KEGG   PATHWAY: caty04072
Entry
caty04072                   Pathway                                
Name
Phospholipase D signaling pathway - Cercocebus atys (sooty mangabey)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
caty04072  Phospholipase D signaling pathway
caty04072

Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105571434  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105571784  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105572960  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105588762  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105597890  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105596830  KITLG; kit ligand [KO:K05461]
105577261  INS; insulin [KO:K04526]
105588269  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105592013  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105589876  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105591986  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105589163  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
105577731  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105580774  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
105578686  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
105585292  LOW QUALITY PROTEIN: SHC-transforming protein 1-like [KO:K06279]
105585293  LOW QUALITY PROTEIN: SHC-transforming protein 1-like [KO:K06279]
105593504  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
105591876  SHC2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
105584282  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
105588205  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
105573167  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
105586728  SOS2; son of sevenless homolog 2 [KO:K03099]
105597205  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105577198  HRAS; GTPase HRas isoform X1 [KO:K02833]
105585038  KRAS; GTPase KRas isoform X1 [KO:K07827]
105596344  NRAS; GTPase NRas isoform X1 [KO:K07828]
105586388  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
105595298  RRAS; ras-related protein R-Ras [KO:K07829]
105595718  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105594177  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
105575634  LOW QUALITY PROTEIN: ral-GDS-related protein-like [KO:K08732]
105575857  ral-GDS-related protein-like [KO:K08732]
105599414  LOW QUALITY PROTEIN: ral-GDS-related protein-like [KO:K08732]
105597017  RALA; ras-related protein Ral-A [KO:K07834]
105588111  RALB; ras-related protein Ral-B [KO:K07835]
105586383  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105580892  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105597716  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105571321  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105594576  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105599262  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105596769  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105597977  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105574942  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105594171  TSC1; hamartin isoform X1 [KO:K07206]
105573530  TSC2; tuberin isoform X1 [KO:K07207]
105584756  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
105580870  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105573691  RHOA; transforming protein RhoA [KO:K04513]
105597683  ARF1; ADP-ribosylation factor 1 [KO:K07937]
105586590  ARF6; ADP-ribosylation factor 6 [KO:K07941]
105588401  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105589398  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105577130  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105577139  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105577141  uncharacterized protein LOC105577141 [KO:K06856]
105577142  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105577143  uncharacterized protein LOC105577143 [KO:K06856]
105577144  uncharacterized protein LOC105577144 [KO:K06856]
105577151  LOW QUALITY PROTEIN: uncharacterized protein LOC105577151 [KO:K06856]
105594283  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105574042  LOW QUALITY PROTEIN: putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105574050  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105574052  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105574060  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105574071  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105574077  Ig heavy chain Mem5-like [KO:K06856]
105574081  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105574082  LOW QUALITY PROTEIN: uncharacterized protein LOC105574082 [KO:K06856]
105574084  LOW QUALITY PROTEIN: uncharacterized protein LOC105574084 [KO:K06856]
105575920  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 isoform X1 [KO:K06856]
105575923  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105575925  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105576625  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105576626  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105601252  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha isoform X1 [KO:K08089]
105573016  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
105589248  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma isoform X1 [KO:K07983]
105581387  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
105579756  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
105599331  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105586073  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
105583465  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
105579889  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
105595443  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
105574211  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574213  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
105574214  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574265  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105580577  AGPAT2; LOW QUALITY PROTEIN: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
105574094  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1 [KO:K13509] [EC:2.3.1.51]
105594237  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
105575508  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
105594201  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
105577691  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
105595245  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105591800  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105590224  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
105584145  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
105591788  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
105592794  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
105585504  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
105587318  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
105571913  DGKK; diacylglycerol kinase kappa isoform X1 [KO:K00901] [EC:2.7.1.107]
105587814  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
105589572  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
105589636  DGKI; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
105573940  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
105583288  DGKE; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
105591642  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
105595985  PPAP2B; lipid phosphate phosphohydrolase 3 [KO:K01080] [EC:3.1.3.4]
105597707  PPAP2A; lipid phosphate phosphohydrolase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
105591665  PPAP2C; lipid phosphate phosphohydrolase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
105592805  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
105574840  AGT; angiotensinogen [KO:K09821]
105582406  AVP; vasopressin-neurophysin 2-copeptin [KO:K05242]
105596231  CXCL8; interleukin-8 [KO:K10030]
105587504  AGTR1; type-1 angiotensin II receptor isoform X1 [KO:K04166]
105599189  F2R; proteinase-activated receptor 1 [KO:K03914]
105588798  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
105574284  GRM2; metabotropic glutamate receptor 2 [KO:K04605]
105595512  GRM3; metabotropic glutamate receptor 3 [KO:K04606]
105593189  GRM4; metabotropic glutamate receptor 4 isoform X1 [KO:K04607]
105592965  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
105590396  GRM6; metabotropic glutamate receptor 6 [KO:K04608]
105585735  GRM7; metabotropic glutamate receptor 7 isoform X1 [KO:K04609]
105598529  GRM8; metabotropic glutamate receptor 8 isoform X1 [KO:K04610]
105600547  AVPR1A; vasopressin V1a receptor [KO:K04226]
105576573  AVPR1B; vasopressin V1b receptor [KO:K04227]
105598724  AVPR2; vasopressin V2 receptor isoform X1 [KO:K04228]
105595544  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105601742  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105593574  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
105596153  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105583023  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105587763  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
105595818  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
105587075  C-X-C chemokine receptor type 1 [KO:K04175]
105587076  C-X-C chemokine receptor type 2 [KO:K05050]
105577494  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
105574260  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105582089  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105582092  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105571739  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
105579176  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
105573047  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
105583147  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
105581686  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
105581693  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
105577643  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
105595237  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
105575822  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
105584352  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
105585318  neuroendocrine secretory protein 55 [KO:K04632]
105585319  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
105588320  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105585972  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
105578529  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
105600225  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105589787  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
105580404  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105588901  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105588369  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105572097  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
105580438  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
105579810  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
105597552  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
105576234  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
105601459  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
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PMID:10807766
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Chemokine receptors and their role in inflammation and infectious diseases.
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Blood 95:3032-43 (2000)
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PMID:8135758
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Sugiyama T, Sakai T, Nozawa Y, Oka N
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Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
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Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
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PMID:17210675
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Foster DA
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Regulation of mTOR by phosphatidic acid?
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Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
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PMID:15310762
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Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
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J Biol Chem 279:44763-74 (2004)
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Phospholipase signalling networks in cancer.
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Nat Rev Cancer 12:782-92 (2012)
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Related
pathway
caty00561  Glycerolipid metabolism
caty04010  MAPK signaling pathway
caty04014  Ras signaling pathway
caty04020  Calcium signaling pathway
caty04024  cAMP signaling pathway
caty04071  Sphingolipid signaling pathway
caty04144  Endocytosis
caty04150  mTOR signaling pathway
caty04151  PI3K-Akt signaling pathway
caty04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
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