KEGG   PATHWAY: cjc05206
Entry
cjc05206                    Pathway                                
Name
MicroRNAs in cancer - Callithrix jacchus (white-tufted-ear marmoset)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
Pathway map
cjc05206  MicroRNAs in cancer
cjc05206

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100393460  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100387508  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100410397  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
100385604  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100408832  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
100395201  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
100387914  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
100403708  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
103796419  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100390172  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100396520  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100403750  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100390206  CRKL; crk-like protein [KO:K04438]
100399916  CRK; adapter molecule crk isoform X1 [KO:K04438]
100400747  HDAC5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
100386059  HDAC4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
100394913  FOXP1; forkhead box protein P1 isoform X5 [KO:K23582]
100391311  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
100408551  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100390655  LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 3A-like [KO:K17398] [EC:2.1.1.37]
100413373  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
100412936  DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X6 [KO:K17399] [EC:2.1.1.37]
100406790  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
100412158  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100389629  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100386906  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
100390586  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100404022  EZR; ezrin isoform X2 [KO:K08007]
100415118  LOW QUALITY PROTEIN: ezrin [KO:K08007]
100413000  PDCD4; LOW QUALITY PROTEIN: programmed cell death protein 4 [KO:K16865]
100395278  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100405037  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100393554  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
100409423  SPRY2; protein sprouty homolog 2 [KO:K17383]
100408947  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100409665  SERPINB5; serpin B5 [KO:K10139]
100411816  ST14; suppressor of tumorigenicity 14 protein [KO:K08670] [EC:3.4.21.109]
100395270  CYP1B1; cytochrome P450 1B1 isoform X1 [KO:K07410] [EC:1.14.14.1]
100406608  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100413313  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
100393283  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [KO:K07436] [EC:1.14.15.16]
100391332  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100409758  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100398414  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100386953  TP63; tumor protein 63 isoform X5 [KO:K10149]
100398476  ZEB2; zinc finger E-box-binding homeobox 2 isoform X7 [KO:K23560]
100385514  FSCN1; fascin [KO:K23551]
100407858  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
100408283  HOXD10; homeobox protein Hox-D10 [KO:K09295]
100397684  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100388482  BMF; bcl-2-modifying factor isoform X1 [KO:K17460]
100394713  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100415095  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100407198  SLC7A1; high affinity cationic amino acid transporter 1 [KO:K13863]
100406045  CCNG1; cyclin-G1 [KO:K10145]
100414343  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
100401759  STMN1; stathmin isoform X2 [KO:K04381]
100404965  stathmin [KO:K04381]
103793637  stathmin-like [KO:K04381]
100389282  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100407754  MYC; myc proto-oncogene protein [KO:K04377]
100387570  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100406017  HRAS; GTPase HRas [KO:K02833]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
108591807  GTPase NRas-like [KO:K07828]
100401356  DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]
100397972  APC2; adenomatous polyposis coli protein 2 isoform X2 [KO:K02085]
100385653  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100387742  IRS1; insulin receptor substrate 1 [KO:K16172]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100400023  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100390554  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
100413494  RECK; reversion-inducing cysteine-rich protein with Kazal motifs isoform X1 [KO:K17461]
100390235  E2F3; transcription factor E2F3 isoform X4 [KO:K06620]
100404822  IRS2; insulin receptor substrate 2 [KO:K07187]
103795708  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
100393852  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
100408994  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
108587674  NOTCH4; neurogenic locus notch homolog protein 4 isoform X4 [KO:K20996]
100386061  BMI1; polycomb complex protein BMI-1 [KO:K11459]
100403505  MMP16; matrix metalloproteinase-16 isoform X1 [KO:K07996] [EC:3.4.24.-]
100402387  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100402275  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
100390910  CD44; CD44 antigen isoform X17 [KO:K06256]
100398032  DICER1; endoribonuclease Dicer isoform X1 [KO:K11592] [EC:3.1.26.-]
100396334  FZD3; frizzled-3 isoform X1 [KO:K02329]
100386674  ITGA5; integrin alpha-5 [KO:K06484]
100405284  RDX; radixin isoform X1 [KO:K05762]
100393236  RHOA; transforming protein RhoA [KO:K04513]
100404129  transforming protein RhoA-like [KO:K04513]
100411934  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
100387945  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100385410  ZFPM2; zinc finger protein ZFPM2 isoform X1 [KO:K17442]
100386042  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100407836  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
100388067  SOX4; transcription factor SOX-4 [KO:K23581]
100414580  TNC; tenascin isoform X1 [KO:K06252]
100395051  TNR; tenascin-R isoform X1 [KO:K06252]
100395776  TNN; tenascin-N [KO:K06252]
100396269  TNXB; tenascin-X isoform X1 [KO:K06252]
100398256  ABCB1; ATP-dependent translocase ABCB1 [KO:K05658] [EC:7.6.2.2]
100391747  ABCC1; multidrug resistance-associated protein 1 isoform X1 [KO:K05665] [EC:7.6.2.3]
100388186  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
100894215  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100394813  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100395416  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100395773  EFNA1; ephrin-A1 [KO:K05462]
100396146  EFNA2; ephrin-A2 [KO:K05462]
100388282  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100390178  THBS1; thrombospondin-1 [KO:K16857]
100395821  IGF2BP1; insulin-like growth factor 2 mRNA-binding protein 1 isoform X1 [KO:K17391]
100396005  TRIM71; E3 ubiquitin-protein ligase TRIM71 [KO:K12035] [EC:2.3.2.27]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100407639  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100395682  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100409938  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100411926  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
100415710  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100415620  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100396301  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
100401846  MDM4; protein Mdm4 isoform X6 [KO:K10127]
100412331  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100397497  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100390347  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100414931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100410124  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100390337  SHC1; SHC-transforming protein 1 isoform X5 [KO:K06279]
100412906  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
100392220  SHC4; SHC-transforming protein 4 [KO:K17449]
100388628  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100389852  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100394189  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100414261  E2F1; transcription factor E2F1 [KO:K17454]
100414776  E2F2; transcription factor E2F2 [KO:K09389]
100399968  BCL2L11; bcl-2-like protein 11 isoform X16 [KO:K16341]
100400860  MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561]
100402963  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
100402327  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100399690  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
100401228  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
100394758  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
100395945  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
100385124  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
100395149  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
100385309  WNT3A; protein Wnt-3a [KO:K00312]
100398579  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100409415  CDCA5; sororin isoform X3 [KO:K17390]
100403456  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
100394652  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100388620  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100412806  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
100408168  VIM; vimentin [KO:K07606]
Reference
PMID:18817506
  Authors
Lee YS, Dutta A
  Title
MicroRNAs in cancer.
  Journal
Annu Rev Pathol 4:199-227 (2009)
DOI:10.1146/annurev.pathol.4.110807.092222
Reference
PMID:21402473
  Authors
Babashah S, Soleimani M
  Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
  Journal
Eur J Cancer 47:1127-37 (2011)
DOI:10.1016/j.ejca.2011.02.008
Reference
PMID:19630570
  Authors
Garzon R, Calin GA, Croce CM
  Title
MicroRNAs in Cancer.
  Journal
Annu Rev Med 60:167-79 (2009)
DOI:10.1146/annurev.med.59.053006.104707
Reference
PMID:23075324
  Authors
Chen PS, Su JL, Hung MC
  Title
Dysregulation of microRNAs in cancer.
  Journal
J Biomed Sci 19:90 (2012)
DOI:10.1186/1423-0127-19-90
Reference
PMID:22035854
  Authors
Ling H, Zhang W, Calin GA
  Title
Principles of microRNA involvement in human cancers.
  Journal
Chin J Cancer 30:739-48 (2011)
DOI:10.5732/cjc.011.10243
Reference
PMID:22351564
  Authors
Iorio MV, Croce CM
  Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
  Journal
EMBO Mol Med 4:143-59 (2012)
DOI:10.1002/emmm.201100209
Reference
PMID:21742789
  Authors
Sayed D, Abdellatif M
  Title
MicroRNAs in development and disease.
  Journal
Physiol Rev 91:827-87 (2011)
DOI:10.1152/physrev.00006.2010
Reference
PMID:22345301
  Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
  Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
  Journal
Exp Biol Med (Maywood) 237:227-35 (2012)
DOI:10.1258/ebm.2011.011192
Reference
PMID:22580099
  Authors
Song JH, Meltzer SJ
  Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
  Journal
Gastroenterology 143:35-47.e2 (2012)
DOI:10.1053/j.gastro.2012.05.003
Reference
PMID:23462054
  Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
  Title
MiRNA s in oesophageal squamous cancer.
  Journal
Neth J Med 71:69-75 (2013)
Reference
PMID:19773200
  Authors
Kan T, Meltzer SJ
  Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
  Journal
Curr Opin Pharmacol 9:727-32 (2009)
DOI:10.1016/j.coph.2009.08.009
Reference
PMID:20128019
  Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
  Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
  Journal
World J Gastroenterol 16:531-7 (2010)
DOI:10.3748/wjg.v16.i5.531
Reference
PMID:23165235
  Authors
Song S, Ajani JA
  Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
  Journal
Nat Rev Gastroenterol Hepatol 10:109-18 (2013)
DOI:10.1038/nrgastro.2012.210
Reference
PMID:21565290
  Authors
Liu WH, Yeh SH, Chen PJ
  Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
  Journal
Biochim Biophys Acta 1809:678-85 (2011)
DOI:10.1016/j.bbagrm.2011.04.008
Reference
PMID:23091478
  Authors
Hrasovec S, Glavac D
  Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
  Journal
Front Genet 3:180 (2012)
DOI:10.3389/fgene.2012.00180
Reference
PMID:22926415
  Authors
Liu H
  Title
MicroRNAs in breast cancer initiation and progression.
  Journal
Cell Mol Life Sci 69:3587-99 (2012)
DOI:10.1007/s00018-012-1128-9
Reference
PMID:20345848
  Authors
Li SD, Zhang JR, Wang YQ, Wan XP
  Title
The role of microRNAs in ovarian cancer initiation and progression.
  Journal
J Cell Mol Med 14:2240-9 (2010)
DOI:10.1111/j.1582-4934.2010.01058.x
Reference
PMID:23316212
  Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
  Title
Characteristic patterns of microRNA expression in human bladder cancer.
  Journal
Front Genet 3:310 (2012)
DOI:10.3389/fgene.2012.00310
Reference
PMID:20221895
  Authors
Saini S, Majid S, Dahiya R
  Title
Diet, microRNAs and prostate cancer.
  Journal
Pharm Res 27:1014-26 (2010)
DOI:10.1007/s11095-010-0086-x
Related
pathway
cjc05210  Colorectal cancer
cjc05214  Glioma
cjc05215  Prostate cancer
cjc05219  Bladder cancer
cjc05222  Small cell lung cancer
cjc05223  Non-small cell lung cancer
KO pathway
ko05206   
LinkDB

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