KEGG   PATHWAY: cge04145
Entry
cge04145                    Pathway                                
Name
Phagosome - Cricetulus griseus (Chinese hamster)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
cge04145  Phagosome
cge04145

Other DBs
GO: 0045335
Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100763068  Vamp3; vesicle-associated membrane protein 3 isoform X2 [KO:K13505]
100773207  Stx12; syntaxin-12 [KO:K13813]
100758402  Stx7; syntaxin-7 [KO:K08488]
113830633  Actg1; actin, cytoplasmic 2 isoform X2 [KO:K05692]
100689477  Actb; actin, cytoplasmic 1 [KO:K05692]
113834559  coronin-1A [KO:K13882]
100772503  Stx18; syntaxin-18 isoform X2 [KO:K08492]
100689313  Sec22b; vesicle-trafficking protein SEC22b precursor [KO:K08517]
100689010  MHC class I antigen Hm1-C2 precursor [KO:K06751]
100689011  MHC class I antigen Hm1-C3 precursor [KO:K06751]
103162117  H-2 class I histocompatibility antigen, K-D alpha chain [KO:K06751]
100751667  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100771128  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X2 [KO:K06751]
100751953  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
113832472  class I histocompatibility antigen, Gogo-A*0101 alpha chain-like [KO:K06751]
113832473  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
100772658  HLA class I histocompatibility antigen, alpha chain F [KO:K06751]
100772949  saoe class I histocompatibility antigen, A alpha chain isoform X2 [KO:K06751]
100757234  H-2 class I histocompatibility antigen, alpha chain [KO:K06751]
100757524  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X2 [KO:K06751]
100758961  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
100758095  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
100753528  RT1 class I histocompatibility antigen, AA alpha chain isoform X2 [KO:K06751]
100762763  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2 [KO:K06751]
100762478  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
100757615  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
100759246  H-2 class I histocompatibility antigen, Q10 alpha chain [KO:K06751]
100751378  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
100689009  MHC class I antigen Hm1-C4 precursor [KO:K06751]
100689008  MHC class I antigen Hm1-C5 isoform X1 [KO:K06751]
103158895  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
100761901  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
113831254  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X4 [KO:K06751]
100773242  patr class I histocompatibility antigen, A-2 alpha chain [KO:K06751]
118237718  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
100750512  H-2 class II histocompatibility antigen, E-S beta chain isoform X2 [KO:K06752]
100759913  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
100760208  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100759342  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
100760794  class II histocompatibility antigen, M alpha chain [KO:K06752]
103161518  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100761373  rano class II histocompatibility antigen, A beta chain isoform X2 [KO:K06752]
100752328  H-2 class II histocompatibility antigen, I-E alpha chain [KO:K06752]
100761951  LOW QUALITY PROTEIN: H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
100766775  LOW QUALITY PROTEIN: H-2 class II histocompatibility antigen, E-S beta chain-like isoform X2 [KO:K06752]
100767068  H-2 class II histocompatibility antigen, E-D beta chain [KO:K06752]
100762240  H-2 class II histocompatibility antigen, E-D beta chain-like isoform X2 [KO:K06752]
100767639  H-2 class II histocompatibility antigen, E-U alpha chain isoform X2 [KO:K06752]
100774703  LOW QUALITY PROTEIN: H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
100761082  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
100772343  Rab5a; ras-related protein Rab-5A [KO:K07887]
100768837  Rab5b; ras-related protein Rab-5B [KO:K07888]
100754413  Rab5c; ras-related protein Rab-5C [KO:K07889]
100758601  early endosome antigen 1 isoform X5 [KO:K12478]
100765741  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
100689395  Tfrc; transferrin receptor protein 1 [KO:K06503]
100765681  Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
100768315  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100774665  Atp6v1b2; V-type proton ATPase subunit B, brain isoform isoform X2 [KO:K02147]
100756094  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100763093  Atp6v1c2; V-type proton ATPase subunit C 2 [KO:K02148]
100773930  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
100762500  Atp6v1d; V-type proton ATPase subunit D isoform X1 [KO:K02149]
100765179  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
100755187  Atp6v1e1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
100752884  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
118239696  V-type proton ATPase subunit F-like [KO:K02151]
100774299  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
100765359  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
100763970  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
100769759  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
100769769  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
100755303  Tcirg1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
100766909  Atp6v0a2; V-type proton ATPase 116 kDa subunit a2 isoform X3 [KO:K02154]
100756648  Atp6v0a1; V-type proton ATPase 116 kDa subunit a1 isoform X4 [KO:K02154]
100758035  Atp6v0d2; V-type proton ATPase subunit d 2 isoform X3 [KO:K02146]
100762360  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
100754134  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100772184  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100754687  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
100760638  Atp6ap1; V-type proton ATPase subunit S1 isoform X2 [KO:K03662]
100763105  Rab7a; ras-related protein Rab-7a [KO:K07897]
100756922  Rab7b; ras-related protein Rab-7b [KO:K07898]
100767148  Rilp; rab-interacting lysosomal protein isoform X1 [KO:K13883]
100771366  Dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X2 [KO:K10413]
100758806  Dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X2 [KO:K10414]
100773761  Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X2 [KO:K10415]
100765135  Dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
100768032  Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X2 [KO:K10416]
100770140  Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
100682526  Tuba1c; tubulin alpha-1C chain [KO:K07374]
100682527  Tuba1a; tubulin alpha-1A chain [KO:K07374]
100682528  Tuba1b; tubulin alpha-1B chain [KO:K07374]
113832602  tubulin alpha-1C chain-like [KO:K07374]
100767686  Tuba4a; tubulin alpha-4A chain isoform X1 [KO:K07374]
100755907  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
100767630  tubulin alpha chain [KO:K07374]
100765599  tubulin alpha-8 chain isoform X2 [KO:K07374]
100762888  tubulin alpha-3 chain [KO:K07374]
100753526  Tuba8; tubulin alpha-8 chain isoform X1 [KO:K07374]
100772797  Tubb1; tubulin beta-1 chain isoform X2 [KO:K07375]
100760055  tubulin beta-3 chain isoform X2 [KO:K07375]
100689091  Tubb; tubulin beta-5 chain [KO:K07375]
100761889  tubulin beta-2A chain isoform X6 [KO:K07375]
100689363  Tubb6; tubulin beta-6 chain [KO:K07375]
100763390  Tubb4a; tubulin beta-4A chain isoform X2 [KO:K07375]
100689089  Tubb4b; tubulin beta-4B chain [KO:K07375]
100758633  tubulin beta-2B chain isoform X4 [KO:K07375]
100772093  lysosome-associated membrane glycoprotein 1 [KO:K06528]
100689316  Lamp2; lysosome-associated membrane glycoprotein 2 precursor [KO:K06528]
100689406  Lamp1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528]
100758487  Pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
100759169  M6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
100758127  Nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100752227  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
100757792  LOW QUALITY PROTEIN: myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
100768693  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100751823  Ctss; cathepsin S [KO:K01368] [EC:3.4.22.27]
100771837  Sec61a2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
100767375  Sec61a1; protein transport protein Sec61 subunit alpha isoform X2 [KO:K10956]
100768703  Sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
100773904  protein transport protein Sec61 subunit beta-like [KO:K09481]
100761941  protein transport protein Sec61 subunit gamma isoform X2 [KO:K07342]
100757015  protein transport protein Sec61 subunit gamma-like [KO:K07342]
100772250  Sec61g; protein transport protein Sec61 subunit gamma isoform X1 [KO:K07342]
103159882  protein transport protein Sec61 subunit gamma-like [KO:K07342]
103159941  protein transport protein Sec61 subunit gamma-like [KO:K07342]
118239045  protein transport protein Sec61 subunit gamma-like [KO:K07342]
118239408  protein transport protein Sec61 subunit gamma-like [KO:K07342]
100751458  Tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100752033  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100760153  calreticulin [KO:K08057]
100689096  Calr; calreticulin precursor [KO:K08057]
100689345  Canx; calnexin precursor [KO:K08054]
100774550  Fcgr1a; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
103161891  low affinity immunoglobulin gamma Fc region receptor III isoform X1 [KO:K06472]
103161893  low affinity immunoglobulin gamma Fc region receptor II isoform X1 [KO:K12560]
103161892  low affinity immunoglobulin gamma Fc region receptor IV isoform X2 [KO:K06463]
113831736  immunoglobulin heavy variable 3-48 [KO:K06856]
113831730  uncharacterized protein LOC113831730 [KO:K06856]
113838236  uncharacterized protein LOC113838236 [KO:K06856]
100768476  C1r; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
100758889  Itgam; integrin alpha-M isoform X2 [KO:K06461]
100756135  Itgb2; integrin beta-2 [KO:K06464]
100763958  C3; complement C3 [KO:K03990]
100765657  Colec11; collectin-11 isoform X1 [KO:K10066]
100771704  Colec12; collectin-12 isoform X2 [KO:K10062]
100757517  mannose-binding protein A [KO:K03991]
100769668  Mbl2; mannose-binding protein C isoform X2 [KO:K03991]
100757798  pulmonary surfactant-associated protein A [KO:K10067]
100757227  Sftpd; pulmonary surfactant-associated protein D [KO:K10068]
100752313  Itgav; integrin alpha-V isoform X2 [KO:K06487]
100774579  Itga2; integrin alpha-2 isoform X2 [KO:K06481]
100768174  Itga5; integrin alpha-5 isoform X2 [KO:K06484]
100763033  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
100775048  Itgb3; integrin beta-3 isoform X2 [KO:K06493]
100765378  Itgb5; integrin beta-5 isoform X3 [KO:K06588]
100760878  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
100756924  Thbs3; thrombospondin-3 isoform X1 [KO:K04659]
100766091  Comp; cartilage oligomeric matrix protein isoform X2 [KO:K04659]
100752022  Thbs2; thrombospondin-2 [KO:K04659]
100762358  Thbs4; thrombospondin-4 isoform X2 [KO:K04659]
100771475  Tlr2; LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
100689185  Tlr6; toll-like receptor 6 isoform X1 [KO:K10169]
100689329  Tlr4; toll-like receptor 4 precursor [KO:K10160]
100757057  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
100771586  Mrc1; macrophage mannose receptor 1 isoform X2 [KO:K06560]
100752611  Mrc2; C-type mannose receptor 2 isoform X2 [KO:K06560]
100768806  Pla2r1; secretory phospholipase A2 receptor [KO:K06560]
100770076  CD209 antigen-like protein A [KO:K06563]
100756903  CD209 antigen-like protein A isoform X2 [KO:K06563]
100773817  CD209 antigen-like protein C [KO:K06563]
100755286  LOW QUALITY PROTEIN: CD209 antigen-like protein 2 [KO:K06563]
100772951  CD209 antigen-like protein E [KO:K06563]
100773244  CD209 antigen-like protein D [KO:K06563]
100773525  CD209 antigen-like protein B isoform X1 [KO:K06563]
100755579  LOW QUALITY PROTEIN: CD209 antigen-like protein C isoform X2 [KO:K06563]
100772766  C-type lectin domain family 7 member A isoform X2 [KO:K10074]
100774161  Msr1; macrophage scavenger receptor types I and II [KO:K06558]
100760468  Marco; macrophage receptor MARCO [KO:K13884]
100771035  Olr1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
100736552  Scarb1; scavenger receptor class B member 1 [KO:K13885]
100765055  Cd36; platelet glycoprotein 4 [KO:K06259]
100766833  cytochrome b-245 light chain [KO:K08009]
100760802  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100756792  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
113837706  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100769204  Ncf1; neutrophil cytosol factor 1 isoform X2 [KO:K08011]
100767090  Ncf2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
100773086  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
cge04142  Lysosome
cge04144  Endocytosis
cge04610  Complement and coagulation cascades
cge04612  Antigen processing and presentation
cge04620  Toll-like receptor signaling pathway
cge04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
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