KEGG   PATHWAY: ecb04145
Entry
ecb04145                    Pathway                                
Name
Phagosome - Equus caballus (horse)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
ecb04145  Phagosome
ecb04145

Other DBs
GO: 0045335
Organism
Equus caballus (horse) [GN:ecb]
Gene
100630321  VAMP3; vesicle-associated membrane protein 3 isoform X1 [KO:K13505]
100056769  STX12; syntaxin-12 [KO:K13813]
100073104  STX7; syntaxin-7 isoform X2 [KO:K08488]
100050139  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100033878  ACTB; actin, cytoplasmic 1 [KO:K05692]
100064170  CORO1A; coronin-1A [KO:K13882]
100056340  STX18; syntaxin-18 isoform X1 [KO:K08492]
100059997  vesicle-trafficking protein SEC22b [KO:K08517]
100034212  MHCB3; MHC class I heavy chain precursor [KO:K06751]
100056062  MHC class I antigen 9.2 precursor [KO:K06751]
100034210  EQMHCB2; MHC class I heavy chain precursor [KO:K06751]
100054114  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100051657  7-51 putative nonclassical MHC class I antigen precursor [KO:K06751]
100057920  HLA class I histocompatibility antigen, Cw-12 alpha chain isoform X2 [KO:K06751]
100050550  EQMCE1; MHC class I antigen 3.7 precursor [KO:K06751]
100056182  HLA class I histocompatibility antigen, B-40 alpha chain isoform X1 [KO:K06751]
100056391  MHCX1; MHC class I antigen 3.5 precursor [KO:K06751]
100034211  EQMHCC1; MHC class I heavy chain precursor [KO:K06751]
100049798  class I histocompatibility antigen, Gogo-OKO alpha chain isoform X12 [KO:K06751]
100050473  class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751]
100050706  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
100053918  HLA class I histocompatibility antigen, B-46 alpha chain isoform X2 [KO:K06751]
100054397  saoe class I histocompatibility antigen, A alpha chain [KO:K06751]
100054448  HLA class I histocompatibility antigen, alpha chain G isoform X3 [KO:K06751]
100056309  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
100056099  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100056231  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100059994  HLA class I histocompatibility antigen, B-15 alpha chain isoform X1 [KO:K06751]
100060096  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
100061035  HLA class II histocompatibility antigen, DM alpha chain-like precursor [KO:K06752]
100060770  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
100052249  DQA; MHC class II DQ-alpha precursor [KO:K06752]
100052310  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100052364  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100051944  DRA; MHC class II DR alpha chain precursor [KO:K06752]
100052184  DQB; MHC class II DQ-beta chain precursor [KO:K06752]
100061127  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100060996  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
100052006  DRB; MHC class II DR-beta chain precursor [KO:K06752]
100052125  DQA; MHC class II DQ-alpha chain precursor [KO:K06752]
100060531  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
100052063  DQA; MHC class II DQ-alpha chain [KO:K06752]
100060320  DQB; MHC class II DQ-beta chain precursor [KO:K06752]
111767457  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
100060697  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
100051997  RAB5A; ras-related protein Rab-5A [KO:K07887]
100059099  RAB5B; ras-related protein Rab-5B [KO:K07888]
100053004  RAB5C; ras-related protein Rab-5C [KO:K07889]
100064347  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
100053039  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
100034089  TFRC; transferrin receptor protein 1 [KO:K06503]
100055613  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
100061223  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100055525  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100050282  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100057005  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X5 [KO:K02148]
100056307  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
111767396  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
100052659  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100053341  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
100049854  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
102148469  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100051640  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
100064677  V-type proton ATPase subunit G 3-like [KO:K02152]
100051132  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
102150189  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
100069785  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
100629184  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
100052802  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X4 [KO:K02154]
100146660  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
100064797  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
100061140  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100049996  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
100053316  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
100054947  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100065783  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100146553  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
100630677  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
100050015  RAB7A; ras-related protein Rab-7a [KO:K07897]
100050772  RAB7B; ras-related protein Rab-7b isoform X3 [KO:K07898]
100060052  RILP; rab-interacting lysosomal protein isoform X3 [KO:K13883]
100058101  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
100061459  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
100052139  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
100053015  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X5 [KO:K10415]
100065490  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
100056767  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
100059285  tubulin alpha-1D chain [KO:K07374]
100051840  TUBA1A; tubulin alpha-1A chain [KO:K07374]
100051901  tubulin alpha-1C chain [KO:K07374]
100052388  tubulin alpha-3 chain [KO:K07374]
100054576  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
100065732  tubulin alpha-3 chain [KO:K07374]
100059249  TUBA4A; tubulin alpha-4A chain [KO:K07374]
100146855  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
100059091  tubulin alpha-1B chain [KO:K07374]
100072403  tubulin alpha-3 chain [KO:K07374]
100050361  tubulin beta-2B chain [KO:K07375]
100056684  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100051013  TUBB; tubulin beta chain [KO:K07375]
100058421  TUBB6; tubulin beta-6 chain [KO:K07375]
100629875  TUBB2A; tubulin beta-2A chain [KO:K07375]
100059595  TUBB4B; tubulin beta-4B chain [KO:K07375]
100065776  TUBB4A; tubulin beta-4A chain [KO:K07375]
111772826  TUBB3; tubulin beta-3 chain [KO:K07375]
100061837  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X3 [KO:K06528]
100067211  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
100066445  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
100061559  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
100051079  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100070920  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
100061234  cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
100061532  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100054948  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
100069336  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
100054080  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
100630021  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
100629979  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
100060845  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100052423  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100064107  CALR; calreticulin [KO:K08057]
100062428  calreticulin [KO:K08057]
100067402  CANX; calnexin [KO:K08054]
100050205  FCAR; immunoglobulin alpha Fc receptor precursor [KO:K06513]
100059796  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
111773647  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
100051733  low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472]
100065733  low affinity immunoglobulin gamma Fc region receptor III isoform X1 [KO:K06472]
100147417  uncharacterized protein LOC100147417 isoform X1 [KO:K06472]
102150150  low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
100051526  low affinity immunoglobulin gamma Fc region receptor III-B precursor [KO:K06463]
100146643  immunoglobulin epsilon heavy chain [KO:K06856]
100060297  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
100064803  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
100056128  ITGB2; integrin beta-2 [KO:K06464]
100056049  integrin beta-2 [KO:K06464]
100060539  complement C3 [KO:K03990]
100060505  complement C3-like [KO:K03990]
100072828  COLEC11; collectin-11 isoform X2 [KO:K10066]
100060744  COLEC12; collectin-12 isoform X1 [KO:K10062]
100063271  LOW QUALITY PROTEIN: collectin-12-like [KO:K10062]
100066313  mannose-binding protein A [KO:K03991]
100034103  MBL2; mannose-binding protein C precursor [KO:K03991]
100033826  SFTPA1; pulmonary surfactant-associated protein A precursor [KO:K10067]
100066341  SFTPD; pulmonary surfactant-associated protein D [KO:K10068]
100068706  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100063367  ITGA2; integrin alpha-2 [KO:K06481]
100064655  ITGA5; integrin alpha-5 [KO:K06484]
100055024  ITGB1; integrin beta-1 precursor [KO:K05719]
100009709  ITGB3; integrin beta-3 precursor [KO:K06493]
100070376  ITGB5; integrin beta-5 [KO:K06588]
100057478  THBS1; thrombospondin-1 precursor [KO:K16857]
100063449  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
100073261  THBS4; thrombospondin-4 [KO:K04659]
100050044  THBS2; thrombospondin-2 precursor [KO:K04659]
100033911  COMP; cartilage oligomeric matrix protein precursor [KO:K04659]
100009701  TLR2; toll-like receptor 2 precursor [KO:K10159]
100064554  TLR6; toll-like receptor 6 [KO:K10169]
100066890  TLR4; toll-like receptor 4 precursor [KO:K10160]
111771935  toll-like receptor 4 [KO:K10160]
100630219  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
111772122  monocyte differentiation antigen CD14-like [KO:K04391]
111767791  monocyte differentiation antigen CD14-like [KO:K04391]
100068247  MRC1; macrophage mannose receptor 1 [KO:K06560]
100064998  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
100060317  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
100066738  CD209 antigen-like protein E [KO:K06563]
100629660  CD209; CD209 antigen isoform X1 [KO:K06563]
100053863  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
100053116  MSR1; macrophage scavenger receptor types I and II [KO:K06558]
100052243  MARCO; macrophage receptor MARCO [KO:K13884]
100062370  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
100061529  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
100049847  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
100049843  CYBA; cytochrome b-245 light chain isoform X1 [KO:K08009]
100050132  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100146522  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100051787  NCF2; neutrophil cytosol factor 2 [KO:K08010]
100069566  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
ecb04142  Lysosome
ecb04144  Endocytosis
ecb04610  Complement and coagulation cascades
ecb04612  Antigen processing and presentation
ecb04620  Toll-like receptor signaling pathway
ecb04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

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