(SHARPIN)

CPEA:

104393640

RTD:	128903802(SHARPIN)

AROW:

112976666

DNE:	112991958(SHARPIN)

ASN:	102374341(SHARPIN) 102381829(RBCK1)

AMJ:	102558277 102565394(RBCK1)

CPOO:

109313284(RBCK1)

GGN:	109292532(RBCK1)

CMY:	102930975(SHARPIN) 102933957(RBCK1)

CCAY:

125622660(RBCK1)

DCC:	119842212(RBCK1) 119850834

CPIC:

101952313 101954121(RBCK1)

TST:	117871850 117885616(RBCK1)

CABI:

116816775(RBCK1) 116825915

MRV:	120380894(RBCK1) 120397349

ACS:	100562899(rbck1) 100564158(sharpin)

ASAO:

132772996(RBCK1) 132775190(SHARPIN)

PVT:	110084806 110090830(RBCK1)

SUND:

121928055(SHARPIN) 121929852(RBCK1)

PBI:	103054619 103063472

PMUR:

107294697 107299778 107299797

CTIG:

120317794(SHARPIN) 120317846(RBCK1)

TSR:	106549808 106550246

PGUT:

117666938(SHARPIN)

APRI:

131194056(RBCK1) 131196350(SHARPIN)

PTEX:

113450611(SHARPIN) 113451863(RBCK1)

NSS:	113425129 113428275

VKO:	123035264 123036122(RBCK1)

PMUA:

114599814(RBCK1) 114600121(SHARPIN)

PRAF:

128416633(RBCK1) 128416937(SHARPIN)

ZVI:	118088441(RBCK1) 118089703

HCG:	128324489 128352875(RBCK1)

GJA:	107117859(SHARPIN) 107119331(RBCK1)

STOW:

125425081(SHARPIN) 125433154(RBCK1)

EMC:	129329829(RBCK1) 129333354(SHARPIN)

XLA:	108695474 108719472

XTR:	100491300(rbck1)

NPR:	108802101(RBCK1)

RTEM:

120941652(RBCK1)

BBUF:

121002019

BGAR:

122939674

MUO:	115476482(RBCK1) 115481020(SHARPIN)

GSH:	117353720(SHARPIN)

DRE:	431715(rbck1) 569903(shrprbck1r)

SRX:	107720991 107722400 107739381 107745403

SANH:

107653168 107653293 107656201 107658397

SGH:	107556071 107573567 107586913 107590993

CCAR:

109062850 109062873 109074675 109107407

CAUA:

113039482 113039518 113080107 113106132

CGIB:

127942928 127962747 127986944

PTET:

122327349(rbck1) 122349527(shrprbck1r)

LROH:

127153156(rbck1) 127168672(shrprbck1r)

OMC:	131530837(rbck1) 131544139(shrprbck1r)

PPRM:

120466987(shrprbck1r) 120492962(rbck1)

RKG:	130077325(rbck1)

MAMB:

125263552(rbck1) 125264973(shrprbck1r)

CIDE:

127516420 127519763

MASI:

127437954 127439058 127440740 127453578

TROS:

130548745(rbck1) 130561081(shrprbck1r)

TDW:	130418995(shrprbck1r) 130429906(rbck1) 130430132

MANU:

129445930(shrprbck1r) 129453185(rbck1)

IPU:	108255080 108268220(shrprbck1r)

IFU:	128610488(shrprbck1r) 128625061(rbck1)

PHYP:

113537923 113547215

SMEO:

124387352(shrprbck1r) 124402134(rbck1)

TFD:	113639069(rbck1) 113643295(shrprbck1r)

TVC:	132837885(rbck1) 132849066(shrprbck1r)

AMEX:

103029459 103044240(rbck1)

CMAO:

118799731(rbck1) 118802062(shrprbck1r)

EEE:	113580584(rbck1) 113588870

CHAR:

105912146(rbck1) 122131991(shrprbck1r)

TRU:	101064989 101070545(rbck1)

TFS:	130513973 130524812(rbck1)

TNG:	GSTEN00015499G001 GSTEN00027629G001

LCO:	104922306(rbck1) 104922367

NCC:	104946202(rbck1)

TBEN:

117484081(shrprbck1r) 117489482(rbck1)

CGOB:

115007846(rbck1) 115025613

PGEO:

117447342(rbck1) 117465727(shrprbck1r)

GACU:

117534255(rbck1) 117535560

EMAC:

134882566(rbck1) 134884207(shrprbck1r)

ELY:	117257550(rbck1) 117264809(shrprbck1r)

EFO:	125881538(shrprbck1r) 125897404(rbck1)

PLEP:

121956935(rbck1) 121960591

SLUC:

116037922(shrprbck1r) 116051400(rbck1)

ECRA:

117937785(shrprbck1r) 117943961(rbck1)

ESP:	116672047 116687739(rbck1)

PFLV:

114549303 114554215(rbck1)

GAT:	120811821(shrprbck1r) 120834859(rbck1)

PPUG:

119198746(shrprbck1r) 119229595(rbck1)

AFB:	129105613(rbck1) 129110984(shrprbck1r)

CLUM:

117731330(rbck1) 117749499

PSWI:

130206317(shrprbck1r) 130208465(rbck1)

MSAM:

119886557(rbck1) 119908837(shrprbck1r)

SCHU:

122866900(shrprbck1r) 122882960(rbck1)

CUD:	121527187(shrprbck1r) 121528320(rbck1)

ALAT:

119008722(shrprbck1r) 119020901(rbck1)

MZE:	101476206 101485343(rbck1)

ONL:	100708611 100709282(rbck1)

OAU:	116320730(rbck1) 116328341(shrprbck1r)

OLA:	101166217 101169745

OML:	112144487(rbck1) 112151417(shrprbck1r)

CSAI:

133422933(shrprbck1r) 133448343(rbck1)

XMA:	102226939 102234963(rbck1)

XCO:	114135617(rbck1) 114136946

XHE:	116710657(rbck1) 116712370

PRET:

103482437 108166280(rbck1)

PFOR:

103135233 103135383(rbck1)

PLAI:

106947955(rbck1) 106948836

PMEI:

106919742 106920120(rbck1)

GAF:	122823911(shrprbck1r) 122833984(rbck1)

PPRL:

129352265(rbck1) 129364925(shrprbck1r)

CVG:	107090634(rbck1) 107092260

CTUL:

119773506(shrprbck1r) 119795926(rbck1)

GMU:	124856850(rbck1) 124858100(shrprbck1r)

NFU:	107382942 107385371

KMR:	108231665(rbck1) 108243123(shrprbck1r)

ALIM:

106517640 106524788

NWH:	119412789(rbck1) 119426676(shrprbck1r)

AOCE:

111576256(rbck1) 111587713

MCEP:

124995808 125006710(rbck1)

CSEM:

103376970 103386727

POV:	109629840 109635559

SSEN:

122767556(rbck1) 122778394(shrprbck1r)

HHIP:

117753943(shrprbck1r) 117761568(rbck1)

HSP:	118098502(shrprbck1r) 118104704(rbck1)

SMAU:

118291220(shrprbck1r) 118309666(rbck1)

LCF:	108894452(shrprbck1r) 108902107

SDU:	111237288 111239703(rbck1)

SLAL:

111662905 111669673(rbck1)

XGL:	120783113(rbck1) 120789938(shrprbck1r)

HCQ:	109511977 109521524(rbck1)

SSCV:

125985681

SBIA:

133492505(shrprbck1r) 133507809(rbck1)

PEE:	133396490(shrprbck1r) 133408683(rbck1)

PTAO:

133470109(shrprbck1r) 133483294(rbck1)

BPEC:

110160942 110173735

MALB:

109964848 109965545

BSPL:

114854200(shrprbck1r) 114855664(rbck1)

SJO:	128355007(rbck1) 128382416(shrprbck1r)

SASA:

100194956(ub7i3) 106590417

STRU:

115195522 115208017(rbck1)

OTW:	112215706(rbck1) 112233595(shrprbck1r)

OMY:	110489702(shrprbck1r) 110494153(rbck1)

OGO:	124002558(rbck1) 124039582(shrprbck1r)

ONE:	115104491 115130155 115143025

OKI:	109894051 109899283

OKE:	118370321(shrprbck1r) 118388728(rbck1)

SALP:

111953783 111964877

SNH:	120050994(shrprbck1r) 120062444(rbck1)

CCLU:

121569222 121575111(rbck1)

ELS:	105017073(rbck1) 105019569

SFM:	108936338(rbck1) 108938335 108939041

PKI:	111835617 111850135 111861091(rbck1)

AANG:

118211197(rbck1) 118225147(shrprbck1r)

LOC:	102690636(rbck1) 102691418

PSPA:

121307830 121307840(rbck1) 121312812(shrprbck1r) 121314280

ARUT:

117394674 117399639 117424039 117429619

PSEX:

120515129(rbck1) 120529729(shrprbck1r)

LCM:	102349730(SHARPIN) 102349954(RBCK1)

CMK:	103179690(shrprbck1r) 103188626

RTP:

109938984

CPLA:

122550209(shrprbck1r) 122559969(rbck1)

HOC:	132815896(shrprbck1r) 132823000(rbck1)

LERI:

129707313(rbck1) 129715055(shrprbck1r)

PMRN:

116944207(RBCK1) 116954119(SHARPIN)

LRJ:	133350907(RBCK1) 133355946(SHARPIN)

BFO:

118417455

BBEL:

109479372

CIN:	100169995(zf(ring/rbz)-1)

SCLV:

120340586

SPU:	115920244 592806

LPIC:

APLC:

AGA:

ACOZ:

AAG:	5568606 5575855 5579232

AALB:

109404769 109405172 109408022 109423888 109423911 109430168 115265609

CQU:	CpipJ_CPIJ000386 CpipJ_CPIJ000387 CpipJ_CPIJ000388 CpipJ_CPIJ000389 CpipJ_CPIJ004842 CpipJ_CPIJ004843

CPII:

120415583 120419632 120419646 120419655 120420137 120420177

CNS:

BCOO:

AME:

ACER:

BIM:

BTER:

CCAL:

OBB:	114876449 114876452

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:	124956203 124956259

NVI:

100116938

CSOL:

105364932

MDL:	103568812 103570640

CGLO:

123267796

AGIF:

122847793 122847794 122860692

BMOR:

BMAN:

HAW:

TNL:

OFU:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

NLU:	111049882 111050481

ZNE:

110833674

IEL:

124156355

FCD:	110841960 110844412 110844637

DPX:	DAPPUDRAFT_53583

PPOI:

119090064 119108111 119108112 119108113

DSV:	119461707 119464259

RSAN:

119378828 119379010 119390082

RMP:	119161108 119175455 119176005

VDE:	111244950 111247219 111249704

VJA:	111258762 111258967 111271564

CSCU:

PTEP:

UDV:

SDM:

HRO:	HELRODRAFT_106565

LGI:	LOTGIDRAFT_109179

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:	110466754 110466828

PMAX:

MMER:

RPHI:

OBI:

OSN:

LAK:	106158313 106182035

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:	100634100 100634228

» show all

Reference

PMID:18711448

Authors

Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, Shu HB

Title

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.

Journal

Cell Res 18:1096-104 (2008)
DOI:10.1038/cr.2008.277

Reference

PMID:12629548

Authors

Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA, Morishima I, Minato N, Ishimori K, Iwai K

Title

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.

Journal

Nat Cell Biol 5:336-40 (2003)
DOI:10.1038/ncb952

Sequence

[hsa:10616]

LinkDB

DBGET integrated database retrieval system