KEGG   PATHWAY: bta04020
Entry
bta04020                    Pathway                                
Name
Calcium signaling pathway - Bos taurus (cow)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
bta04020  Calcium signaling pathway
bta04020

Other DBs
GO: 0019722
Organism
Bos taurus (cow) [GN:bta]
Gene
337925  SLC8A1; sodium/calcium exchanger 1 precursor [KO:K05849]
540307  SLC8A3; sodium/calcium exchanger 3 precursor [KO:K05849]
535881  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
282641  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
613800  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
504353  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
282146  ATP2B4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
281684  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
281685  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
281686  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
617828  ADORA2A; adenosine receptor A2a [KO:K04266]
529760  ADORA2B; adenosine receptor A2b [KO:K04267]
281604  ADRB1; beta-1 adrenergic receptor [KO:K04141]
281605  ADRB2; beta-2 adrenergic receptor [KO:K04142]
281606  ADRB3; beta-3 adrenergic receptor [KO:K04143]
281125  DRD1; D(1A) dopamine receptor [KO:K04144]
526221  DRD5; D(1B) dopamine receptor [KO:K05840]
521257  HRH2; histamine H2 receptor isoform X4 [KO:K04150]
317708  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
541200  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
523484  5-hydroxytryptamine receptor 5B [KO:K04161]
512167  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
538510  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
281793  GNAS; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
100124520  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
100125240  PLN; cardiac phospholamban [KO:K05852]
100296455  SLN; sarcolipin [KO:K22642]
101902281  MRLN; myoregulin [KO:K22643]
615008  C6H4orf3; uncharacterized protein C4orf3 homolog isoform X2 [KO:K26467]
100302389  SMIM6; small integral membrane protein 6 [KO:K26468]
518117  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
512313  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
540568  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
617610  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein precursor [KO:K23450]
534816  STIM1; stromal interaction molecule 1 precursor [KO:K16059]
541299  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
517688  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
511233  ORAI2; protein orai-2 [KO:K16057]
515971  ORAI3; protein orai-3 [KO:K16058]
408015  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
408013  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
509779  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100337204  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
282648  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
282410  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
353113  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
282411  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
282412  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
282413  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
282178  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 precursor [KO:K04809]
100336579  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
524212  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
537804  GRIN2B; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210]
535158  GRIN2C; glutamate receptor ionotropic, NMDA 2C precursor [KO:K05211]
618181  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100295209  GRIN3A; glutamate receptor ionotropic, NMDA 3A precursor [KO:K05213]
616000  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
514898  P2RX1; P2X purinoceptor 1 [KO:K05215]
527499  P2RX2; P2X purinoceptor 2 [KO:K05216]
530468  P2RX3; P2X purinoceptor 3 [KO:K05217]
338036  P2RX4; P2X purinoceptor 4 [KO:K05218]
338035  P2RX5; P2X purinoceptor 5 [KO:K05219]
618262  P2RX6; P2X purinoceptor 6 isoform X2 [KO:K05221]
286814  P2RX7; P2X purinoceptor 7 [KO:K05220]
100139857  RYR1; ryanodine receptor 1 [KO:K04961]
537376  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
539899  RYR3; ryanodine receptor 3 [KO:K04963]
534061  TRDN; triadin isoform X49 [KO:K23449]
508394  CASQ1; calsequestrin-1 precursor [KO:K23468]
528555  CASQ2; calsequestrin-2 [KO:K23445]
286771  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
782045  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
540387  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
522170  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
282134  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
407140  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
539543  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
281607  AGTR1; type-1 angiotensin II receptor [KO:K04166]
281749  EDNRA; endothelin-1 receptor precursor [KO:K04197]
281750  EDNRB; endothelin receptor type B precursor [KO:K04198]
526585  F2R; proteinase-activated receptor 1 precursor [KO:K03914]
540485  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
100336861  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
532784  GRPR; gastrin-releasing peptide receptor [KO:K04169]
281231  HRH1; histamine H1 receptor [KO:K04149]
407230  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
407135  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
407134  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
281900  LHCGR; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248]
528416  NTSR1; neurotensin receptor type 1 [KO:K04211]
281371  OXTR; oxytocin receptor [KO:K04229]
538439  AVPR1A; vasopressin V1a receptor [KO:K04226]
282861  AVPR1B; vasopressin V1b receptor [KO:K04227]
513386  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
518283  PTAFR; platelet-activating factor receptor [KO:K04279]
507437  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
282330  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
282020  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
532119  BDKRB1; B1 bradykinin receptor [KO:K03915]
538896  BDKRB2; B2 bradykinin receptor [KO:K03916]
407133  TACR1; substance-P receptor [KO:K04222]
282088  TACR2; substance-K receptor [KO:K04223]
404136  TACR3; neuromedin-K receptor [KO:K04224]
538783  TBXA2R; thromboxane A2 receptor [KO:K04264]
281549  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
517901  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like [KO:K04282]
100847115  thyrotropin-releasing hormone receptor [KO:K04282]
506207  CCKAR; cholecystokinin receptor type A [KO:K04194]
281665  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
281736  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
536654  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
281788  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
281789  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
532029  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
540388  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
505908  PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359]
540106  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
613787  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
525931  PDGFD; platelet-derived growth factor D [KO:K05450]
281160  FGF1; fibroblast growth factor 1 [KO:K18496]
281161  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
326284  FGF8; fibroblast growth factor 8 precursor [KO:K04358]
326285  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
539083  FGF20; fibroblast growth factor 20 [KO:K04358]
540317  FGF6; fibroblast growth factor 6 [KO:K04358]
616885  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
540758  FGF16; fibroblast growth factor 16 [KO:K04358]
618474  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
533929  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
519657  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
618481  FGF3; fibroblast growth factor 3 [KO:K04358]
100300257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
536771  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
613731  FGF9; fibroblast growth factor 9 [KO:K04358]
521475  FGF19; fibroblast growth factor 19 [KO:K22603]
785576  FGF21; fibroblast growth factor 21 [KO:K22429]
530239  FGF23; fibroblast growth factor 23 [KO:K22428]
281572  VEGFA; vascular endothelial growth factor A isoform 3 precursor [KO:K05448]
282121  VEGFB; vascular endothelial growth factor B precursor [KO:K16858]
286799  VEGFD; vascular endothelial growth factor D precursor [KO:K05449]
282122  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
281350  NGF; beta-nerve growth factor precursor [KO:K02582]
282879  HGF; hepatocyte growth factor precursor [KO:K05460]
514667  MST1; hepatocyte growth factor-like protein precursor [KO:K23441]
386587  GDNF; glial cell line-derived neurotrophic factor precursor [KO:K05452]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
505709  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
785655  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
522419  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
282301  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
527165  PDGFRB; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
281768  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
404193  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
281769  FGFR3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
317696  FGFR4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
503620  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
338031  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
407170  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
353111  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
505824  NTRK2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
539126  NTRK3; NT-3 growth factor receptor precursor [KO:K05101] [EC:2.7.10.1]
280855  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
525504  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
515924  RET; proto-oncogene tyrosine-protein kinase receptor Ret precursor [KO:K05126] [EC:2.7.10.1]
100300850  T cell receptor alpha variable 18 [KO:K10784]
509513  uncharacterized LOC509513 precursor [KO:K10785]
100300510  T cell receptor beta constant 1 [KO:K10785]
524810  IgM precursor [KO:K06856]
100300716  immunoglobulin heavy variable 4-38-2 [KO:K06856]
100300806  immunoglobulin heavy variable 4-59 isoform X1 [KO:K06856]
104968484  immunoglobulin heavy variable 4-59 [KO:K06856]
281986  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
540771  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
513057  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
287026  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
281985  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
515669  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
508888  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
281987  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100337091  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
519037  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
497026  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
317697  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
281878  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
281879  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
327677  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
510830  TPCN1; two pore channel protein 1 isoform X4 [KO:K16896]
516679  TPCN2; two pore channel protein 2 [KO:K14077]
505738  MCOLN1; mucolipin-1 isoform 2 [KO:K04992]
532671  MCOLN2; mucolipin-2 [KO:K04993]
514345  MCOLN3; mucolipin-3 [KO:K04994]
618605  SPHK1; sphingosine kinase 1 isoform X3 [KO:K04718] [EC:2.7.1.91]
533103  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
536656  MCU; calcium uniporter protein, mitochondrial precursor [KO:K20858]
282119  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
282120  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
282716  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
282478  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
282479  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
282480  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
541168  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
787122  ADP/ATP translocase 1 [KO:K05863]
132344463  ADP/ATP translocase 3 [KO:K05863]
414346  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor [KO:K09565] [EC:5.2.1.8]
509486  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
615428  TNNC2; troponin C, skeletal muscle [KO:K12042]
326597  CALM; calmodulin [KO:K02183]
520277  CALM3; calmodulin-3 [KO:K02183]
617095  CALM1; calmodulin-1 [KO:K02183]
520404  CALML5; calmodulin-like protein 5 [KO:K02183]
100297344  CALM2; calmodulin-2 [KO:K02183]
617412  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
104973792  uncharacterized protein LOC104973792 [KO:K02183]
539277  CALML4; calmodulin-like protein 4 [KO:K02183]
540682  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
512670  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
511783  PHKB; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta [KO:K07190]
100336808  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X2 [KO:K07190]
515732  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
338037  MYLK; myosin light chain kinase, smooth muscle isoform 1 [KO:K00907] [EC:2.7.11.18]
533378  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
526379  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
518025  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
511504  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
520498  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
526873  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
282162  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
525416  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
530719  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
532713  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
100337083  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
286852  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
533527  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
790867  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
282321  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
617585  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
510032  TFEB; transcription factor EB [KO:K15590]
511224  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
530401  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
541127  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
788119  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
536132  NOS1; nitric oxide synthase 1 isoform X1 [KO:K13240] [EC:1.14.13.39]
282876  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
287024  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
281969  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
281970  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
526211  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6 [KO:K13755] [EC:3.1.4.17]
541008  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
540877  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
615813  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
534051  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Reference
PMID:11413485
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
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Reference
PMID:11299192
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
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  Authors
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  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
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  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Reference
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
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Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
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Reference
PMID:14572802
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Bruce JI, Straub SV, Yule DI.
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
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Reference
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  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
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Reference
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  Authors
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Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
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Reference
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Reference
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Mol Cell Biol 23:7068-81 (2003)
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Hutchins JR, Dikovskaya D, Clarke PR.
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
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Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
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Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Seikagaku 80:1123-8 (2008)
Reference
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
bta04010  MAPK signaling pathway
bta04070  Phosphatidylinositol signaling system
bta04210  Apoptosis
bta04720  Long-term potentiation
bta04730  Long-term depression
KO pathway
ko04020   
LinkDB

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