KEGG   PATHWAY: bacu05208
Entry
bacu05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Balaenoptera acutorostrata scammoni (minke whale)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
bacu05208  Chemical carcinogenesis - reactive oxygen species
bacu05208

Organism
Balaenoptera acutorostrata scammoni (minke whale) [GN:bacu]
Gene
103007103  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
103002179  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
103003757  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103018358  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
103004957  GSTA2; glutathione S-transferase alpha 2 [KO:K00799] [EC:2.5.1.18]
103005234  GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
103000988  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
103003545  GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
103004197  GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
103003182  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
103006745  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
103006828  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
103007320  GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
103002828  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
103003730  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
103018290  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
103020190  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
103002082  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
103016522  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
103008316  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
103012877  NDUFA4L2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
103012110  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
103006826  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
103009458  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
103005817  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
102999953  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
103007690  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
103001609  acyl carrier protein, mitochondrial-like [KO:K03955]
103003298  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
103005308  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
103014946  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
103017626  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
103016811  uncharacterized LOC103016811 [KO:K03957]
103009696  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
103017454  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
103001064  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
103021069  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
103000630  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
103021055  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
103020517  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
103011102  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
103012923  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
103000659  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
103001938  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
103020178  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
103013023  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
103002843  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
103018097  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
103014501  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
103001627  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
102999358  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
103006544  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
102999688  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
103013847  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
103005047  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
103013798  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
103010344  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
103014249  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
103010509  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
103003514  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
103010896  cytochrome b-c1 complex subunit 1, mitochondrial-like [KO:K00414]
102998746  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
103006696  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
102999929  cytochrome b-c1 complex subunit 7-like [KO:K00417]
103012637  cytochrome b-c1 complex subunit 8-like [KO:K00418]
103013784  cytochrome b-c1 complex subunit 8-like [KO:K00418]
103008919  cytochrome b-c1 complex subunit 9-like [KO:K00419]
103006928  cytochrome b-c1 complex subunit 9-like [KO:K00419]
103010463  cytochrome b-c1 complex subunit 10-like [KO:K00420]
103019629  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [KO:K02263]
103015443  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
103003865  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
103015197  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
103001279  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
103006136  cytochrome c oxidase subunit 6A2, mitochondrial-like [KO:K02266]
103008559  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
103015043  cytochrome c oxidase subunit 6B1-like [KO:K02267]
103005093  cytochrome c oxidase subunit 6B2-like [KO:K02267]
103003421  cytochrome c oxidase subunit 7A1, mitochondrial-like [KO:K02270]
103017759  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
103019426  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
103011737  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
103017687  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
103019246  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
103013789  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
103001251  cytochrome c oxidase subunit 8C, mitochondrial-like [KO:K02273]
103010848  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
103010006  cytochrome c oxidase subunit 8C, mitochondrial-like [KO:K02273]
102999628  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
103007275  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
103019263  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
103015009  ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
103003422  ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
103016559  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
103018718  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
103018588  ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
102998854  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
103011431  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
103004252  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
103001215  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
103005559  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
103011094  SOD2; superoxide dismutase 2 [KO:K04564] [EC:1.15.1.1]
103017981  VDAC1; voltage dependent anion channel 1 [KO:K05862]
103000396  VDAC2; voltage dependent anion channel 2 [KO:K15040]
103013826  VDAC3; voltage dependent anion channel 3 [KO:K15041]
103012727  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
102999263  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
103012312  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
103009487  SLC25A6; solute carrier family 25 member 6 [KO:K05863]
103012461  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
103015321  PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
103017098  SOD1; superoxide dismutase 1 [KO:K04565] [EC:1.15.1.1]
103009998  CAT; catalase [KO:K03781] [EC:1.11.1.6]
103019577  SLC26A1; solute carrier family 26 member 1 [KO:K14700]
102997264  SLC26A2; solute carrier family 26 member 2 [KO:K14701]
103007178  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
103007560  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
102997947  cytochrome P450 2E1-like [KO:K07415] [EC:1.14.14.-]
103008057  cytochrome P450 1A1-like [KO:K07408] [EC:1.14.14.1]
103004066  cytochrome P450 1B1-like [KO:K07410] [EC:1.14.14.1]
103003233  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
103015729  EPHX2; epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
102998957  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
103002249  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
103012987  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
103002145  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103003050  aldo-keto reductase family 1 member C3 homolog [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103019756  NQO1; NAD(P)H quinone dehydrogenase 1 [KO:K00355] [EC:1.6.5.2]
103007396  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
103003419  AHR; aryl hydrocarbon receptor [KO:K09093]
103005247  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
103016086  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
102999052  cytochrome b-245 light chain-like [KO:K08009]
103009515  NOX1; NADPH oxidase 1 [KO:K08008]
103021081  neutrophil cytosol factor 1-like [KO:K08011]
103008623  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
103004366  EGF; epidermal growth factor [KO:K04357]
103017029  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102997605  hepatocyte growth factor-like [KO:K05460]
103002086  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
103010512  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102999196  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103019365  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103006545  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103015457  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103004931  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103020975  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
103002372  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103014337  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103017381  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103018627  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102999619  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103002590  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102999328  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103012105  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103011683  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102997603  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103007019  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103008728  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103009947  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102999798  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
103002378  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103008537  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103001311  transcription factor AP-1-like [KO:K04448]
103014668  transcription factor AP-1-like [KO:K04448]
102997242  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103008077  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103009307  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103007464  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103012691  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103012931  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103014043  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103007995  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103010966  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103002026  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103013147  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103004139  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102999779  FOXO3; forkhead box O3 [KO:K09408]
103005702  BAD; BCL2 associated agonist of cell death [KO:K02158]
103020806  PTPN1; protein tyrosine phosphatase, non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
102998704  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103015414  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103015119  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103017855  NF-kappa-B essential modulator-like [KO:K07210]
103002206  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103019614  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102999230  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103000809  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
103018120  PTPRJ; protein tyrosine phosphatase, receptor type J [KO:K05698] [EC:3.1.3.48]
103014263  ACP1; acid phosphatase 1, soluble [KO:K14394] [EC:3.1.3.2 3.1.3.48]
103004467  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
103008474  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
103001801  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102998508  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
103010133  ABL2; ABL proto-oncogene 2, non-receptor tyrosine kinase [KO:K08887] [EC:2.7.10.2]
103014486  PRKD1; protein kinase D1 [KO:K06070] [EC:2.7.11.13]
103006236  PRKD3; protein kinase D3 [KO:K06070] [EC:2.7.11.13]
103002784  PRKD2; protein kinase D2 [KO:K06070] [EC:2.7.11.13]
103013388  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103008865  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
102999715  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
103015859  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103008124  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
103008733  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
103008131  VEGFA; vascular endothelial growth factor A [KO:K05448]
103016742  KEAP1; kelch like ECH associated protein 1 [KO:K10456]
103019273  NFE2L2; nuclear factor, erythroid 2 like 2 [KO:K05638]
103018426  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
Reference
PMID:24281075
  Authors
Henkler F, Brinkmann J, Luch A
  Title
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics.
  Journal
Cancers (Basel) 2:376-96 (2010)
DOI:10.3390/cancers2020376
Reference
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Related
pathway
bacu00190  Oxidative phosphorylation
bacu00980  Metabolism of xenobiotics by cytochrome P450
bacu04010  MAPK signaling pathway
bacu04064  NF-kappa B signaling pathway
bacu04066  HIF-1 signaling pathway
bacu04151  PI3K-Akt signaling pathway
bacu04370  VEGF signaling pathway
bacu05207  Chemical carcinogenesis - receptor activation
bacu05211  Renal cell carcinoma
bacu05215  Prostate cancer
bacu05219  Bladder cancer
bacu05221  Acute myeloid leukemia
bacu05222  Small cell lung cancer
bacu05223  Non-small cell lung cancer
bacu05224  Breast cancer
bacu05225  Hepatocellular carcinoma
KO pathway
ko05208   
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