KEGG   PATHWAY: achc04020
Entry
achc04020                   Pathway                                
Name
Calcium signaling pathway - Aquila chrysaetos chrysaetos (golden eagle)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
achc04020  Calcium signaling pathway
achc04020

Other DBs
GO: 0019722
Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:achc]
Gene
115338163  sodium/calcium exchanger 2-like [KO:K05849]
115352996  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
115335010  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
115333331  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
115336336  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
115334967  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
115350430  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
115334503  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
115346304  ADORA2A; adenosine receptor A2a [KO:K04266]
115346874  ADORA2B; adenosine receptor A2b [KO:K04267]
115348366  ADRB1; beta-1 adrenergic receptor isoform X1 [KO:K04141]
115334257  ADRB2; beta-2 adrenergic receptor [KO:K04142]
115350113  ADRB3; beta-3 adrenergic receptor [KO:K04143]
115334353  DRD1; D(1A) dopamine receptor [KO:K04144]
115346889  DRD5; LOW QUALITY PROTEIN: D(1B) dopamine receptor [KO:K05840]
115348593  D(1)-like dopamine receptor [KO:K05840]
115349762  D(1) dopamine receptor-like [KO:K05840]
115343408  octopamine receptor-like [KO:K04150]
115334397  HRH2; histamine H2 receptor [KO:K04150]
115334255  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
115339644  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
115342801  5-hydroxytryptamine receptor 5A-like [KO:K04161]
115342472  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
115347083  5-hydroxytryptamine receptor 7-like isoform X1 [KO:K04163]
115348464  HTR7; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 7 [KO:K04163]
115338819  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
115340477  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
115352949  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
115353041  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
115351414  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
115345521  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
115340454  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
115336030  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
115349379  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115350193  PLN; cardiac phospholamban [KO:K05852]
115353622  SLN; sarcolipin [KO:K22642]
115346581  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
115347193  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
115353379  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
115341250  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
115345469  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
115347533  ORAI2; protein orai-2 isoform X1 [KO:K16057]
115352314  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
115353734  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
115338229  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
115335203  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
115337976  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
115335049  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
115349117  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
115341261  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
115335855  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
115352684  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
115336528  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
115341855  CHRFAM7A; CHRNA7-FAM7A fusion protein [KO:K04809]
115334958  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
115335791  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
115336240  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
115340970  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
115336587  GRIN3A; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3A [KO:K05213]
115349013  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
115347683  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
115338519  P2RX3; P2X purinoceptor 3 [KO:K05217]
121233149  bone marrow proteoglycan-like [KO:K05217]
115345424  P2RX4; P2X purinoceptor 4 [KO:K05218]
115346870  P2RX5; P2X purinoceptor 5 isoform X2 [KO:K05219]
115346092  P2RX6; LOW QUALITY PROTEIN: P2X purinoceptor 6 [KO:K05221]
115349975  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
115334418  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
115337428  TRDN; triadin [KO:K23449]
115346178  CASQ1; calsequestrin-1 [KO:K23468]
115343934  CASQ2; calsequestrin-2 [KO:K23445]
115340531  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
115333902  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
115350561  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
115352771  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
115350482  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
115334347  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
115345889  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
115347609  AGTR1; type-1 angiotensin II receptor [KO:K04166]
115344336  EDNRA; endothelin-1 receptor [KO:K04197]
115350714  EDNRB; LOW QUALITY PROTEIN: endothelin receptor type B [KO:K04198]
115333912  endothelin receptor type B-like isoform X2 [KO:K04198]
115337319  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
115345049  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
115353418  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
115334591  GRPR; gastrin-releasing peptide receptor [KO:K04169]
115333318  HRH1; histamine H1 receptor [KO:K04149]
115333616  5-hydroxytryptamine receptor 2A-like isoform X1 [KO:K04157]
115350757  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
115347131  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
115350227  lutropin-choriogonadotropic hormone receptor [KO:K04248]
115339737  NTSR1; LOW QUALITY PROTEIN: neurotensin receptor type 1 [KO:K04211]
115333435  OXTR; oxytocin receptor [KO:K04229]
115342238  AVPR1A; LOW QUALITY PROTEIN: vasopressin V1a receptor [KO:K04226]
115335114  AVPR1B; vasopressin V1b receptor [KO:K04227]
115351870  PTAFR; platelet-activating factor receptor [KO:K04279]
115349543  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
115349651  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
115334580  BDKRB1; B1 bradykinin receptor [KO:K03915]
115338673  BDKRB2; B2 bradykinin receptor [KO:K03916]
115350462  TACR1; substance-P receptor [KO:K04222]
115347935  TACR2; substance-K receptor [KO:K04223]
115341566  TACR3; neuromedin-K receptor isoform X1 [KO:K04224]
115348996  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
115339497  thyrotropin-releasing hormone receptor-like [KO:K04282]
115340763  TRHR; thyrotropin-releasing hormone receptor isoform X2 [KO:K04282]
115343419  CCKAR; cholecystokinin receptor type A [KO:K04194]
115353387  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
115342992  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
115337123  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
121232877  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
115349102  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
115337124  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
115344703  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
115350364  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
115335808  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
115352795  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
115346275  PDGFC; platelet-derived growth factor C [KO:K05450]
115353500  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
115334052  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
115343528  FGF2; fibroblast growth factor 2 [KO:K18497]
115349939  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
115337246  FGF10; fibroblast growth factor 10 [KO:K04358]
115351806  FGF3; fibroblast growth factor 3 [KO:K04358]
115351873  FGF4; fibroblast growth factor 4 [KO:K04358]
115352412  FGF6; fibroblast growth factor 6 [KO:K04358]
115353237  FGF9; fibroblast growth factor 9 [KO:K04358]
115347333  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
115333915  FGF16; fibroblast growth factor 16 [KO:K04358]
115341210  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121232827  fibroblast growth factor 10-like [KO:K04358]
115334399  FGF18; fibroblast growth factor 18 [KO:K04358]
115348494  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
115349017  FGF22; fibroblast growth factor 22 [KO:K04358]
115342720  FGF20; fibroblast growth factor 20 [KO:K04358]
115352222  FGF19; fibroblast growth factor 19 [KO:K22603]
115352405  FGF23; fibroblast growth factor 23 [KO:K22428]
115350086  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
115334714  VEGFD; vascular endothelial growth factor D [KO:K05449]
115342576  VEGFC; vascular endothelial growth factor C [KO:K05449]
115334762  NGF; beta-nerve growth factor [KO:K02582]
115341991  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
115353784  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
115337258  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
121233001  glial cell line-derived neurotrophic factor-like isoform X1 [KO:K05452]
115338920  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
115344932  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
115350855  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
115342928  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
115341064  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
115334242  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
115350076  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
115348147  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
115343423  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
115334290  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
115333495  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
115353436  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
115334261  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
115343684  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
115345406  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
115336699  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
115341522  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
115341817  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
115353728  MST1R; LOW QUALITY PROTEIN: macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
115348153  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
121233138  uncharacterized protein LOC121233138 [KO:K10784]
115344553  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
115338844  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
115342634  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2 [KO:K05857] [EC:3.1.4.11]
115344237  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
115344678  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
115351830  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
115339114  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
115340577  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
115345998  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
115348012  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
115352569  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
115353680  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
115352454  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
115334771  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
115342015  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
115345690  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
115352097  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
115348253  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
115349360  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
115348691  MCOLN3; mucolipin-3 [KO:K04994]
115341172  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
115347919  MCU; calcium uniporter protein, mitochondrial isoform X2 [KO:K20858]
115334118  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
115348118  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
115350505  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
115344018  SLC25A31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
115333680  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
115334643  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
115341877  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
115348388  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
115353882  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
115339968  TNNC2; troponin C, skeletal muscle [KO:K12042]
115350477  CALM2; calmodulin-2 [KO:K02183]
115337680  calmodulin-1-like [KO:K02183]
115338111  calmodulin-1-like isoform X2 [KO:K02183]
115351693  CALM1; calmodulin-1 [KO:K02183]
115341975  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
115342303  calmodulin, striated muscle [KO:K02183]
115347122  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
115343647  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
115346406  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
115333669  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
115339138  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
115346654  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
115353120  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
115342719  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
115345195  LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
115353670  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
115341574  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
115335074  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
115349902  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
115339366  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
115334182  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
115348367  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
115337069  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
115348857  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
115350283  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115341327  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115347882  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115344484  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
115335249  TFEB; transcription factor EB [KO:K15590]
115353083  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
115339726  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
115345819  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
115346336  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
115346926  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
115351306  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
115338822  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
115342735  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
115351243  PTK2B; LOW QUALITY PROTEIN: protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
115350219  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
115351308  ITPKA; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
115341437  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
115335844  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
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Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
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Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
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Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
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Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
achc04010  MAPK signaling pathway
achc04070  Phosphatidylinositol signaling system
achc04210  Apoptosis
KO pathway
ko04020   
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