Entry
Name
Oxytocin signaling pathway - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
Ortholog table
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:
dsp ]
Gene
122095118 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
122117295 Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454 ]
122101316 Trpm2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977 ] [EC:3.6.1.13 ]
122103495 Kcnj12; ATP-sensitive inward rectifier potassium channel 12 [KO:K05005 ]
122125876 Kcnj14; ATP-sensitive inward rectifier potassium channel 14 [KO:K05007 ]
122120299 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
122114401 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
122108123 Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
122098776 Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
122126705 Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
122103511 Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
122113099 Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863 ]
122106361 Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864 ]
122110846 Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865 ]
122111799 Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858 ]
122095552 Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859 ]
122108012 Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860 ]
122102546 voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861 ]
122094975 Cacng1; voltage-dependent calcium channel gamma-1 subunit isoform X1 [KO:K04866 ]
122110569 voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867 ]
122119286 Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867 ]
122116183 Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
122094950 Cacng4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869 ]
122094956 Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870 ]
122110699 Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871 ]
122110697 Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872 ]
122110693 Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873 ]
122108136 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
122111510 Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
122127053 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
122096621 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
122116547 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
122097750 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
122124633 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
122126216 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
122113453 Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
122099051 Prkab1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199 ]
122108167 Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199 ]
122105896 Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200 ]
122106330 Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200 ]
122107430 Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200 ]
122123175 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
122116510 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
122118130 Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
122098491 Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
122124417 Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270 ]
122109161 Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329 ]
122110725 Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457 ]
122124612 guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632 ]
122095572 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
122111882 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
122105366 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
122116328 Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
122111901 Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289 ] [EC:2.7.1.153 ]
122119152 Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290 ]
122120285 Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290 ]
122110819 Kcnj3; G protein-activated inward rectifier potassium channel 1 [KO:K04997 ]
122114287 Kcnj6; G protein-activated inward rectifier potassium channel 2 [KO:K05000 ]
122109525 Kcnj9; G protein-activated inward rectifier potassium channel 3 [KO:K05002 ]
122104229 Kcnj5; G protein-activated inward rectifier potassium channel 4 [KO:K04999 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Devost D, Wrzal P, Zingg HH
Title
Oxytocin receptor signalling.
Journal
Reference
Authors
Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G
Title
REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.
Journal
Reference
Authors
Gutkowska J, Jankowski M
Title
Oxytocin revisited: its role in cardiovascular regulation.
Journal
Reference
Authors
Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z
Title
The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.
Journal
Reference
Authors
Tom N, Assinder SJ
Title
Oxytocin in health and disease.
Journal
Reference
Authors
Strakova Z, Copland JA, Lolait SJ, Soloff MS
Title
ERK2 mediates oxytocin-stimulated PGE2 synthesis.
Journal
Reference
Authors
Slater DM, Zervou S, Thornton S
Title
Prostaglandins and prostanoid receptors in human pregnancy and parturition.
Journal
J Soc Gynecol Investig 9:118-24 (2002)
Reference
Authors
Shmygol A, Gullam J, Blanks A, Thornton S
Title
Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility.
Journal
Reference
Authors
Tahara M, Morishige K, Sawada K, Ikebuchi Y, Kawagishi R, Tasaka K, Murata Y
Title
RhoA/Rho-kinase cascade is involved in oxytocin-induced rat uterine contraction.
Journal
Reference
Authors
Slattery MM, Morrison JJ
Title
Preterm delivery.
Journal
Reference
Authors
Pont JN, McArdle CA, Lopez Bernal A
Title
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
Journal
Reference
Authors
Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg HH, McCann SM
Title
Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart.
Journal
Reference
Authors
Antunes-Rodrigues J, de Castro M, Elias LL, Valenca MM, McCann SM
Title
Neuroendocrine control of body fluid metabolism.
Journal
Reference
Authors
Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH
Title
Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.
Journal
Reference
Authors
Cassoni P, Sapino A, Fortunati N, Munaron L, Chini B, Bussolati G
Title
Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A.
Journal
Reference
Authors
Busnelli M, Peverelli E, Mantovani G, Spada A, Chini B
Title
Deciphering the specific role of G(alphai/o) isoforms: functional selective oxytocin ligands and somatostatin SST5 receptor mutants.
Journal
Reference
Authors
Reversi A, Rimoldi V, Brambillasca S, Chini B
Title
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
Journal
Reference
Authors
Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H
Title
CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour.
Journal
Reference
Authors
Higashida H, Yokoyama S, Kikuchi M, Munesue T
Title
CD38 and its role in oxytocin secretion and social behavior.
Journal
Reference
Authors
Lopatina O, Inzhutova A, Salmina AB, Higashida H
Title
The roles of oxytocin and CD38 in social or parental behaviors.
Journal
Reference
Authors
Guse AH
Title
Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).
Journal
Related pathway
KO pathway
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