KEGG   PATHWAY: dsp04921
Entry
dsp04921                    Pathway                                
Name
Oxytocin signaling pathway - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation.
Class
Organismal Systems; Endocrine system
Pathway map
dsp04921  Oxytocin signaling pathway
dsp04921

Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122094950  Cacng4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
122094956  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
122094975  Cacng1; voltage-dependent calcium channel gamma-1 subunit isoform X1 [KO:K04866]
122095011  Hras; GTPase HRas isoform X1 [KO:K02833]
122095118  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122095552  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
122095572  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
122095683  Rhoa; transforming protein RhoA [KO:K04513]
122095844  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122096287  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122096621  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122096833  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122096857  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
122097395  Ryr1; ryanodine receptor 1 isoform X1 [KO:K04961]
122097750  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122097862  Gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
122097873  Gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
122097950  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
122098491  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
122098568  Camkk2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
122098679  Kcnj2; inward rectifier potassium channel 2 [KO:K04996]
122098776  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
122098786  Elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
122098841  Kras; GTPase KRas isoform X1 [KO:K07827]
122099051  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
122099290  Eef2; elongation factor 2 [KO:K03234]
122099331  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122099409  Actg1; actin, cytoplasmic 2 [KO:K05692]
122099882  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
122100994  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
122101316  Trpm2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
122102546  [KO:K04861]
122103406  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
122103495  Kcnj12; ATP-sensitive inward rectifier potassium channel 12 [KO:K05005]
122103511  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
122103768  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
122103830  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
122103834  Rgs2; regulator of G-protein signaling 2 [KO:K18154]
122104097  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
122104229  Kcnj5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
122104238  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
122104508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122104536  Calm2; calmodulin-2 [KO:K02183]
122104673  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
122105124  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
122105366  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
122105896  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
122105913  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
122106258  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
122106330  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
122106361  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
122107430  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
122107826  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122108012  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
122108121  Camk1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
122108123  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
122108136  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122108167  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
122108197  Oxtr; oxytocin receptor [KO:K04229]
122108406  [KO:K12751]
122108431  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
122108760  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
122108943  Jun; transcription factor AP-1 [KO:K04448]
122109161  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
122109507  Camk1g; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
122109525  Kcnj9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
122109556  Npr1; LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
122110513  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
122110569  [KO:K04867]
122110671  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
122110693  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
122110697  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
122110699  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
122110725  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
122110819  Kcnj3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
122110846  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
122110931  [KO:K18154]
122111380  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
122111510  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
122111799  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
122111882  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
122111901  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
122112209  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122112891  [KO:K12319] [EC:4.6.1.2]
122113053  Camk1d; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
122113099  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
122113232  Ryr2; ryanodine receptor 2 [KO:K04962]
122113235  Calml3; calmodulin-like protein 3 [KO:K02183]
122113280  Calml5; calmodulin-like protein 5 [KO:K02183]
122113375  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
122113453  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
122113601  Actb; actin, cytoplasmic 1 [KO:K05692]
122114274  Rcan1; calcipressin-1 isoform X1 [KO:K17901]
122114287  Kcnj6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
122114391  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122114401  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122114409  Ryr3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
122114427  Pla2g4e; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
122114429  Pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
122114577  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
122114610  [KO:K16342] [EC:3.1.1.4]
122114616  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
122115017  [KO:K04513]
122116145  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122116183  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
122116185  Eef2k; eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
122116328  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
122116510  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122116547  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122116928  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
122117295  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
122118075  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
122118130  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
122118367  Nras; GTPase NRas [KO:K07828]
122118832  Calm1; calmodulin-1 [KO:K02183]
122118881  Fos; proto-oncogene c-Fos [KO:K04379]
122119152  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
122119158  Kcnj4; inward rectifier potassium channel 4 [KO:K04998]
122119286  Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
122119361  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122119798  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
122120285  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
122120299  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122120360  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
122120381  Oxt; oxytocin-neurophysin 1 [KO:K05243]
122120488  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
122120489  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
122120491  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
122120987  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
122121425  Nppa; natriuretic peptides A [KO:K12334]
122122409  Npr2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
122122432  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
122122500  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
122122799  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
122122996  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
122123175  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
122123783  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
122124059  [KO:K02183]
122124093  Myl6b; myosin light chain 6B [KO:K12751]
122124094  Myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
122124417  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
122124516  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
122124612  [KO:K04632]
122124614  [KO:K04632]
122124633  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
122125337  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122125680  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
122125740  Calm3; calmodulin-3 [KO:K02183]
122125876  Kcnj14; ATP-sensitive inward rectifier potassium channel 14 [KO:K05007]
122126216  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122126705  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
122126861  [KO:K02183]
122127053  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
122128054  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
122128067  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
122128350  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C13050  Cyclic ADP-ribose
Reference
PMID:18655881
  Authors
Devost D, Wrzal P, Zingg HH
  Title
Oxytocin receptor signalling.
  Journal
Prog Brain Res 170:167-76 (2008)
DOI:10.1016/S0079-6123(08)00415-9
Reference
PMID:20626426
  Authors
Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G
  Title
REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.
  Journal
CNS Neurosci Ther 16:e138-56 (2010)
DOI:10.1111/j.1755-5949.2010.00185.x
Reference
PMID:21981277
  Authors
Gutkowska J, Jankowski M
  Title
Oxytocin revisited: its role in cardiovascular regulation.
  Journal
J Neuroendocrinol 24:599-608 (2012)
DOI:10.1111/j.1365-2826.2011.02235.x
Reference
PMID:22190926
  Authors
Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z
  Title
The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.
  Journal
Int J Endocrinol 2011:350546 (2011)
DOI:10.1155/2011/350546
Reference
PMID:19840865
  Authors
Tom N, Assinder SJ
  Title
Oxytocin in health and disease.
  Journal
Int J Biochem Cell Biol 42:202-5 (2010)
DOI:10.1016/j.biocel.2009.10.008
Reference
PMID:9575824
  Authors
Strakova Z, Copland JA, Lolait SJ, Soloff MS
  Title
ERK2 mediates oxytocin-stimulated PGE2 synthesis.
  Journal
Am J Physiol 274:E634-41 (1998)
DOI:10.1152/ajpendo.1998.274.4.E634
Reference
PMID:12009385
  Authors
Slater DM, Zervou S, Thornton S
  Title
Prostaglandins and prostanoid receptors in human pregnancy and parturition.
  Journal
J Soc Gynecol Investig 9:118-24 (2002)
Reference
PMID:16787565
  Authors
Shmygol A, Gullam J, Blanks A, Thornton S
  Title
Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility.
  Journal
Acta Pharmacol Sin 27:827-32 (2006)
DOI:10.1111/j.1745-7254.2006.00393.x
Reference
PMID:11861513
  Authors
Tahara M, Morishige K, Sawada K, Ikebuchi Y, Kawagishi R, Tasaka K, Murata Y
  Title
RhoA/Rho-kinase cascade is involved in oxytocin-induced rat uterine contraction.
  Journal
Endocrinology 143:920-9 (2002)
DOI:10.1210/endo.143.3.8696
Reference
PMID:12433531
  Authors
Slattery MM, Morrison JJ
  Title
Preterm delivery.
  Journal
Lancet 360:1489-97 (2002)
DOI:10.1016/S0140-6736(02)11476-0
Reference
PMID:22902539
  Authors
Pont JN, McArdle CA, Lopez Bernal A
  Title
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
  Journal
Mol Endocrinol 26:1743-56 (2012)
DOI:10.1210/me.2012-1057
Reference
PMID:9326674
  Authors
Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg HH, McCann SM
  Title
Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart.
  Journal
Proc Natl Acad Sci U S A 94:11704-9 (1997)
DOI:10.1073/pnas.94.21.11704
Reference
PMID:14715914
  Authors
Antunes-Rodrigues J, de Castro M, Elias LL, Valenca MM, McCann SM
  Title
Neuroendocrine control of body fluid metabolism.
  Journal
Physiol Rev 84:169-208 (2004)
DOI:10.1152/physrev.00017.2003
Reference
PMID:18555543
  Authors
Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH
  Title
Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.
  Journal
Regul Pept 151:71-4 (2008)
DOI:10.1016/j.regpep.2008.05.001
Reference
PMID:9219843
  Authors
Cassoni P, Sapino A, Fortunati N, Munaron L, Chini B, Bussolati G
  Title
Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A.
  Journal
Int J Cancer 72:340-4 (1997)
DOI:10.1002/(SICI)1097-0215(19970717)72:2<340::AID-IJC23>3.0.CO;2-I
Reference
PMID:23356278
  Authors
Busnelli M, Peverelli E, Mantovani G, Spada A, Chini B
  Title
Deciphering the specific role of G(alphai/o) isoforms: functional selective oxytocin ligands and somatostatin SST5 receptor mutants.
  Journal
Biochem Soc Trans 41:166-71 (2013)
DOI:10.1042/BST20120306
Reference
PMID:16966388
  Authors
Reversi A, Rimoldi V, Brambillasca S, Chini B
  Title
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
  Journal
Am J Physiol Regul Integr Comp Physiol 291:R861-9 (2006)
DOI:10.1152/ajpregu.00333.2006
Reference
PMID:20141572
  Authors
Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H
  Title
CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour.
  Journal
J Neuroendocrinol 22:380-92 (2010)
DOI:10.1111/j.1365-2826.2010.01970.x
Reference
PMID:22227279
  Authors
Higashida H, Yokoyama S, Kikuchi M, Munesue T
  Title
CD38 and its role in oxytocin secretion and social behavior.
  Journal
Horm Behav 61:351-8 (2012)
DOI:10.1016/j.yhbeh.2011.12.011
Reference
PMID:23335873
  Authors
Lopatina O, Inzhutova A, Salmina AB, Higashida H
  Title
The roles of oxytocin and CD38 in social or parental behaviors.
  Journal
Front Neurosci 6:182 (2012)
DOI:10.3389/fnins.2012.00182
Reference
PMID:16156781
  Authors
Guse AH
  Title
Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).
  Journal
FEBS J 272:4590-7 (2005)
DOI:10.1111/j.1742-4658.2005.04863.x
Related
pathway
dsp00590  Arachidonic acid metabolism
dsp04010  MAPK signaling pathway
dsp04020  Calcium signaling pathway
dsp04110  Cell cycle
KO pathway
ko04921   

DBGET integrated database retrieval system