KEGG   PATHWAY: csyr05163
Entry
csyr05163                   Pathway                                
Name
Human cytomegalovirus infection - Carlito syrichta (Philippine tarsier)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
csyr05163  Human cytomegalovirus infection
csyr05163

Disease
H00368  Cytomegalovirus infection
Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103249185  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103249397  CALR; calreticulin [KO:K08057]
103249454  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103249455  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103249543  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
103249547  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
103249555  TMEM173; stimulator of interferon genes protein [KO:K12654]
103249709  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103249777  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
103250119  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
103250130  HRAS; GTPase HRas isoform X1 [KO:K02833]
103250373  [KO:K06643] [EC:2.3.2.27]
103250483  [KO:K02183]
103250566  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103250930  TSC1; hamartin isoform X1 [KO:K07206]
103250976  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103251206  ARHGEF11; rho guanine nucleotide exchange factor 11 [KO:K12331]
103251325  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103251393  [KO:K06751]
103251411  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
103251444  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103251518  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
103251539  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103251553  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103251606  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
103251709  [KO:K04369] [EC:2.7.12.2]
103251768  [KO:K04632]
103252103  RELA; transcription factor p65 [KO:K04735]
103252136  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
103252197  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103252293  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103252426  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103252789  [KO:K04635]
103252808  [KO:K02183]
103252919  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103253155  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
103253311  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
103253660  [KO:K04513]
103253965  E2F1; transcription factor E2F1 [KO:K17454]
103254023  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103254239  [KO:K04456] [EC:2.7.11.1]
103254297  [KO:K04433] [EC:2.7.12.2]
103254389  [KO:K12964]
103254433  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
103254816  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103254833  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103254879  B2M; beta-2-microglobulin [KO:K08055]
103255326  [KO:K08738]
103255431  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103255466  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
103255498  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103255636  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103255674  [KO:K04537]
103255683  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
103255823  [KO:K04632]
103255950  [KO:K02183]
103256231  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103256847  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103256992  [KO:K04958]
103257302  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103257479  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103257728  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103257846  [KO:K02187] [EC:3.4.22.56]
103257967  [KO:K02183]
103258382  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
103258399  [KO:K04634]
103258632  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
103258755  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
103258883  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103259236  NRAS; GTPase NRas [KO:K07828]
103259274  RB1; retinoblastoma-associated protein [KO:K06618]
103259317  CXCL8; interleukin-8 [KO:K10030]
103259338  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103259440  IL1B; interleukin-1 beta [KO:K04519]
103259932  [KO:K06621]
103260226  [KO:K04684]
103260228  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
103260483  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103260528  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
103260636  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
103260907  [KO:K05414]
103260908  [KO:K05414]
103260910  [KO:K05414]
103260915  IFNB1; interferon beta [KO:K05415]
103260979  E2F3; transcription factor E2F3 [KO:K06620]
103261167  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103261218  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
103261438  [KO:K02183]
103261835  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
103262024  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103262441  FADD; FAS-associated death domain protein [KO:K02373]
103262464  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103262537  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103262563  TAPBP; tapasin [KO:K08058]
103262642  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103262814  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
103262860  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103262949  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
103263189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103263391  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103263392  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103263431  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
103263630  KRAS; GTPase KRas isoform X2 [KO:K07827]
103263669  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103263745  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
103263755  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103263958  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103264057  MYC; myc proto-oncogene protein [KO:K04377]
103264171  E2F2; transcription factor E2F2 [KO:K09389]
103264241  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
103264336  [KO:K04392]
103264423  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103264637  TP53; cellular tumor antigen p53 [KO:K04451]
103264772  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
103264824  [KO:K14624]
103264952  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103265017  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
103265359  CCR1; C-C chemokine receptor type 1 [KO:K04176]
103265435  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103265465  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
103265808  CCL5; C-C motif chemokine 5 [KO:K12499]
103265906  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103266092  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103266097  AKAP13; A-kinase anchor protein 13 isoform X2 [KO:K16529]
103266233  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103266387  [KO:K10030]
103266637  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103266669  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103266974  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103267309  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X2 [KO:K04374]
103267743  STAT3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 3 [KO:K04692]
103267869  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103267985  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
103268107  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103268155  ITGAV; integrin alpha-V [KO:K06487]
103268196  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103268263  [KO:K04545]
103268467  [KO:K06751]
103268605  [KO:K02183]
103268608  IL6; interleukin-6 [KO:K05405]
103269228  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103269243  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103269358  IL10RB; LOW QUALITY PROTEIN: interleukin-10 receptor subunit beta [KO:K05135]
103269400  [KO:K08057]
103269764  [KO:K10031]
103269994  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103270149  TNF; tumor necrosis factor [KO:K03156]
103270389  [KO:K07208]
103270507  CX3CL1; fractalkine isoform X2 [KO:K05508]
103270607  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103270864  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
103271195  [KO:K05408]
103271306  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X3 [KO:K09049]
103271341  CRKL; crk-like protein [KO:K04438]
103271374  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
103271375  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103271436  [KO:K06751]
103271808  PXN; LOW QUALITY PROTEIN: paxillin [KO:K05760]
103271912  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103271932  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103271934  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103272007  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103272136  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103272225  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103272228  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
103272291  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103272341  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103272758  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
103272783  [KO:K07208]
103273032  [KO:K04692]
103273050  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
103273211  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
103273365  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103273417  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103273462  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103273492  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
103273534  [KO:K06751]
103273536  [KO:K06751]
103273601  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
103273680  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103273775  CCR3; C-C chemokine receptor type 3 [KO:K04178]
103273777  CCR5; C-C chemokine receptor type 5 [KO:K04180]
103273857  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103273938  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103273943  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103273984  CXCR4; C-X-C chemokine receptor type 4 isoform X2 [KO:K04189]
103273993  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103274154  [KO:K05414]
103274155  [KO:K05414]
103274156  [KO:K05414]
103274157  [KO:K05414]
103274161  [KO:K05414]
103274163  [KO:K05414]
103274165  [KO:K05414]
103274168  [KO:K05414]
103274188  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103274231  BID; BH3-interacting domain death agonist [KO:K04726]
103274648  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103274844  CALML6; calmodulin-like protein 6 [KO:K02183]
103274909  [KO:K08738]
103275147  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
103275187  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
103275306  RHEB; GTP-binding protein Rheb [KO:K07208]
103275362  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103275922  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103275951  CRK; adapter molecule crk isoform X1 [KO:K04438]
103276035  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103276054  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
103276381  [KO:K05050]
103276389  [KO:K05050]
103276422  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
103276439  [KO:K02091] [EC:2.7.11.22]
103276479  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103276998  [KO:K06751]
103277080  [KO:K06751]
103277171  [KO:K04692]
103277206  [KO:K10031]
103277453  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110594660  [KO:K04542]
110594710  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110594775  [KO:K04542]
110595246  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
110595573  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110595842  [KO:K04545]
110596118  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
110596190  [KO:K08738]
110596243  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
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Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
PMID:28035083
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
  Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:10.4062/biomolther.2016.208
Reference
PMID:23145028
  Authors
Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ
  Title
Constitutive beta-catenin signaling by the viral chemokine receptor US28.
  Journal
PLoS One 7:e48935 (2012)
DOI:10.1371/journal.pone.0048935
Reference
PMID:15990176
  Authors
Couty JP, Gershengorn MC
  Title
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Trends Pharmacol Sci 26:405-11 (2005)
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Human cytomegalovirus gene expression in long-term infected glioma stem cells.
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PLoS One 9:e116178 (2014)
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Vischer HF, Siderius M, Leurs R, Smit MJ
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Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
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Nat Rev Drug Discov 13:123-39 (2014)
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Herpesvirus-encoded GPCRs rewire cellular signaling.
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Mol Cell Endocrinol 331:179-84 (2011)
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Viral exploitation and subversion of the immune system through chemokine mimicry.
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Nat Immunol 2:116-22 (2001)
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HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks.
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Trends Pharmacol Sci 27:56-63 (2006)
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Front Pharmacol 6:40 (2015)
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Viruses 9:E249 (2017)
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HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
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Cell Rep 15:1542-1553 (2016)
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Wang X, Sanchez J, Stone MJ, Payne RJ
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Related
pathway
csyr00590  Arachidonic acid metabolism
csyr03050  Proteasome
csyr04010  MAPK signaling pathway
csyr04064  NF-kappa B signaling pathway
csyr04110  Cell cycle
csyr04150  mTOR signaling pathway
csyr04151  PI3K-Akt signaling pathway
csyr04210  Apoptosis
csyr04612  Antigen processing and presentation
csyr04623  Cytosolic DNA-sensing pathway
csyr04630  JAK-STAT signaling pathway
csyr04668  TNF signaling pathway
csyr04810  Regulation of actin cytoskeleton
KO pathway
ko05163   

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