KEGG   PATHWAY: fpg05132
Entry
fpg05132                    Pathway                                
Name
Salmonella infection - Falco peregrinus (peregrine falcon)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
fpg05132  Salmonella infection
fpg05132

Organism
Falco peregrinus (peregrine falcon) [GN:fpg]
Gene
101919462  PODXL; podocalyxin like [KO:K06817]
101920198  PTPRC; protein tyrosine phosphatase, receptor type C [KO:K06478] [EC:3.1.3.48]
101922651  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
101910524  RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
101918606  RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
101923473  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101917086  RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
101912193  RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
101911931  PLEKHM1; pleckstrin homology and RUN domain containing M1 [KO:K23282]
101921404  VPS11; VPS11, CORVET/HOPS core subunit [KO:K20179]
101924005  VPS16; VPS16, CORVET/HOPS core subunit [KO:K20180]
101924380  VPS18; VPS18, CORVET/HOPS core subunit [KO:K20181]
101911337  VPS33A; VPS33A, CORVET/HOPS core subunit [KO:K20182]
101914596  VPS39; VPS39, HOPS complex subunit [KO:K20183]
101918034  VPS41; VPS41, HOPS complex subunit [KO:K20184]
101919556  RILP; Rab interacting lysosomal protein [KO:K13883]
101911012  DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
101914146  DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
101922455  DYNC1I1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415]
101923534  DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
101912253  DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416]
101922100  DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
101918914  DYNC2LI1; dynein cytoplasmic 2 light intermediate chain 1 [KO:K10417]
101914441  DYNLL2; dynein light chain LC8-type 2 [KO:K10418]
101920228  dynein light chain 1, cytoplasmic [KO:K10418]
101920411  dynein light chain 1, cytoplasmic-like [KO:K10418]
101917484  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
101915301  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
101920290  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
101924352  DCTN1; dynactin subunit 1 [KO:K04648]
101919926  DCTN4; dynactin subunit 4 [KO:K10426]
101921253  DCTN5; dynactin subunit 5 [KO:K10427]
101921359  DCTN6; dynactin subunit 6 [KO:K10428]
101924285  ACTR1A; ARP1 actin-related protein 1 homolog A, centractin alpha [KO:K16575]
101921095  ACTR10; actin-related protein 10 homolog [KO:K16576]
101915456  tubulin alpha-8 chain [KO:K07374]
101923111  tubulin alpha-3 chain-like [KO:K07374]
101914680  tubulin alpha-4 chain-like [KO:K07374]
101914857  tubulin alpha-4 chain [KO:K07374]
106112377  tubulin alpha chain [KO:K07374]
101916357  tubulin alpha-1A chain [KO:K07374]
101923113  tubulin alpha-5 chain-like [KO:K07374]
101922942  tubulin alpha-5 chain [KO:K07374]
101924094  TUBA1C; tubulin alpha-3 chain [KO:K07374]
101915369  TUBB4B; tubulin beta 4B class IVb [KO:K07375]
101919929  tubulin beta-7 chain [KO:K07375]
101918064  TUBB1; tubulin beta 1 class VI [KO:K07375]
101913765  TUBB3; tubulin beta 3 class III [KO:K07375]
101914645  TUBB6; tubulin beta 6 class V [KO:K07375]
101912752  tubulin beta-2 chain-like [KO:K07375]
101912926  tubulin beta-2 chain [KO:K07375]
101923782  FYCO1; FYVE and coiled-coil domain containing 1 [KO:K21954]
101918941  ADP-ribosylation factor-like protein 8A [KO:K07955]
101915105  ARL8A; ADP ribosylation factor like GTPase 8A [KO:K07955]
101916777  ARL8B; ADP ribosylation factor like GTPase 8B [KO:K07955]
101921853  PLEKHM2; pleckstrin homology and RUN domain containing M2 [KO:K15348]
101917218  KIF5B; kinesin family member 5B [KO:K10396]
101920315  KIF5C; kinesin family member 5C [KO:K10396]
101920564  KLC1; kinesin light chain 1 [KO:K10407]
101918307  KLC4; kinesin light chain 4 [KO:K10407]
101918578  ACBD3; acyl-CoA binding domain containing 3 [KO:K23935]
101911200  RHOA; ras homolog family member A [KO:K04513]
101912794  M6PR; mannose-6-phosphate receptor, cation dependent [KO:K10089]
101921308  RAB9A; RAB9A, member RAS oncogene family [KO:K07899]
101911865  RAB9B; RAB9B, member RAS oncogene family [KO:K07900]
101910611  GCC2; GRIP and coiled-coil domain containing 2 [KO:K20282]
101912552  PFN2; profilin 2 [KO:K05759]
101922030  PFN4; profilin family member 4 [KO:K05759]
101921354  PFN3; profilin 3 [KO:K05759]
101911542  EXOC7; exocyst complex component 7 [KO:K07195]
101910662  EXOC5; exocyst complex component 5 [KO:K19984]
101914394  EXOC4; exocyst complex component 4 [KO:K06111]
106112470  exocyst complex component 4 [KO:K06111]
101913947  EXOC2; exocyst complex component 2 [KO:K17637]
101917513  RALA; RAS like proto-oncogene A [KO:K07834]
101924846  actin, cytoplasmic type 5 [KO:K05692]
101912716  ACTB; actin beta [KO:K05692]
101919774  ACTG1; actin gamma 1 [KO:K05692]
101914307  S100A10; S100 calcium binding protein A10 [KO:K17274]
101921751  ANXA2; annexin A2 [KO:K17092]
101922004  AHNAK2; protein AHNAK2 [KO:K23934]
101921437  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
101924297  RHOJ; ras homolog family member J [KO:K07864]
101913063  ARHGEF26; Rho guanine nucleotide exchange factor 26 [KO:K13744]
101915606  RHOG; ras homolog family member G [KO:K07863]
101924225  rho-related GTP-binding protein RhoG-like [KO:K07863]
101918304  engulfment and cell motility protein 1 [KO:K12366]
106112785  ELMO1; engulfment and cell motility 1 [KO:K12366]
101913104  ELMO2; engulfment and cell motility 2 [KO:K18985]
101916990  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101916533  MYL2; myosin light chain 2 [KO:K10351]
101911603  myosin regulatory light polypeptide 9 [KO:K12755]
101923421  MYL10; myosin light chain 10 [KO:K12756]
101921847  MYL12B; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
101922135  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
101920572  FHOD1; formin homology 2 domain containing 1 [KO:K23938]
101914879  CDC42; cell division cycle 42 [KO:K04393]
101921306  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
101924535  NCKAP1; NCK associated protein 1 [KO:K05750]
101922062  NCKAP1L; NCK associated protein 1 like [KO:K05750]
101920742  CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
101923862  CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
101918551  ABI1; abl interactor 1 [KO:K23649]
101912273  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
101924043  WASF3; WAS protein family member 3 [KO:K06083]
101913819  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
101923086  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
101916999  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
101913406  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
101913234  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
101923881  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
101913433  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
101916633  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
101913874  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
101923101  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
101915790  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
101921863  MYO6; myosin VI [KO:K10358]
101923805  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
101919202  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
101911441  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
101910831  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
101914006  PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
101915094  PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
101911413  CYTH2; GTP exchange factor for ARFs 1 [KO:K18441]
101916069  CYTH4; cytohesin 4 [KO:K18441]
101917606  CYTH1; cytohesin 1 [KO:K18441]
101921481  CYTH3; cytohesin 3 [KO:K18441]
101911142  ARF6; ADP ribosylation factor 6 [KO:K07941]
101924756  ARF1; ADP ribosylation factor 1 [KO:K07937]
101911934  SNX33; sorting nexin 33 [KO:K17923]
101915416  SNX18; sorting nexin 18 [KO:K17923]
101915819  SNX9; sorting nexin 9 [KO:K17923]
101918244  WASL; Wiskott-Aldrich syndrome like [KO:K23612]
101912266  DNM2; dynamin 2 [KO:K23484] [EC:3.6.5.5]
101914363  toll-like receptor 6 [KO:K10169]
101923386  TLR2; toll like receptor 2 [KO:K10159]
101923563  toll-like receptor 2 type-1 [KO:K10159]
101910723  TIRAP; TIR domain containing adaptor protein [KO:K05403]
101922907  MYD88; myeloid differentiation primary response 88 [KO:K04729]
101922930  TLR4; toll like receptor 4 [KO:K10160]
101914202  LY96; lymphocyte antigen 96 [KO:K05400]
101916146  TLR5; toll like receptor 5 [KO:K10168]
101914647  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101912003  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
101917746  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
101921035  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
101920039  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
101921953  TAB3; TGF-beta activated kinase 1/MAP3K7 binding protein 3 [KO:K12793]
101922064  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101923842  NFKBIA; NFKB inhibitor alpha [KO:K04734]
101920008  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
101912704  NOD1; nucleotide binding oligomerization domain containing 1 [KO:K08727]
101913777  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
101916896  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
101923175  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
101916675  RIPK2; receptor interacting serine/threonine kinase 2 [KO:K08846] [EC:2.7.11.1]
101922525  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
101922181  CSE1L; chromosome segregation 1 like [KO:K18423]
101920708  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
101911878  KPNA3; karyopherin subunit alpha 3 [KO:K23583]
101912187  KPNA4; karyopherin subunit alpha 4 [KO:K23583]
101914959  RPS3; ribosomal protein S3 [KO:K02985]
101916982  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
101911761  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
101924998  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101924296  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101914611  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101919170  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101913671  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101922433  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101920170  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101920353  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101921635  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
101918161  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101924219  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
101917138  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
101924129  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101921076  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101921708  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
101918818  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
101924267  interleukin-1 receptor antagonist protein-like [KO:K04519]
101911163  IL6; interleukin 6 [KO:K05405]
101918584  interleukin-8-like [KO:K10030]
101911124  interleukin-8 [KO:K10030]
101918932  growth-regulated alpha protein-like [KO:K10030]
101921588  CTNNB1; catenin beta 1 [KO:K02105]
101919678  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
101922879  TCF7L1; transcription factor 7 like 1 [KO:K04490]
101911463  TCF7L2; transcription factor 7 like 2 [KO:K04491]
101917929  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
101923426  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
101923993  FBXO22; F-box protein 22 [KO:K10302]
101911889  SKP1; S-phase kinase associated protein 1 [KO:K03094]
101917376  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
101911961  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
101921498  TRADD; TNFRSF1A associated via death domain [KO:K03171]
101924079  BIRC2; baculoviral IAP repeat containing 2 [KO:K16060]
101913441  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
101917630  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
101922846  TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
101919474  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
101918701  FADD; Fas associated via death domain [KO:K02373]
106113022  CASP8 and FADD-like apoptosis regulator [KO:K04398] [EC:3.4.22.61]
101916968  CASP8; caspase-3 [KO:K04398] [EC:3.4.22.61]
101920283  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
101924229  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
101923643  cytochrome c [KO:K08738]
101921728  BCL2; BCL2, apoptosis regulator [KO:K02161]
101913355  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
101911113  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
101922533  caspase-3-like [KO:K04397] [EC:3.4.22.60]
101923562  RHOB; ras homolog family member B [KO:K07856]
101912125  RHOH; ras homolog family member H [KO:K07873]
101910975  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
101918846  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
101918868  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
101919582  MLKL; mixed lineage kinase domain like pseudokinase [KO:K08849] [EC:2.7.11.1]
101912196  TXN2; thioredoxin 2 [KO:K03671]
101921003  TXN; thioredoxin [KO:K03671]
101918175  NLRP6; NLR family pyrin domain containing 6 [KO:K12800]
101914004  caspase-1-like [KO:K01370] [EC:3.4.22.36]
101910930  IL18; interleukin 18 [KO:K05482]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
fpg04010  MAPK signaling pathway
fpg04210  Apoptosis
fpg04217  Necroptosis
fpg04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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