KEGG   PATHWAY: csyr05165
Entry
csyr05165                   Pathway                                
Name
Human papillomavirus infection - Carlito syrichta (Philippine tarsier)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
csyr05165  Human papillomavirus infection
csyr05165

Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103273454  WNT1; proto-oncogene Wnt-1 [KO:K03209]
103264112  WNT2; protein Wnt-2 [KO:K00182]
103257117  WNT2B; protein Wnt-2b [KO:K00182]
103263952  WNT3A; protein Wnt-3a [KO:K00312]
103265025  WNT4; protein Wnt-4 [KO:K00408]
103270844  WNT5A; protein Wnt-5a [KO:K00444]
103262227  WNT5B; protein Wnt-5b [KO:K00444]
103261268  WNT6; protein Wnt-6 [KO:K00445]
103249204  WNT7A; LOW QUALITY PROTEIN: protein Wnt-7a [KO:K00572]
103271330  WNT7B; protein Wnt-7b [KO:K00572]
103261699  WNT8A; protein Wnt-8a [KO:K00714]
103263950  WNT9A; protein Wnt-9a [KO:K01064]
103266311  WNT9B; protein Wnt-9b [KO:K01064]
103261269  WNT10A; protein Wnt-10a [KO:K01357]
103273455  WNT10B; protein Wnt-10b [KO:K01357]
103260166  WNT11; protein Wnt-11 [KO:K01384]
103266254  WNT16; protein Wnt-16 [KO:K01558]
103262031  frizzled-1 [KO:K02432]
103257061  frizzled-1 [KO:K02432]
103267611  FZD7; frizzled-7 [KO:K02432]
103272217  FZD3; frizzled-3 [KO:K02329]
103269658  FZD4; frizzled-4 [KO:K02354]
103254909  FZD6; frizzled-6 isoform X1 [KO:K02376]
103269630  FZD9; frizzled-9 [KO:K02842]
103271891  FZD10; frizzled-10 [KO:K02842]
103250886  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
103263236  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
103273282  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
103258382  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
103270394  AXIN1; axin-1 [KO:K02157]
103252794  AXIN2; axin-2 [KO:K04385]
103263000  APC; adenomatous polyposis coli protein isoform X2 [KO:K02085]
103258755  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
103250326  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
103265719  CSNK1A1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
103271221  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
103268315  TCF7; transcription factor 7 isoform X4 [KO:K02620]
103266761  transcription factor 7-like 1 [KO:K04490]
103256089  TCF7L2; transcription factor 7-like 2 isoform X3 [KO:K04491]
103271596  UBE3A; ubiquitin-protein ligase E3A isoform X2 [KO:K10587] [EC:2.3.2.26]
103258420  TLR3; toll-like receptor 3 [KO:K05401]
103250762  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103257998  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
103271912  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103249777  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
103260915  IFNB1; interferon beta [KO:K05415]
103271980  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
103273679  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
103270581  TADA3; transcriptional adapter 3 [KO:K11315]
103264637  TP53; cellular tumor antigen p53 [KO:K04451]
103275489  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7 [KO:K05631]
103274296  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103268248  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
103255421  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
103268225  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
103258823  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
103255106  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
103251445  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
103265024  CDC42; cell division control protein 42 homolog [KO:K04393]
103259050  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
103276722  DLG1; disks large homolog 1 isoform X2 [KO:K12076]
103269154  disks large homolog 2 [KO:K12075]
103261387  DLG3; disks large homolog 3 isoform X3 [KO:K21098]
103268781  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
103275938  LLGL2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
103252383  CRB3; protein crumbs homolog 3 [KO:K06090]
103266918  PATJ; inaD-like protein [KO:K06092]
103274452  MPP5; MAGUK p55 subfamily member 5 [KO:K06091]
103271056  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
103255767  THBS1; thrombospondin-1 [KO:K16857]
103251500  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
103257001  THBS2; thrombospondin-2 [KO:K04659]
103266515  THBS4; thrombospondin-4 [KO:K04659]
103256200  FN1; fibronectin isoform X1 [KO:K05717]
103271377  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
103267665  COL1A1; collagen alpha-1(I) chain [KO:K06236]
103271765  COL2A1; collagen alpha-1(II) chain [KO:K19719]
103252306  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
103274755  COL4A6; collagen alpha-6(IV) chain isoform X2 [KO:K06237]
103274763  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
103276803  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
103259283  collagen alpha-4(IV) chain [KO:K06237]
103259286  collagen alpha-3(IV) chain-like [KO:K06237]
103276539  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
103261796  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
103272299  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
103272302  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
103257841  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
103257842  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
103272112  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
103264072  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
103267938  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
103253595  LAMA1; laminin subunit alpha-1 [KO:K05637]
103267277  laminin subunit alpha-2 [KO:K05637]
103259778  LAMA5; laminin subunit alpha-5 [KO:K06240]
103261307  laminin subunit alpha-3 [KO:K06240]
103261363  LAMA4; laminin subunit alpha-4 [KO:K06241]
103254415  LAMB1; laminin subunit beta-1 [KO:K05636]
103270613  LAMB2; laminin subunit beta-2 [KO:K06243]
103262369  LAMB3; laminin subunit beta-3 [KO:K06244]
103254416  LAMB4; laminin subunit beta-4 [KO:K06245]
103276983  LAMC1; laminin subunit gamma-1 [KO:K05635]
103276965  LAMC2; laminin subunit gamma-2 [KO:K06246]
103259784  LAMC3; laminin subunit gamma-3 [KO:K06247]
103249865  CHAD; chondroadherin [KO:K06248]
103267817  RELN; reelin [KO:K06249] [EC:3.4.21.-]
103259835  SPP1; osteopontin isoform X1 [KO:K06250]
103269135  VTN; vitronectin [KO:K06251]
103271304  TNXB; tenascin-X [KO:K06252]
103273155  TNN; tenascin-N isoform X1 [KO:K06252]
103267853  LOW QUALITY PROTEIN: tenascin-R [KO:K06252]
103259510  TNC; tenascin isoform X1 [KO:K06252]
103273167  IBSP; bone sialoprotein 2 [KO:K06253]
103272898  ITGA1; integrin alpha-1 [KO:K06480]
103272895  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
103272352  ITGA2B; integrin alpha-IIb [KO:K06476]
103276493  integrin alpha-3-like [KO:K06482]
103273427  ITGA4; integrin alpha-4 [KO:K06483]
103256307  ITGA5; integrin alpha-5 [KO:K06484]
103273336  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
103255294  ITGA7; integrin alpha-7 [KO:K06583]
103264529  ITGA8; integrin alpha-8 [KO:K06584]
103256188  integrin alpha-9-like [KO:K06585]
103263605  ITGA9; integrin alpha-9 [KO:K06585]
103268448  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
103252907  ITGA11; integrin alpha-11 [KO:K06587]
103268155  ITGAV; integrin alpha-V [KO:K06487]
103267282  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
103252761  ITGB4; integrin beta-4 [KO:K06525]
103275476  ITGB5; integrin beta-5 [KO:K06588]
103261773  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
103274618  ITGB7; integrin beta-7 [KO:K06590]
103270895  ITGB8; integrin beta-8 [KO:K06591]
103249709  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103271808  PXN; LOW QUALITY PROTEIN: paxillin [KO:K05760]
103270149  TNF; tumor necrosis factor [KO:K03156]
103250566  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103269228  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103273211  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
103273943  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103262441  FADD; FAS-associated death domain protein [KO:K02373]
103273365  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103257846  caspase-3 [KO:K02187] [EC:3.4.22.56]
103259736  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
103261468  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
103268313  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
103256338  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
103258353  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
103254381  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
103252361  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
103263175  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
103262435  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform-like [KO:K04354]
103273997  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
103259194  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
103266449  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [KO:K11584]
103275607  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
103276158  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
103268163  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
103268546  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
103250930  TSC1; hamartin isoform X1 [KO:K07206]
103250119  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
103270389  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
103272783  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
103275306  RHEB; GTP-binding protein Rheb [KO:K07208]
103272291  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103251539  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103273417  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103262464  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103263367  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103251553  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103266233  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103276054  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
103262537  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103272136  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103257728  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103254239  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103263958  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103260494  FOXO1; forkhead box protein O1 [KO:K07201]
103264812  CDKN1B; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1B [KO:K06624]
103266974  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103252197  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103250109  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103264876  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103264423  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103276439  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103267956  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
103277250  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
103266414  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103259274  RB1; retinoblastoma-associated protein [KO:K06618]
103251062  RBL1; retinoblastoma-like protein 1 [KO:K04681]
103270226  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
103252809  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
103253965  E2F1; transcription factor E2F1 [KO:K17454]
103270886  CCNA2; cyclin-A2 [KO:K06627]
103262730  CCNA1; cyclin-A1 [KO:K06627]
103257608  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
103269735  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
103262949  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
103263189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103256847  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103255498  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103274648  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103252103  RELA; transcription factor p65 [KO:K04735]
103250373  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
103277044  NFX1; transcriptional repressor NF-X1 isoform X2 [KO:K12236]
103269606  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103269170  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
103275368  histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
103251756  CHD4; chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
103259254  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
103269933  TBP; TATA-box-binding protein [KO:K03120]
103251388  TATA box-binding protein-like protein 2 [KO:K03120]
103251434  TATA box-binding protein-like protein 2 [KO:K03120]
103253471  TATA box-binding protein-like protein 2 [KO:K03120]
103253472  TATA box-binding protein-like protein 2 [KO:K03120]
103277012  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
103251393  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
103273534  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
103268467  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
103271436  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
103273536  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
103276998  HLA class I histocompatibility antigen, B-37 alpha chain-like [KO:K06751]
103277080  HLA class I histocompatibility antigen, A-23 alpha chain-like [KO:K06751]
103251038  BCAP31; B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
103257766  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
103261161  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
103276577  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
103254908  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
103267979  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
103274462  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
103255516  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
103274224  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
103265947  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
103270146  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
103264706  ATP6V1G3; LOW QUALITY PROTEIN: V-type proton ATPase subunit G 3 [KO:K02152]
103259547  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
103251850  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
103250233  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X3 [KO:K02154]
103259170  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
103259682  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
103269045  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
103267631  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
103259075  V-type proton ATPase subunit d 1-like [KO:K02146]
103272319  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
103268380  V-type proton ATPase subunit e 1 [KO:K02153]
103268402  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
103251303  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
103255146  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
103270920  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
103258166  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
103260759  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X2 [KO:K03661]
103274664  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
103267942  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
103268107  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103275922  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103270607  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103276422  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
103250130  HRAS; GTPase HRas isoform X1 [KO:K02833]
103263630  KRAS; GTPase KRas isoform X2 [KO:K07827]
103259236  NRAS; GTPase NRas [KO:K07828]
103263745  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
103277453  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103251709  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103265435  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103274188  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103275362  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103254433  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
103251768  neuroendocrine secretory protein 55 [KO:K04632]
103255823  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
103253311  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
103266092  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103256231  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103252293  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103249547  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
103252136  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
103263755  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103265465  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
103257302  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103273492  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
103276137  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X2 [KO:K10691] [EC:2.3.2.27]
103250228  tubulin gamma-1 chain isoform X1 [KO:K10389]
103270692  tubulin gamma-2 chain isoform X2 [KO:K10389]
103249802  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
103260907  interferon alpha-5-like [KO:K05414]
103260908  interferon alpha-5-like [KO:K05414]
103260910  interferon alpha-5-like [KO:K05414]
103274154  interferon alpha-5-like [KO:K05414]
103274155  interferon alpha-5-like [KO:K05414]
103274156  interferon alpha-10-like [KO:K05414]
103274157  interferon alpha-17-like [KO:K05414]
103274161  interferon alpha-5-like [KO:K05414]
103274163  interferon alpha-17-like [KO:K05414]
103274165  interferon alpha-5-like [KO:K05414]
103274168  interferon alpha-5-like [KO:K05414]
103269359  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103269362  interferon alpha/beta receptor 2 [KO:K05131]
103262860  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103250948  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103256404  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103258295  LOW QUALITY PROTEIN: signal transducer and activator of transcription 2-like [KO:K11221]
103272248  IRF9; interferon regulatory factor 9 [KO:K04693]
103271654  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
103255383  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
103271660  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
103271661  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
103277220  LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx1-like [KO:K14754]
103277221  interferon-induced GTP-binding protein Mx2-like [KO:K14754]
103271092  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
103265222  interferon-induced GTP-binding protein Mx2-like [KO:K14754]
103250044  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
103261980  JAG1; protein jagged-1 [KO:K06052]
103250668  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
103249203  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
103260800  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
103271316  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
103272106  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
103269780  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
103251328  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
103273020  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe-like [KO:K05948] [EC:2.4.1.222]
103250676  MAML1; mastermind-like protein 1 [KO:K06061]
103259884  MAML3; mastermind-like protein 3 [KO:K06061]
103257989  RBPJ; recombining binding protein suppressor of hairless isoform X2 [KO:K06053]
103259852  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
103254216  HES1; transcription factor HES-1 [KO:K06054]
103260093  HES6; transcription cofactor HES-6 [KO:K09087]
103263466  HES7; transcription factor HES-7 [KO:K09087]
103264995  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091]
103256519  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Reference
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Related
pathway
csyr04064  NF-kappa B signaling pathway
csyr04110  Cell cycle
csyr04115  p53 signaling pathway
csyr04150  mTOR signaling pathway
csyr04151  PI3K-Akt signaling pathway
csyr04210  Apoptosis
csyr04310  Wnt signaling pathway
csyr04330  Notch signaling pathway
csyr04510  Focal adhesion
csyr04520  Adherens junction
csyr04530  Tight junction
csyr04612  Antigen processing and presentation
csyr04620  Toll-like receptor signaling pathway
csyr04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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