Entry
Name
Salmonella infection - Carlito syrichta (Philippine tarsier)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Carlito syrichta (Philippine tarsier) [GN:
csyr ]
Gene
103256214 PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282 ]
103270713 VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
103249362 VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
103275328 VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
103262121 VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182 ]
103266510 VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
103276440 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X2 [KO:K10415 ]
103260794 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
103252054 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
103260468 DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417 ]
103270083 DYNLRB1; dynein light chain roadblock-type 1 isoform X2 [KO:K10419 ]
103267366 DYNLRB2; dynein light chain roadblock-type 2 isoform X2 [KO:K10419 ]
103273925 FYCO1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
103260479 PLEKHM2; pleckstrin homology domain-containing family M member 2 [KO:K15348 ]
103261842 M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089 ]
103260360 GCC2; GRIP and coiled-coil domain-containing protein 2 isoform X2 [KO:K20282 ]
103265342 AHNAK; LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK [KO:K23934 ]
103273478 LOW QUALITY PROTEIN: rho-related GTP-binding protein RhoG-like [KO:K07863 ]
103254823 ELMO2; engulfment and cell motility protein 2 isoform X2 [KO:K18985 ]
103258791 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
103259590 MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754 ]
103267542 LOW QUALITY PROTEIN: myosin regulatory light chain, striated muscle, 25 kDa isoform-like [KO:K12757 ]
103270153 MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
103269268 FHOD1; LOW QUALITY PROTEIN: FH1/FH2 domain-containing protein 1 [KO:K23938 ]
103274640 CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749 ]
103257756 CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X4 [KO:K05749 ]
103261540 WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
103276281 ARPC2; actin-related protein 2/3 complex subunit 2 isoform X2 [KO:K05758 ]
103273728 ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756 ]
103270580 ARPC4; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 4 [KO:K05755 ]
103257872 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
103251553 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
103266233 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
103276054 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
103252973 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
103269093 PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923 ] [EC:2.7.1.154 ]
103269762 PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
103275236 PIK3C2G; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923 ] [EC:2.7.1.154 ]
103270561 TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403 ]
103270832 MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
103254079 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
103261330 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793 ]
103274648 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
103270056 NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727 ]
103254297 LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433 ] [EC:2.7.12.2 ]
103250566 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
103269228 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171 ]
103274715 RHOB; rho-related GTP-binding protein RhoB isoform X1 [KO:K07856 ]
103263576 NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800 ]
103264397 PYCARD; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
csyr04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
All DBs