KEGG   PATHWAY: cge04024
Entry
cge04024                    Pathway                                
Name
cAMP signaling pathway - Cricetulus griseus (Chinese hamster)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
cge04024  cAMP signaling pathway
cge04024

Other DBs
GO: 0019933
Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100773469  Vip; VIP peptides [KO:K05264]
113833763  corticoliberin [KO:K05256]
100689452  Cga; glycoprotein hormones alpha chain precursor [KO:K08522]
100689384  Lhb; lutropin subunit beta precursor [KO:K08521]
100759178  Gpha2; glycoprotein hormone alpha-2 [KO:K25483]
100762212  Gphb5; glycoprotein hormone beta-5 [KO:K25484]
100751072  Tshb; thyrotropin subunit beta isoform X2 [KO:K05251]
100756311  Pomc; pro-opiomelanocortin isoform X2 [KO:K05228]
100767021  Gcg; glucagon [KO:K05259]
100753817  Gip; gastric inhibitory polypeptide isoform X2 [KO:K05258]
100689453  Fshb; follitropin subunit beta precursor [KO:K05250]
100774350  Nppa; natriuretic peptides A [KO:K12334]
100760233  Adcyap1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
113834807  beta-1 adrenergic receptor [KO:K04141]
100758902  Adrb2; beta-2 adrenergic receptor isoform X2 [KO:K04142]
100760963  Drd1; D(1A) dopamine receptor [KO:K04144]
100752680  Drd5; D(1B) dopamine receptor isoform X2 [KO:K05840]
100762652  Adora2a; adenosine receptor A2a [KO:K04266]
100763863  Htr4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
100752934  Htr6; 5-hydroxytryptamine receptor 6 isoform X2 [KO:K04162]
100774710  Ptger2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100772260  Adcyap1r1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
100760918  Vipr2; vasoactive intestinal polypeptide receptor 2 isoform X2 [KO:K04590]
100769844  corticotropin-releasing factor receptor 1 isoform X3 [KO:K04578]
100774100  Crhr2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
100772530  Lhcgr; lutropin-choriogonadotropic hormone receptor isoform X2 [KO:K04248]
100775040  Tshr; thyrotropin receptor isoform X1 [KO:K04249]
100757427  Mc2r; adrenocorticotropic hormone receptor [KO:K04200]
100763400  Glp1r; glucagon-like peptide 1 receptor isoform X2 [KO:K04581]
113837293  gastric inhibitory polypeptide receptor [KO:K04580]
100770518  Gpr119; glucose-dependent insulinotropic receptor [KO:K08424]
100769953  Fshr; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
100752423  Npr1; atrial natriuretic peptide receptor 1 isoform X3 [KO:K12323] [EC:4.6.1.2]
100689067  Gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
103158534  neuroendocrine secretory protein 55 [KO:K04632]
100768493  Edn1; endothelin-1 [KO:K16366]
100754793  Edn2; endothelin-2 isoform X2 [KO:K16367]
100772506  Edn3; endothelin-3 [KO:K05227]
100774243  Sst; somatostatin [KO:K05237]
100758436  Npy; pro-neuropeptide Y [KO:K05232]
100759101  Ghrl; appetite-regulating hormone isoform X2 [KO:K05254]
100769463  oxytocin-neurophysin 1 [KO:K05243]
100750370  oxytocin-neurophysin 1 [KO:K05243]
100767570  Htr1d; 5-hydroxytryptamine receptor 1D [KO:K04153]
100766950  Htr1f; 5-hydroxytryptamine receptor 1F [KO:K04153]
100753851  Htr1a; 5-hydroxytryptamine receptor 1A [KO:K04153]
100689321  Htr1b; 5-hydroxytryptamine receptor 1B [KO:K04153]
100755522  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
100770997  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
100751925  Drd2; D(2) dopamine receptor isoform X1 [KO:K04145]
100770643  Gabbr1; gamma-aminobutyric acid type B receptor subunit 1 isoform X2 [KO:K04615]
100771574  Gabbr2; LOW QUALITY PROTEIN: gamma-aminobutyric acid type B receptor subunit 2 isoform X2 [KO:K04615]
100751346  Adora1; adenosine receptor A1 [KO:K04265]
100774176  Ednra; endothelin-1 receptor isoform X1 [KO:K04197]
100757157  Npy1r; neuropeptide Y receptor type 1 [KO:K04204]
100766048  Sstr1; somatostatin receptor type 1 isoform X2 [KO:K04217]
100753171  Sstr2; somatostatin receptor type 2 [KO:K04218]
100774959  Sstr5; somatostatin receptor type 5 [KO:K04221]
100766347  Hcar1; hydroxycarboxylic acid receptor 1 [KO:K08401]
100765472  Hcar2; LOW QUALITY PROTEIN: hydroxycarboxylic acid receptor 2 [KO:K08402]
103161441  Ffar2; free fatty acid receptor 2 isoform X2 [KO:K04328]
100771524  Sucnr1; succinate receptor 1 [KO:K10042]
100752421  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
100774839  Oxtr; oxytocin receptor isoform X2 [KO:K04229]
100755255  Ghsr; growth hormone secretagogue receptor type 1 [KO:K04284]
100689068  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100689072  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
100689070  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100764561  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100773811  Adcy2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
100770498  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100768998  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100765958  Adcy5; LOW QUALITY PROTEIN: adenylate cyclase type 5 isoform X2 [KO:K08045] [EC:4.6.1.1]
100768368  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100756132  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
113837458  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100751372  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100767272  Adcy10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
100768599  Cnga1; cGMP-gated cation channel alpha-1 isoform X2 [KO:K04948]
100771809  Cnga2; cyclic nucleotide-gated olfactory channel isoform X2 [KO:K04949]
100771361  Cnga3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
100753462  Cnga4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
103159708  Cngb1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
100757356  Cngb3; cyclic nucleotide-gated cation channel beta-3 isoform X2 [KO:K04953]
100766751  Calml3; calmodulin-like protein 3 [KO:K02183]
100767046  Calml5; calmodulin-like protein 5 isoform X1 [KO:K02183]
100762749  Calm3; calmodulin-3 isoform X2 [KO:K02183]
100765281  Calm2; calmodulin-2 isoform X2 [KO:K02183]
100771772  Calm1; calmodulin-1 isoform X2 [KO:K02183]
100757500  Calml4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
100751814  calmodulin-like isoform X2 [KO:K02183]
100769205  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
100763272  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
100752268  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
100765253  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X3 [KO:K04515] [EC:2.7.11.17]
100774010  Camk4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
100770468  Bves; blood vessel epicardial substance [KO:K21108]
100760618  Popdc2; popeye domain-containing protein 2 [KO:K26206]
100769896  Popdc3; popeye domain-containing protein 3 [KO:K26207]
100751502  Kcnk2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
100751563  Hcn2; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X2 [KO:K04955]
100758754  Hcn4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X2 [KO:K04957]
100766754  Abcc4; multidrug resistance-associated protein 4 isoform X3 [KO:K05673]
100767619  Rapgef3; rap guanine nucleotide exchange factor 3 [KO:K08014]
100774346  rap guanine nucleotide exchange factor 4 isoform X6 [KO:K04351]
100766263  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
100771410  Rras2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
100752582  Pld2; phospholipase D2 isoform X4 [KO:K01115] [EC:3.1.4.4]
100689404  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100754217  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100771734  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100754361  mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
100764964  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100751497  Rap1a; ras-related protein Rap-1A [KO:K04353]
100769542  Rap1b; ras-related protein Rap-1b [KO:K07836]
100756100  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
100768658  Vav3; guanine nucleotide exchange factor VAV3 isoform X5 [KO:K05730]
100765426  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
100759294  Vav2; guanine nucleotide exchange factor VAV2 isoform X2 [KO:K05730]
100756792  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
113837706  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100767225  ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100757479  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
100767503  Pak1; serine/threonine-protein kinase PAK 1 isoform X4 [KO:K04409] [EC:2.7.11.1]
100752046  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2 [KO:K12490]
100762797  Rhoa; transforming protein RhoA [KO:K04513]
100757042  transforming protein RhoA isoform X1 [KO:K04513]
100751158  Afdn; afadin isoform X11 [KO:K05702]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100768351  Akt2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100752454  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100769460  Akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100771486  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100769018  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100689403  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113835540  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
103158537  dual specificity mitogen-activated protein kinase kinase 1-like isoform X2 [KO:K04368] [EC:2.7.12.2]
100774204  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100768997  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100767097  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100758739  Ppp1r1b; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
100761524  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
100760810  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100774547  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
100761582  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100762192  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
100771872  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100766300  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100774488  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100772940  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100764159  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
100762260  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100770451  histone lysine acetyltransferase CREBBP isoform X3 [KO:K04498] [EC:2.3.1.48]
113836414  LOW QUALITY PROTEIN: brain-derived neurotrophic factor-like [KO:K04355]
100689418  Fos; proto-oncogene c-Fos [KO:K04379]
113834001  transcription factor AP-1 [KO:K04448]
100762738  Gli3; transcriptional activator GLI3 isoform X1 [KO:K06230]
100763229  Gli1; zinc finger protein GLI1 isoform X1 [KO:K16797]
100763926  Ptch1; protein patched homolog 1 isoform X3 [KO:K06225]
100771283  Hhip; hedgehog-interacting protein [KO:K06231]
100754153  Nfkbia; NF-kappa-B inhibitor alpha isoform X2 [KO:K04734]
100770607  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100763542  Rela; transcription factor p65 isoform X4 [KO:K04735]
100762861  Sox9; transcription factor SOX-9 isoform X2 [KO:K18435]
100759997  Amh; muellerian-inhibiting factor isoform X2 [KO:K04665]
100758990  Ppara; peroxisome proliferator-activated receptor alpha isoform X3 [KO:K07294]
100689199  Acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X3 [KO:K00232] [EC:1.3.3.6]
100767060  Acox3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
100764851  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100758351  F2r; proteinase-activated receptor 1 isoform X2 [KO:K03914]
100760426  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100755300  Lipe; hormone-sensitive lipase isoform X2 [KO:K07188] [EC:3.1.1.79]
100770074  Rock1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.39]
100767265  Rock2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.39]
100754718  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270]
100753477  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
113837253  troponin I, cardiac muscle [KO:K12044]
100762952  Pln; cardiac phospholamban [KO:K05852]
100763714  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
100756356  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3 [KO:K05853] [EC:7.2.2.10]
100751820  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
100774683  Ryr2; ryanodine receptor 2 isoform X2 [KO:K04962]
100770880  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100764315  Grin2a; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
118239276  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100758804  Grin2c; glutamate receptor ionotropic, NMDA 2C isoform X3 [KO:K05211]
100750615  Grin2d; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D isoform X2 [KO:K05212]
100758947  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X2 [KO:K05213]
100753630  Grin3b; glutamate receptor ionotropic, NMDA 3B isoform X2 [KO:K05214]
100769392  Gria1; glutamate receptor 1 isoform X2 [KO:K05197]
100764344  Gria2; glutamate receptor 2 isoform X2 [KO:K05198]
100770349  glutamate receptor 3 isoform X2 [KO:K05199]
100755681  Gria4; glutamate receptor 4 isoform X1 [KO:K05200]
100754506  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
100771378  Atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X2 [KO:K01539] [EC:7.2.2.13]
100763478  Atp1a2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
100763191  Atp1a4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
100758209  Atp1a3; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-3 isoform X2 [KO:K01539] [EC:7.2.2.13]
100765669  Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 isoform X2 [KO:K01540]
100762833  Atp1b4; protein ATP1B4 isoform X3 [KO:K01540]
100760718  Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
100757379  Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 isoform X2 [KO:K01540]
100771061  Fxyd2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
103162414  phospholemman [KO:K13360]
100689320  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
100752394  Orai1; calcium release-activated calcium channel protein 1 isoform X2 [KO:K16056]
100764066  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
100753233  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X2 [KO:K05850] [EC:7.2.2.10]
100759670  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
100764868  Atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100754788  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X30 [KO:K04850]
100772497  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100757994  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X2 [KO:K04853]
100765508  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X5 [KO:K04857]
100774584  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X2 [KO:K19021] [EC:3.1.4.17]
100775064  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X2 [KO:K13296] [EC:3.1.4.17]
100759696  Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X2 [KO:K13293] [EC:3.1.4.53]
100774886  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
100754362  Pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
100770327  Pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X2 [KO:K13293] [EC:3.1.4.53]
100751551  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
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Am J Respir Cell Mol Biol 39:127-32 (2008)
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Pharmaceuticals (Basel) 5:1291-331 (2012)
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Ahuja M, Jha A, Maleth J, Park S, Muallem S
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cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
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Cell Calcium 55:385-393 (2014)
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Biochemistry (Mosc) 76:981-98 (2011)
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Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
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Biochem Soc Trans 42:89-97 (2014)
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J Mol Cell Cardiol 41:183-214 (2006)
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J Am Coll Cardiol 54:1747-62 (2009)
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Prog Biophys Mol Biol 85:261-78 (2004)
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Computational models reduce complexity and accelerate insight into cardiac signaling networks.
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Circ Res 108:85-97 (2011)
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Front Physiol 2:67 (2011)
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Exp Cell Res 312:1925-38 (2006)
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SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
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Am J Physiol Endocrinol Metab 301:E539-47 (2011)
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Mol Endocrinol 14:1962-75 (2000)
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Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
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Related
pathway
cge00071  Fatty acid degradation
cge04015  Rap1 signaling pathway
cge04020  Calcium signaling pathway
cge04151  PI3K-Akt signaling pathway
cge04210  Apoptosis
cge04260  Cardiac muscle contraction
cge04340  Hedgehog signaling pathway
cge04720  Long-term potentiation
cge04740  Olfactory transduction
cge04972  Pancreatic secretion
cge04976  Bile secretion
KO pathway
ko04024   
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