KEGG   PATHWAY: chx05152
Entry
chx05152                    Pathway                                
Name
Tuberculosis - Capra hircus (goat)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
chx05152  Tuberculosis
chx05152

Organism
Capra hircus (goat) [GN:chx]
Gene
100861232  TNF; tumor necrosis factor [KO:K03156]
102190310  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102180248  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102170760  FADD; FAS-associated death domain protein [KO:K02373]
102169919  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102177031  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102176106  BID; BH3-interacting domain death agonist [KO:K04726]
100846984  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
106501717  cytochrome c 2 [KO:K08738]
102173997  cytochrome c [KO:K08738]
102174681  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102188830  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102189930  BAD; bcl2-associated agonist of cell death [KO:K02158]
100861254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102176762  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102185715  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
102185084  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102175934  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100860815  IFNG; interferon gamma precursor [KO:K04687]
102182698  IFNGR1; interferon gamma receptor 1 isoform X2 [KO:K05132]
102191269  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
102182846  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102180670  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
102189170  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
102172509  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
102171562  RFX5; DNA-binding protein RFX5 [KO:K08061]
102189385  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
102185753  RFXAP; regulatory factor X-associated protein [KO:K08063]
102187277  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
102182108  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
102183386  NFYC; nuclear transcription factor Y subunit gamma isoform X2 [KO:K08066]
102186065  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102180664  boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1 [KO:K06752]
102179937  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
102187356  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
102190745  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
102188267  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
102188986  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
102187998  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102186727  HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1 [KO:K06752]
106503481  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
102186442  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
102189356  HLA class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
100860813  HA25 [KO:K06752]
102185560  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
102187824  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102187383  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100860746  IL10; interleukin-10 [KO:K05443]
102188959  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
102174776  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
102183747  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
102183403  CLEC4E; C-type lectin domain family 4 member E [KO:K10059]
102191004  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
102185903  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
102182890  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102174120  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
102170987  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
102173520  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
102188458  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
102186424  NOD2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
102169397  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
102188849  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
100861238  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
102186029  LBP; lipopolysaccharide-binding protein [KO:K05399]
102186320  lipopolysaccharide-binding protein [KO:K05399]
100860747  TLR2; toll-like receptor 2 precursor [KO:K10159]
100861260  TLR1; toll-like receptor 1 [KO:K05398]
100860932  TLR6; toll-like receptor 6 [KO:K10169]
100860955  TLR4; toll-like receptor 4 precursor [KO:K10160]
102177056  CD14; monocyte differentiation antigen CD14 [KO:K04391]
102184789  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
102174883  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102171575  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102177432  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102180544  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X2 [KO:K04731] [EC:2.7.11.1]
102172830  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
102175660  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102174096  RELA; transcription factor p65 [KO:K04735]
102180926  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100860996  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102189174  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102184510  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100860742  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100860785  IL6; interleukin-6 precursor [KO:K05405]
100861293  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
100860845  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
100861190  IL18; interleukin-18 [KO:K05482]
102190023  IL23A; interleukin-23 subunit alpha [KO:K05426]
100861289  IL1A; LOW QUALITY PROTEIN: interleukin-1 alpha [KO:K04383]
100860816  IL1B; interleukin-1 beta [KO:K04519]
108637430  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
102177433  CEBPG; CCAAT/enhancer-binding protein gamma [KO:K10049]
100860819  TLR9; toll-like receptor 9 precursor [KO:K10161]
108635529  interferon alpha-H-like [KO:K05414]
108633160  interferon alpha-1-like [KO:K05414]
100860850  IFNA; interferon-alpha precursor [KO:K05414]
102174842  interferon alpha-1-like [KO:K05414]
102179943  interferon alpha-H-like [KO:K05414]
102180761  interferon alpha-H [KO:K05414]
102181299  interferon alpha-H-like [KO:K05414]
108636621  interferon alpha-H-like [KO:K05414]
108636627  interferon alpha-H-like [KO:K05414]
102181867  interferon beta-2 [KO:K05415]
102189208  LOW QUALITY PROTEIN: interferon beta-2 [KO:K05415]
102181595  interferon beta-2-like [KO:K05415]
108636544  interferon beta-2-like [KO:K05415]
108636629  interferon beta-2-like [KO:K05415]
108636632  interferon beta-2-like [KO:K05415]
108636634  interferon beta-2 [KO:K05415]
108633243  interferon beta-2-like [KO:K05415]
102172254  CD209; CD209 antigen [KO:K06563]
102179302  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
102181169  RHOA; transforming protein RhoA [KO:K04513]
102177038  LSP1; lymphocyte-specific protein 1 isoform X1 [KO:K14957]
106501977  PLK3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
102189340  kinase suppressor of Ras 1 isoform X1 [KO:K14958]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102191364  TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
100861228  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
102189962  TGFB3; transforming growth factor beta-3 [KO:K13377]
102170758  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
102177594  VDR; vitamin D3 receptor [KO:K08539]
100861191  BAC7.5; Bac7.5 protein precursor [KO:K13916]
100861213  BAC5; cathelicidin-2 precursor [KO:K13916]
100861192  MAP28; MAP28 protein precursor [KO:K13916]
100861275  MAP34-B; MAP34-B protein precursor [KO:K13916]
102181444  LOW QUALITY PROTEIN: cathelicidin-3-like [KO:K13916]
102170003  cathelicidin-2 [KO:K13916]
102169231  cathelicidin-1 [KO:K13916]
102171106  cathelin-related peptide SC5 [KO:K13916]
100860826  C3; LOW QUALITY PROTEIN: complement C3 [KO:K03990]
102187247  LOW QUALITY PROTEIN: complement receptor type 1 [KO:K04011]
102180910  ITGAX; integrin alpha-X [KO:K06462]
100861185  ITGB2; integrin beta-2 precursor [KO:K06464]
102180100  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
102168670  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
102181218  MRC1; macrophage mannose receptor 1 [KO:K06560]
102171371  MRC2; C-type mannose receptor 2 [KO:K06560]
102168201  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
102184187  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
102185007  CALM1; calmodulin [KO:K02183]
102172164  CALM2; calmodulin isoform X1 [KO:K02183]
102175311  calmodulin [KO:K02183]
106502751  calmodulin-like protein 3 [KO:K02183]
102187248  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
102169697  CALM3; calmodulin [KO:K02183]
102171428  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102171561  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
102184478  RAB5A; ras-related protein Rab-5A [KO:K07887]
102174814  RAB5B; ras-related protein Rab-5B [KO:K07888]
102185034  RAB5C; ras-related protein Rab-5C [KO:K07889]
102175190  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
102168869  RAB7A; ras-related protein Rab-7a [KO:K07897]
106504021  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
102179797  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102186995  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
102186280  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102171404  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102172556  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
102178477  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
102181518  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
108635054  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
106502862  V-type proton ATPase subunit S1 [KO:K03662]
108633881  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
102191393  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
102189841  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
102175491  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
102176770  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102179767  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102184033  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102177339  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102182602  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102185330  CORO1A; coronin-1A [KO:K13882]
102173987  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
102184859  low affinity immunoglobulin gamma Fc region receptor II isoform X1 [KO:K06472]
102186356  low affinity immunoglobulin gamma Fc region receptor II isoform X1 [KO:K12560]
102185698  low affinity immunoglobulin gamma Fc region receptor III isoform X1 [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
chx04010  MAPK signaling pathway
chx04210  Apoptosis
chx04612  Antigen processing and presentation
chx04620  Toll-like receptor signaling pathway
chx04621  NOD-like receptor signaling pathway
chx04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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