KEGG   PATHWAY: ccw04510
Entry
ccw04510                    Pathway                                
Name
Focal adhesion - Corvus cornix (hooded crow)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ccw04510  Focal adhesion
ccw04510

Other DBs
GO: 0005925
Organism
Corvus cornix (hooded crow) [GN:ccw]
Gene
104689333  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
120411203  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
104694452  COL4A5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
104693432  COL4A4; collagen alpha-4(IV) chain isoform X3 [KO:K06237]
104693493  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
104686327  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
104694483  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
104686326  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
104694557  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
104694583  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
104694607  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
104689285  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
104687648  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
104693161  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
104687288  LAMA1; laminin subunit alpha-1 [KO:K05637]
104690723  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
104687364  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
104687815  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
104691288  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
104686917  LAMB1; laminin subunit beta-1 [KO:K05636]
104683487  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
120410702  laminin subunit beta-2-like [KO:K06243]
104692501  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
104686860  LAMB4; laminin subunit beta-4 [KO:K06245]
104693655  LAMC1; laminin subunit gamma-1 [KO:K05635]
104693621  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
104688476  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
104694290  CHAD; chondroadherin [KO:K06248]
104686928  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
104684025  THBS1; thrombospondin-1 [KO:K16857]
104695692  THBS4; thrombospondin-4 [KO:K04659]
104697387  LOW QUALITY PROTEIN: cartilage oligomeric matrix protein [KO:K04659]
104684330  THBS2; thrombospondin-2 isoform X2 [KO:K04659]
104694587  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
104697257  SPP1; osteopontin [KO:K06250]
104691062  VTN; vitronectin [KO:K06251]
104693645  TNN; LOW QUALITY PROTEIN: tenascin-N [KO:K06252]
104693643  TNR; LOW QUALITY PROTEIN: tenascin-R [KO:K06252]
104688240  TNC; tenascin isoform X2 [KO:K06252]
120412068  LOW QUALITY PROTEIN: tenascin-X-like [KO:K06252]
104696117  VWF; von Willebrand factor [KO:K03900]
104697259  bone sialoprotein 2 [KO:K06253]
104686656  integrin alpha-1 [KO:K06480]
104686657  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
109143276  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
120411187  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
104694156  ITGA4; integrin alpha-4 [KO:K06483]
104693875  ITGA6; integrin alpha-6 isoform X3 [KO:K06485]
104689346  ITGA8; integrin alpha-8 [KO:K06584]
104689248  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
104683868  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
104693720  ITGAV; integrin alpha-V [KO:K06487]
104686529  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
104698490  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
104694382  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
104694025  ITGB5; integrin beta-5 [KO:K06588]
104693933  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
104689120  ITGB8; LOW QUALITY PROTEIN: integrin beta-8 [KO:K06591]
104684703  EMP2; epithelial membrane protein 2 [KO:K26256]
104685042  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
104696330  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104697317  PDGFC; platelet-derived growth factor C [KO:K05450]
104690110  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
104697130  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
104696228  IGF1; insulin-like growth factor I [KO:K05459]
104684484  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
104688590  PGF; placenta growth factor isoform X1 [KO:K16859]
104686165  VEGFD; vascular endothelial growth factor D [KO:K05449]
104690559  VEGFC; vascular endothelial growth factor C [KO:K05449]
104686934  HGF; hepatocyte growth factor [KO:K05460]
104690630  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104689579  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104684080  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
104690864  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104689262  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
104689893  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
104691716  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
104689586  FLT4; vascular endothelial growth factor receptor 3 isoform X3 [KO:K05097] [EC:2.7.10.1]
104698290  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
104697788  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
104696381  EMP1; epithelial membrane protein 1 [KO:K26255]
104687766  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
104684659  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
104683253  RHOA; transforming protein RhoA [KO:K04513]
104687309  ROCK1; rho-associated protein kinase 1 isoform X4 [KO:K04514] [EC:2.7.11.1]
104685437  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
104688679  MYL2; LOW QUALITY PROTEIN: myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104698028  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
104691114  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
104687298  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
120409655  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
104684134  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
104688680  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104685699  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104698411  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
104692457  PPP1R12B; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12B [KO:K12329]
104698538  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
104687441  MYLK3; myosin light chain kinase 3 isoform X2 [KO:K00907] [EC:2.7.11.18]
104687839  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104694020  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104698150  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
104685216  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
104696960  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
104684799  ACTB; actin, cytoplasmic 1 [KO:K05692]
120410965  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
104684051  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
104685555  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
104683694  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
120412105  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
104686746  TLN1; talin-1 isoform X1 [KO:K06271]
104683798  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
104683467  FLNB; filamin-B isoform X2 [KO:K27392]
104688534  PXN; paxillin isoform X1 [KO:K05760]
104698082  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
104687143  ZYX; LOW QUALITY PROTEIN: zyxin [KO:K06273]
104697492  VCL; vinculin isoform X1 [KO:K05700]
104692968  PARVA; alpha-parvin isoform X3 [KO:K06275]
104696125  PARVG; gamma-parvin [KO:K06275]
104696126  PARVB; beta-parvin isoform X2 [KO:K06275]
104684909  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
104684403  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
104687008  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104687192  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104688979  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
104696032  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
104684988  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104692616  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104688020  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104693039  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104693336  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104695234  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104686712  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104696977  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104695072  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104688489  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
104695579  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
104684856  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
104696295  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104698185  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
104690290  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104696713  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
104694460  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104689265  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
104689817  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
104691726  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
104691523  PAK5; serine/threonine-protein kinase PAK 5 isoform X7 [KO:K05736] [EC:2.7.11.1]
104692978  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
104697540  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104687562  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
104688581  CRKL; crk-like protein [KO:K04438]
104691074  CRK; adapter molecule crk isoform X1 [KO:K04438]
104694938  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
104688313  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
104692321  RAP1A; ras-related protein Rap-1A [KO:K04353]
104698372  RAP1B; ras-related protein Rap-1b [KO:K07836]
104689594  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104696634  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104697227  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
104695158  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
104696191  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104698449  CAV1; caveolin-1 [KO:K06278]
104698291  CAV2; caveolin-2 [KO:K12958]
104683396  CAV3; caveolin-3 [KO:K12959]
104691303  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
104697005  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
104689719  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
104683990  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
104694312  GRB2; LOW QUALITY PROTEIN: growth factor receptor-bound protein 2 [KO:K04364]
104695922  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
104696641  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
104691739  HRAS; GTPase HRas [KO:K02833]
104695743  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104683880  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104688782  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104697629  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104696177  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
104692524  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
104690066  inhibitor of apoptosis protein [KO:K16060]
104694440  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
104698161  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
ccw04010  MAPK signaling pathway
ccw04060  Cytokine-cytokine receptor interaction
ccw04070  Phosphatidylinositol signaling system
ccw04110  Cell cycle
ccw04310  Wnt signaling pathway
ccw04512  ECM-receptor interaction
ccw04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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