KEGG   PATHWAY: etf04014
Entry
etf04014                    Pathway                                
Name
Ras signaling pathway - Echinops telfairi (small Madagascar hedgehog)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
etf04014  Ras signaling pathway
etf04014

Other DBs
GO: 0032318
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101645300  EGF; pro-epidermal growth factor [KO:K04357]
101659761  TGFA; protransforming growth factor alpha [KO:K08774]
101654974  FGF1; fibroblast growth factor 1 [KO:K18496]
101640090  FGF2; fibroblast growth factor 2 [KO:K18497]
101657384  FGF6; fibroblast growth factor 6 [KO:K04358]
101655892  FGF7; fibroblast growth factor 7 [KO:K04358]
101645725  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101658407  FGF3; fibroblast growth factor 3 [KO:K04358]
101654224  FGF20; fibroblast growth factor 20 [KO:K04358]
101659774  FGF18; fibroblast growth factor 18 [KO:K04358]
101641057  FGF9; fibroblast growth factor 9 [KO:K04358]
101645168  FGF16; fibroblast growth factor 16 [KO:K04358]
101649614  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101656763  FGF22; fibroblast growth factor 22 [KO:K04358]
101644233  FGF8; fibroblast growth factor 8 [KO:K04358]
101657770  FGF19; fibroblast growth factor 19 [KO:K22603]
101645758  FGF21; fibroblast growth factor 21 [KO:K22429]
101659280  FGF23; fibroblast growth factor 23 [KO:K22428]
101658298  NGF; beta-nerve growth factor [KO:K02582]
101643198  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101649580  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
101647770  NTF4; neurotrophin-4 [KO:K12457]
101641705  INS; insulin [KO:K04526]
101644114  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101657076  IGF2; insulin-like growth factor II [KO:K13769]
101657212  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101642424  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101647643  PDGFC; platelet-derived growth factor C [KO:K05450]
101654830  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101657479  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
101644116  KITLG; kit ligand isoform X1 [KO:K05461]
101655782  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
101655464  VEGFA; vascular endothelial growth factor A [KO:K05448]
101650383  VEGFB; vascular endothelial growth factor B [KO:K16858]
101654245  PGF; placenta growth factor [KO:K16859]
101664676  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101649959  VEGFC; vascular endothelial growth factor C [KO:K05449]
101659919  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101640418  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101645535  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
101648310  ANGPT4; angiopoietin-4 [KO:K05467]
101641001  EFNA5; ephrin-A5 [KO:K05462]
123520870  EFNA4; ephrin-A4 [KO:K05462]
101660733  EFNA1; ephrin-A1 [KO:K05462]
101660415  EFNA3; ephrin-A3 [KO:K05462]
101652848  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101650479  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101658234  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
101644525  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101644075  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101662350  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101647167  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101654367  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101657077  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101643319  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101663213  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101650381  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101650070  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101663524  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
101654556  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101653928  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101648303  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101643189  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101651069  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101658503  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
101657615  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101660259  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101653483  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
101647958  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
101638643  SHC1; SHC-transforming protein 1 [KO:K06279]
101644867  SHC2; SHC-transforming protein 2 [KO:K17447]
101644193  SHC3; SHC-transforming protein 3 [KO:K17448]
101654517  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
101642693  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101649001  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101646109  SOS2; son of sevenless homolog 2 [KO:K03099]
101651012  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101644253  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101655797  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
101660297  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
101664472  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
101646752  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
101641301  tyrosine-protein kinase ZAP-70 isoform X1 [KO:K07360] [EC:2.7.10.2]
101638667  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
101650965  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101648866  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101664254  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101642783  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101663735  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
115868702  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
115871448  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101643112  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
115871023  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115872076  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115869664  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
101661086  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115869972  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115873712  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
101659312  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115868780  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115869401  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115873058  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
115870368  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
115868657  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8-like [KO:K04544]
115871976  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101646564  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
115869515  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
115870155  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115872073  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101653350  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101646247  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
115872861  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101649991  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101645802  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101655627  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101644988  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
101650392  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
101648867  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101644422  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
115871000  calmodulin-A-like [KO:K02183]
101651650  neo-calmodulin-like [KO:K02183]
101662569  CALML6; calmodulin-like protein 6 [KO:K02183]
101656820  CALM3; calmodulin-3 [KO:K02183]
101638094  calmodulin-alpha-like [KO:K02183]
101650375  CALML3; calmodulin-like protein 3 [KO:K02183]
101662916  CALML5; calmodulin-like protein 5 [KO:K02183]
101654870  CALM1; calmodulin-1 [KO:K02183]
101649322  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101643468  CALM2; calmodulin-2 [KO:K02183]
101663997  HRAS; GTPase HRas isoform X1 [KO:K02833]
101639926  KRAS; GTPase KRas isoform X3 [KO:K07827]
101649328  GTPase NRas-like [KO:K07828]
101653520  NRAS; GTPase NRas [KO:K07828]
101655065  MRAS; ras-related protein M-Ras [KO:K07831]
101657858  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101661008  NF1; neurofibromin [KO:K08052]
101638369  RASA1; LOW QUALITY PROTEIN: ras GTPase-activating protein 1 [KO:K04352]
101649748  RASA2; ras GTPase-activating protein 2 isoform X2 [KO:K08053]
101649919  RASA3; ras GTPase-activating protein 3 [KO:K12380]
101643817  RASA4B; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
101654843  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X2 [KO:K17631]
101644272  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
101642776  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
101661369  RASAL3; RAS protein activator like-3 [KO:K17634]
101663982  RASSF1; ras association domain-containing protein 1 [KO:K09850]
101649790  RASSF5; ras association domain-containing protein 5 [KO:K08015]
101651219  STK4; serine/threonine-protein kinase 4 [KO:K04411]
101647656  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101644576  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101656762  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101660384  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101645746  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101655687  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101657127  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
101640920  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101646840  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101658717  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101662299  RHOA; transforming protein RhoA [KO:K04513]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101657368  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101648136  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101649582  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101657011  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101662652  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101663870  RELA; transcription factor p65 [KO:K04735]
101658729  BAD; bcl2-associated agonist of cell death [KO:K02158]
101644838  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101659262  bcl-2-like protein 1 [KO:K04570]
101657904  FOXO4; forkhead box protein O4 isoform X2 [KO:K12358]
101646524  RALGAPA2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
101656550  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X9 [KO:K25768]
101642507  RALGAPB; ral GTPase-activating protein subunit beta isoform X6 [KO:K25769]
101654227  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
101658995  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X2 [KO:K17635]
101643962  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X2 [KO:K17636]
101657728  RALA; ras-related protein Ral-A [KO:K07834]
101652430  RALB; ras-related protein Ral-B [KO:K07835]
105978518  LOW QUALITY PROTEIN: ras-related protein Ral-B-like [KO:K07835]
101646573  PLD1; phospholipase D1 isoform X2 [KO:K01115] [EC:3.1.4.4]
101662946  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101662594  EXOC2; exocyst complex component 2 [KO:K17637]
101649686  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101645232  REL; proto-oncogene c-Rel [KO:K09254]
101654493  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101653598  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101645489  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101640315  RALBP1; ralA-binding protein 1 [KO:K08773]
101644037  cell division control protein 42 homolog [KO:K04393]
101647533  CDC42; cell division control protein 42 homolog [KO:K04393]
101651254  AFDN; afadin isoform X1 [KO:K05702]
101644011  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
101656360  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101650474  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101643986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101648971  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101661786  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101659806  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101654316  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101643393  PLA2G12A; group XIIA secretory phospholipase A2 isoform X6 [KO:K01047] [EC:3.1.1.4]
101647317  PLA2G2F; group IIF secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101650543  group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101647629  group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101647942  phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
101653471  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101639298  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101644594  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101645229  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101653474  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101643951  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101638035  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
101645350  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101647149  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101661568  ETS1; protein C-ets-1 isoform X2 [KO:K02678]
101656630  ETS2; protein C-ets-2 [KO:K21932]
101663005  BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
101657723  KSR1; kinase suppressor of Ras 1 isoform X6 [KO:K14958]
101654946  KSR2; LOW QUALITY PROTEIN: kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
101661777  RAP1A; ras-related protein Rap-1A [KO:K04353]
101659498  RAP1B; ras-related protein Rap-1b [KO:K07836]
101664314  ras-related protein Rap-1b-like [KO:K07836]
101641765  ras-related protein Rap-1b [KO:K07836]
101659910  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
101638289  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101657103  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101651846  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101641778  RIN1; ras and Rab interactor 1 [KO:K17638]
101659985  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
101639968  ABL2; tyrosine-protein kinase ABL2 isoform X2 [KO:K08887] [EC:2.7.10.2]
101652923  ras-related protein Rab-5A-like [KO:K07887]
101652509  RAB5A; ras-related protein Rab-5A [KO:K07887]
101643370  RAB5B; ras-related protein Rab-5B [KO:K07888]
101655554  RAB5C; ras-related protein Rab-5C [KO:K07889]
101645468  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
etf04010  MAPK signaling pathway
etf04015  Rap1 signaling pathway
etf04020  Calcium signaling pathway
etf04144  Endocytosis
etf04151  PI3K-Akt signaling pathway
etf04660  T cell receptor signaling pathway
etf04720  Long-term potentiation
etf04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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