KEGG   PATHWAY: dord05206
Entry
dord05206                   Pathway                                
Name
MicroRNAs in cancer - Dipodomys ordii (Ord's kangaroo rat)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
Pathway map
dord05206  MicroRNAs in cancer
dord05206

Organism
Dipodomys ordii (Ord's kangaroo rat) [GN:dord]
Gene
105986227  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105992216  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105992061  Timp3; metalloproteinase inhibitor 3 [KO:K16866]
105992272  Kras; GTPase KRas isoform X1 [KO:K07827]
105992920  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105994612  Cdc25a; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
105981746  Cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
105988647  Cdc25c; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
105987335  Hmga2; high mobility group protein HMGI-C [KO:K09283]
105989065  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
105991130  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
105993146  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
105982827  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105985676  Crk; adapter molecule crk [KO:K04438]
105997164  Crkl; crk-like protein [KO:K04438]
105991595  Hdac4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
105997563  Hdac5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
105981351  Foxp1; forkhead box protein P1 isoform X1 [KO:K23582]
105995733  Pim1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
106002925  LOW QUALITY PROTEIN: serine/threonine-protein kinase pim-1-like [KO:K04702] [EC:2.7.11.1]
105988408  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105983697  Dnmt3a; DNA (cytosine-5)-methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
105981550  Dnmt3b; DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]
105984886  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
105992523  Bcl2l2; bcl-2-like protein 2 [KO:K02163]
106000675  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105987731  uncharacterized protein LOC105987731 [KO:K05448]
105987800  vascular endothelial growth factor A isoform X1 [KO:K05448]
105984506  Zeb1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
105984796  Tgfb2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105991826  Ezr; ezrin isoform X1 [KO:K08007]
105986688  Pdcd4; programmed cell death protein 4 isoform X1 [KO:K16865]
105991983  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
105981875  Crebbp; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
105981120  Tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
105990926  Spry2; protein sprouty homolog 2 [KO:K17383]
105987599  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
105987630  Serpinb5; serpin B5 [KO:K10139]
105980548  St14; suppressor of tumorigenicity 14 protein [KO:K08670] [EC:3.4.21.109]
105986861  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
105997410  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
106001092  Rptor; regulatory-associated protein of mTOR [KO:K07204]
105991653  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [KO:K07436] [EC:1.14.15.16]
106003227  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105989461  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105989403  Abl1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
105987920  Tp63; tumor protein 63 isoform X1 [KO:K10149]
105996098  Zeb2; zinc finger E-box-binding homeobox 2 [KO:K23560]
105991002  Fscn1; fascin [KO:K23551]
105994610  Rassf1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
105996692  Hoxd10; homeobox protein Hox-D10 [KO:K09295]
105992687  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
105981143  Bmf; bcl-2-modifying factor isoform X1 [KO:K17460]
105993174  Pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
105981538  Mmp9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
105993890  Slc7a1; high affinity cationic amino acid transporter 1 [KO:K13863]
105994980  Ccng1; cyclin-G1 [KO:K10145]
105992110  Hmox1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
106000271  Stmn1; stathmin [KO:K04381]
106003143  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105992358  Myc; myc proto-oncogene protein [KO:K04377]
105992928  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105998617  Hras; GTPase HRas isoform X1 [KO:K02833]
105991947  Nras; GTPase NRas [KO:K07828]
105999111  Dnmt1; DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]
105990328  Apc2; adenomatous polyposis coli protein 2 [KO:K02085]
105988701  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
105982400  Irs1; insulin receptor substrate 1 [KO:K16172]
105985370  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105986178  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105985870  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
105999080  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105999614  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106000559  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
106001473  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105996842  Hnrnpk; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
105993361  Reck; reversion-inducing cysteine-rich protein with Kazal motifs [KO:K17461]
105996367  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
105995603  Notch1; neurogenic locus notch homolog protein 1 [KO:K02599]
105987058  neurogenic locus notch homolog protein 2 [KO:K20994]
105994647  Notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
105999892  Notch4; neurogenic locus notch homolog protein 4 [KO:K20996]
105984494  polycomb complex protein BMI-1 [KO:K11459]
105982768  Mmp16; matrix metalloproteinase-16 [KO:K07996] [EC:3.4.24.-]
105980824  Atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
105988115  Cd44; CD44 antigen isoform X1 [KO:K06256]
105985008  Dicer1; endoribonuclease Dicer isoform X1 [KO:K11592] [EC:3.1.26.-]
105991571  Fzd3; frizzled-3 [KO:K02329]
105997953  Itga5; integrin alpha-5 [KO:K06484]
105980787  Rdx; radixin isoform X1 [KO:K05762]
105994567  Rhoa; transforming protein RhoA [KO:K04513]
105992685  Plau; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
105999887  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
105982804  Zfpm2; zinc finger protein ZFPM2 isoform X1 [KO:K17442]
105998521  Itgb3; integrin beta-3 [KO:K06493]
105981964  Ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
106000012  Sox4; transcription factor SOX-4 [KO:K23581]
105985114  Tnn; tenascin-N [KO:K06252]
105985189  Tnr; tenascin-R [KO:K06252]
105996131  Tnc; tenascin [KO:K06252]
105999822  Tnxb; tenascin-X [KO:K06252]
105992917  multidrug resistance protein 1-like [KO:K05658] [EC:7.6.2.2]
105992960  Abcb1; multidrug resistance protein 1 [KO:K05658] [EC:7.6.2.2]
105981853  Abcc1; multidrug resistance-associated protein 1 [KO:K05665] [EC:7.6.2.3]
105997512  Brca1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
105995758  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105984789  Efna1; ephrin-A1 [KO:K05462]
105984800  Efna3; ephrin-A3 isoform X1 [KO:K05462]
105984831  Efna4; ephrin-A4 [KO:K05462]
105990326  Efna2; ephrin-A2 [KO:K05462]
105988668  Efna5; ephrin-A5 isoform X1 [KO:K05462]
105981135  Thbs1; thrombospondin-1 [KO:K16857]
106001827  Igf2bp1; insulin-like growth factor 2 mRNA-binding protein 1 [KO:K17391]
105994843  Trim71; E3 ubiquitin-protein ligase TRIM71 [KO:K12035] [EC:2.3.2.27]
105991225  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
105991714  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105989626  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105981830  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105997225  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106003156  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105981822  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105994311  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
106003155  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
105991261  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
105983461  Rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
105983546  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105990389  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
105986364  Mdm4; protein Mdm4 [KO:K10127]
105980318  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
105981663  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
105982979  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105981244  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
105981136  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105990471  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105986795  Sos1; son of sevenless homolog 1 [KO:K03099]
105982575  Sos2; son of sevenless homolog 2 [KO:K03099]
105984949  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
105990925  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105980977  Shc4; SHC-transforming protein 4 [KO:K17449]
105992028  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
105992616  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105988993  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
105981580  E2f1; transcription factor E2F1 [KO:K17454]
105997893  E2f2; transcription factor E2F2 [KO:K09389]
105988277  Bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
105985161  Bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
105988767  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
105998184  Hdac2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
105989599  Ezh2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
105990572  Gls2; glutaminase liver isoform, mitochondrial [KO:K01425] [EC:3.5.1.2]
105994187  Gls; glutaminase kidney isoform, mitochondrial [KO:K01425] [EC:3.5.1.2]
105986341  Sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
105985164  Wnt3a; protein Wnt-3a [KO:K00312]
105998530  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
105989137  Cdca5; sororin [KO:K17390]
105982477  Kif23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
105984641  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
105986806  Prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
105986555  Slc45a3; solute carrier family 45 member 3 [KO:K15379]
105984427  Vim; vimentin [KO:K07606]
Reference
PMID:18817506
  Authors
Lee YS, Dutta A
  Title
MicroRNAs in cancer.
  Journal
Annu Rev Pathol 4:199-227 (2009)
DOI:10.1146/annurev.pathol.4.110807.092222
Reference
PMID:21402473
  Authors
Babashah S, Soleimani M
  Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
  Journal
Eur J Cancer 47:1127-37 (2011)
DOI:10.1016/j.ejca.2011.02.008
Reference
PMID:19630570
  Authors
Garzon R, Calin GA, Croce CM
  Title
MicroRNAs in Cancer.
  Journal
Annu Rev Med 60:167-79 (2009)
DOI:10.1146/annurev.med.59.053006.104707
Reference
PMID:23075324
  Authors
Chen PS, Su JL, Hung MC
  Title
Dysregulation of microRNAs in cancer.
  Journal
J Biomed Sci 19:90 (2012)
DOI:10.1186/1423-0127-19-90
Reference
PMID:22035854
  Authors
Ling H, Zhang W, Calin GA
  Title
Principles of microRNA involvement in human cancers.
  Journal
Chin J Cancer 30:739-48 (2011)
DOI:10.5732/cjc.011.10243
Reference
PMID:22351564
  Authors
Iorio MV, Croce CM
  Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
  Journal
EMBO Mol Med 4:143-59 (2012)
DOI:10.1002/emmm.201100209
Reference
PMID:21742789
  Authors
Sayed D, Abdellatif M
  Title
MicroRNAs in development and disease.
  Journal
Physiol Rev 91:827-87 (2011)
DOI:10.1152/physrev.00006.2010
Reference
PMID:22345301
  Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
  Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
  Journal
Exp Biol Med (Maywood) 237:227-35 (2012)
DOI:10.1258/ebm.2011.011192
Reference
PMID:22580099
  Authors
Song JH, Meltzer SJ
  Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
  Journal
Gastroenterology 143:35-47.e2 (2012)
DOI:10.1053/j.gastro.2012.05.003
Reference
PMID:23462054
  Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
  Title
MiRNA s in oesophageal squamous cancer.
  Journal
Neth J Med 71:69-75 (2013)
Reference
PMID:19773200
  Authors
Kan T, Meltzer SJ
  Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
  Journal
Curr Opin Pharmacol 9:727-32 (2009)
DOI:10.1016/j.coph.2009.08.009
Reference
PMID:20128019
  Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
  Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
  Journal
World J Gastroenterol 16:531-7 (2010)
DOI:10.3748/wjg.v16.i5.531
Reference
PMID:23165235
  Authors
Song S, Ajani JA
  Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
  Journal
Nat Rev Gastroenterol Hepatol 10:109-18 (2013)
DOI:10.1038/nrgastro.2012.210
Reference
PMID:21565290
  Authors
Liu WH, Yeh SH, Chen PJ
  Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
  Journal
Biochim Biophys Acta 1809:678-85 (2011)
DOI:10.1016/j.bbagrm.2011.04.008
Reference
PMID:23091478
  Authors
Hrasovec S, Glavac D
  Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
  Journal
Front Genet 3:180 (2012)
DOI:10.3389/fgene.2012.00180
Reference
PMID:22926415
  Authors
Liu H
  Title
MicroRNAs in breast cancer initiation and progression.
  Journal
Cell Mol Life Sci 69:3587-99 (2012)
DOI:10.1007/s00018-012-1128-9
Reference
PMID:20345848
  Authors
Li SD, Zhang JR, Wang YQ, Wan XP
  Title
The role of microRNAs in ovarian cancer initiation and progression.
  Journal
J Cell Mol Med 14:2240-9 (2010)
DOI:10.1111/j.1582-4934.2010.01058.x
Reference
PMID:23316212
  Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
  Title
Characteristic patterns of microRNA expression in human bladder cancer.
  Journal
Front Genet 3:310 (2012)
DOI:10.3389/fgene.2012.00310
Reference
PMID:20221895
  Authors
Saini S, Majid S, Dahiya R
  Title
Diet, microRNAs and prostate cancer.
  Journal
Pharm Res 27:1014-26 (2010)
DOI:10.1007/s11095-010-0086-x
Related
pathway
dord05210  Colorectal cancer
dord05214  Glioma
dord05215  Prostate cancer
dord05219  Bladder cancer
dord05222  Small cell lung cancer
dord05223  Non-small cell lung cancer
KO pathway
ko05206   
LinkDB

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