KEGG   PATHWAY: amex04150
Entry
amex04150                   Pathway                                
Name
mTOR signaling pathway - Astyanax mexicanus (Mexican tetra)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
amex04150  mTOR signaling pathway
amex04150

Organism
Astyanax mexicanus (Mexican tetra) [GN:amex]
Gene
103037667  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
103045737  4F2 cell-surface antigen heavy chain-like [KO:K06519]
103024422  4F2 cell-surface antigen heavy chain-like [KO:K06519]
103041902  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
103041856  atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
103045016  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
103034689  V-type proton ATPase subunit B, brain isoform [KO:K02147]
103038866  V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
103030451  V-type proton ATPase subunit C 1-A [KO:K02148]
103027342  V-type proton ATPase subunit C 1-B-like [KO:K02148]
103028372  atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
103046603  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
103026420  V-type proton ATPase subunit E 1-like [KO:K02150]
103026244  V-type proton ATPase subunit E 1-like [KO:K02150]
103042149  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
103024358  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
103032938  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
103042268  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
103042042  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
103047036  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
103042469  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
103026438  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
103032296  flcn; folliculin [KO:K09594]
103028369  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
103027074  folliculin-interacting protein 2-like isoform X1 [KO:K20401]
103043211  ras-related GTP-binding protein A [KO:K16185]
103047828  ras-related GTP-binding protein D [KO:K16186]
103024452  rragc; ras-related GTP-binding protein C [KO:K16186]
103036251  sestrin-2-like [KO:K20394]
103038945  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
103024111  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
103044809  mios; GATOR complex protein MIOS isoform X2 [KO:K20407]
103047511  seh1l; nucleoporin SEH1 isoform X2 [KO:K14299]
103027339  wdr24; GATOR complex protein WDR24 [KO:K20408]
103043604  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
103043631  sec13; protein SEC13 homolog [KO:K14004]
103045874  depdc5; LOW QUALITY PROTEIN: GATOR complex protein DEPDC5 [KO:K20404]
103041375  nprl2; GATOR complex protein NPRL2 [KO:K20405]
103023768  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
103047278  skp2; S-phase kinase-associated protein 2 [KO:K03875]
103024149  rnf152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
103025211  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
111193360  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
103042377  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111189841  deptor; LOW QUALITY PROTEIN: DEP domain-containing mTOR-interacting protein [KO:K20402]
103022626  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
103023621  tti1; LOW QUALITY PROTEIN: TELO2-interacting protein 1 homolog [KO:K20403]
111191575  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
103043214  CAP-Gly domain-containing linker protein 1 [KO:K10421]
103031323  grb10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
103044570  lpin2; phosphatidate phosphatase LPIN2 isoform X2 [KO:K15728] [EC:3.1.3.4]
103029457  LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
103043587  phosphatidate phosphatase LPIN1 isoform X2 [KO:K15728] [EC:3.1.3.4]
103045975  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
103030941  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
103021360  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
103042154  ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
103026407  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
103026948  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
103021705  eif4e2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
103032634  eukaryotic translation initiation factor 4E-like isoform X2 [KO:K03259]
103036796  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
103045086  eukaryotic translation initiation factor 4E-1B-like [KO:K03259]
103043156  eukaryotic translation initiation factor 4E-1A isoform X1 [KO:K03259]
103043705  eukaryotic translation initiation factor 4E-1A [KO:K03259]
103035647  rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103031203  rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103022088  eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
103046153  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
103029232  rps6; 40S ribosomal protein S6 [KO:K02991]
103033410  strada; STE20-related kinase adapter protein alpha isoform X2 [KO:K08271]
103045027  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
103025761  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
103025953  calcium-binding protein 39-like [KO:K08272]
103044326  cab39l; calcium-binding protein 39-like [KO:K08272]
103022500  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
103028619  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103023802  hamartin [KO:K07206]
103025705  tsc1; hamartin isoform X1 [KO:K07206]
103033522  tsc2; tuberin isoform X1 [KO:K07207]
103040096  TBC1 domain family member 7 [KO:K20396]
111196194  GTP-binding protein Rheb-like isoform X1 [KO:K07208]
103021747  LOW QUALITY PROTEIN: GTP-binding protein Rheb [KO:K07208]
103035598  GTP-binding protein Rheb-like [KO:K07208]
103024026  DNA damage-inducible transcript 4 protein-like [KO:K08270]
103022257  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
103042266  wnt1; proto-oncogene Wnt-1 [KO:K03209]
103029625  protein Wnt-2b-like [KO:K00182]
103033339  wnt2; protein Wnt-2 [KO:K00182]
103046094  wnt2b; protein Wnt-2b [KO:K00182]
103027712  LOW QUALITY PROTEIN: proto-oncogene Wnt-3 [KO:K00312]
103046291  protein Wnt-3a isoform X1 [KO:K00312]
103046581  wnt4; protein Wnt-4 [KO:K00408]
103021666  protein Wnt-4 [KO:K00408]
103037231  wnt5a; protein Wnt-5a [KO:K00444]
103026771  LOW QUALITY PROTEIN: protein Wnt-5b [KO:K00444]
103038704  protein Wnt-6-like [KO:K00445]
103041984  wnt6; protein Wnt-6 [KO:K00445]
103028473  wnt7b; protein Wnt-7b [KO:K00572]
103046044  LOW QUALITY PROTEIN: protein Wnt-7a [KO:K00572]
103026929  protein Wnt-7b isoform X1 [KO:K00572]
103027182  wnt7a; protein Wnt-7a [KO:K00572]
103036405  protein Wnt-8a-like [KO:K00714]
103036102  protein Wnt-8a-like [KO:K00714]
103022456  wnt8b; protein Wnt-8b [KO:K00714]
103034815  wnt9a; LOW QUALITY PROTEIN: protein Wnt-9a [KO:K01064]
103044946  wnt9b; protein Wnt-9b [KO:K01064]
103044775  wnt10a; protein Wnt-10a [KO:K01357]
103039496  wnt10b; protein Wnt-10b [KO:K01357]
111196811  protein Wnt-11-like [KO:K01384]
103022398  protein Wnt-11-like [KO:K01384]
103044788  protein Wnt-11 [KO:K01384]
107197694  wnt16; protein Wnt-16 [KO:K01558]
103024641  frizzled-7-A-like [KO:K02432]
103021589  frizzled-7-A-like [KO:K02432]
103037293  fzd2; frizzled-2 [KO:K02235]
103040861  fzd3; frizzled-3 isoform X1 [KO:K02329]
103039803  fzd4; frizzled-4 [KO:K02354]
103036224  fzd5; frizzled-5 [KO:K02375]
103033371  fzd8; frizzled-8 [KO:K02375]
103040270  fzd6; frizzled-6 isoform X2 [KO:K02376]
103027133  frizzled-9 [KO:K02842]
103026992  frizzled-9-like [KO:K02842]
103024082  fzd10; frizzled-10 [KO:K02842]
103025328  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
103034759  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
103042896  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
103045219  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
103035729  segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
103046093  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
103039544  dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
103021870  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103043574  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
103032568  tumor necrosis factor-like [KO:K03156]
103040024  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103041971  insulin-like [KO:K04526]
103028544  insulin-like [KO:K04526]
103030099  ins; insulin [KO:K04526]
103036238  igf1; insulin-like growth factor I [KO:K05459]
103039445  insulin receptor [KO:K04527] [EC:2.7.10.1]
103034736  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
103045439  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103037538  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111188768  growth factor receptor-bound protein 2-like [KO:K04364]
111191028  growth factor receptor-bound protein 2 [KO:K04364]
103046713  growth factor receptor-bound protein 2 [KO:K04364]
103037386  sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
103028577  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103021516  hras; GTPase HRas [KO:K02833]
103040103  GTPase HRas [KO:K02833]
103038241  GTPase KRas isoform X1 [KO:K07827]
103023536  GTPase HRas-like [KO:K07827]
103039914  nras; GTPase NRas [KO:K07828]
103036930  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103027930  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103025658  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
103028644  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103030512  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103041389  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103047585  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103021949  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103026282  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
103028303  ribosomal protein S6 kinase alpha-1-like [KO:K04373] [EC:2.7.11.1]
103039395  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
103036630  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
103025632  irs1; insulin receptor substrate 1 isoform X2 [KO:K16172]
103042975  insulin receptor substrate 1-B-like [KO:K16172]
111190801  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
103035767  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
103029972  pik3r3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103046618  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103032909  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103045036  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103041606  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103022173  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103046962  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103025186  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103022926  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103033547  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103040659  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103026930  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103023390  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103040186  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
103024575  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103033415  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103031846  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
103035403  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
103031508  rictor; rapamycin-insensitive companion of mTOR [KO:K08267]
107197522  prr5; proline-rich protein 5 isoform X1 [KO:K20411]
103036594  proline-rich protein 5-like isoform X2 [KO:K20411]
103041946  proline-rich protein 5-like isoform X1 [KO:K20411]
103024524  prr5l; proline-rich protein 5-like [KO:K20411]
103028705  rho-related GTP-binding protein RhoA-A [KO:K04513]
103027457  rho-related GTP-binding protein RhoA-B [KO:K04513]
103031338  rho-related GTP-binding protein RhoA-D [KO:K04513]
103035456  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
103029431  transforming protein RhoA-like [KO:K04513]
103044047  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
111192909  LOW QUALITY PROTEIN: protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
103036012  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103025973  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103036792  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
103022302  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
amex00561  Glycerolipid metabolism
amex04010  MAPK signaling pathway
amex04140  Autophagy - animal
amex04810  Regulation of actin cytoskeleton
amex04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

DBGET integrated database retrieval system