KEGG   PATHWAY: bta04936
Entry
bta04936                    Pathway                                
Name
Alcoholic liver disease - Bos taurus (cow)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
bta04936  Alcoholic liver disease
bta04936

Organism
Bos taurus (cow) [GN:bta]
Gene
534961  C1QA; complement C1q subcomponent subunit A precursor [KO:K03986]
617435  C1QB; complement C1q subcomponent subunit B precursor [KO:K03987]
509968  C1QC; complement C1q subcomponent subunit C precursor [KO:K03988]
515440  C2; complement C2 precursor [KO:K01332] [EC:3.4.21.43]
280678  C4A; complement C4 precursor [KO:K03989]
781663  LOW QUALITY PROTEIN: complement C4-A-like [KO:K03989]
107131209  complement C4 isoform X1 [KO:K03989]
280677  C3; complement C3 preproprotein [KO:K03990]
540702  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
512045  C5; complement C5a anaphylatoxin precursor [KO:K03994]
493645  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
512242  LBP; lipopolysaccharide-binding protein precursor [KO:K05399]
514978  lipopolysaccharide-binding protein isoform X2 [KO:K05399]
281048  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
613753  LY96; lymphocyte antigen 96 precursor [KO:K05400]
281536  TLR4; toll-like receptor 4 precursor [KO:K10160]
531079  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
444881  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
533692  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
533953  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
539124  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
782032  LOW QUALITY PROTEIN: TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
519958  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
540203  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
529146  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
282291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
508233  RELA; transcription factor p65 [KO:K04735]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
280943  TNF; tumor necrosis factor [KO:K03156]
281251  IL1B; interleukin-1 beta precursor [KO:K04519]
280826  IL6; interleukin-6 precursor [KO:K05405]
281856  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
281857  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
280828  CXCL8; interleukin-8 precursor [KO:K10030]
510427  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
506182  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
533216  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
533141  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
516979  IRF3; interferon regulatory factor 3 [KO:K05411]
281236  IFNAC; interferon alpha-C precursor [KO:K05414]
510726  IFNA16; interferon alpha-H [KO:K05414]
523244  interferon alpha-B-like [KO:K05414]
517108  interferon alpha-2 [KO:K05414]
618947  interferon alpha-B-like [KO:K05414]
787343  interferon alpha-2 [KO:K05414]
515951  IFNAA; interferon alpha-A precursor [KO:K05414]
100329207  IFNAH; interferon alpha-H precursor [KO:K05414]
100335490  interferon alpha-G-like [KO:K05414]
100329204  IFNAD; interferon alpha-D [KO:K05414]
100329206  IFNAG; interferon alpha-G precursor [KO:K05414]
100329210  INFAF; interferon alpha-F precursor [KO:K05414]
783912  interferon alpha-H [KO:K05414]
617556  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
132345931  interferon alpha-H-like [KO:K05414]
281845  IFNB1; interferon beta precursor [KO:K05415]
525550  interferon beta-2 [KO:K05415]
517016  interferon beta-2 precursor [KO:K05415]
784525  interferon beta-2 [KO:K05415]
618946  IFNB3; interferon beta-3 precursor [KO:K05415]
100848709  interferon beta-3 [KO:K05415]
616977  interferon beta-2 [KO:K05415]
112441480  interferon beta-3 [KO:K05415]
112447877  interferon beta-3 [KO:K05415]
112447878  interferon beta-3 [KO:K05415]
112447879  interferon beta-3 [KO:K05415]
112447880  interferon beta-3 [KO:K05415]
112441471  interferon beta [KO:K05415]
282863  IL17A; interleukin-17A precursor [KO:K05489]
525040  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
504855  IL17RC; interleukin-17 receptor C precursor [KO:K05166]
281212  GRO1; growth-regulated protein homolog alpha precursor [KO:K05505]
281214  CXCL2; growth-regulated protein homolog gamma precursor [KO:K05505]
613667  CXCL3; chemokine (C-X-C motif) ligand 3 precursor [KO:K05505]
407111  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
282488  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
493720  FADD; FAS-associated death domain protein [KO:K02373]
282527  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
504707  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
507481  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
408016  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
504727  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
788288  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
539361  SREBF1; sterol regulatory element-binding protein 1 [KO:K07197]
281152  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
281590  ACACA; acetyl-CoA carboxylase 1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
280924  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
617419  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
537224  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
521637  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
514448  LPIN2; phosphatidate phosphatase LPIN2 isoform X4 [KO:K15728] [EC:3.1.3.4]
100313369  MIR217; bta-miR-217 [KO:K17125]
613629  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
534586  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
615156  TRA2B; transformer-2 protein homolog beta [KO:K12897]
282865  ADIPOQ; adiponectin isoform X2 [KO:K07296]
407234  ADIPOR2; adiponectin receptor protein 2 [KO:K07297]
407235  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
509084  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
538954  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
540404  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
512665  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
534107  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
282324  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
504219  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
511961  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform 1 [KO:K07200]
506618  FOXO1; forkhead box protein O1 [KO:K07201]
535530  FOXO3; forkhead box protein O3 [KO:K09408]
338446  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202]
281992  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
506812  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
282130  ACADVL; very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor [KO:K09479] [EC:1.3.8.9]
505968  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor [KO:K00249] [EC:1.3.8.7]
101906837  medium-chain specific acyl-CoA dehydrogenase, mitochondrial-like [KO:K00249] [EC:1.3.8.7]
513996  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
510065  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
327700  FABP1; fatty acid-binding protein, liver [KO:K08750]
534808  ADH7; LOW QUALITY PROTEIN: all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
509744  ADH1C; alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
520508  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
505515  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
510551  ADH6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
513967  ALDH3A2; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
508629  ALDH2; aldehyde dehydrogenase, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
281618  ALDH1B1; LOW QUALITY PROTEIN: aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
507477  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
537539  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
282213  CYP2E1; cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
515338  ACACB; acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
512341  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
509459  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
513710  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
378474  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
539003  CTNNB1; catenin beta-1 [KO:K02105]
782690  TCF7; transcription factor 7 [KO:K02620]
515303  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
540481  TCF7L2; transcription factor 7-like 2 [KO:K04491]
535399  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
537380  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
526469  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
787278  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
516039  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
286883  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
534492  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
535327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
512943  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
618906  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
508367  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
bta00061  Fatty acid biosynthesis
bta00071  Fatty acid degradation
bta01040  Biosynthesis of unsaturated fatty acids
bta03040  Spliceosome
bta04010  MAPK signaling pathway
bta04064  NF-kappa B signaling pathway
bta04152  AMPK signaling pathway
bta04210  Apoptosis
bta04310  Wnt signaling pathway
bta04610  Complement and coagulation cascades
bta04620  Toll-like receptor signaling pathway
bta04657  IL-17 signaling pathway
bta04668  TNF signaling pathway
bta04920  Adipocytokine signaling pathway
bta05034  Alcoholism
bta05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

DBGET integrated database retrieval system