KEGG   PATHWAY: cdk05152
Entry
cdk05152                    Pathway                                
Name
Tuberculosis - Camelus dromedarius (Arabian camel)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
cdk05152  Tuberculosis
cdk05152

Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105087473  TNF; tumor necrosis factor [KO:K03156]
105098228  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
105088459  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105104389  FADD; LOW QUALITY PROTEIN: FAS-associated death domain protein [KO:K02373]
105099181  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105099180  CASP10; LOW QUALITY PROTEIN: caspase-10 [KO:K04400] [EC:3.4.22.63]
105084433  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105100737  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
105102890  BAX; apoptosis regulator BAX [KO:K02159]
105098528  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
105095080  cytochrome c [KO:K08738]
105092650  cytochrome c [KO:K08738]
105107056  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
105097442  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
105099264  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
105104845  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105093393  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105101547  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
105088999  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
105089916  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X8 [KO:K04515] [EC:2.7.11.17]
105098484  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
105092453  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
105092345  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105101111  IFNG; interferon gamma [KO:K04687]
105092040  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
105089867  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
105107124  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105101970  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105088783  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
105089048  CIITA; MHC class II transactivator isoform X2 [KO:K08060] [EC:2.7.11.1]
105103216  RFX5; DNA-binding protein RFX5 isoform X2 [KO:K08061]
105103715  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
105100832  RFXAP; regulatory factor X-associated protein [KO:K08063]
105086741  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
105097480  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
105103382  NFYC; nuclear transcription factor Y subunit gamma isoform X2 [KO:K08066]
105093562  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
105101397  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
105101401  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
105101402  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
105101408  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
105101409  LOW QUALITY PROTEIN: SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
105101412  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
105101414  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
105101433  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
105101434  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
105101437  HLA class II histocompatibility antigen, DRB1-1 beta chain-like isoform X2 [KO:K06752]
105101410  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
116147669  LOW QUALITY PROTEIN: boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
105101411  boLa class II histocompatibility antigen, DQB*0101 beta chain [KO:K06752]
116147670  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
105101413  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
105098481  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
105091909  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
105099829  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
105098609  IL10; interleukin-10 [KO:K05443]
105090182  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
105089870  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
105098182  C-type lectin domain family 4 member E [KO:K10059]
105100105  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
105094212  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
105084996  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116149854  LOW QUALITY PROTEIN: tyrosine-protein kinase SYK-like [KO:K05855] [EC:2.7.10.2]
105106413  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
105105766  LOW QUALITY PROTEIN: tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
105106036  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
105088984  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
105095053  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
105097522  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
105087544  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
105090727  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
105088805  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
105085042  lipopolysaccharide-binding protein-like [KO:K05399]
105085010  LBP; lipopolysaccharide-binding protein isoform X4 [KO:K05399]
105099662  TLR2; toll-like receptor 2 [KO:K10159]
105089346  TLR1; toll-like receptor 1 [KO:K05398]
105089347  TLR6; toll-like receptor 6 isoform X1 [KO:K10169]
105104576  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
105098101  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105094263  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
105090692  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
105097094  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
105098727  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105093117  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
105106823  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105089560  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105102595  RELA; transcription factor p65 isoform X1 [KO:K04735]
105101337  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
105101338  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105090355  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105090356  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105095214  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105102769  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105091591  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
105094659  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105100625  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105088198  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
105095065  IL6; interleukin-6 [KO:K05405]
105094260  IL12A; interleukin-12 subunit alpha isoform X2 [KO:K05406]
105099900  IL12B; interleukin-12 subunit beta [KO:K05425]
105094167  IL18; interleukin-18 isoform X1 [KO:K05482]
105086361  IL23A; interleukin-23 subunit alpha [KO:K05426]
105093151  IL1A; interleukin-1 alpha [KO:K04383]
105093155  IL1B; interleukin-1 beta [KO:K04519]
105087878  CEBPB; LOW QUALITY PROTEIN: CCAAT/enhancer-binding protein beta [KO:K10048]
105096716  CEBPG; CCAAT/enhancer-binding protein gamma isoform X1 [KO:K10049]
105105541  interferon alpha-1-like [KO:K05414]
105105457  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
105105461  LOW QUALITY PROTEIN: interferon alpha-14-like [KO:K05414]
105095932  interferon alpha-14-like [KO:K05414]
116152603  interferon alpha-14-like [KO:K05414]
116152604  interferon alpha-14-like [KO:K05414]
105095933  IFNB1; interferon beta [KO:K05415]
105087570  CD209 antigen-like protein E [KO:K06563]
105090126  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
105087723  RHOA; transforming protein RhoA [KO:K04513]
105106395  LSP1; lymphocyte-specific protein 1 isoform X1 [KO:K14957]
105090883  serine/threonine-protein kinase PLK3 isoform X4 [KO:K08862] [EC:2.7.11.21]
105088200  KSR1; kinase suppressor of Ras 1 isoform X4 [KO:K14958]
105093099  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105093367  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
105100091  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
105086078  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
105100328  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
105103804  VDR; vitamin D3 receptor [KO:K08539]
116158223  uncharacterized protein LOC116158223 [KO:K13916]
105105181  antibacterial peptide PMAP-23-like [KO:K13916]
116158224  LOW QUALITY PROTEIN: antibacterial peptide PMAP-23-like [KO:K13916]
105106592  antibacterial peptide PMAP-23-like [KO:K13916]
116158346  LOW QUALITY PROTEIN: cathelin-like [KO:K13916]
116158347  antibacterial peptide PMAP-37-like [KO:K13916]
105104550  C3; complement C3 [KO:K03990]
116148703  CR1L; complement component receptor 1-like protein [KO:K04011]
105100014  CR1; LOW QUALITY PROTEIN: complement receptor type 1 [KO:K04011]
105089720  ITGAX; integrin alpha-X [KO:K06462]
105101515  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
105089721  ITGAM; integrin alpha-M [KO:K06461]
105100053  MRC1; macrophage mannose receptor 1 [KO:K06560]
105093732  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
105090422  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
105102906  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
105092188  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
105096001  CALM1; calmodulin-1 [KO:K02183]
105093281  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105104026  CALM3; calmodulin-3 [KO:K02183]
105105602  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105092364  CALM2; calmodulin-2 [KO:K02183]
116147086  calmodulin-like [KO:K02183]
105085253  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
105085148  RAB5A; ras-related protein Rab-5A [KO:K07887]
105086384  RAB5B; ras-related protein Rab-5B isoform X2 [KO:K07888]
105090453  RAB5C; ras-related protein Rab-5C [KO:K07889]
105092206  early endosome antigen 1 [KO:K12478]
105106375  RAB7A; ras-related protein Rab-7a [KO:K07897]
105105228  CTSD; cathepsin D isoform X1 [KO:K01379] [EC:3.4.23.5]
105091627  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
105094334  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105104407  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
105090506  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
105088499  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
105088444  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
105097066  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
105106493  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
105099703  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit isoform X1 [KO:K02155]
105090899  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
105098892  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
105091341  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
105102643  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105092463  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105089593  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116152568  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116157512  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105102770  CORO1A; coronin-1A [KO:K13882]
105102978  uncharacterized protein LOC105102978 [KO:K06856]
116151844  uncharacterized protein LOC116151844 [KO:K06856]
116153639  immunoglobulin mu heavy chain-like [KO:K06856]
105103159  high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
105105394  low affinity immunoglobulin gamma Fc region receptor II isoform X2 [KO:K06472]
105092686  low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560]
116151293  low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560]
105105185  low affinity immunoglobulin gamma Fc region receptor III isoform X1 [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
cdk04010  MAPK signaling pathway
cdk04210  Apoptosis
cdk04612  Antigen processing and presentation
cdk04620  Toll-like receptor signaling pathway
cdk04621  NOD-like receptor signaling pathway
cdk04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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