KEGG   PATHWAY: aml04062
Entry
aml04062                    Pathway                                
Name
Chemokine signaling pathway - Ailuropoda melanoleuca (giant panda)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
aml04062  Chemokine signaling pathway
aml04062

Other DBs
GO: 0070098
Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100463732  growth-regulated alpha protein [KO:K05505]
100466241  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
100471490  growth-regulated alpha protein [KO:K05505]
100484431  platelet basic protein isoform X1 [KO:K10029]
100472054  CXCL8; interleukin-8 [KO:K10030]
100469185  CXCL9; C-X-C motif chemokine 9 isoform X2 [KO:K05416]
100469693  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100469949  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
100482629  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
105234669  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
100470282  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
100484936  platelet factor 4-like [KO:K05407]
100478539  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
100482046  cytokine SCM-1 beta [KO:K22675]
100470482  CX3CL1; fractalkine isoform X2 [KO:K05508]
105240106  CCL1; C-C motif chemokine 1 [KO:K05514]
100474348  C-C motif chemokine 2 [KO:K14624]
100469047  C-C motif chemokine 3 [KO:K05408]
100469295  C-C motif chemokine 3 isoform X1 [KO:K05408]
100464006  regakine-1-like [KO:K05408]
100468796  C-C motif chemokine 4 [KO:K12964]
100463753  CCL5; C-C motif chemokine 5 [KO:K12499]
100474600  C-C motif chemokine 7 [KO:K05509]
100474856  C-C motif chemokine 8 [KO:K16596]
100475112  C-C motif chemokine 13 [KO:K16595]
100468009  C-C motif chemokine 14-like isoform X1 [KO:K05511]
117795398  C-C motif chemokine 15-like isoform X1 [KO:K05511]
100467253  CCL16; C-C motif chemokine 16 [KO:K21093]
100470736  CCL17; C-C motif chemokine 17 [KO:K21083]
100481549  CCL19; C-C motif chemokine 19 [KO:K05512]
105239958  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
100480794  CCL21; C-C motif chemokine 21 isoform X1 [KO:K16062]
100470232  CCL22; C-C motif chemokine 22 [KO:K21095]
100465518  CCL24; C-C motif chemokine 24 [KO:K21097]
105238779  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
100465767  CCL26; C-C motif chemokine 26 [KO:K21096]
100480543  CCL27; C-C motif chemokine 27 [KO:K16598]
109488513  uncharacterized protein LOC109488513 isoform X2 [KO:K16598]
100474043  CCL28; C-C motif chemokine 28 [KO:K05513]
100470409  CXCR2; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2 [KO:K05050]
100466219  C-X-C chemokine receptor type 2 [KO:K05050]
100470159  C-X-C chemokine receptor type 2 isoform X1 [KO:K04175]
100475682  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
100468194  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100466449  CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
100464292  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
100464543  XCR1; chemokine XC receptor 1 [KO:K04193]
100481132  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
100481381  CCR8; C-C chemokine receptor type 8 [KO:K04183]
100481089  CCR6; C-C chemokine receptor type 6 [KO:K04181]
100464037  CCR9; C-C chemokine receptor type 9 [KO:K04184]
100475059  CCR4; C-C chemokine receptor type 4 [KO:K04179]
100464680  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
100484065  CCR2; C-C chemokine receptor type 2 [KO:K04177]
100465045  C-C chemokine receptor type 5 [KO:K04180]
100483811  C-C chemokine receptor type 1 [KO:K04176]
100464796  C-C chemokine receptor type 3 [KO:K04178]
100480758  CCR10; C-C chemokine receptor type 10 isoform X2 [KO:K04185]
100481360  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100474005  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
100474026  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100472167  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100469938  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100479246  signal transducer and activator of transcription 5B [KO:K11224]
100471767  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100484933  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100466408  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
100472777  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100473195  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100471164  ADCY3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
100471940  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100482519  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100476922  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100466965  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100474121  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100476495  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100468252  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100469628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100479606  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100468494  HCK; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
100467541  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
100474271  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100480856  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
100480694  SHC2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
100468080  SHC3; SHC-transforming protein 3 [KO:K17448]
100475137  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
100468916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100474396  SOS2; son of sevenless homolog 2 isoform X9 [KO:K03099]
100482526  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100473836  HRAS; GTPase HRas isoform X1 [KO:K02833]
100483919  KRAS; GTPase KRas isoform X1 [KO:K07827]
100464196  NRAS; GTPase NRas [KO:K07828]
100482255  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100469346  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100478039  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100475291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100483828  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100467916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100470322  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2 [KO:K21289] [EC:2.7.1.153]
100477067  PIK3R5; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
100477324  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100477838  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100480992  FOXO3; forkhead box protein O3 [KO:K09408]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100466997  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100466767  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100473937  BAD; bcl2-associated agonist of cell death [KO:K02158]
100478597  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
100479224  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100475688  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
100480126  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
100480092  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100476091  VAV1; proto-oncogene vav isoform X3 [KO:K05730]
100465648  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100469737  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100468971  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100472811  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100465076  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100479480  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
100476723  RHOA; transforming protein RhoA [KO:K04513]
100474469  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100466003  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100474825  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100484553  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100475485  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
100480040  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100467255  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100482029  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100483209  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100468197  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100476938  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100483125  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100471622  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
105236417  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
105236905  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
100475394  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100477221  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100477225  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
100476214  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100475635  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100476550  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100467037  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
100473639  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
100465542  dedicator of cytokinesis protein 2 [KO:K12367]
100464496  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100474505  PXN; paxillin isoform X4 [KO:K05760]
100479448  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
100466609  CRKL; crk-like protein [KO:K04438]
100467322  CRK; adapter molecule crk isoform X1 [KO:K04438]
100478801  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100464853  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100481755  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100480603  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100465232  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100474779  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100480586  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100481994  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
105236463  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
100471801  RAP1A; ras-related protein Rap-1A [KO:K04353]
100480240  RAP1B; ras-related protein Rap-1b [KO:K07836]
100473914  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
105242089  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100478007  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100481918  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
100472606  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100464147  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
100479760  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
100469854  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
100475417  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
100466557  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
100478616  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
100480732  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
100478601  ARRB2; LOW QUALITY PROTEIN: beta-arrestin-2 [KO:K04439]
100470249  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
aml04010  MAPK signaling pathway
aml04060  Cytokine-cytokine receptor interaction
aml04120  Ubiquitin mediated proteolysis
aml04630  JAK-STAT signaling pathway
aml04670  Leukocyte transendothelial migration
aml04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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