KEGG   PATHWAY: caty05132
Entry
caty05132                   Pathway                                
Name
Salmonella infection - Cercocebus atys (sooty mangabey)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
caty05132  Salmonella infection
caty05132

Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105571968  PODXL; podocalyxin isoform X1 [KO:K06817]
105575053  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
105578300  RAB5A; ras-related protein Rab-5A [KO:K07887]
105578386  ras-related protein Rab-5B [KO:K07888]
105587349  RAB5B; ras-related protein Rab-5B [KO:K07888]
105579663  RAB5C; ras-related protein Rab-5C [KO:K07889]
105592559  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
105585865  RAB7A; ras-related protein Rab-7a [KO:K07897]
105576541  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
105585620  PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
105573052  putative pleckstrin homology domain-containing family M member 1P [KO:K23282]
105582496  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
105582159  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
105574185  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
105590981  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
105574215  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
105597008  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
105584229  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
105596716  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
105588763  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
105592199  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
105579799  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
105587473  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
105575255  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
105597082  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
105583304  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
105590942  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
105582429  DYNLRB1; LOW QUALITY PROTEIN: dynein light chain roadblock-type 1 [KO:K10419]
105599423  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
105581148  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
105588896  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
105596855  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
105587256  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
105590052  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
105589891  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
105586090  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
105579138  DCTN6; LOW QUALITY PROTEIN: dynactin subunit 6 [KO:K10428]
105581884  ACTR1A; alpha-centractin [KO:K16575]
105583701  ACTR1B; beta-centractin [KO:K16575]
105586676  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
105587029  tubulin alpha-4A chain isoform X1 [KO:K07374]
105571676  tubulin alpha-3 chain isoform X1 [KO:K07374]
105580387  LOW QUALITY PROTEIN: tubulin alpha-1C chain-like [KO:K07374]
105580388  tubulin alpha-1B chain [KO:K07374]
105574111  TUBA3E; LOW QUALITY PROTEIN: tubulin alpha-3E chain [KO:K07374]
105597442  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105591250  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
105577167  tubulin beta-8 chain-like [KO:K07375]
105600022  TUBB; tubulin beta chain isoform X1 [KO:K07375]
105600115  LOW QUALITY PROTEIN: tubulin beta-8 chain-like [KO:K07375]
105585313  TUBB1; tubulin beta-1 chain [KO:K07375]
105601184  tubulin gamma chain-like [KO:K07375]
105593855  LOW QUALITY PROTEIN: tubulin beta-8 chain-like [KO:K07375]
105595229  TUBB3; tubulin beta-3 chain [KO:K07375]
105580625  tubulin beta chain [KO:K07375]
105580626  TUBB4B; tubulin beta-4B chain [KO:K07375]
105580651  LOW QUALITY PROTEIN: tubulin beta-8 chain-like [KO:K07375]
105581289  tubulin beta-8 chain [KO:K07375]
105596432  TUBB2A; tubulin beta-2A chain [KO:K07375]
105596434  tubulin beta-2B chain isoform X1 [KO:K07375]
105598939  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
105591865  TUBB4A; tubulin beta-4A chain [KO:K07375]
105573598  FYCO1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
105585731  ARL8B; LOW QUALITY PROTEIN: ADP-ribosylation factor-like protein 8B [KO:K07955]
105575469  ARL8A; ADP-ribosylation factor-like protein 8A [KO:K07955]
105599426  PLEKHM2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
105587250  KIF5A; kinesin heavy chain isoform 5A [KO:K10396]
105596973  KIF5B; kinesin-1 heavy chain [KO:K10396]
105575961  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
105577402  KLC2; kinesin light chain 2 [KO:K10407]
105595144  KLC3; LOW QUALITY PROTEIN: kinesin light chain 3 [KO:K10407]
105596749  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
105591521  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105576929  ACBD3; Golgi resident protein GCP60 [KO:K23935]
105573691  RHOA; transforming protein RhoA [KO:K04513]
105587961  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
105574701  RAB9A; ras-related protein Rab-9A [KO:K07899]
105591171  GCC2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282]
105601558  STX10; syntaxin-10 isoform X1 [KO:K23937]
105578536  PFN4; profilin-4 [KO:K05759]
105581725  PFN3; profilin-3 [KO:K05759]
105597363  PFN2; profilin-2 isoform X1 [KO:K05759]
105583310  PFN1; profilin-1 [KO:K05759]
105598710  FLNA; filamin-A isoform X1 [KO:K04437]
105577700  EXOC7; exocyst complex component 7 isoform X1 [KO:K07195]
105586667  EXOC5; exocyst complex component 5 isoform X1 [KO:K19984]
105571962  EXOC4; exocyst complex component 4 isoform X1 [KO:K06111]
105596401  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
105597017  RALA; ras-related protein Ral-A [KO:K07834]
105577106  LOW QUALITY PROTEIN: actin, alpha skeletal muscle-like [KO:K05692]
105588610  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105574978  LOW QUALITY PROTEIN: actin-like [KO:K05692]
105598339  ACTB; actin, cytoplasmic 1 [KO:K05692]
105590245  S100A10; protein S100-A10 isoform X1 [KO:K17274]
105574672  protein S100-A10 [KO:K17274]
105601074  ANXA2; annexin A2 [KO:K17092]
105577559  AHNAK; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934]
105596812  AHNAK2; protein AHNAK2 [KO:K23934]
105582810  RHOJ; rho-related GTP-binding protein RhoJ isoform X1 [KO:K07864]
105597746  ARHGEF26; rho guanine nucleotide exchange factor 26 [KO:K13744]
105578809  RHOG; rho-related GTP-binding protein RhoG isoform X1 [KO:K07863]
105596759  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
105588512  ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
105578625  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
105573192  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
105585509  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
105596911  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
105582343  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105593398  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
105583964  myosin regulatory light chain 12B [KO:K12757]
105583966  myosin regulatory light chain 12A isoform X1 [KO:K12757]
105599117  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105587136  FHOD1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
105595026  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105571986  cell division control protein 42 homolog [KO:K04393]
105584356  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105579906  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
105580471  NCKAP1L; nck-associated protein 1-like [KO:K05750]
105592980  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
105581560  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
105583768  ABI1; abl interactor 1 isoform X1 [KO:K23649]
105585774  BRK1; protein BRICK1 [KO:K05752]
105597042  WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
105576480  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
105584768  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
105590323  ACTR3; actin-related protein 3 [KO:K18584]
105584379  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
105584380  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
105587073  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
105573201  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
105580226  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
105576287  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
105578700  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105598444  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
105588090  MYO6; unconventional myosin-VI [KO:K10358]
105586383  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105580892  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105597716  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105583147  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
105585089  PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
105598902  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
105576153  PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
105577643  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
105595237  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
105575822  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
105584352  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
105586590  ARF6; ADP-ribosylation factor 6 [KO:K07941]
105597683  ARF1; ADP-ribosylation factor 1 [KO:K07937]
105588885  SNX9; sorting nexin-9 isoform X1 [KO:K17923]
105598084  SNX18; sorting nexin-18 [KO:K17923]
105576156  SNX33; sorting nexin-33 [KO:K17923]
105598511  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
105601459  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
105584857  TLR6; toll-like receptor 6 [KO:K10169]
105580685  TLR2; toll-like receptor 2 [KO:K10159]
105582622  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
105573904  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
105599891  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105600415  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
105585279  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
105576968  TLR5; toll-like receptor 5 [KO:K10168]
105585549  TLR9; toll-like receptor 9 isoform X1 [KO:K10161]
105598716  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
105574390  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105586809  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105589048  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105572923  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
105588814  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
105574577  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
105573773  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105581830  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105595759  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105589068  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105571369  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105577432  RELA; transcription factor p65 isoform X1 [KO:K04735]
105596128  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
105596717  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105591024  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105573294  HSP90B1; endoplasmin [KO:K09487]
105572870  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
105572300  CSE1L; exportin-2 [KO:K18423]
105589776  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
105587747  KPNA3; importin subunit alpha-4 [KO:K23583]
105598257  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
105578730  RPS3; 40S ribosomal protein S3 [KO:K02985]
105577198  HRAS; GTPase HRas isoform X1 [KO:K02833]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105591800  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105593750  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
105577799  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105592690  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
105592727  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105586882  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105586884  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105581389  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
105589128  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105590417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105591436  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105576775  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105590868  FOS; proto-oncogene c-Fos [KO:K04379]
105595973  JUN; transcription factor AP-1 [KO:K04448]
105573465  TNF; tumor necrosis factor [KO:K03156]
105591123  IL1B; interleukin-1 beta [KO:K04519]
105595383  IL6; interleukin-6 isoform X1 [KO:K05405]
105596231  CXCL8; interleukin-8 [KO:K10030]
105573861  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
105599768  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
105587638  TCF7L1; transcription factor 7-like 1 [KO:K04490]
105577906  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
105571411  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
105588384  MYC; myc proto-oncogene protein [KO:K04377]
105601587  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
105601324  FBXO22; F-box only protein 22 isoform X1 [KO:K10302]
105599767  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
105583011  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105580591  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105587262  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
105591400  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
105591401  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
105596428  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
105583018  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
105586081  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
105579211  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
105579216  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
105577297  FADD; FAS-associated death domain protein [KO:K02373]
105580035  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105600226  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
105595265  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105593255  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105597193  uncharacterized protein LOC105597193 [KO:K08738]
105571593  cytochrome c-like [KO:K08738]
105588083  cytochrome c [KO:K08738]
105595720  cytochrome c-like [KO:K08738]
105589984  cytochrome c-like [KO:K08738]
105590205  cytochrome c-like [KO:K08738]
105590006  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
105593734  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
105597738  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105577913  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
105578571  RHOB; rho-related GTP-binding protein RhoB [KO:K07856]
105584835  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
105595298  RRAS; ras-related protein R-Ras [KO:K07829]
105596769  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105597977  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105574942  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105574056  MLKL; mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
105595549  TXN; thioredoxin isoform X1 [KO:K03671]
105575800  TXN2; thioredoxin, mitochondrial isoform X1 [KO:K03671]
105599484  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
105599242  NAIP; baculoviral IAP repeat-containing protein 1 isoform X1 [KO:K12807]
105578400  NLRC4; NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805]
105599574  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
105588753  caspase-1-like [KO:K01370] [EC:3.4.22.36]
105588757  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
105588688  IL18; interleukin-18 isoform X1 [KO:K05482]
105588758  CASP4; caspase-4 isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
105588791  LOW QUALITY PROTEIN: caspase-5-like [KO:K04395] [EC:3.4.22.58]
105581203  GSDMD; gasdermin-D isoform X1 [KO:K20917]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
caty04010  MAPK signaling pathway
caty04064  NF-kappa B signaling pathway
caty04210  Apoptosis
caty04217  Necroptosis
caty04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

DBGET integrated database retrieval system